| Organism |  Ratio1 |  Gene1 |  Name1 |  Description1 |  Ratio2 |  Gene2 |  Name2 |  Description2 |  Cofit |  Rank | 
 | Sphingobium sp. HT1-2 |  1.0 |  GFF4076 |   |  Two-component transcriptional response regulator, LuxR family |  1.0 |  GFF377 |   |  Protein-export protein SecB (maintains pre-export unfolded state) |  low |  > 95 | 
 | Sphingomonas koreensis DSMZ 15582 |  0.90 |  Ga0059261_1369 |   |  Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain |  0.59 |  Ga0059261_0802 |   |  protein-export chaperone SecB |  low |  > 68 | 
 | Rhodopseudomonas palustris CGA009 |  0.73 |  TX73_009870 |   |  response regulator transcription factor |  0.47 |  TX73_001570 |   |  protein-export chaperone SecB |  low |  > 86 | 
 | Agrobacterium fabrum C58 |  0.72 |  Atu0970 |   |  two component response regulator |  0.33 |  Atu0006 |   |  protein-export protein SECB |  — |  — | 
 | Sinorhizobium meliloti 1021 |  0.72 |  SMc00458 |   |  transcriptional regulator |  0.34 |  SMc02788 |   |  preprotein translocase subunit SecB |  — |  — | 
 | Azospirillum sp. SherDot2 |  0.71 |  MPMX19_04078 |   |  Virulence transcriptional regulatory protein PhoP |  0.38 |  MPMX19_02553 |   |  Protein-export protein SecB |  low |  > 112 | 
 | Rhizobium sp. OAE497 |  0.71 |  ABIE40_RS05660 |   |  response regulator transcription factor |  0.38 |  ABIE40_RS19265 |   |  protein-export chaperone SecB |  low |  > 107 | 
 | Bosea sp. OAE506 |  0.71 |  ABIE41_RS21475 |   |  response regulator transcription factor |  0.39 |  ABIE41_RS04630 |   |  protein-export chaperone SecB |  low |  > 77 | 
 | Azospirillum brasilense Sp245 |  0.69 |  AZOBR_RS18790 |   |  transcriptional regulator |  0.39 |  AZOBR_RS01720 |   |  preprotein translocase subunit SecB |  low |  > 97 | 
 | Xanthobacter sp. DMC5 |  0.66 |  GFF3491 |   |  Transcriptional regulatory protein PhoP |  0.43 |  GFF3714 |   |  Protein-export protein SecB |  — |  — | 
 | Magnetospirillum magneticum AMB-1 |  0.63 |  AMB_RS00960 |   |  DNA-binding response regulator |  0.31 |  AMB_RS22995 |   |  protein-export protein SecB |  low |  > 64 | 
 | Brevundimonas sp. GW460-12-10-14-LB2 |  0.63 |  A4249_RS15665 |   |  response regulator transcription factor |  0.35 |  A4249_RS13480 |   |  protein-export chaperone SecB |  low |  > 48 | 
 | Rhodospirillum rubrum S1H |  0.62 |  Rru_A3187 |   |  Two component Transcriptional regulator, Winged helix family (NCBI) |  0.36 |  Rru_A3610 |   |  protein export chaperone SecB (NCBI) |  low |  > 58 | 
 | Castellaniella sp019104865 MT123 |  0.62 |  ABCV34_RS15610 |   |  response regulator transcription factor |  0.29 |  ABCV34_RS14255 |   |  protein-export chaperone SecB |  low |  > 48 | 
 | Caulobacter crescentus NA1000 |  0.61 |  CCNA_02854 |   |  two-component response regulator |  0.35 |  CCNA_03858 |   |  protein translocase subunit secB |  low |  > 66 | 
 | Caulobacter crescentus NA1000 Δfur |  0.61 |  CCNA_02854 |   |  two-component response regulator |  0.35 |  CCNA_03858 |   |  protein translocase subunit secB |  low |  > 67 | 
 | Vibrio cholerae E7946 ATCC 55056 |  0.59 |  CSW01_08235 |   |  DNA-binding response regulator |  0.24 |  CSW01_13410 |   |  protein-export protein SecB |  low |  > 62 | 
 | Shewanella amazonensis SB2B |  0.55 |  Sama_3303 |   |  response regulator receiver protein (RefSeq) |  0.29 |  Sama_0062 |   |  preprotein translocase subunit SecB (RefSeq) |  — |  — | 
 | Shewanella oneidensis MR-1 |  0.54 |  SO4647 |   |  DNA-binding response regulator (NCBI ptt file) |  0.27 |  SO0052 |  secB |  protein-export protein SecB (NCBI ptt file) |  — |  — | 
 | Shewanella loihica PV-4 |  0.53 |  Shew_2695 |   |  two component transcriptional regulator (RefSeq) |  0.27 |  Shew_3804 |   |  preprotein translocase subunit SecB (RefSeq) |  — |  — | 
