Conservation of cofitness between ECD_03708 and ECD_00075 in Escherichia coli BL21

65 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BL21 1.0 ECD_03708 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 1.0 ECD_00075 3-isopropylmalate dehydrogenase, NAD(+)-dependent 0.99 1
Escherichia coli Nissle 1917 1.00 ECOLIN_RS21980 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.99 ECOLIN_RS00395 3-isopropylmalate dehydrogenase 0.97 9
Escherichia fergusonii Becca 1.00 EFB2_04808 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.99 EFB2_03972 3-isopropylmalate dehydrogenase low > 86
Escherichia coli BW25113 1.00 b3829 metE 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) 1.00 b0073 leuB 3-isopropylmalate dehydrogenase (VIMSS) 0.64 46
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_04222 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1.00 OHPLBJKB_03584 3-isopropylmalate dehydrogenase low > 73
Escherichia coli ECOR27 0.99 NOLOHH_06455 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 NOLOHH_03065 leuA 2-isopropylmalate synthase 0.91 20
Escherichia coli ECRC62 0.99 BNILDI_05075 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 BNILDI_08545 leuA 2-isopropylmalate synthase 0.98 13
Escherichia coli ECOR38 0.99 HEPCGN_13025 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 HEPCGN_08700 leuB 3-isopropylmalate dehydrogenase 0.97 12
Escherichia coli ECRC99 0.99 KEDOAH_13825 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 KEDOAH_17435 leuB 3-isopropylmalate dehydrogenase — —
Escherichia coli ECRC100 0.99 OKFHMN_14325 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 OKFHMN_10720 leuB 3-isopropylmalate dehydrogenase 0.97 32
Escherichia coli ECRC101 0.99 MCAODC_04830 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 MCAODC_01235 leuB 3-isopropylmalate dehydrogenase 0.94 16
Escherichia coli ECRC98 0.99 JDDGAC_17950 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 JDDGAC_14315 leuB 3-isopropylmalate dehydrogenase low > 86
Escherichia coli ECRC102 0.99 NIAGMN_12080 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 NIAGMN_08570 leuB 3-isopropylmalate dehydrogenase — —
Enterobacter asburiae PDN3 0.95 EX28DRAFT_4494 methionine synthase (B12-independent) (EC 2.1.1.14) 0.93 EX28DRAFT_3669 3-isopropylmalate dehydrogenase 0.74 26
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.94 GFF254 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.95 GFF165 3-isopropylmalate dehydrogenase (EC 1.1.1.85) 0.43 50
Klebsiella michiganensis M5al 0.94 BWI76_RS01280 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.93 BWI76_RS04675 3-isopropylmalate dehydrogenase low > 92
Enterobacter sp. TBS_079 0.94 MPMX20_04451 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.94 MPMX20_00768 3-isopropylmalate dehydrogenase 0.33 41
Pectobacterium carotovorum WPP14 0.86 HER17_RS20685 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.87 HER17_RS03080 3-isopropylmalate dehydrogenase low > 75
Dickeya dadantii 3937 0.85 DDA3937_RS20380 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.88 DDA3937_RS18120 3-isopropylmalate dehydrogenase 0.46 63
Dickeya dianthicola ME23 0.85 DZA65_RS00875 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.87 DZA65_RS19205 3-isopropylmalate dehydrogenase 0.56 9
Dickeya dianthicola 67-19 0.85 HGI48_RS00820 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.88 HGI48_RS18060 3-isopropylmalate dehydrogenase 0.76 68
Erwinia tracheiphila SCR3 0.84 LU632_RS24030 metE 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.82 LU632_RS02875 leuB 3-isopropylmalate dehydrogenase low > 74
Serratia liquefaciens MT49 0.84 IAI46_01035 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.86 IAI46_03350 3-isopropylmalate dehydrogenase 0.75 24
Rahnella sp. WP5 0.83 EX31_RS14710 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.88 EX31_RS03685 3-isopropylmalate dehydrogenase low > 89
Pantoea sp. MT58 0.83 IAI47_18310 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.83 IAI47_16005 3-isopropylmalate dehydrogenase low > 76
Pseudomonas fluorescens FW300-N2E2 0.62 Pf6N2E2_5472 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.52 Pf6N2E2_66 3-isopropylmalate dehydrogenase (EC 1.1.1.85) low > 103
Pseudomonas fluorescens FW300-N1B4 0.62 Pf1N1B4_783 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.53 Pf1N1B4_12 3-isopropylmalate dehydrogenase (EC 1.1.1.85) low > 87
Pseudomonas sp. RS175 0.61 PFR28_03477 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.52 PFR28_02821 3-isopropylmalate dehydrogenase low > 88
Pseudomonas fluorescens FW300-N2E3 0.61 AO353_16215 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.53 AO353_20635 3-isopropylmalate dehydrogenase low > 101
Pseudomonas fluorescens FW300-N2C3 0.61 AO356_17740 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.52 AO356_21415 3-isopropylmalate dehydrogenase low > 104
Pseudomonas stutzeri RCH2 0.60 Psest_1452 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase 0.50 Psest_2589 3-isopropylmalate dehydrogenase 0.42 19
Vibrio cholerae E7946 ATCC 55056 0.60 CSW01_08575 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.76 CSW01_12600 3-isopropylmalate dehydrogenase low > 62
Pseudomonas fluorescens GW456-L13 0.59 PfGW456L13_3767 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.51 PfGW456L13_3945 3-isopropylmalate dehydrogenase (EC 1.1.1.85) low > 87
