| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Sphingobium sp. HT1-2 | 1.0 | GFF4227 | | dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) | 1.0 | GFF1520 | | Protein containing domains DUF404, DUF407 | 0.88 | 3 |
| Agrobacterium fabrum C58 | 0.71 | Atu4617 | | dTDP-D-glucose-4,6-dehydratase | 0.61 | Atu2338 | | hypothetical protein | low | > 89 |
| Rhizobium sp. OAE497 | 0.70 | ABIE40_RS08670 | | dTDP-glucose 4,6-dehydratase | 0.61 | ABIE40_RS14005 | | circularly permuted type 2 ATP-grasp protein | low | > 107 |
| Caulobacter crescentus NA1000 Δfur | 0.65 | CCNA_03744 | | dTDP-glucose 4,6-dehydratase | 0.49 | CCNA_01674 | | circularly permuted ATP-grasp type 2 protein | low | > 67 |
| Caulobacter crescentus NA1000 | 0.65 | CCNA_03744 | | dTDP-glucose 4,6-dehydratase | 0.49 | CCNA_01674 | | circularly permuted ATP-grasp type 2 protein | low | > 66 |
| Xanthobacter sp. DMC5 | 0.63 | GFF1115 | | dTDP-glucose 4,6-dehydratase 2 | 0.60 | GFF1129 | | putative protein | — | — |
| Klebsiella pneumoniae MKP103 | 0.60 | KDGMDA_26190 | | dTDP-glucose 4 6-dehydratase | 0.59 | KDGMDA_25015 | | Circularly permuted ATP-grasp type 2 | low | > 95 |
| Rahnella sp. WP5 | 0.60 | EX31_RS11515 | | dTDP-glucose 4,6-dehydratase | 0.58 | EX31_RS12770 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Dickeya dianthicola ME23 | 0.59 | DZA65_RS07110 | | dTDP-glucose 4,6-dehydratase | 0.60 | DZA65_RS01940 | | circularly permuted type 2 ATP-grasp protein | low | > 75 |
| Rhodospirillum rubrum S1H | 0.59 | Rru_B0050 | | dTDP-glucose 4,6-dehydratase (NCBI) | 0.59 | Rru_A3390 | | hypothetical protein (NCBI) | low | > 58 |
| Dickeya dianthicola 67-19 | 0.59 | HGI48_RS06755 | | dTDP-glucose 4,6-dehydratase | 0.60 | HGI48_RS01870 | | circularly permuted type 2 ATP-grasp protein | low | > 71 |
| Pseudomonas fluorescens FW300-N2C3 | 0.59 | AO356_10040 | | dTDP-glucose 4,6-dehydratase | 0.58 | AO356_20375 | | hypothetical protein | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.59 | Pf6N2E2_3878 | | dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) | 0.58 | Pf6N2E2_5995 | | Protein containing domains DUF404, DUF407 | — | — |
| Pseudomonas sp. RS175 | 0.59 | PFR28_04894 | | dTDP-glucose 4,6-dehydratase 2 | 0.57 | PFR28_01625 | | hypothetical protein | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.59 | AO353_11885 | | dTDP-glucose 4,6-dehydratase | 0.58 | AO353_01180 | | hypothetical protein | — | — |
| Azospirillum sp. SherDot2 | 0.58 | MPMX19_06725 | | dTDP-glucose 4,6-dehydratase 2 | 0.48 | MPMX19_01348 | | hypothetical protein | — | — |
| Pseudomonas sp. SVBP6 | 0.58 | COO64_RS00570 | rfbB | dTDP-glucose 4,6-dehydratase | 0.58 | COO64_RS06175 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Pseudomonas simiae WCS417 | 0.58 | PS417_01330 | | dTDP-glucose 4,6-dehydratase | 0.57 | PS417_21245 | | hypothetical protein | — | — |
| Pseudomonas segetis P6 | 0.58 | MPMX49_02877 | | dTDP-glucose 4,6-dehydratase 2 | 0.56 | MPMX49_02777 | | hypothetical protein | — | — |
| Pantoea sp. MT58 | 0.58 | IAI47_18500 | | dTDP-glucose 4,6-dehydratase | 0.59 | IAI47_07235 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Pseudomonas fluorescens SBW25 | 0.58 | PFLU_RS01425 | | dTDP-glucose 4,6-dehydratase | 0.58 | PFLU_RS22865 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.58 | PFLU_RS01425 | | dTDP-glucose 4,6-dehydratase | 0.58 | PFLU_RS22865 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.58 | Psyr_4935 | | dTDP-glucose 4,6-dehydratase | 0.57 | Psyr_1869 | | Protein of unknown function DUF404:Protein of unknown function DUF407 | low | > 86 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.58 | Psyr_4935 | | dTDP-glucose 4,6-dehydratase | 0.57 | Psyr_1869 | | Protein of unknown function DUF404:Protein of unknown function DUF407 | low | > 86 |
