Conservation of cofitness between OKFHMN_10730 and OKFHMN_14325 in Escherichia coli ECRC100

65 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli ECRC100 1.0 OKFHMN_10730 leuD 3-isopropylmalate dehydratase small subunit 1.0 OKFHMN_14325 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.95 12
Escherichia coli ECRC98 1.00 JDDGAC_14325 leuD 3-isopropylmalate dehydratase small subunit 1.00 JDDGAC_17950 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase low > 86
Escherichia coli ECRC101 1.00 MCAODC_01245 leuD 3-isopropylmalate dehydratase small subunit 1.00 MCAODC_04830 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.92 26
Escherichia coli ECRC102 1.00 NIAGMN_08580 leuD 3-isopropylmalate dehydratase small subunit 1.00 NIAGMN_12080 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase — —
Escherichia coli ECRC99 1.00 KEDOAH_17425 leuD 3-isopropylmalate dehydratase small subunit 1.00 KEDOAH_13825 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase — —
Escherichia coli BL21 0.99 ECD_00073 3-isopropylmalate dehydratase small subunit 0.99 ECD_03708 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 0.95 3
Escherichia coli ECRC62 0.99 BNILDI_08535 leuD 3-isopropylmalate dehydratase small subunit 0.99 BNILDI_05075 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.96 13
Escherichia coli BW25113 0.99 b0071 leuD isopropylmalate isomerase small subunit (NCBI) 1.00 b3829 metE 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) low > 76
Escherichia coli ECOR27 0.99 NOLOHH_03075 leuD 3-isopropylmalate dehydratase small subunit 0.99 NOLOHH_06455 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.82 63
Escherichia coli ECOR38 0.99 HEPCGN_08710 leuD 3-isopropylmalate dehydratase small subunit 0.99 HEPCGN_13025 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.88 41
Escherichia fergusonii Becca 0.99 EFB2_03974 3-isopropylmalate dehydratase small subunit 0.99 EFB2_04808 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase low > 86
Escherichia coli Nissle 1917 0.99 ECOLIN_RS00385 3-isopropylmalate dehydratase small subunit 0.99 ECOLIN_RS21980 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.92 2
Escherichia coli HS(pFamp)R (ATCC 700891) 0.98 OHPLBJKB_03586 3-isopropylmalate dehydratase small subunit 0.99 OHPLBJKB_04222 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase low > 73
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.92 GFF167 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.94 GFF254 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) low > 78
Enterobacter sp. TBS_079 0.89 MPMX20_00766 3-isopropylmalate dehydratase small subunit 1 0.94 MPMX20_04451 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase low > 85
Enterobacter asburiae PDN3 0.89 EX28DRAFT_3667 3-isopropylmalate dehydratase, small subunit 0.95 EX28DRAFT_4494 methionine synthase (B12-independent) (EC 2.1.1.14) 0.71 37
Klebsiella michiganensis M5al 0.87 BWI76_RS04665 3-isopropylmalate dehydratase small subunit 0.94 BWI76_RS01280 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 92
Dickeya dadantii 3937 0.83 DDA3937_RS18130 3-isopropylmalate dehydratase small subunit 0.85 DDA3937_RS20380 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 74
Rahnella sp. WP5 0.83 EX31_RS03695 3-isopropylmalate dehydratase small subunit 0.83 EX31_RS14710 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 89
Dickeya dianthicola ME23 0.82 DZA65_RS19215 3-isopropylmalate dehydratase small subunit 0.85 DZA65_RS00875 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 75
Dickeya dianthicola 67-19 0.82 HGI48_RS18070 3-isopropylmalate dehydratase small subunit 0.85 HGI48_RS00820 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 71
Pectobacterium carotovorum WPP14 0.80 HER17_RS03070 3-isopropylmalate dehydratase small subunit 0.86 HER17_RS20685 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 75
Serratia liquefaciens MT49 0.80 IAI46_03340 3-isopropylmalate dehydratase small subunit 0.84 IAI46_01035 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 86
Pantoea sp. MT58 0.79 IAI47_16015 3-isopropylmalate dehydratase small subunit 0.83 IAI47_18310 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 76
Erwinia tracheiphila SCR3 0.72 LU632_RS02865 leuD 3-isopropylmalate dehydratase small subunit 0.84 LU632_RS24030 metE 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 74
Vibrio cholerae E7946 ATCC 55056 0.72 CSW01_12610 3-isopropylmalate dehydratase small subunit 0.59 CSW01_08575 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase low > 62
Pseudomonas fluorescens GW456-L13 0.64 PfGW456L13_3947 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.59 PfGW456L13_3767 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) low > 87
Pseudomonas fluorescens FW300-N2E3 0.64 AO353_20625 3-isopropylmalate dehydratase 0.61 AO353_16215 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase low > 101
Pseudomonas sp. RS175 0.63 PFR28_02823 3-isopropylmalate dehydratase small subunit 1 0.61 PFR28_03477 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase low > 88
Pseudomonas fluorescens FW300-N2E2 0.63 Pf6N2E2_64 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.62 Pf6N2E2_5472 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) low > 103
Pseudomonas fluorescens FW300-N1B4 0.63 Pf1N1B4_14 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.62 Pf1N1B4_783 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) — —
Pseudomonas fluorescens SBW25 0.63 PFLU_RS20575 3-isopropylmalate dehydratase small subunit 0.59 PFLU_RS17405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 109
Pseudomonas fluorescens SBW25-INTG 0.63 PFLU_RS20575 3-isopropylmalate dehydratase small subunit 0.59 PFLU_RS17405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 109
