| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_02430 | | non-canonical purine NTP pyrophosphatase | 1.0 | CSW01_05825 | | transcriptional regulator HexR | 0.54 | 9 |
| Escherichia coli ECRC99 | 0.66 | KEDOAH_08900 | rdgB | XTP/dITP diphosphatase | 0.73 | KEDOAH_01780 | hexR | DNA-binding transcriptional regulator HexR | — | — |
| Escherichia coli ECRC98 | 0.66 | JDDGAC_22870 | rdgB | XTP/dITP diphosphatase | 0.73 | JDDGAC_00900 | hexR | DNA-binding transcriptional regulator HexR | low | > 87 |
| Escherichia coli ECRC100 | 0.66 | OKFHMN_19240 | rdgB | XTP/dITP diphosphatase | 0.73 | OKFHMN_26325 | hexR | DNA-binding transcriptional regulator HexR | low | > 79 |
| Escherichia coli ECRC102 | 0.66 | NIAGMN_17005 | rdgB | XTP/dITP diphosphatase | 0.73 | NIAGMN_01735 | hexR | DNA-binding transcriptional regulator HexR | low | > 80 |
| Escherichia coli Nissle 1917 | 0.66 | ECOLIN_RS16430 | | XTP/dITP diphosphatase | 0.73 | ECOLIN_RS10325 | | DNA-binding transcriptional regulator HexR | low | > 55 |
| Escherichia fergusonii Becca | 0.66 | EFB2_00948 | | dITP/XTP pyrophosphatase | 0.73 | EFB2_02089 | | HTH-type transcriptional regulator HexR | low | > 86 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.66 | OHPLBJKB_00762 | | dITP/XTP pyrophosphatase | 0.73 | OHPLBJKB_01875 | | HTH-type transcriptional regulator HexR | low | > 74 |
| Escherichia coli ECOR27 | 0.66 | NOLOHH_11110 | rdgB | XTP/dITP diphosphatase | 0.73 | NOLOHH_16840 | hexR | DNA-binding transcriptional regulator HexR | low | > 76 |
| Enterobacter asburiae PDN3 | 0.66 | EX28DRAFT_2992 | | non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family | 0.74 | EX28DRAFT_0703 | | transcriptional regulator, RpiR family | low | > 76 |
| Escherichia coli ECRC62 | 0.66 | BNILDI_09690 | rdgB | XTP/dITP diphosphatase | 0.73 | BNILDI_15635 | hexR | DNA-binding transcriptional regulator HexR | low | > 75 |
| Enterobacter sp. TBS_079 | 0.65 | MPMX20_03812 | | dITP/XTP pyrophosphatase | 0.74 | MPMX20_02758 | | HTH-type transcriptional regulator HexR | low | > 85 |
| Escherichia coli BW25113 | 0.65 | b2954 | yggV | putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) | 0.73 | b1853 | yebK | predicted DNA-binding transcriptional regulator (NCBI) | low | > 76 |
| Escherichia coli ECOR38 | 0.65 | HEPCGN_18545 | rdgB | XTP/dITP diphosphatase | 0.73 | HEPCGN_04730 | hexR | DNA-binding transcriptional regulator HexR | low | > 88 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.65 | GFF3057 | | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) | 0.72 | GFF1632 | | Phosphogluconate repressor HexR, RpiR family | low | > 78 |
| Rahnella sp. WP5 | 0.65 | EX31_RS02705 | | XTP/dITP diphosphatase | 0.76 | EX31_RS10635 | | MurR/RpiR family transcriptional regulator | low | > 89 |
| Escherichia coli BL21 | 0.65 | ECD_02784 | | dITP/XTP pyrophosphatase | 0.73 | ECD_01824 | | putative DNA-binding transcriptional regulator | — | — |
| Klebsiella pneumoniae MKP103 | 0.65 | KDGMDA_04630 | | XTP/dITP diphosphatase | 0.72 | KDGMDA_25375 | | transcriptional regulator HexR | low | > 95 |
| Escherichia coli ECRC101 | 0.65 | MCAODC_09760 | rdgB | XTP/dITP diphosphatase | 0.73 | MCAODC_19080 | hexR | DNA-binding transcriptional regulator HexR | low | > 88 |
| Klebsiella michiganensis M5al | 0.65 | BWI76_RS24115 | | non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family | 0.72 | BWI76_RS18110 | | transcriptional regulator HexR | low | > 92 |
