Conservation of cofitness between ECD_03708 and ECD_03843 in Escherichia coli BL21

62 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BL21 1.0 ECD_03708 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 1.0 ECD_03843 N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding 0.89 31
Escherichia coli Nissle 1917 1.00 ECOLIN_RS21980 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.99 ECOLIN_RS22845 N-acetyl-gamma-glutamyl-phosphate reductase 0.83 31
Escherichia coli BW25113 1.00 b3829 metE 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) 1.00 b3958 argC N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) 0.62 58
Escherichia fergusonii Becca 1.00 EFB2_04808 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.99 EFB2_04656 N-acetyl-gamma-glutamyl-phosphate reductase low > 86
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_04222 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1.00 OHPLBJKB_04092 N-acetyl-gamma-glutamyl-phosphate reductase low > 73
Escherichia coli ECOR27 0.99 NOLOHH_06455 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 NOLOHH_05730 argC N-acetyl-gamma-glutamyl-phosphate reductase 0.77 71
Escherichia coli ECRC62 0.99 BNILDI_05075 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 BNILDI_05795 argC N-acetyl-gamma-glutamyl-phosphate reductase 0.97 32
Escherichia coli ECOR38 0.99 HEPCGN_13025 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 HEPCGN_12230 argC N-acetyl-gamma-glutamyl-phosphate reductase 0.96 32
Escherichia coli ECRC99 0.99 KEDOAH_13825 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 KEDOAH_14575 argC N-acetyl-gamma-glutamyl-phosphate reductase — —
Escherichia coli ECRC100 0.99 OKFHMN_14325 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 OKFHMN_13585 argC N-acetyl-gamma-glutamyl-phosphate reductase 0.98 19
Escherichia coli ECRC101 0.99 MCAODC_04830 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 MCAODC_04085 argC N-acetyl-gamma-glutamyl-phosphate reductase 0.90 34
Escherichia coli ECRC98 0.99 JDDGAC_17950 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 JDDGAC_17210 argC N-acetyl-gamma-glutamyl-phosphate reductase low > 86
Escherichia coli ECRC102 0.99 NIAGMN_12080 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 0.99 NIAGMN_11335 argC N-acetyl-gamma-glutamyl-phosphate reductase — —
Enterobacter asburiae PDN3 0.95 EX28DRAFT_4494 methionine synthase (B12-independent) (EC 2.1.1.14) 0.90 EX28DRAFT_4420 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) low > 76
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.94 GFF254 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.92 GFF2344 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) low > 78
Klebsiella michiganensis M5al 0.94 BWI76_RS01280 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.91 BWI76_RS00845 N-acetyl-gamma-glutamyl-phosphate reductase 0.27 51
Enterobacter sp. TBS_079 0.94 MPMX20_04451 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.89 MPMX20_04522 N-acetyl-gamma-glutamyl-phosphate reductase low > 85
Pectobacterium carotovorum WPP14 0.86 HER17_RS20685 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.79 HER17_RS20630 N-acetyl-gamma-glutamyl-phosphate reductase 0.59 71
Dickeya dadantii 3937 0.85 DDA3937_RS20380 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.78 DDA3937_RS20350 N-acetyl-gamma-glutamyl-phosphate reductase 0.56 16
Dickeya dianthicola ME23 0.85 DZA65_RS00875 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.78 DZA65_RS00935 N-acetyl-gamma-glutamyl-phosphate reductase low > 75
Dickeya dianthicola 67-19 0.85 HGI48_RS00820 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.79 HGI48_RS00875 N-acetyl-gamma-glutamyl-phosphate reductase low > 71
Erwinia tracheiphila SCR3 0.84 LU632_RS24030 metE 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.78 LU632_RS19615 argC N-acetyl-gamma-glutamyl-phosphate reductase low > 74
Serratia liquefaciens MT49 0.84 IAI46_01035 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.82 IAI46_24515 N-acetyl-gamma-glutamyl-phosphate reductase 0.61 56
Rahnella sp. WP5 0.83 EX31_RS14710 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.79 EX31_RS14190 N-acetyl-gamma-glutamyl-phosphate reductase low > 89
Pantoea sp. MT58 0.83 IAI47_18310 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.78 IAI47_00905 N-acetyl-gamma-glutamyl-phosphate reductase 0.36 66
Pseudomonas fluorescens FW300-N2E2 0.62 Pf6N2E2_5472 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.31 Pf6N2E2_4836 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) low > 103
Pseudomonas fluorescens FW300-N1B4 0.62 Pf1N1B4_783 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.31 Pf1N1B4_2559 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) — —
Pseudomonas sp. RS175 0.61 PFR28_03477 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.30 PFR28_04033 N-acetyl-gamma-glutamyl-phosphate reductase low > 88
Pseudomonas fluorescens FW300-N2E3 0.61 AO353_16215 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.31 AO353_07155 N-acetyl-gamma-glutamyl-phosphate reductase low > 101
Pseudomonas fluorescens FW300-N2C3 0.61 AO356_17740 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.31 AO356_14490 N-acetyl-gamma-glutamyl-phosphate reductase low > 104
Pseudomonas stutzeri RCH2 0.60 Psest_1452 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase 0.29 Psest_3639 N-acetyl-gamma-glutamyl-phosphate reductase, common form — —
Vibrio cholerae E7946 ATCC 55056 0.60 CSW01_08575 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.63 CSW01_13380 N-acetyl-gamma-glutamyl-phosphate reductase low > 62