Pseudomonas fluorescens FW300-N2C3 0.62 AO356_21405 3-isopropylmalate dehydratase 0.61 AO356_17740 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase low > 104
Pseudomonas sp. S08-1 0.62 OH686_04475 3-isopropylmalate dehydratase small subunit 0.58 OH686_20470 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 80
Pseudomonas stutzeri RCH2 0.61 Psest_2590 3-isopropylmalate dehydratase, small subunit 0.60 Psest_1452 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase low > 67
Shewanella loihica PV-4 0.61 Shew_3469 isopropylmalate isomerase small subunit (RefSeq) 0.55 Shew_2986 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (RefSeq) low > 60
Ralstonia solanacearum PSI07 0.58 RPSI07_RS14700 3-isopropylmalate dehydratase small subunit 0.55 RPSI07_RS02545 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase — —
Shewanella sp. ANA-3 0.58 Shewana3_3758 leuD isopropylmalate isomerase small subunit (RefSeq) 0.55 Shewana3_3469 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) low > 73
Variovorax sp. SCN45 0.58 GFF3889 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.55 GFF795 5-methyltetrahydropteroyltriglutamate--homocystei ne methyltransferase (EC 2.1.1.14) low > 127
Shewanella oneidensis MR-1 0.58 SO4233 leuD 3-isopropylmalate dehydratase, small subunit (NCBI ptt file) 0.54 SO0818 metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (NCBI ptt file) 0.96 23
Burkholderia phytofirmans PsJN 0.58 BPHYT_RS33905 3-isopropylmalate dehydratase small subunit 0.53 BPHYT_RS26655 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase low > 109
Shewanella amazonensis SB2B 0.58 Sama_0338 leuD isopropylmalate isomerase small subunit (RefSeq) 0.53 Sama_2627 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.98 4
Ralstonia solanacearum GMI1000 0.57 RS_RS09995 3-isopropylmalate dehydratase small subunit 0.55 RS_RS20360 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase — —
Paraburkholderia sabiae LMG 24235 0.57 QEN71_RS17615 3-isopropylmalate dehydratase small subunit 0.57 QEN71_RS19725 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.61 70
Ralstonia sp. UNC404CL21Col 0.57 ABZR87_RS14535 3-isopropylmalate dehydratase small subunit 0.55 ABZR87_RS20880 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 80
Cupriavidus basilensis FW507-4G11 0.57 RR42_RS14390 3-isopropylmalate dehydratase 0.53 RR42_RS30660 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.79 16
Ralstonia solanacearum UW163 0.57 UW163_RS11110 3-isopropylmalate dehydratase small subunit 0.55 UW163_RS18855 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase — —
Ralstonia solanacearum IBSBF1503 0.57 RALBFv3_RS02615 3-isopropylmalate dehydratase small subunit 0.55 RALBFv3_RS20320 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 76
Variovorax sp. OAS795 0.56 ABID97_RS08460 3-isopropylmalate dehydratase small subunit 0.52 ABID97_RS19395 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase — —
Acidovorax sp. GW101-3H11 0.56 Ac3H11_1527 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.55 Ac3H11_2345 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.91 9
Marinobacter adhaerens HP15 0.54 HP15_1833 isopropylmalate isomerase small subunit 0.54 HP15_457 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 0.59 54
Castellaniella sp019104865 MT123 0.53 ABCV34_RS04285 3-isopropylmalate dehydratase small subunit 0.59 ABCV34_RS04445 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 48
Rhodopseudomonas palustris CGA009 0.49 TX73_001215 3-isopropylmalate dehydratase small subunit 0.52 TX73_012380 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase — —
Rhodospirillum rubrum S1H 0.48 Rru_A1190 3-isopropylmalate dehydratase small subunit region (NCBI) 0.48 Rru_A1718 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (NCBI) low > 58
Azospirillum brasilense Sp245 0.47 AZOBR_RS14135 isopropylmalate isomerase 0.56 AZOBR_RS24275 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase low > 97
Rhodanobacter denitrificans MT42 0.45 LRK55_RS07100 3-isopropylmalate dehydratase small subunit 0.49 LRK55_RS11870 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 63
Rhodanobacter denitrificans FW104-10B01 0.45 LRK54_RS07370 3-isopropylmalate dehydratase small subunit 0.49 LRK54_RS12135 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 59
Pedobacter sp. GW460-11-11-14-LB5 0.42 CA265_RS15840 3-isopropylmalate dehydratase small subunit 0.53 CA265_RS21095 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 88
Mucilaginibacter yixingensis YX-36 DSM 26809 0.42 ABZR88_RS11600 3-isopropylmalate dehydratase small subunit 0.53 ABZR88_RS18615 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase — —
Caulobacter crescentus NA1000 Δfur 0.41 CCNA_00195 3-isopropylmalate dehydratase small subunit 0.52 CCNA_00515 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase low > 67
Caulobacter crescentus NA1000 0.41 CCNA_00195 3-isopropylmalate dehydratase small subunit 0.52 CCNA_00515 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.97 3
Bifidobacterium breve UCC2003 0.41 BBR_RS19625 3-isopropylmalate dehydratase small subunit 0.42 BBR_RS15405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 34
Dyella japonica UNC79MFTsu3.2 0.39 ABZR86_RS15955 3-isopropylmalate dehydratase small subunit 0.50 ABZR86_RS03225 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase low > 74
Echinicola vietnamensis KMM 6221, DSM 17526 0.38 Echvi_2060 3-isopropylmalate dehydratase, small subunit 0.51 Echvi_2559 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase — —
Mycobacterium tuberculosis H37Rv 0.37 Rv2987c Probable 3-isopropylmalate dehydratase (small subunit) LeuD (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI) 0.44 Rv1133c Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE (methionine synthase, vitamin-B12 independent isozyme) — —

Not shown: 32 genomes with orthologs for OKFHMN_10730 only; 2 genomes with orthologs for OKFHMN_14325 only