| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
|---|
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_09720 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 1.0 | CSW01_05825 | | transcriptional regulator HexR | 0.78 | 17 |
| Rahnella sp. WP5 | 0.69 | EX31_RS22835 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.76 | EX31_RS10635 | | MurR/RpiR family transcriptional regulator | — | — |
| Klebsiella michiganensis M5al | 0.68 | BWI76_RS07100 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.72 | BWI76_RS18110 | | transcriptional regulator HexR | — | — |
| Serratia liquefaciens MT49 | 0.68 | IAI46_05400 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.78 | IAI46_14580 | | MurR/RpiR family transcriptional regulator | — | — |
| Klebsiella pneumoniae MKP103 | 0.68 | KDGMDA_15035 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.72 | KDGMDA_25375 | | transcriptional regulator HexR | — | — |
| Pantoea sp. MT58 | 0.68 | IAI47_14320 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.63 | IAI47_08490 | | MurR/RpiR family transcriptional regulator | — | — |
| Enterobacter asburiae PDN3 | 0.68 | EX28DRAFT_2449 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.74 | EX28DRAFT_0703 | | transcriptional regulator, RpiR family | — | — |
| Shewanella amazonensis SB2B | 0.68 | Sama_1222 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | 0.77 | Sama_1813 | | DNA-binding transcriptional regulator HexR (RefSeq) | — | — |
| Enterobacter sp. TBS_079 | 0.68 | MPMX20_01107 | | Bifunctional protein FolD protein | 0.74 | MPMX20_02758 | | HTH-type transcriptional regulator HexR | — | — |
| Escherichia coli BL21 | 0.68 | ECD_00479 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.73 | ECD_01824 | | putative DNA-binding transcriptional regulator | — | — |
| Escherichia fergusonii Becca | 0.68 | EFB2_03532 | | Bifunctional protein FolD protein | 0.73 | EFB2_02089 | | HTH-type transcriptional regulator HexR | — | — |
| Pantoea agglomerans CFBP13505 P0401 | 0.68 | PagCFBP13505_RS10890 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.61 | PagCFBP13505_RS02370 | | transcriptional regulator HexR | — | — |
| Escherichia coli ECRC98 | 0.68 | JDDGAC_11455 | | Bifunctional protein FolD | 0.73 | JDDGAC_00900 | hexR | DNA-binding transcriptional regulator HexR | — | — |
| Escherichia coli ECRC99 | 0.68 | KEDOAH_20165 | | Bifunctional protein FolD | 0.73 | KEDOAH_01780 | hexR | DNA-binding transcriptional regulator HexR | — | — |
| Escherichia coli ECOR27 | 0.68 | NOLOHH_00795 | | Bifunctional protein FolD | 0.73 | NOLOHH_16840 | hexR | DNA-binding transcriptional regulator HexR | — | — |
| Escherichia coli ECRC102 | 0.68 | NIAGMN_05860 | | Bifunctional protein FolD | 0.73 | NIAGMN_01735 | hexR | DNA-binding transcriptional regulator HexR | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.68 | OHPLBJKB_03152 | | Bifunctional protein FolD protein | 0.73 | OHPLBJKB_01875 | | HTH-type transcriptional regulator HexR | — | — |
| Escherichia coli BW25113 | 0.68 | b0529 | folD | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase (NCBI) | 0.73 | b1853 | yebK | predicted DNA-binding transcriptional regulator (NCBI) | — | — |
| Shewanella sp. ANA-3 | 0.68 | Shewana3_2663 | | methenyltetrahydrofolate cyclohydrolase (RefSeq) | 0.77 | Shewana3_2152 | | DNA-binding transcriptional regulator HexR (RefSeq) | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.68 | GFF4447 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.72 | GFF1632 | | Phosphogluconate repressor HexR, RpiR family | — | — |
| Escherichia coli ECRC101 | 0.68 | MCAODC_27025 | | Bifunctional protein FolD | 0.73 | MCAODC_19080 | hexR | DNA-binding transcriptional regulator HexR | — | — |
| Escherichia coli Nissle 1917 | 0.68 | ECOLIN_RS03065 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.73 | ECOLIN_RS10325 | | DNA-binding transcriptional regulator HexR | — | — |
| Escherichia coli ECRC100 | 0.68 | OKFHMN_07805 | | Bifunctional protein FolD | 0.73 | OKFHMN_26325 | hexR | DNA-binding transcriptional regulator HexR | — | — |
| Escherichia coli ECOR38 | 0.67 | HEPCGN_06445 | | Bifunctional protein FolD | 0.73 | HEPCGN_04730 | hexR | DNA-binding transcriptional regulator HexR | — | — |
| Escherichia coli ECRC62 | 0.67 | BNILDI_22225 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.73 | BNILDI_15635 | hexR | DNA-binding transcriptional regulator HexR | — | — |
| Shewanella loihica PV-4 | 0.67 | Shew_2510 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | 0.78 | Shew_2049 | | DNA-binding transcriptional regulator HexR (RefSeq) | — | — |
| Pectobacterium carotovorum WPP14 | 0.67 | HER17_RS06505 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.77 | HER17_RS11785 | | MurR/RpiR family transcriptional regulator | — | — |
