Conservation of cofitness between BWI76_RS04665 and BWI76_RS04680 in Klebsiella michiganensis M5al

68 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS04665 3-isopropylmalate dehydratase small subunit 1.0 BWI76_RS04680 2-isopropylmalate synthase 0.98 1
Enterobacter sp. TBS_079 0.93 MPMX20_00766 3-isopropylmalate dehydratase small subunit 1 0.95 MPMX20_00769 2-isopropylmalate synthase 0.96 3
Enterobacter asburiae PDN3 0.92 EX28DRAFT_3667 3-isopropylmalate dehydratase, small subunit 0.96 EX28DRAFT_3670 2-isopropylmalate synthase (EC 2.3.3.13) 0.84 8
Escherichia coli ECOR27 0.88 NOLOHH_03075 leuD 3-isopropylmalate dehydratase small subunit 0.95 NOLOHH_03060 2-isopropylmalate synthase 0.90 27
Escherichia coli BW25113 0.88 b0071 leuD isopropylmalate isomerase small subunit (NCBI) 0.95 b0074 leuA 2-isopropylmalate synthase (NCBI) 0.98 3
Escherichia coli BL21 0.88 ECD_00073 3-isopropylmalate dehydratase small subunit 0.95 ECD_00076 2-isopropylmalate synthase 0.92 8
Escherichia coli ECRC62 0.88 BNILDI_08535 leuD 3-isopropylmalate dehydratase small subunit 0.95 BNILDI_08550 2-isopropylmalate synthase 0.96 5
Escherichia coli HS(pFamp)R (ATCC 700891) 0.88 OHPLBJKB_03586 3-isopropylmalate dehydratase small subunit 0.95 OHPLBJKB_03583 2-isopropylmalate synthase low > 73
Escherichia coli ECOR38 0.88 HEPCGN_08710 leuD 3-isopropylmalate dehydratase small subunit 0.95 HEPCGN_08695 2-isopropylmalate synthase 0.92 14
Escherichia fergusonii Becca 0.88 EFB2_03974 3-isopropylmalate dehydratase small subunit 0.94 EFB2_03971 2-isopropylmalate synthase low > 86
Escherichia coli Nissle 1917 0.88 ECOLIN_RS00385 3-isopropylmalate dehydratase small subunit 0.95 ECOLIN_RS00400 2-isopropylmalate synthase 0.89 9
Escherichia coli ECRC100 0.87 OKFHMN_10730 leuD 3-isopropylmalate dehydratase small subunit 0.94 OKFHMN_10715 2-isopropylmalate synthase 0.96 7
Escherichia coli ECRC102 0.87 NIAGMN_08580 leuD 3-isopropylmalate dehydratase small subunit 0.94 NIAGMN_08565 2-isopropylmalate synthase — —
Escherichia coli ECRC101 0.87 MCAODC_01245 leuD 3-isopropylmalate dehydratase small subunit 0.94 MCAODC_01230 2-isopropylmalate synthase 0.97 5
Escherichia coli ECRC98 0.87 JDDGAC_14325 leuD 3-isopropylmalate dehydratase small subunit 0.94 JDDGAC_14310 2-isopropylmalate synthase 0.98 2
Escherichia coli ECRC99 0.87 KEDOAH_17425 leuD 3-isopropylmalate dehydratase small subunit 0.94 KEDOAH_17440 2-isopropylmalate synthase — —
Serratia liquefaciens MT49 0.84 IAI46_03340 3-isopropylmalate dehydratase small subunit 0.85 IAI46_03355 2-isopropylmalate synthase low > 86
Rahnella sp. WP5 0.84 EX31_RS03695 3-isopropylmalate dehydratase small subunit 0.82 EX31_RS03680 2-isopropylmalate synthase 0.94 38
Pectobacterium carotovorum WPP14 0.84 HER17_RS03070 3-isopropylmalate dehydratase small subunit 0.87 HER17_RS03085 2-isopropylmalate synthase 0.98 3
Dickeya dadantii 3937 0.84 DDA3937_RS18130 3-isopropylmalate dehydratase small subunit 0.86 DDA3937_RS18115 2-isopropylmalate synthase 0.94 3
Dickeya dianthicola ME23 0.84 DZA65_RS19215 3-isopropylmalate dehydratase small subunit 0.86 DZA65_RS19200 2-isopropylmalate synthase 0.94 3
Dickeya dianthicola 67-19 0.83 HGI48_RS18070 3-isopropylmalate dehydratase small subunit 0.86 HGI48_RS18055 2-isopropylmalate synthase 0.88 1
Pantoea sp. MT58 0.83 IAI47_16015 3-isopropylmalate dehydratase small subunit 0.83 IAI47_16000 2-isopropylmalate synthase 0.97 6
Erwinia tracheiphila SCR3 0.74 LU632_RS02865 leuD 3-isopropylmalate dehydratase small subunit 0.85 LU632_RS02880 leuA 2-isopropylmalate synthase 0.93 3