 | Shewanella sp. ANA-3 |  0.53 |  Shewana3_4025 |   |  two component transcriptional regulator (RefSeq) |  0.27 |  Shewana3_0053 |   |  preprotein translocase subunit SecB (RefSeq) |  — |  — | 
 | Rhodanobacter sp000427505 FW510-R12 |  0.52 |  LRK53_RS17390 |   |  response regulator transcription factor |  0.33 |  LRK53_RS03645 |   |  protein-export chaperone SecB |  — |  — | 
 | Alteromonas macleodii MIT1002 |  0.51 |  MIT1002_01421 |   |  Transcriptional regulatory protein PhoP |  0.28 |  MIT1002_00486 |   |  Protein-export protein SecB |  low |  > 70 | 
 | Rhodanobacter denitrificans FW104-10B01 |  0.51 |  LRK54_RS05985 |   |  response regulator transcription factor |  0.32 |  LRK54_RS10855 |   |  protein-export chaperone SecB |  low |  > 59 | 
 | Xanthomonas campestris pv. campestris strain 8004 |  0.51 |  Xcc-8004.5008.1 |   |  Two-component system regulatory protein |  0.31 |  Xcc-8004.270.1 |   |  Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) |  — |  — | 
 | Lysobacter sp. OAE881 |  0.51 |  ABIE51_RS03940 |   |  response regulator transcription factor |  0.31 |  ABIE51_RS00490 |   |  protein-export chaperone SecB |  low |  > 62 | 
 | Rhodanobacter denitrificans MT42 |  0.51 |  LRK55_RS05740 |   |  response regulator transcription factor |  0.32 |  LRK55_RS10545 |   |  protein-export chaperone SecB |  — |  — | 
 | Rhodanobacter sp. FW510-T8 |  0.50 |  OKGIIK_00635 |  ompR |  DNA-binding response regulator |  0.32 |  OKGIIK_13020 |  secB |  protein-export chaperone SecB |  — |  — | 
 | Marinobacter adhaerens HP15 |  0.50 |  HP15_2937 |   |  two component transcriptional regulator, winged helix family |  0.30 |  HP15_3003 |   |  protein-export protein SecB |  low |  > 73 | 
 | Dyella japonica UNC79MFTsu3.2 |  0.50 |  ABZR86_RS18360 |   |  response regulator transcription factor |  0.31 |  ABZR86_RS13255 |   |  protein-export chaperone SecB |  — |  — | 
 | Pseudomonas segetis P6 |  0.50 |  MPMX49_02578 |   |  Transcriptional regulatory protein QseB |  0.27 |  MPMX49_04291 |   |  Protein-export protein SecB |  low |  > 75 | 
 | Kangiella aquimarina DSM 16071 |  0.50 |  B158DRAFT_1560 |   |  Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain |  0.25 |  B158DRAFT_0711 |   |  protein translocase subunit secB |  — |  — | 
 | Methylophilus sp. DMC18 |  0.48 |  GFF417 |   |  Transcriptional regulatory protein QseB |  0.33 |  GFF1796 |   |  Protein-export protein SecB |  — |  — | 
 | Pseudomonas aeruginosa PA14 |  0.48 |  IKLFDK_13340 |   |  two-component system response regulator CarR |  0.27 |  IKLFDK_27865 |   |  protein-export chaperone SecB |  low |  > 100 | 
 | Pseudomonas stutzeri RCH2 |  0.47 |  Psest_3533 |   |  Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain |  0.24 |  Psest_0165 |   |  protein-export chaperone SecB |  low |  > 67 | 
 | Pseudomonas sp. SVBP6 |  0.47 |  COO64_RS17260 |   |  response regulator transcription factor |  0.27 |  COO64_RS13310 |  secB |  protein-export chaperone SecB |  low |  > 93 | 
 | Pseudomonas sp. DMC3 |  0.47 |  GFF1365 |   |  Transcriptional regulatory protein QseB |  0.29 |  GFF4086 |   |  Protein-export protein SecB |  low |  > 89 | 
 | Pseudomonas fluorescens GW456-L13 |  0.47 |  PfGW456L13_2451 |   |  Two-component system response regulator QseB |  0.30 |  PfGW456L13_350 |   |  Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) |  low |  > 87 | 
 | Pseudomonas fluorescens FW300-N2E3 |  0.47 |  AO353_19775 |   |  transcriptional regulator |  0.30 |  AO353_12130 |   |  preprotein translocase subunit SecB |  low |  > 101 | 