| Dickeya dadantii 3937 | 0.67 | DDA3937_RS15075 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.75 | DDA3937_RS10130 | | MurR/RpiR family transcriptional regulator | — | — |
| Alteromonas macleodii MIT1002 | 0.66 | MIT1002_02770 | | hypothetical protein | 0.73 | MIT1002_02408 | | putative HTH-type transcriptional regulator YbbH | — | — |
| Erwinia tracheiphila SCR3 | 0.66 | LU632_RS15195 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.64 | LU632_RS13365 | | MurR/RpiR family transcriptional regulator | — | — |
| Dickeya dianthicola 67-19 | 0.66 | HGI48_RS15155 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.75 | HGI48_RS10160 | | MurR/RpiR family transcriptional regulator | — | — |
| Shewanella oneidensis MR-1 | 0.66 | SO1792 | folD | methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase (NCBI ptt file) | 0.77 | SO2490 | | transcriptional regulator, RpiR family (NCBI ptt file) | — | — |
| Dickeya dianthicola ME23 | 0.66 | DZA65_RS15960 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.75 | DZA65_RS10575 | | MurR/RpiR family transcriptional regulator | — | — |
| Erwinia tracheiphila HP pepo 2.2 | 0.66 | IJEDHG_00975 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.64 | IJEDHG_22185 | | transcriptional regulator HexR | — | — |
| Pseudomonas simiae WCS417 | 0.62 | PS417_17265 | | methenyltetrahydrofolate cyclohydrolase | 0.57 | PS417_22115 | | transcriptional regulator | — | — |
| Pseudomonas sp. S08-1 | 0.62 | OH686_03670 | | Methenyltetrahydrofolate cyclohydrolase / Methylenetetrahydrofolate dehydrogenase (NADP+) | 0.58 | OH686_02440 | | Phosphogluconate repressor HexR, RpiR family | — | — |
| Pseudomonas aeruginosa PA14 | 0.62 | IKLFDK_08690 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.55 | IKLFDK_16180 | | HTH-type transcriptional regulator HexR | — | — |
| Pseudomonas orientalis W4I3 | 0.62 | QF045_RS18930 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.57 | QF045_RS24250 | | MurR/RpiR family transcriptional regulator | — | — |
| Pseudomonas aeruginosa PUPa3 | 0.62 | DQ20_RS54755 | folD;go_function=methylenetetrahydrofolate | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.55 | DQ20_RS34520 | | MurR/RpiR family transcriptional regulator | — | — |
| Pseudomonas aeruginosa MRSN321 | 0.62 | DY961_RS20675 | folD;go_function=methylenetetrahydrofolate | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.55 | DY961_RS01015 | | MurR/RpiR family transcriptional regulator | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.62 | PfGW456L13_2550 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.57 | PfGW456L13_1900 | | Phosphogluconate repressor HexR, RpiR family | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.61 | AO356_01775 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.57 | AO356_05165 | | transcriptional regulator | — | — |
| Marinobacter adhaerens HP15 | 0.61 | HP15_2187 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.55 | HP15_2180 | | transcriptional regulator, RpiR family protein | — | — |
| Pseudomonas sp. RS175 | 0.61 | PFR28_01223 | | Bifunctional protein FolD protein | 0.57 | PFR28_00572 | | HTH-type transcriptional regulator HexR | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.61 | Pf6N2E2_2221 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.57 | Pf6N2E2_2886 | | Phosphogluconate repressor HexR, RpiR family | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.61 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.57 | PFLU_RS23730 | | MurR/RpiR family transcriptional regulator | — | — |
| Pseudomonas lactucae CFBP13502 | 0.61 | GEMAOFIL_03749 | | Bifunctional protein FolD protein | 0.57 | GEMAOFIL_04559 | | HTH-type transcriptional regulator HexR | — | — |
| Pseudomonas fluorescens SBW25 | 0.61 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.57 | PFLU_RS23730 | | MurR/RpiR family transcriptional regulator | — | — |
| Pseudomonas putida KT2440 | 0.61 | PP_2265 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.57 | PP_1021 | | DNA-binding transcriptional regulator | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.61 | Pf1N1B4_3943 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.57 | Pf1N1B4_590 | | Phosphogluconate repressor HexR, RpiR family | — | — |
| Pseudomonas sp. DMC3 | 0.61 | GFF1441 | | Bifunctional protein FolD protein | 0.58 | GFF5141 | | HTH-type transcriptional regulator HexR | — | — |
| Pseudomonas sp. SVBP6 | 0.61 | COO64_RS19115 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.58 | COO64_RS04585 | hexR | DNA-binding transcriptional regulator HexR | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.61 | AO353_20145 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.57 | AO353_03365 | | transcriptional regulator | — | — |
| Pseudomonas sp. BP01 | 0.61 | JOY50_RS25950 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.57 | JOY50_RS11445 | hexR | DNA-binding transcriptional regulator HexR | — | — |
