Conservation of cofitness between OKFHMN_20250 and OKFHMN_10840 in Escherichia coli ECRC100

65 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli ECRC100 1.0 OKFHMN_20250 relA GTP diphosphokinase 1.0 OKFHMN_10840 apaG Co2+/Mg2+ efflux protein ApaG 0.76 14
Escherichia coli ECRC99 1.00 KEDOAH_07880 relA GTP diphosphokinase 1.00 KEDOAH_17315 apaG Co2+/Mg2+ efflux protein ApaG
Escherichia coli Nissle 1917 1.00 ECOLIN_RS15515 GTP diphosphokinase 1.00 ECOLIN_RS00280 Co2+/Mg2+ efflux protein ApaG low > 55
Escherichia coli ECRC62 1.00 BNILDI_10630 relA GTP diphosphokinase 1.00 BNILDI_08420 apaG Co2+/Mg2+ efflux protein ApaG low > 75
Escherichia coli ECRC98 1.00 JDDGAC_23915 relA GTP diphosphokinase 1.00 JDDGAC_14435 apaG Co2+/Mg2+ efflux protein ApaG low > 86
Escherichia coli ECOR27 1.00 NOLOHH_12125 relA GTP diphosphokinase 1.00 NOLOHH_03185 apaG Co2+/Mg2+ efflux protein ApaG low > 75
Escherichia coli BL21 1.00 ECD_02629 (p)ppGpp synthetase I/GTP pyrophosphokinase 1.00 ECD_00054 protein associated with Co2+ and Mg2+ efflux low > 61
Escherichia coli ECRC102 1.00 NIAGMN_18020 relA GTP diphosphokinase 1.00 NIAGMN_08690 apaG Co2+/Mg2+ efflux protein ApaG
Escherichia coli ECRC101 1.00 MCAODC_10775 relA GTP diphosphokinase 1.00 MCAODC_01355 apaG Co2+/Mg2+ efflux protein ApaG low > 87
Escherichia coli ECOR38 1.00 HEPCGN_19500 relA GTP diphosphokinase 1.00 HEPCGN_08830 apaG Co2+/Mg2+ efflux protein ApaG low > 87
Escherichia coli BW25113 1.00 b2784 relA (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) 1.00 b0050 apaG hypothetical protein (NCBI) low > 76
Escherichia fergusonii Becca 1.00 EFB2_01133 GTP pyrophosphokinase 1.00 EFB2_03993 Protein ApaG low > 86
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_00947 GTP pyrophosphokinase 1.00 OHPLBJKB_03606 Protein ApaG low > 73
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.96 GFF4837 'GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)' transl_table=11 0.95 GFF191 ApaG protein low > 78
Klebsiella michiganensis M5al 0.94 BWI76_RS22805 GTP diphosphokinase 0.87 BWI76_RS04515 Co2+/Mg2+ efflux protein ApaG low > 92
Enterobacter asburiae PDN3 0.94 EX28DRAFT_2864 (p)ppGpp synthetase, RelA/SpoT family 0.84 EX28DRAFT_3644 Uncharacterized protein affecting Mg2+/Co2+ transport low > 76
Enterobacter sp. TBS_079 0.93 MPMX20_03653 GTP pyrophosphokinase 0.84 MPMX20_00746 Protein ApaG low > 85
Dickeya dadantii 3937 0.87 DDA3937_RS17015 GTP diphosphokinase 0.77 DDA3937_RS18270 Co2+/Mg2+ efflux protein ApaG low > 74
Dickeya dianthicola 67-19 0.87 HGI48_RS17070 GTP diphosphokinase 0.77 HGI48_RS18205 Co2+/Mg2+ efflux protein ApaG low > 71
Dickeya dianthicola ME23 0.87 DZA65_RS18145 GTP diphosphokinase 0.77 DZA65_RS19345 Co2+/Mg2+ efflux protein ApaG low > 75
Pectobacterium carotovorum WPP14 0.86 HER17_RS04115 GTP diphosphokinase 0.81 HER17_RS02955 Co2+/Mg2+ efflux protein ApaG low > 75
Erwinia tracheiphila SCR3 0.86 LU632_RS06350 relA GTP diphosphokinase 0.73 LU632_RS02735 apaG Co2+/Mg2+ efflux protein ApaG 0.67 44
Serratia liquefaciens MT49 0.85 IAI46_03600 GTP diphosphokinase 0.82 IAI46_03240 Co2+/Mg2+ efflux protein ApaG low > 86
