Conservation of cofitness between ECD_03708 and ECD_03077 in Escherichia coli BL21

63 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BL21 1.0 ECD_03708 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 1.0 ECD_03077 glutamate synthase, large subunit low > 61
Escherichia coli Nissle 1917 1.00 ECOLIN_RS21980 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.98 ECOLIN_RS18475 glutamate synthase large subunit low > 55
Escherichia fergusonii Becca 1.00 EFB2_04808 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1.00 EFB2_00611 Glutamate synthase [NADPH] large chain low > 86
Escherichia coli BW25113 1.00 b3829 metE 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) 0.98 b3212 gltB glutamate synthase, large subunit (NCBI) low > 76
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_04222 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1.00 OHPLBJKB_00488 Glutamate synthase [NADPH] large chain low > 73
Escherichia coli ECOR27 0.99 NOLOHH_06455 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 NOLOHH_09685 gltB glutamate synthase large subunit 0.79 64
Escherichia coli ECRC62 0.99 BNILDI_05075 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 BNILDI_01850 gltB glutamate synthase large subunit 0.97 37
Escherichia coli ECOR38 0.99 HEPCGN_13025 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 HEPCGN_16760 gltB3 Glutamate synthase domain 3 0.94 46
Escherichia coli ECRC101 0.99 MCAODC_04830 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 MCAODC_08405 gltB glutamate synthase large subunit low > 87
Escherichia coli ECRC98 0.99 JDDGAC_17950 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 JDDGAC_21510 gltB glutamate synthase large subunit low > 86
Escherichia coli ECRC99 0.99 KEDOAH_13825 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 KEDOAH_10265 gltB glutamate synthase large subunit — —
Escherichia coli ECRC100 0.99 OKFHMN_14325 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 OKFHMN_17885 gltB glutamate synthase large subunit 0.91 57
Escherichia coli ECRC102 0.99 NIAGMN_12080 metE 5-methyltetrahydropteroyltriglutamate--homocystei ne S-methyltransferase 1.00 NIAGMN_15645 gltB glutamate synthase large subunit — —
Enterobacter asburiae PDN3 0.95 EX28DRAFT_4494 methionine synthase (B12-independent) (EC 2.1.1.14) 0.93 EX28DRAFT_3275 Glutamate synthase domain 2 0.79 8
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.94 GFF254 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.93 GFF2956 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) low > 78
Klebsiella michiganensis M5al 0.94 BWI76_RS01280 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.93 BWI76_RS25315 glutamate synthase large subunit 0.28 40
Enterobacter sp. TBS_079 0.94 MPMX20_04451 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.93 MPMX20_04126 Glutamate synthase [NADPH] large chain low > 85
Pectobacterium carotovorum WPP14 0.86 HER17_RS20685 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.87 HER17_RS19910 glutamate synthase large subunit low > 75
Dickeya dadantii 3937 0.85 DDA3937_RS20380 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.86 DDA3937_RS01665 glutamate synthase large subunit 0.50 39
Dickeya dianthicola ME23 0.85 DZA65_RS00875 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.86 DZA65_RS01635 glutamate synthase large subunit 0.48 31
Dickeya dianthicola 67-19 0.85 HGI48_RS00820 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.86 HGI48_RS01560 glutamate synthase large subunit low > 71
Erwinia tracheiphila SCR3 0.84 LU632_RS24030 metE 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.87 LU632_RS21315 gltB glutamate synthase large subunit low > 74
Serratia liquefaciens MT49 0.84 IAI46_01035 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.87 IAI46_22345 glutamate synthase large subunit 0.79 15
Rahnella sp. WP5 0.83 EX31_RS14710 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.85 EX31_RS12515 glutamate synthase large subunit low > 89
Pseudomonas fluorescens FW300-N2E2 0.62 Pf6N2E2_5472 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.59 Pf6N2E2_3752 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) low > 103
Pseudomonas fluorescens FW300-N1B4 0.62 Pf1N1B4_783 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.58 Pf1N1B4_1534 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) low > 87
Pseudomonas sp. RS175 0.61 PFR28_03477 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.59 PFR28_05015 Glutamate synthase [NADPH] large chain low > 88
Pseudomonas fluorescens FW300-N2E3 0.61 AO353_16215 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.59 AO353_12515 glutamate synthase low > 101
Pseudomonas fluorescens FW300-N2C3 0.61 AO356_17740 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.59 AO356_09375 glutamate synthase low > 104
Pseudomonas stutzeri RCH2 0.60 Psest_1452 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase 0.59 Psest_3711 Glutamate synthase domain 2 low > 67
Vibrio cholerae E7946 ATCC 55056 0.60 CSW01_08575 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.74 CSW01_12030 glutamate synthase large subunit low > 62
Pseudomonas fluorescens GW456-L13 0.59 PfGW456L13_3767 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.59 PfGW456L13_272 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) low > 87
Pseudomonas fluorescens SBW25-INTG 0.59 PFLU_RS17405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.59 PFLU_RS02045 glutamate synthase large subunit low > 109