| Serratia liquefaciens MT49 | 0.58 | IAI46_00610 | | dTDP-glucose 4,6-dehydratase | 0.59 | IAI46_02250 | | circularly permuted type 2 ATP-grasp protein | low | > 87 |
| Pseudomonas orientalis W4I3 | 0.58 | QF045_RS04450 | | dTDP-glucose 4,6-dehydratase | 0.58 | QF045_RS23330 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Marinobacter adhaerens HP15 | 0.58 | HP15_p187g47 | | dTDP-glucose 4,6-dehydratase | 0.48 | HP15_3594 | | uncharacterized conserved protein UCP005522 | low | > 73 |
| Pseudomonas fluorescens FW300-N1B4 | 0.57 | Pf1N1B4_5939 | | dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) | 0.58 | Pf1N1B4_3790 | | Protein containing domains DUF404, DUF407 | low | > 87 |
| Pseudomonas lactucae CFBP13502 | 0.57 | GEMAOFIL_02615 | | dTDP-glucose 4,6-dehydratase 2 | 0.58 | GEMAOFIL_04391 | | hypothetical protein | low | > 96 |
| Bosea sp. OAE506 | 0.57 | ABIE41_RS02850 | | dTDP-glucose 4,6-dehydratase | 0.60 | ABIE41_RS13805 | | circularly permuted type 2 ATP-grasp protein | low | > 77 |
| Pseudomonas sp. S08-1 | 0.57 | OH686_14380 | | dTDP-glucose 4,6-dehydratase | 0.58 | OH686_22280 | | Protein containing domains DUF404, DUF407 | — | — |
| Pseudomonas sp. DMC3 | 0.56 | GFF4669 | | dTDP-glucose 4,6-dehydratase | 0.58 | GFF2645 | | putative protein | — | — |
| Klebsiella michiganensis M5al | 0.55 | BWI76_RS19065 | | dTDP-glucose 4,6-dehydratase | 0.59 | BWI76_RS17680 | | hypothetical protein | low | > 92 |
| Sphingomonas koreensis DSMZ 15582 | 0.54 | Ga0059261_3099 | | dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) | 0.55 | Ga0059261_3690 | | Uncharacterized conserved protein | low | > 68 |
| Paraburkholderia graminis OAS925 | 0.54 | ABIE53_001137 | | dTDP-glucose 4,6-dehydratase | 0.59 | ABIE53_004164 | | putative circularly permuted ATP-grasp superfamily protein | — | — |
| Azospirillum brasilense Sp245 | 0.54 | AZOBR_RS33415 | | dTDP-glucose 4 6-dehydratase | 0.48 | AZOBR_RS20035 | | hypothetical protein | low | > 97 |
| Paraburkholderia bryophila 376MFSha3.1 | 0.54 | H281DRAFT_04822 | | dTDP-glucose 4,6-dehydratase | 0.60 | H281DRAFT_03134 | | Uncharacterized conserved protein, circularly permuted ATPgrasp superfamily | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.53 | PfGW456L13_2200 | | dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) | 0.58 | PfGW456L13_4152 | | Protein containing domains DUF404, DUF407 | — | — |
| Acinetobacter radioresistens SK82 | 0.53 | MPMX26_00450 | | dTDP-glucose 4,6-dehydratase 2 | 0.49 | MPMX26_01149 | | hypothetical protein | — | — |
| Dinoroseobacter shibae DFL-12 | 0.53 | Dshi_4115 | | dTDP-glucose 4,6-dehydratase (RefSeq) | 0.59 | Dshi_3242 | | protein of unknown function DUF404 (RefSeq) | low | > 64 |
| Ralstonia solanacearum PSI07 | 0.53 | RPSI07_RS20615 | | dTDP-glucose 4,6-dehydratase | 0.59 | RPSI07_RS18590 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Burkholderia phytofirmans PsJN | 0.53 | BPHYT_RS04265 | | dTDP-glucose 4,6-dehydratase | 0.59 | BPHYT_RS22075 | | hypothetical protein | — | — |
| Pseudomonas putida KT2440 | 0.53 | PP_1785 | | dTDP-glucose 4,6-dehydratase 2 | 0.58 | PP_2688 | | conserved protein of unknown function | — | — |
| Ralstonia solanacearum UW163 | 0.53 | UW163_RS00920 | | dTDP-glucose 4,6-dehydratase | 0.59 | UW163_RS12240 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Ralstonia sp. UNC404CL21Col | 0.53 | ABZR87_RS08645 | | dTDP-glucose 4,6-dehydratase | 0.58 | ABZR87_RS10430 | | circularly permuted type 2 ATP-grasp protein | low | > 80 |
| Synechococcus elongatus PCC 7942 | 0.53 | Synpcc7942_2100 | rfbB | dTDP-glucose 4,6-dehydratase | 0.51 | Synpcc7942_1032 | | hypothetical protein | low | > 38 |