Vibrio cholerae E7946 ATCC 55056 0.73 CSW01_12610 3-isopropylmalate dehydratase small subunit 0.68 CSW01_12595 2-isopropylmalate synthase 0.67 42
Pseudomonas stutzeri RCH2 0.63 Psest_2590 3-isopropylmalate dehydratase, small subunit 0.46 Psest_1056 2-isopropylmalate synthase, bacterial type low > 67
Shewanella loihica PV-4 0.63 Shew_3469 isopropylmalate isomerase small subunit (RefSeq) 0.66 Shew_3472 2-isopropylmalate synthase (RefSeq) 0.98 5
Alteromonas macleodii MIT1002 0.62 MIT1002_00946 3-isopropylmalate dehydratase small subunit 1 0.62 MIT1002_00949 2-isopropylmalate synthase 0.97 9
Xanthomonas campestris pv. campestris strain 8004 0.61 Xcc-8004.1050.1 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.38 Xcc-8004.1056.1 2-isopropylmalate synthase (EC 2.3.3.13) 0.86 11
Shewanella amazonensis SB2B 0.60 Sama_0338 leuD isopropylmalate isomerase small subunit (RefSeq) 0.66 Sama_0335 2-isopropylmalate synthase (RefSeq) 0.97 7
Variovorax sp. SCN45 0.60 GFF3889 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.40 GFF1165 2-isopropylmalate synthase (EC 2.3.3.13) low > 127
Shewanella oneidensis MR-1 0.60 SO4233 leuD 3-isopropylmalate dehydratase, small subunit (NCBI ptt file) 0.66 SO4236 leuA 2-isopropylmalate synthase (NCBI ptt file) 0.99 1
Ralstonia sp. UNC404CL21Col 0.60 ABZR87_RS14535 3-isopropylmalate dehydratase small subunit 0.41 ABZR87_RS14930 2-isopropylmalate synthase low > 80
Cupriavidus basilensis FW507-4G11 0.59 RR42_RS14390 3-isopropylmalate dehydratase 0.40 RR42_RS05465 2-isopropylmalate synthase 0.35 109
Ralstonia solanacearum GMI1000 0.59 RS_RS09995 3-isopropylmalate dehydratase small subunit 0.41 RS_RS10395 2-isopropylmalate synthase — —
Ralstonia solanacearum PSI07 0.59 RPSI07_RS14700 3-isopropylmalate dehydratase small subunit 0.41 RPSI07_RS14285 2-isopropylmalate synthase — —
Shewanella sp. ANA-3 0.59 Shewana3_3758 leuD isopropylmalate isomerase small subunit (RefSeq) 0.66 Shewana3_3761 2-isopropylmalate synthase (RefSeq) 0.98 2
Paraburkholderia bryophila 376MFSha3.1 0.59 H281DRAFT_06073 3-isopropylmalate dehydratase, small subunit 0.42 H281DRAFT_04556 2-isopropylmalate synthase low > 103
Paraburkholderia sabiae LMG 24235 0.58 QEN71_RS17615 3-isopropylmalate dehydratase small subunit 0.41 QEN71_RS24195 2-isopropylmalate synthase low > 153
Variovorax sp. OAS795 0.58 ABID97_RS08460 3-isopropylmalate dehydratase small subunit 0.40 ABID97_RS14910 2-isopropylmalate synthase — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.58 GFF3361 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.40 GFF4281 2-isopropylmalate synthase (EC 2.3.3.13) 0.58 59
Ralstonia solanacearum IBSBF1503 0.58 RALBFv3_RS02615 3-isopropylmalate dehydratase small subunit 0.41 RALBFv3_RS03025 2-isopropylmalate synthase low > 76
Burkholderia phytofirmans PsJN 0.58 BPHYT_RS33905 3-isopropylmalate dehydratase small subunit 0.41 BPHYT_RS06570 2-isopropylmalate synthase low > 109
Ralstonia solanacearum UW163 0.58 UW163_RS11110 3-isopropylmalate dehydratase small subunit 0.41 UW163_RS10700 2-isopropylmalate synthase — —
Paraburkholderia graminis OAS925 0.57 ABIE53_004803 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit 0.42 ABIE53_001580 2-isopropylmalate synthase low > 113
Acidovorax sp. GW101-3H11 0.57 Ac3H11_1527 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.40 Ac3H11_530 2-isopropylmalate synthase (EC 2.3.3.13) low > 79