Pseudomonas fluorescens SBW25 0.59 PFLU_RS17405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.53 PFLU_RS20565 3-isopropylmalate dehydrogenase low > 109
Pseudomonas fluorescens SBW25-INTG 0.59 PFLU_RS17405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.53 PFLU_RS20565 3-isopropylmalate dehydrogenase low > 109
Castellaniella sp019104865 MT123 0.59 ABCV34_RS04445 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.47 ABCV34_RS04280 3-isopropylmalate dehydrogenase low > 48
Pseudomonas sp. S08-1 0.59 OH686_20470 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.49 OH686_04470 3-isopropylmalate dehydrogenase low > 80
Paraburkholderia sabiae LMG 24235 0.57 QEN71_RS19725 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.47 QEN71_RS17620 3-isopropylmalate dehydrogenase 0.57 41
Azospirillum brasilense Sp245 0.56 AZOBR_RS24275 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 0.45 AZOBR_RS14130 3-isopropylmalate dehydrogenase low > 97
Ralstonia sp. UNC404CL21Col 0.56 ABZR87_RS20880 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.46 ABZR87_RS14530 3-isopropylmalate dehydrogenase low > 80
Ralstonia solanacearum PSI07 0.55 RPSI07_RS02545 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.46 RPSI07_RS14705 3-isopropylmalate dehydrogenase low > 81
Acidovorax sp. GW101-3H11 0.55 Ac3H11_2345 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.49 Ac3H11_1528 3-isopropylmalate dehydrogenase (EC 1.1.1.85) 0.92 12
Ralstonia solanacearum GMI1000 0.55 RS_RS20360 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.47 RS_RS09990 3-isopropylmalate dehydrogenase low > 80
Ralstonia solanacearum UW163 0.55 UW163_RS18855 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.46 UW163_RS11115 3-isopropylmalate dehydrogenase — —
Ralstonia solanacearum IBSBF1503 0.55 RALBFv3_RS20320 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.46 RALBFv3_RS02610 3-isopropylmalate dehydrogenase low > 76
Variovorax sp. SCN45 0.55 GFF795 5-methyltetrahydropteroyltriglutamate--homocystei ne methyltransferase (EC 2.1.1.14) 0.49 GFF3888 3-isopropylmalate dehydrogenase (EC 1.1.1.85) low > 127
Shewanella loihica PV-4 0.55 Shew_2986 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (RefSeq) 0.68 Shew_3471 3-isopropylmalate dehydrogenase (RefSeq) low > 60
Shewanella sp. ANA-3 0.55 Shewana3_3469 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.69 Shewana3_3760 3-isopropylmalate dehydrogenase (RefSeq) low > 73
Shewanella oneidensis MR-1 0.55 SO0818 metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (NCBI ptt file) 0.69 SO4235 leuB 3-isopropylmalate dehydrogenase (NCBI ptt file) 0.97 6
Marinobacter adhaerens HP15 0.54 HP15_457 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 0.51 HP15_1832 3-isopropylmalate dehydrogenase low > 73
Mucilaginibacter yixingensis YX-36 DSM 26809 0.53 ABZR88_RS18615 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.42 ABZR88_RS11605 3-isopropylmalate dehydrogenase — —
Pedobacter sp. GW460-11-11-14-LB5 0.53 CA265_RS21095 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.42 CA265_RS15850 3-isopropylmalate dehydrogenase low > 88
Cupriavidus basilensis FW507-4G11 0.53 RR42_RS30660 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.47 RR42_RS14385 3-isopropylmalate dehydrogenase 0.79 17
Shewanella amazonensis SB2B 0.53 Sama_2627 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.68 Sama_0336 3-isopropylmalate dehydrogenase (RefSeq) 0.98 8
Variovorax sp. OAS795 0.52 ABID97_RS19395 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.50 ABID97_RS08455 3-isopropylmalate dehydrogenase — —
Burkholderia phytofirmans PsJN 0.52 BPHYT_RS26655 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.47 BPHYT_RS33900 3-isopropylmalate dehydrogenase low > 109
Rhodopseudomonas palustris CGA009 0.52 TX73_012380 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.43 TX73_001175 3-isopropylmalate dehydrogenase — —
Caulobacter crescentus NA1000 0.52 CCNA_00515 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.42 CCNA_00193 3-isopropylmalate dehydrogenase 0.97 7
Caulobacter crescentus NA1000 Δfur 0.52 CCNA_00515 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.42 CCNA_00193 3-isopropylmalate dehydrogenase low > 67
Echinicola vietnamensis KMM 6221, DSM 17526 0.51 Echvi_2559 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase 0.43 Echvi_2062 3-isopropylmalate dehydrogenase — —
Dyella japonica UNC79MFTsu3.2 0.50 ABZR86_RS03225 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.37 ABZR86_RS15950 3-isopropylmalate dehydrogenase low > 74
Desulfovibrio vulgaris Miyazaki F 0.50 DvMF_2035 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.53 DvMF_1794 3-isopropylmalate dehydrogenase (RefSeq) low > 51
Desulfovibrio vulgaris Hildenborough JW710 0.49 DVU3371 metE 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (TIGR) 0.53 DVU2985 leuB 3-isopropylmalate dehydrogenase (TIGR) low > 55
Rhodanobacter denitrificans FW104-10B01 0.49 LRK54_RS12135 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.39 LRK54_RS10325 3-isopropylmalate dehydrogenase low > 59
Rhodanobacter denitrificans MT42 0.49 LRK55_RS11870 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.39 LRK55_RS09965 3-isopropylmalate dehydrogenase low > 63
Rhodospirillum rubrum S1H 0.48 Rru_A1718 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (NCBI) 0.41 Rru_A1191 3-isopropylmalate dehydrogenase (NCBI) low > 58

Not shown: 2 genomes with orthologs for ECD_03708 only; 33 genomes with orthologs for ECD_00075 only