| Ralstonia solanacearum IBSBF1503 | 0.53 | RALBFv3_RS12645 | | dTDP-glucose 4,6-dehydratase | 0.59 | RALBFv3_RS14770 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Ralstonia solanacearum GMI1000 | 0.53 | RS_RS03430 | | dTDP-glucose 4,6-dehydratase | 0.59 | RS_RS05580 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Magnetospirillum magneticum AMB-1 | 0.52 | AMB_RS00295 | | dTDP-glucose 4,6-dehydratase | 0.47 | AMB_RS04180 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Sinorhizobium meliloti 1021 | 0.52 | SM_b21326 | | dTDP-D-glucose 4,6-dehydratase | 0.61 | SM_b20886 | | hypothetical protein | low | > 103 |
| Paraburkholderia sabiae LMG 24235 | 0.52 | QEN71_RS25755 | | dTDP-glucose 4,6-dehydratase | 0.59 | QEN71_RS18385 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.51 | RR42_RS15840 | | spore coat protein | 0.58 | RR42_RS06135 | | hypothetical protein | — | — |
| Methylophilus sp. DMC18 | 0.51 | GFF1321 | | dTDP-glucose 4,6-dehydratase | 0.61 | GFF2132 | | putative protein | — | — |
| Pseudomonas sp. BP01 | 0.50 | JOY50_RS16040 | rfbB | dTDP-glucose 4,6-dehydratase | 0.58 | JOY50_RS03000 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Variovorax sp. OAS795 | 0.50 | ABID97_RS05660 | | dTDP-glucose 4,6-dehydratase | 0.56 | ABID97_RS19985 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Variovorax sp. SCN45 | 0.50 | GFF6882 | | dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) | 0.56 | GFF2683 | | Protein containing domains DUF404, DUF407 | — | — |
| Pseudomonas aeruginosa PUPa3 | 0.49 | DQ20_RS50445 | rfbB;go_function=dTDP-glucose | dTDP-glucose 4 6-dehydratase | 0.57 | DQ20_RS54415 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Pseudomonas aeruginosa MRSN321 | 0.49 | DY961_RS11655 | rfbB;go_function=dTDP-glucose | dTDP-glucose 4 6-dehydratase | 0.57 | DY961_RS20325 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Acidovorax sp. GW101-3H11 | 0.49 | Ac3H11_1880 | | dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) | 0.55 | Ac3H11_265 | | Protein containing domains DUF404, DUF407 | — | — |
| Pseudomonas aeruginosa PA14 | 0.49 | IKLFDK_27680 | | dTDP-glucose 4 6-dehydratase | 0.57 | IKLFDK_08350 | | Circularly permuted type 2 ATP-grasp protein | — | — |
| Mucilaginibacter yixingensis YX-36 DSM 26809 | 0.49 | ABZR88_RS17425 | | dTDP-glucose 4,6-dehydratase | 0.52 | ABZR88_RS00345 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Synechocystis sp000284455 PCC 6803 | 0.49 | SGL_RS15130 | | dTDP-glucose 4,6-dehydratase | 0.51 | SGL_RS12915 | | circularly permuted type 2 ATP-grasp protein | low | > 52 |
| Dechlorosoma suillum PS | 0.49 | Dsui_1948 | | dTDP-glucose 4,6-dehydratase | 0.60 | Dsui_3236 | | hypothetical protein | — | — |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.49 | GFF1837 | | dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) | 0.56 | GFF5540 | | Protein containing domains DUF404, DUF407 | — | — |
| Herbaspirillum seropedicae SmR1 | 0.48 | HSERO_RS22050 | | spore coat protein | 0.58 | HSERO_RS03180 | | hypothetical protein | — | — |
| Echinicola vietnamensis KMM 6221, DSM 17526 | 0.47 | Echvi_2329 | | dTDP-glucose 4,6-dehydratase | 0.50 | Echvi_3991 | | Uncharacterized conserved protein | — | — |
| Pedobacter sp. GW460-11-11-14-LB5 | 0.46 | CA265_RS19340 | | dTDP-glucose 4,6-dehydratase | 0.50 | CA265_RS05130 | | hypothetical protein | — | — |
| Cellulophaga baltica 18 | 0.42 | M666_RS05585 | | dTDP-glucose 4,6-dehydratase | 0.49 | M666_RS16080 | | circularly permuted type 2 ATP-grasp protein | — | — |
| Mycobacterium tuberculosis H37Rv | 0.36 | Rv3464 | | dTDP-glucose 4,6-dehydratase RmlB | 0.46 | Rv2411c | | Conserved hypothetical protein | — | — |
| Rhodopseudomonas palustris CGA009 | 0.19 | TX73_020345 | | GDP-mannose 4,6-dehydratase | 0.61 | TX73_011235 | | circularly permuted type 2 ATP-grasp protein | low | > 86 |
Not shown: 49 genomes with orthologs for GFF4227 only; 2 genomes with orthologs for GFF1520 only