| Pseudomonas segetis P6 | 0.60 | MPMX49_02256 | | Bifunctional protein FolD protein | 0.57 | MPMX49_02832 | | HTH-type transcriptional regulator HexR | — | — |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.60 | Psyr_1743 | | methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | 0.56 | Psyr_1119 | | Helix-turn-helix protein RpiR:Sugar isomerase (SIS) | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.60 | Psyr_1743 | | methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | 0.56 | Psyr_1119 | | Helix-turn-helix protein RpiR:Sugar isomerase (SIS) | — | — |
| Pseudomonas stutzeri RCH2 | 0.58 | Psest_2301 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.57 | Psest_0851 | | Transcriptional regulators | — | — |
| Castellaniella sp019104865 MT123 | 0.48 | ABCV34_RS04175 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.39 | ABCV34_RS08655 | | SIS domain-containing protein | — | — |
| Herbaspirillum seropedicae SmR1 | 0.46 | HSERO_RS07295 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.32 | HSERO_RS05505 | | transcriptional regulator | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.46 | RR42_RS07345 | | methenyltetrahydrofolate cyclohydrolase | 0.34 | RR42_RS06120 | | transcriptional regulator | — | — |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.45 | GFF4894 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.33 | GFF1364 | | Phosphogluconate repressor HexR, RpiR family | — | — |
| Ralstonia solanacearum PSI07 | 0.45 | RPSI07_RS15800 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.22 | RPSI07_RS05455 | | MurR/RpiR family transcriptional regulator | — | — |
| Ralstonia solanacearum UW163 | 0.45 | UW163_RS14995 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.22 | UW163_RS20950 | | MurR/RpiR family transcriptional regulator | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.45 | RALBFv3_RS01685 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.22 | RALBFv3_RS18180 | | MurR/RpiR family transcriptional regulator | — | — |
| Ralstonia sp. UNC404CL21Col | 0.45 | ABZR87_RS13485 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.22 | ABZR87_RS03145 | | MurR/RpiR family transcriptional regulator | — | — |
| Acidovorax sp. GW101-3H11 | 0.45 | Ac3H11_4096 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.34 | Ac3H11_2055 | | Probable transcriptional regulator | — | — |
| Ralstonia solanacearum GMI1000 | 0.45 | RS_RS08040 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.23 | RS_RS22855 | | MurR/RpiR family transcriptional regulator | — | — |
| Variovorax sp. SCN45 | 0.44 | GFF964 | | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) / Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) | 0.20 | GFF6715 | | Transcriptional regulator of RpiR family in catabolic operon | — | — |
| Variovorax sp. OAS795 | 0.44 | ABID97_RS14085 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.20 | ABID97_RS22860 | | MurR/RpiR family transcriptional regulator | — | — |
| Paraburkholderia sabiae LMG 24235 | 0.43 | QEN71_RS05700 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.30 | QEN71_RS26925 | | MurR/RpiR family transcriptional regulator | — | — |
| Phaeobacter inhibens DSM 17395 | 0.43 | PGA1_c06010 | | bifunctional protein FolD | 0.10 | PGA1_c27130 | | putative HTH-type transcriptional regulator | — | — |
| Burkholderia phytofirmans PsJN | 0.42 | BPHYT_RS12865 | | bifunctional protein FolD | 0.34 | BPHYT_RS16740 | | transcriptional regulator | — | — |
| Paraburkholderia graminis OAS925 | 0.42 | ABIE53_002796 | | methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase | 0.35 | ABIE53_003518 | | RpiR family carbohydrate utilization transcriptional regulator | — | — |
| Paraburkholderia bryophila 376MFSha3.1 | 0.42 | H281DRAFT_00463 | | methenyltetrahydrofolate cyclohydrolase /5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | 0.33 | H281DRAFT_04279 | | transcriptional regulator, RpiR family | — | — |
| Azospirillum brasilense Sp245 | 0.40 | AZOBR_RS00650 | | 5 10-methylene-tetrahydrofolate dehydrogenase | 0.35 | AZOBR_RS30190 | | transcriptional regulator | — | — |
| Azospirillum sp. SherDot2 | 0.40 | MPMX19_02743 | | Bifunctional protein FolD protein | 0.33 | MPMX19_05117 | | HTH-type transcriptional regulator HexR | — | — |
| Sinorhizobium meliloti 1021 | 0.38 | SMc03059 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.38 | SMc02460 | | hypothetical protein | — | — |
| Rhizobium sp. OAE497 | 0.37 | ABIE40_RS03150 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.25 | ABIE40_RS21410 | | MurR/RpiR family transcriptional regulator | — | — |
| Agrobacterium fabrum C58 | 0.36 | Atu0589 | | methylenetetrahydrofolate dehydrogenase | 0.25 | Atu2598 | | transcriptional regulator, RpiR family | — | — |
Not shown: 41 genomes with orthologs for CSW01_09720 only; 0 genomes with orthologs for CSW01_05825 only