| Serratia liquefaciens MT49 | 0.65 | IAI46_21430 | | XTP/dITP diphosphatase | 0.78 | IAI46_14580 | | MurR/RpiR family transcriptional regulator | low | > 86 |
| Dickeya dianthicola ME23 | 0.64 | DZA65_RS18455 | | XTP/dITP diphosphatase | 0.75 | DZA65_RS10575 | | MurR/RpiR family transcriptional regulator | low | > 75 |
| Pantoea sp. MT58 | 0.64 | IAI47_03585 | | XTP/dITP diphosphatase | 0.63 | IAI47_08490 | | MurR/RpiR family transcriptional regulator | low | > 76 |
| Dickeya dadantii 3937 | 0.64 | DDA3937_RS17320 | | XTP/dITP diphosphatase | 0.75 | DDA3937_RS10130 | | MurR/RpiR family transcriptional regulator | low | > 74 |
| Dickeya dianthicola 67-19 | 0.63 | HGI48_RS17365 | | XTP/dITP diphosphatase | 0.75 | HGI48_RS10160 | | MurR/RpiR family transcriptional regulator | low | > 71 |
| Pantoea agglomerans CFBP13505 P0401 | 0.61 | PagCFBP13505_RS16110 | | XTP/dITP diphosphatase | 0.61 | PagCFBP13505_RS02370 | | transcriptional regulator HexR | low | > 74 |
| Erwinia tracheiphila HP pepo 2.2 | 0.61 | IJEDHG_03460 | rdgB | XTP/dITP diphosphatase | 0.64 | IJEDHG_22185 | | transcriptional regulator HexR | low | > 61 |
| Erwinia tracheiphila SCR3 | 0.61 | LU632_RS05450 | | XTP/dITP diphosphatase | 0.64 | LU632_RS13365 | | MurR/RpiR family transcriptional regulator | low | > 74 |
| Alteromonas macleodii MIT1002 | 0.60 | MIT1002_00940 | | dITP/XTP pyrophosphatase | 0.73 | MIT1002_02408 | | putative HTH-type transcriptional regulator YbbH | — | — |
| Shewanella loihica PV-4 | 0.60 | Shew_1132 | | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase (RefSeq) | 0.78 | Shew_2049 | | DNA-binding transcriptional regulator HexR (RefSeq) | — | — |
| Pectobacterium carotovorum WPP14 | 0.59 | HER17_RS03790 | | XTP/dITP diphosphatase | 0.77 | HER17_RS11785 | | MurR/RpiR family transcriptional regulator | low | > 75 |
| Shewanella sp. ANA-3 | 0.59 | Shewana3_1189 | | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase (RefSeq) | 0.77 | Shewana3_2152 | | DNA-binding transcriptional regulator HexR (RefSeq) | low | > 73 |
| Shewanella oneidensis MR-1 | 0.58 | SO3358 | | HAM1 protein (NCBI ptt file) | 0.77 | SO2490 | | transcriptional regulator, RpiR family (NCBI ptt file) | low | > 76 |
| Shewanella amazonensis SB2B | 0.56 | Sama_2482 | | Ham1-like protein (RefSeq) | 0.77 | Sama_1813 | | DNA-binding transcriptional regulator HexR (RefSeq) | low | > 62 |
| Marinobacter adhaerens HP15 | 0.56 | HP15_281 | | non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family | 0.55 | HP15_2180 | | transcriptional regulator, RpiR family protein | low | > 73 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.54 | Psyr_0472 | | Ham1-like protein | 0.56 | Psyr_1119 | | Helix-turn-helix protein RpiR:Sugar isomerase (SIS) | low | > 86 |
| Pseudomonas syringae pv. syringae B728a | 0.54 | Psyr_0472 | | Ham1-like protein | 0.56 | Psyr_1119 | | Helix-turn-helix protein RpiR:Sugar isomerase (SIS) | low | > 86 |
| Pseudomonas fluorescens FW300-N2C3 | 0.53 | AO356_13395 | | non-canonical purine NTP pyrophosphatase | 0.57 | AO356_05165 | | transcriptional regulator | low | > 104 |
| Pseudomonas segetis P6 | 0.53 | MPMX49_00604 | | dITP/XTP pyrophosphatase | 0.57 | MPMX49_02832 | | HTH-type transcriptional regulator HexR | low | > 75 |
| Pseudomonas sp. RS175 | 0.53 | PFR28_04248 | | dITP/XTP pyrophosphatase | 0.57 | PFR28_00572 | | HTH-type transcriptional regulator HexR | low | > 88 |