Rahnella sp. WP5 0.85 EX31_RS07955 GTP diphosphokinase 0.77 EX31_RS03785 Co2+/Mg2+ efflux protein ApaG low > 89
Pantoea sp. MT58 0.84 IAI47_04120 GTP diphosphokinase 0.79 IAI47_16090 Co2+/Mg2+ efflux protein ApaG low > 76
Vibrio cholerae E7946 ATCC 55056 0.67 CSW01_12405 GTP diphosphokinase 0.55 CSW01_02320 Co2+/Mg2+ efflux protein ApaG low > 62
Shewanella sp. ANA-3 0.59 Shewana3_1111 (p)ppGpp synthetase I, SpoT/RelA (RefSeq) 0.51 Shewana3_3210 apaG ApaG (RefSeq) low > 73
Shewanella amazonensis SB2B 0.58 Sama_1033 GTP diphosphokinase (RefSeq) 0.53 Sama_2820 apaG ApaG (RefSeq) low > 62
Shewanella oneidensis MR-1 0.58 SO3455 relA GTP pyrophosphokinase (NCBI ptt file) 0.51 SO3640 apaG apaG protein (NCBI ptt file) low > 76
Shewanella loihica PV-4 0.58 Shew_1202 (p)ppGpp synthetase I, SpoT/RelA (RefSeq) 0.52 Shew_0878 apaG ApaG (RefSeq)
Alteromonas macleodii MIT1002 0.53 MIT1002_00794 GTP pyrophosphokinase 0.48 MIT1002_00780 CO2+/MG2+ efflux protein ApaG low > 70
Pseudomonas sp. RS175 0.47 PFR28_03223 GTP pyrophosphokinase 0.50 PFR28_04065 Protein ApaG low > 88
Pseudomonas fluorescens GW456-L13 0.47 PfGW456L13_2035 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) 0.50 PfGW456L13_1199 ApaG protein low > 87
Pseudomonas fluorescens FW300-N2C3 0.47 AO356_19060 (p)ppGpp synthetase 0.51 AO356_14330 magnesium transporter ApaG low > 104
Pseudomonas fluorescens FW300-N2E3 0.47 AO353_02710 (p)ppGpp synthetase 0.47 AO353_07320 magnesium transporter ApaG low > 101
Pseudomonas fluorescens FW300-N2E2 0.47 Pf6N2E2_5723 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) 0.51 Pf6N2E2_4804 ApaG protein low > 103
Pseudomonas sp. S08-1 0.47 OH686_18960 Inactive (p)ppGpp 3'-pyrophosphohydrolase domain / GTP pyrophosphokinase , (p)ppGpp synthetase I 0.47 OH686_15035 ApaG protein low > 80
Pseudomonas fluorescens SBW25 0.47 PFLU_RS22095 GTP diphosphokinase 0.46 PFLU_RS27470 Co2+/Mg2+ efflux protein ApaG low > 109
Pseudomonas fluorescens SBW25-INTG 0.47 PFLU_RS22095 GTP diphosphokinase 0.46 PFLU_RS27470 Co2+/Mg2+ efflux protein ApaG low > 109
Pseudomonas fluorescens FW300-N1B4 0.47 Pf1N1B4_3508 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) 0.48 Pf1N1B4_2527 ApaG protein low > 87
Pseudomonas simiae WCS417 0.47 PS417_20150 (p)ppGpp synthetase 0.46 PS417_25815 magnesium transporter ApaG
Pseudomonas syringae pv. syringae B728a 0.47 Psyr_3695 RelA/SpoT protein 0.48 Psyr_4628 Protein of unknown function DUF525 low > 86
Pseudomonas syringae pv. syringae B728a ΔmexB 0.47 Psyr_3695 RelA/SpoT protein 0.48 Psyr_4628 Protein of unknown function DUF525 low > 86
Pseudomonas putida KT2440 0.46 PP_1656 ATP:GTP 3'-pyrophosphotransferase 0.52 PP_0400 CO2+/MG2+ efflux protein low > 96
Pseudomonas stutzeri RCH2 0.46 Psest_1640 (p)ppGpp synthetase, RelA/SpoT family 0.53 Psest_3669 Uncharacterized protein affecting Mg2+/Co2+ transport low > 67
Kangiella aquimarina DSM 16071 0.43 B158DRAFT_2277 (p)ppGpp synthetase, RelA/SpoT family 0.55 B158DRAFT_0584 Uncharacterized protein affecting Mg2+/Co2+ transport low > 40