Pseudomonas fluorescens SBW25 0.59 PFLU_RS17405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.59 PFLU_RS02045 glutamate synthase large subunit low > 109
Castellaniella sp019104865 MT123 0.59 ABCV34_RS04445 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.40 ABCV34_RS11150 glutamate synthase-related protein low > 48
Pseudomonas sp. S08-1 0.59 OH686_20470 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.59 OH686_10005 Glutamate synthase [NADPH] large chain low > 80
Paraburkholderia sabiae LMG 24235 0.57 QEN71_RS19725 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.39 QEN71_RS28010 glutamate synthase-related protein low > 153
Ralstonia sp. UNC404CL21Col 0.56 ABZR87_RS20880 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.40 ABZR87_RS02570 glutamate synthase-related protein low > 80
Ralstonia solanacearum PSI07 0.55 RPSI07_RS02545 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.40 RPSI07_RS10320 glutamate synthase subunit alpha 0.65 44
Ralstonia solanacearum GMI1000 0.55 RS_RS20360 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.40 RS_RS14860 glutamate synthase subunit alpha 0.65 38
Acidovorax sp. GW101-3H11 0.55 Ac3H11_2345 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14) 0.39 Ac3H11_4710 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) 0.80 43
Ralstonia solanacearum IBSBF1503 0.55 RALBFv3_RS20320 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.40 RALBFv3_RS06915 glutamate synthase subunit alpha low > 76
Ralstonia solanacearum UW163 0.55 UW163_RS18855 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.40 UW163_RS06700 glutamate synthase subunit alpha — —
Shewanella sp. ANA-3 0.55 Shewana3_3469 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.65 Shewana3_3050 gltB glutamate synthase subunit alpha (RefSeq) low > 73
Shewanella loihica PV-4 0.55 Shew_2986 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (RefSeq) 0.66 Shew_1032 gltB glutamate synthase subunit alpha (RefSeq) low > 60
Variovorax sp. SCN45 0.55 GFF795 5-methyltetrahydropteroyltriglutamate--homocystei ne methyltransferase (EC 2.1.1.14) 0.39 GFF5332 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) low > 127
Shewanella oneidensis MR-1 0.55 SO0818 metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (NCBI ptt file) 0.65 SO1325 gltB glutamate synthase, large subunit (NCBI ptt file) 0.85 66
Marinobacter adhaerens HP15 0.54 HP15_457 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase 0.58 HP15_482 glutamate synthase subunit alpha — —
Mucilaginibacter yixingensis YX-36 DSM 26809 0.53 ABZR88_RS18615 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.40 ABZR88_RS06905 glutamate synthase large subunit — —
Pedobacter sp. GW460-11-11-14-LB5 0.53 CA265_RS21095 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.40 CA265_RS08700 glutamate synthase large subunit low > 88
Cupriavidus basilensis FW507-4G11 0.53 RR42_RS30660 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.39 RR42_RS18990 glutamate synthase 0.65 35
Shewanella amazonensis SB2B 0.53 Sama_2627 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (RefSeq) 0.65 Sama_0857 gltB glutamate synthase subunit alpha (RefSeq) low > 62
Variovorax sp. OAS795 0.52 ABID97_RS19395 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.39 ABID97_RS23225 glutamate synthase-related protein low > 91
Burkholderia phytofirmans PsJN 0.52 BPHYT_RS26655 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.39 BPHYT_RS17855 glutamate synthase low > 109
Rhodopseudomonas palustris CGA009 0.52 TX73_012380 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.41 TX73_004590 glutamate synthase large subunit — —
Caulobacter crescentus NA1000 Δfur 0.52 CCNA_00515 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.37 CCNA_03722 glutamate synthase (NADPH) large chain GltB low > 67
Caulobacter crescentus NA1000 0.52 CCNA_00515 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 0.37 CCNA_03722 glutamate synthase (NADPH) large chain GltB 0.90 52
Echinicola vietnamensis KMM 6221, DSM 17526 0.51 Echvi_2559 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase 0.38 Echvi_1244 Glutamate synthase domain 2 low > 79
Dyella japonica UNC79MFTsu3.2 0.50 ABZR86_RS03225 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.49 ABZR86_RS16795 glutamate synthase large subunit low > 74
Rhodanobacter denitrificans FW104-10B01 0.49 LRK54_RS12135 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.49 LRK54_RS10960 glutamate synthase large subunit low > 59
Rhodanobacter denitrificans MT42 0.49 LRK55_RS11870 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.49 LRK55_RS10665 glutamate synthase large subunit low > 63
Rhodospirillum rubrum S1H 0.48 Rru_A1718 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (NCBI) 0.38 Rru_A0019 Glutamate synthase (ferredoxin) (NCBI) — —
Mycobacterium tuberculosis H37Rv 0.45 Rv1133c Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE (methionine synthase, vitamin-B12 independent isozyme) 0.37 Rv3859c Probable ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH))(NADPH-GOGAT) — —
Bifidobacterium breve UCC2003 0.42 BBR_RS15405 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 0.38 BBR_RS15255 glutamate synthase large subunit low > 34

Not shown: 4 genomes with orthologs for ECD_03708 only; 29 genomes with orthologs for ECD_03077 only