| Pseudomonas fluorescens FW300-N2E2 | 0.52 | Pf6N2E2_4594 | | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) | 0.57 | Pf6N2E2_2886 | | Phosphogluconate repressor HexR, RpiR family | low | > 103 |
| Pseudomonas sp. SVBP6 | 0.52 | COO64_RS12970 | rdgB | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase | 0.58 | COO64_RS04585 | hexR | DNA-binding transcriptional regulator HexR | low | > 93 |
| Pseudomonas lactucae CFBP13502 | 0.52 | GEMAOFIL_05488 | | dITP/XTP pyrophosphatase | 0.57 | GEMAOFIL_04559 | | HTH-type transcriptional regulator HexR | low | > 93 |
| Pseudomonas simiae WCS417 | 0.52 | PS417_26755 | | nucleoside-triphosphate diphosphatase | 0.57 | PS417_22115 | | transcriptional regulator | low | > 88 |
| Pseudomonas sp. DMC3 | 0.52 | GFF215 | | dITP/XTP pyrophosphatase | 0.58 | GFF5141 | | HTH-type transcriptional regulator HexR | low | > 89 |
| Pseudomonas putida KT2440 | 0.52 | PP_5100 | | dITP/XTP pyrophosphatase | 0.57 | PP_1021 | | DNA-binding transcriptional regulator | low | > 96 |
| Pseudomonas aeruginosa PA14 | 0.52 | IKLFDK_23490 | | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase | 0.55 | IKLFDK_16180 | | HTH-type transcriptional regulator HexR | low | > 100 |
| Pseudomonas sp. BP01 | 0.52 | JOY50_RS20880 | rdgB | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase | 0.57 | JOY50_RS11445 | hexR | DNA-binding transcriptional regulator HexR | low | > 84 |
| Pseudomonas fluorescens FW300-N2E3 | 0.51 | AO353_08195 | | non-canonical purine NTP pyrophosphatase | 0.57 | AO353_03365 | | transcriptional regulator | low | > 101 |
| Paraburkholderia bryophila 376MFSha3.1 | 0.51 | H281DRAFT_04009 | | XTP/dITP diphosphohydrolase | 0.33 | H281DRAFT_04279 | | transcriptional regulator, RpiR family | low | > 103 |
| Paraburkholderia sabiae LMG 24235 | 0.51 | QEN71_RS03640 | | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase | 0.30 | QEN71_RS26925 | | MurR/RpiR family transcriptional regulator | low | > 153 |
| Pseudomonas fluorescens SBW25-INTG | 0.51 | PFLU_RS28400 | | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase | 0.57 | PFLU_RS23730 | | MurR/RpiR family transcriptional regulator | low | > 109 |
| Pseudomonas fluorescens SBW25 | 0.51 | PFLU_RS28400 | | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase | 0.57 | PFLU_RS23730 | | MurR/RpiR family transcriptional regulator | low | > 109 |
| Pseudomonas fluorescens GW456-L13 | 0.51 | PfGW456L13_1004 | | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) | 0.57 | PfGW456L13_1900 | | Phosphogluconate repressor HexR, RpiR family | low | > 87 |
| Paraburkholderia graminis OAS925 | 0.51 | ABIE53_003235 | | XTP/dITP diphosphohydrolase | 0.35 | ABIE53_003518 | | RpiR family carbohydrate utilization transcriptional regulator | low | > 113 |
| Pseudomonas fluorescens FW300-N1B4 | 0.51 | Pf1N1B4_2335 | | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) | 0.57 | Pf1N1B4_590 | | Phosphogluconate repressor HexR, RpiR family | low | > 87 |
| Burkholderia phytofirmans PsJN | 0.50 | BPHYT_RS15330 | | nucleoside-triphosphate diphosphatase | 0.34 | BPHYT_RS16740 | | transcriptional regulator | low | > 109 |
| Pseudomonas stutzeri RCH2 | 0.50 | Psest_0277 | | non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family | 0.57 | Psest_0851 | | Transcriptional regulators | low | > 67 |
| Pseudomonas sp. S08-1 | 0.50 | OH686_11015 | | non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family | 0.58 | OH686_02440 | | Phosphogluconate repressor HexR, RpiR family | low | > 80 |