 | Pseudomonas sp. S08-1 |  0.46 |  OH686_00055 |   |  Two-component system response regulator QseB |  0.26 |  OH686_14670 |   |  protein-export chaperone SecB |  low |  > 80 | 
 | Pseudomonas sp. BP01 |  0.46 |  JOY50_RS10885 |   |  response regulator transcription factor |  0.27 |  JOY50_RS09435 |  secB |  protein-export chaperone SecB |  — |  — | 
 | Pseudomonas fluorescens SBW25 |  0.46 |  PFLU_RS10435 |   |  response regulator transcription factor |  0.26 |  PFLU_RS01670 |   |  protein-export chaperone SecB |  low |  > 109 | 
 | Pseudomonas lactucae CFBP13502 |  0.46 |  GEMAOFIL_02165 |   |  Transcriptional regulatory protein QseB |  0.27 |  GEMAOFIL_00544 |   |  Protein-export protein SecB |  low |  > 93 | 
 | Pseudomonas fluorescens SBW25-INTG |  0.46 |  PFLU_RS10435 |   |  response regulator transcription factor |  0.26 |  PFLU_RS01670 |   |  protein-export chaperone SecB |  low |  > 109 | 
 | Pseudomonas putida KT2440 |  0.46 |  PP_2347 |   |  DNA-binding response regulator |  0.27 |  PP_5053 |   |  Protein-export protein SecB |  low |  > 96 | 
 | Pseudomonas sp. RS175 |  0.46 |  PFR28_02847 |   |  Transcriptional regulatory protein QseB |  0.29 |  PFR28_04941 |   |  Protein-export protein SecB |  low |  > 88 | 
 | Pseudomonas simiae WCS417 |  0.46 |  PS417_10270 |   |  transcriptional regulator |  0.27 |  PS417_01620 |   |  preprotein translocase subunit SecB |  low |  > 88 | 
 | Pseudomonas syringae pv. syringae B728a |  0.46 |  Psyr_3212 |   |  Response regulator receiver:Transcriptional regulatory protein, C-terminal |  0.26 |  Psyr_4882 |   |  protein translocase subunit secB |  low |  > 86 | 
 | Pseudomonas syringae pv. syringae B728a ΔmexB |  0.46 |  Psyr_3212 |   |  Response regulator receiver:Transcriptional regulatory protein, C-terminal |  0.26 |  Psyr_4882 |   |  protein translocase subunit secB |  low |  > 86 | 
 | Pseudomonas fluorescens FW300-N2C3 |  0.46 |  AO356_21280 |   |  transcriptional regulator |  0.30 |  AO356_09755 |   |  preprotein translocase subunit SecB |  low |  > 104 | 
 | Pseudomonas fluorescens FW300-N2E2 |  0.46 |  Pf6N2E2_41 |   |  Two-component system response regulator QseB |  0.30 |  Pf6N2E2_3829 |   |  Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) |  low |  > 103 | 
 | Pseudomonas fluorescens FW300-N1B4 |  0.46 |  Pf1N1B4_105 |   |  Two-component system response regulator QseB |  0.29 |  Pf1N1B4_1614 |   |  Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) |  — |  — | 
 | Enterobacter asburiae PDN3 |  0.44 |  EX28DRAFT_3057 |   |  Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain |  0.29 |  EX28DRAFT_3860 |   |  protein-export chaperone SecB |  — |  — | 
 | Erwinia amylovora T8 |  0.44 |  OLJFJH_07175 |   |  two-component system response regulator PmrA |  0.30 |  OLJFJH_05910 |   |  protein-export chaperone SecB |  low |  > 58 | 
 | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 |  0.44 |  GFF3138 |   |  Two-component system response regulator QseB |  0.30 |  GFF401 |   |  Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) |  low |  > 78 | 
 | Rahnella sp. WP5 |  0.43 |  EX31_RS08605 |   |  two-component system response regulator PmrA |  0.27 |  EX31_RS14345 |   |  protein-export chaperone SecB |  low |  > 89 | 
 | Klebsiella michiganensis M5al |  0.43 |  BWI76_RS24335 |   |  two-component system response regulator QseB |  0.28 |  BWI76_RS27215 |   |  protein-export protein SecB |  — |  — | 
 | Escherichia coli HS(pFamp)R (ATCC 700891) |  0.42 |  OHPLBJKB_00677 |   |  Transcriptional regulatory protein QseB |  0.29 |  OHPLBJKB_00090 |   |  Protein-export protein SecB |  — |  — | 
 | Dechlorosoma suillum PS |  0.42 |  Dsui_2248 |   |  response regulator with CheY-like receiver domain and winged-helix DNA-binding domain |  0.34 |  Dsui_1275 |   |  protein-export chaperone SecB |  low |  > 51 | 