Dyella japonica UNC79MFTsu3.2 0.40 ABZR86_RS19725 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.52 ABZR86_RS11275 Co2+/Mg2+ efflux protein ApaG low > 74
Rhodanobacter sp. FW510-T8 0.39 OKGIIK_02170 relA GTP diphosphokinase 0.56 OKGIIK_11630 apaG Co2+/Mg2+ efflux protein ApaG low > 52
Rhodanobacter denitrificans FW104-10B01 0.39 LRK54_RS12725 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.55 LRK54_RS12300 Co2+/Mg2+ efflux protein ApaG low > 59
Rhodanobacter denitrificans MT42 0.39 LRK55_RS12430 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.55 LRK55_RS12035 Co2+/Mg2+ efflux protein ApaG low > 63
Dechlorosoma suillum PS 0.37 Dsui_2816 (p)ppGpp synthetase, RelA/SpoT family 0.55 Dsui_0222 uncharacterized protein affecting Mg2+/Co2+ transport low > 51
Herbaspirillum seropedicae SmR1 0.36 HSERO_RS09855 GTP pyrophosphokinase 0.47 HSERO_RS19420 cobalt transporter
Xanthomonas campestris pv. campestris strain 8004 0.36 Xcc-8004.1489.1 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I 0.49 Xcc-8004.4273.1 ApaG protein low > 74
Ralstonia sp. UNC404CL21Col 0.36 ABZR87_RS13745 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.47 ABZR87_RS02125 Co2+/Mg2+ efflux protein ApaG low > 80
Ralstonia solanacearum PSI07 0.36 RPSI07_RS15685 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.49 RPSI07_RS10770 Co2+/Mg2+ efflux protein ApaG low > 81
Ralstonia solanacearum GMI1000 0.36 RS_RS07930 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.49 RS_RS14415 Co2+/Mg2+ efflux protein ApaG low > 80
Paraburkholderia sabiae LMG 24235 0.36 QEN71_RS05265 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.46 QEN71_RS27535 Co2+/Mg2+ efflux protein ApaG low > 153
Ralstonia solanacearum IBSBF1503 0.35 RALBFv3_RS01805 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.48 RALBFv3_RS06470 Co2+/Mg2+ efflux protein ApaG low > 76
Ralstonia solanacearum UW163 0.35 UW163_RS15115 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.48 UW163_RS07155 Co2+/Mg2+ efflux protein ApaG
Cupriavidus basilensis FW507-4G11 0.35 RR42_RS06585 GTP pyrophosphokinase 0.46 RR42_RS18280 magnesium transporter ApaG low > 128
Burkholderia phytofirmans PsJN 0.35 BPHYT_RS13655 GTP pyrophosphokinase 0.47 BPHYT_RS17375 magnesium transporter ApaG low > 109
Paraburkholderia graminis OAS925 0.34 ABIE53_002905 GTP pyrophosphokinase 0.46 ABIE53_003637 ApaG protein low > 113
Paraburkholderia bryophila 376MFSha3.1 0.34 H281DRAFT_04499 GTP pyrophosphokinase 0.46 H281DRAFT_05718 ApaG protein low > 103
Lysobacter sp. OAE881 0.34 ABIE51_RS05170 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 0.46 ABIE51_RS05380 Co2+/Mg2+ efflux protein ApaG low > 62
Acidovorax sp. GW101-3H11 0.33 Ac3H11_362 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I 0.44 Ac3H11_756 ApaG protein low > 79
Variovorax sp. SCN45 0.32 GFF403 Inactive (p)ppGpp 3'-pyrophosphohydrolase domain / GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I 0.43 GFF6247 ApaG protein low > 127

Not shown: 6 genomes with orthologs for OKFHMN_20250 only; 17 genomes with orthologs for OKFHMN_10840 only