Dechlorosoma suillum PS 0.56 Dsui_3199 3-isopropylmalate dehydratase, small subunit 0.46 Dsui_3519 2-isopropylmalate synthase, bacterial type — —
Marinobacter adhaerens HP15 0.55 HP15_1833 isopropylmalate isomerase small subunit 0.45 HP15_538 2-isopropylmalate synthase low > 73
Magnetospirillum magneticum AMB-1 0.51 AMB_RS20565 3-isopropylmalate dehydratase small subunit 0.41 AMB_RS17765 2-isopropylmalate synthase — —
Dinoroseobacter shibae DFL-12 0.51 Dshi_0083 3-isopropylmalate dehydratase, small subunit (RefSeq) 0.38 Dshi_0596 2-isopropylmalate synthase (RefSeq) 0.78 1
Rhodopseudomonas palustris CGA009 0.51 TX73_001215 3-isopropylmalate dehydratase small subunit 0.41 TX73_010545 2-isopropylmalate synthase — —
Phaeobacter inhibens DSM 17395 0.49 PGA1_c29790 3-isopropylmalate dehydratase small subunit 0.39 PGA1_c26470 2-isopropylmalate synthase LeuA 0.93 3
Sinorhizobium meliloti 1021 0.49 SMc03795 isopropylmalate isomerase small subunit 0.15 SMc02546 alpha-isopropylmalate/homocitrate synthase family transferase low > 103
Rhizobium sp. OAE497 0.48 ABIE40_RS19040 3-isopropylmalate dehydratase small subunit 0.14 ABIE40_RS06220 citramalate synthase low > 107
Bosea sp. OAE506 0.47 ABIE41_RS11640 3-isopropylmalate dehydratase small subunit 0.41 ABIE41_RS13000 2-isopropylmalate synthase — —
Rhodanobacter denitrificans MT42 0.45 LRK55_RS07100 3-isopropylmalate dehydratase small subunit 0.40 LRK55_RS09985 2-isopropylmalate synthase low > 63
Rhodanobacter denitrificans FW104-10B01 0.45 LRK54_RS07370 3-isopropylmalate dehydratase small subunit 0.40 LRK54_RS10345 2-isopropylmalate synthase low > 59
Bacteroides stercoris CC31F 0.43 HMPREF1181_RS14140 3-isopropylmalate dehydratase small subunit 0.42 HMPREF1181_RS14150 2-isopropylmalate synthase 0.94 3
Caulobacter crescentus NA1000 0.42 CCNA_00195 3-isopropylmalate dehydratase small subunit 0.40 CCNA_01610 2-isopropylmalate synthase low > 66
Lysobacter sp. OAE881 0.42 ABIE51_RS17580 3-isopropylmalate dehydratase small subunit 0.39 ABIE51_RS17570 2-isopropylmalate synthase 0.84 52
Phocaeicola dorei CL03T12C01 0.42 ABI39_RS10205 3-isopropylmalate dehydratase small subunit 0.43 ABI39_RS10195 2-isopropylmalate synthase 0.83 10
Caulobacter crescentus NA1000 Δfur 0.42 CCNA_00195 3-isopropylmalate dehydratase small subunit 0.40 CCNA_01610 2-isopropylmalate synthase low > 67
Phocaeicola vulgatus CL09T03C04 0.42 HMPREF1058_RS14555 3-isopropylmalate dehydratase small subunit 0.43 HMPREF1058_RS14545 2-isopropylmalate synthase 0.75 31
Parabacteroides merdae CL09T00C40 0.42 HMPREF1078_RS16655 3-isopropylmalate dehydratase small subunit 0.43 HMPREF1078_RS16665 2-isopropylmalate synthase 0.88 9
Rhodanobacter sp. FW510-T8 0.40 OKGIIK_13590 leuD 3-isopropylmalate dehydratase small subunit 0.39 OKGIIK_13575 leuA 2-isopropylmalate synthase low > 52
Dyella japonica UNC79MFTsu3.2 0.40 ABZR86_RS15955 3-isopropylmalate dehydratase small subunit 0.42 ABZR86_RS15970 2-isopropylmalate synthase 0.94 13
Bacteroides ovatus ATCC 8483 0.39 BACOVA_04602 3-isopropylmalate dehydratase, small subunit 0.42 BACOVA_04604 2-isopropylmalate synthase 0.95 11
Bacteroides thetaiotaomicron VPI-5482 0.39 BT1859 3-isopropylmalate dehydratase small subunit (NCBI ptt file) 0.42 BT1861 2-isopropylmalate synthase (EC 2.3.3.13) (from data) 0.83 23
Synechococcus elongatus PCC 7942 0.27 Synpcc7942_2548 leuD isopropylmalate isomerase small subunit 0.40 Synpcc7942_1410 leuA 2-isopropylmalate synthase — —

Not shown: 30 genomes with orthologs for BWI76_RS04665 only; 4 genomes with orthologs for BWI76_RS04680 only