Pseudomonas fluorescens GW456-L13 0.59 PfGW456L13_3767 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.31 PfGW456L13_1233 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) low > 87
Pseudomonas fluorescens SBW25-INTG 0.59 PFLU_RS17405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.32 PFLU_RS27315 N-acetyl-gamma-glutamyl-phosphate reductase — —
Pseudomonas fluorescens SBW25 0.59 PFLU_RS17405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.32 PFLU_RS27315 N-acetyl-gamma-glutamyl-phosphate reductase — —
Castellaniella sp019104865 MT123 0.59 ABCV34_RS04445 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.30 ABCV34_RS10590 N-acetyl-gamma-glutamyl-phosphate reductase — —
Pseudomonas sp. S08-1 0.59 OH686_20470 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.31 OH686_15195 N-acetyl-gamma-glutamyl-phosphate reductase low > 80
Azospirillum brasilense Sp245 0.56 AZOBR_RS24275 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 0.26 AZOBR_RS07795 N-acetyl-gamma-glutamyl-phosphate reductase — —
Ralstonia sp. UNC404CL21Col 0.56 ABZR87_RS20880 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.14 ABZR87_RS05600 N-acetyl-gamma-glutamyl-phosphate reductase low > 80
Ralstonia solanacearum PSI07 0.55 RPSI07_RS02545 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.14 RPSI07_RS23280 N-acetyl-gamma-glutamyl-phosphate reductase low > 81
Acidovorax sp. GW101-3H11 0.55 Ac3H11_2345 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.11 Ac3H11_2950 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) low > 79
Ralstonia solanacearum GMI1000 0.55 RS_RS20360 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.14 RS_RS00700 N-acetyl-gamma-glutamyl-phosphate reductase — —
Ralstonia solanacearum UW163 0.55 UW163_RS18855 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.14 UW163_RS03490 N-acetyl-gamma-glutamyl-phosphate reductase — —
Ralstonia solanacearum IBSBF1503 0.55 RALBFv3_RS20320 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.14 RALBFv3_RS10090 N-acetyl-gamma-glutamyl-phosphate reductase low > 76
Variovorax sp. SCN45 0.55 GFF795 5-methyltetrahydropteroyltriglutamate--homocystei ne methyltransferase (EC 2.1.1.14) 0.13 GFF4146 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) low > 127
Shewanella loihica PV-4 0.55 Shew_2986 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (RefSeq) 0.44 Shew_0202 argC N-acetyl-gamma-glutamyl-phosphate reductase (RefSeq) low > 60
Shewanella sp. ANA-3 0.55 Shewana3_3469 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.45 Shewana3_3905 argC N-acetyl-gamma-glutamyl-phosphate reductase (RefSeq) low > 73
Shewanella oneidensis MR-1 0.55 SO0818 metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (NCBI ptt file) 0.44 SO0275 argC N-acetyl-gamma-glutamyl-phosphate reductase (NCBI ptt file) 0.92 39
Marinobacter adhaerens HP15 0.54 HP15_457 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 0.29 HP15_352 N-acetyl-gamma-glutamyl-phosphate reductase low > 73
Mucilaginibacter yixingensis YX-36 DSM 26809 0.53 ABZR88_RS18615 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.21 ABZR88_RS15505 N-acetyl-gamma-glutamyl-phosphate reductase — —
Pedobacter sp. GW460-11-11-14-LB5 0.53 CA265_RS21095 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.21 CA265_RS18540 N-succinylglutamylphosphate reductase (EC 1.2.1.38) (from data) low > 88
Cupriavidus basilensis FW507-4G11 0.53 RR42_RS30660 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.13 RR42_RS01210 n-acetyl-gamma-glutamyl-phosphate reductase low > 128
Shewanella amazonensis SB2B 0.53 Sama_2627 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.44 Sama_0256 argC N-acetyl-gamma-glutamyl-phosphate reductase (RefSeq) 0.96 31
Variovorax sp. OAS795 0.52 ABID97_RS19395 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.09 ABID97_RS02250 N-acetyl-gamma-glutamyl-phosphate reductase — —
Echinicola vietnamensis KMM 6221, DSM 17526 0.51 Echvi_2559 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase 0.20 Echvi_3847 N-succinylglutamylphosphate reductase (EC 1.2.1.-) (from data) low > 79
Dyella japonica UNC79MFTsu3.2 0.50 ABZR86_RS03225 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.18 ABZR86_RS08700 N-acetylglutamylphosphate reductase (EC 1.2.1.38) (from data) low > 74
Desulfovibrio vulgaris Miyazaki F 0.50 DvMF_2035 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.29 DvMF_1717 argC N-acetyl-gamma-glutamyl-phosphate reductase (RefSeq) low > 51
Desulfovibrio vulgaris Hildenborough JW710 0.49 DVU3371 metE 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (TIGR) 0.29 DVU0492 argC N-acetyl-gamma-glutamyl-phosphate reductase (TIGR) low > 55
Rhodanobacter denitrificans MT42 0.49 LRK55_RS11870 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.17 LRK55_RS02140 N-acetyl-gamma-glutamyl-phosphate reductase low > 63
Rhodanobacter denitrificans FW104-10B01 0.49 LRK54_RS12135 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.17 LRK54_RS02385 N-acetyl-gamma-glutamyl-phosphate reductase low > 59
Rhodospirillum rubrum S1H 0.48 Rru_A1718 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (NCBI) 0.31 Rru_A2421 N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) low > 58
Mycobacterium tuberculosis H37Rv 0.45 Rv1133c Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE (methionine synthase, vitamin-B12 independent isozyme) 0.21 Rv1652 Probable N-acetyl-gamma-glutamyl-phoshate reductase ArgC — —
Bifidobacterium breve UCC2003 0.42 BBR_RS15405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.17 BBR_RS13885 N-acetyl-gamma-glutamyl-phosphate reductase low > 34

Not shown: 5 genomes with orthologs for ECD_03708 only; 27 genomes with orthologs for ECD_03843 only