 | Enterobacter sp. TBS_079 |  0.42 |  MPMX20_03863 |   |  Transcriptional regulatory protein QseB |  0.29 |  MPMX20_00124 |   |  Protein-export protein SecB |  — |  — | 
 | Escherichia coli BW25113 |  0.42 |  b3025 |  qseB |  DNA-binding response regulator in two-component regulatory system with QseC (NCBI) |  0.29 |  b3609 |  secB |  export protein SecB (NCBI) |  low |  > 76 | 
 | Erwinia tracheiphila SCR3 |  0.42 |  LU632_RS21175 |  pmrA |  two-component system response regulator PmrA |  0.28 |  LU632_RS21880 |  secB |  protein-export chaperone SecB |  low |  > 74 | 
 | Escherichia fergusonii Becca |  0.42 |  EFB2_00788 |   |  Transcriptional regulatory protein QseB |  0.29 |  EFB2_00201 |   |  Protein-export protein SecB |  — |  — | 
 | Escherichia coli BL21 |  0.42 |  ECD_02897 |   |  quorum sensing DNA-binding response regulator in two-component regulatory system with QseC |  0.29 |  ECD_03467 |   |  protein export chaperone |  — |  — | 
 | Erwinia tracheiphila HP pepo 2.2 |  0.42 |  IJEDHG_13855 |  pmrA |  two-component system response regulator PmrA |  0.28 |  IJEDHG_07915 |  secB |  protein-export chaperone SecB |  — |  — | 
 | Escherichia coli ECOR38 |  0.42 |  HEPCGN_17740 |   |  Quorum sensing DNA-binding response regulator in two-component regulatory system with QseC |  0.29 |  HEPCGN_14590 |  secB |  protein-export chaperone SecB |  — |  — | 
 | Pectobacterium carotovorum WPP14 |  0.42 |  HER17_RS11640 |   |  two-component system response regulator PhoP |  0.29 |  HER17_RS20740 |   |  protein-export chaperone SecB |  low |  > 75 | 
 | Escherichia coli ECRC102 |  0.42 |  NIAGMN_16645 |   |  Transcriptional regulatory protein QseB |  0.29 |  NIAGMN_13510 |  secB |  protein-export chaperone SecB |  low |  > 80 | 
 | Escherichia coli ECRC99 |  0.42 |  KEDOAH_09265 |   |  Transcriptional regulatory protein QseB |  0.29 |  KEDOAH_12400 |  secB |  protein-export chaperone SecB |  — |  — | 
 | Escherichia coli ECRC100 |  0.42 |  OKFHMN_18880 |   |  Transcriptional regulatory protein QseB |  0.29 |  OKFHMN_15750 |  secB |  protein-export chaperone SecB |  — |  — | 
 | Escherichia coli ECRC101 |  0.42 |  MCAODC_09395 |   |  Transcriptional regulatory protein QseB |  0.29 |  MCAODC_06260 |  secB |  protein-export chaperone SecB |  — |  — | 
 | Escherichia coli ECRC62 |  0.42 |  BNILDI_00855 |   |  Transcriptional regulatory protein QseB |  0.29 |  BNILDI_03885 |  secB |  protein-export chaperone SecB |  — |  — | 
 | Escherichia coli ECOR27 |  0.42 |  NOLOHH_10660 |   |  Transcriptional regulatory protein QseB |  0.29 |  NOLOHH_07630 |  secB |  protein-export chaperone SecB |  low |  > 76 | 
 | Escherichia coli ECRC98 |  0.42 |  JDDGAC_22515 |   |  Transcriptional regulatory protein QseB |  0.29 |  JDDGAC_19375 |  secB |  protein-export chaperone SecB |  — |  — | 
 | Escherichia coli Nissle 1917 |  0.42 |  ECOLIN_RS17425 |   |  quorum sensing response regulator transcription factor QseB |  0.29 |  ECOLIN_RS20600 |   |  protein-export chaperone SecB |  — |  — | 
 | Klebsiella pneumoniae MKP103 |  0.41 |  KDGMDA_05180 |   |  two-component system response regulator QseB |  0.28 |  KDGMDA_07900 |   |  protein-export chaperone SecB |  low |  > 95 | 
 | Serratia liquefaciens MT49 |  0.41 |  IAI46_10395 |   |  two-component system response regulator PhoP |  0.29 |  IAI46_24695 |   |  protein-export chaperone SecB |  low |  > 86 | 
 | Ralstonia solanacearum PSI07 |  0.40 |  RPSI07_RS08050 |   |  DNA-binding response regulator |  0.29 |  RPSI07_RS22395 |   |  protein-export chaperone SecB |  0.39 |  44 | 
Not shown: 7 genomes with orthologs for GFF4076 only; 13 genomes with orthologs for GFF377 only