| Herbaspirillum seropedicae SmR1 | 0.48 | HSERO_RS10660 | | nucleoside-triphosphate diphosphatase | 0.32 | HSERO_RS05505 | | transcriptional regulator | low | > 78 |
| Ralstonia solanacearum UW163 | 0.45 | UW163_RS10370 | | non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family | 0.22 | UW163_RS20950 | | MurR/RpiR family transcriptional regulator | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.45 | RALBFv3_RS03350 | | non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family | 0.22 | RALBFv3_RS18180 | | MurR/RpiR family transcriptional regulator | low | > 76 |
| Ralstonia sp. UNC404CL21Col | 0.45 | ABZR87_RS15260 | | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase | 0.22 | ABZR87_RS03145 | | MurR/RpiR family transcriptional regulator | low | > 80 |
| Ralstonia solanacearum PSI07 | 0.44 | RPSI07_RS13835 | | non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family | 0.22 | RPSI07_RS05455 | | MurR/RpiR family transcriptional regulator | — | — |
| Castellaniella sp019104865 MT123 | 0.44 | ABCV34_RS03520 | | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase | 0.39 | ABCV34_RS08655 | | SIS domain-containing protein | low | > 48 |
| Ralstonia solanacearum GMI1000 | 0.43 | RS_RS10835 | | non-canonical purine NTP pyrophosphatase | 0.23 | RS_RS22855 | | MurR/RpiR family transcriptional regulator | low | > 80 |
| Cupriavidus basilensis FW507-4G11 | 0.43 | RR42_RS04885 | | nucleoside-triphosphate diphosphatase | 0.34 | RR42_RS06120 | | transcriptional regulator | low | > 128 |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.38 | GFF3255 | | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) | 0.33 | GFF1364 | | Phosphogluconate repressor HexR, RpiR family | low | > 90 |
| Variovorax sp. SCN45 | 0.36 | GFF2382 | | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.66) | 0.20 | GFF6715 | | Transcriptional regulator of RpiR family in catabolic operon | low | > 127 |
| Variovorax sp. OAS795 | 0.35 | ABID97_RS23635 | | non-canonical purine NTP pyrophosphatase | 0.20 | ABID97_RS22860 | | MurR/RpiR family transcriptional regulator | low | > 91 |
| Acidovorax sp. GW101-3H11 | 0.35 | Ac3H11_3671 | | Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) | 0.34 | Ac3H11_2055 | | Probable transcriptional regulator | low | > 79 |
| Agrobacterium fabrum C58 | 0.32 | Atu0326 | | putative deoxyribonucleotide triphosphate pyrophosphatase | 0.25 | Atu2598 | | transcriptional regulator, RpiR family | — | — |
| Phaeobacter inhibens DSM 17395 | 0.31 | PGA1_c35040 | | nucleoside-triphosphatase RdgB | 0.10 | PGA1_c27130 | | putative HTH-type transcriptional regulator | low | > 62 |
| Sinorhizobium meliloti 1021 | 0.30 | SMc01146 | | deoxyribonucleotide triphosphate pyrophosphatase | 0.38 | SMc02460 | | hypothetical protein | low | > 103 |
| Rhizobium sp. OAE497 | 0.29 | ABIE40_RS01630 | | RdgB/HAM1 family non-canonical purine NTP pyrophosphatase | 0.25 | ABIE40_RS21410 | | MurR/RpiR family transcriptional regulator | low | > 107 |
| Azospirillum sp. SherDot2 | 0.27 | MPMX19_02575 | | dITP/XTP pyrophosphatase | 0.33 | MPMX19_05117 | | HTH-type transcriptional regulator HexR | low | > 112 |
| Azospirillum brasilense Sp245 | 0.27 | AZOBR_RS02200 | | nucleoside-triphosphate diphosphatase | 0.35 | AZOBR_RS30190 | | transcriptional regulator | low | > 97 |
Not shown: 43 genomes with orthologs for CSW01_02430 only; 0 genomes with orthologs for CSW01_05825 only