Conservation of cofitness between CSW01_00850 and CSW01_12335 in Vibrio cholerae E7946 ATCC 55056

80 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Vibrio cholerae E7946 ATCC 55056 1.0 CSW01_00850 multidrug resistance protein 1.0 CSW01_12335 outer membrane protein TolC 0.83 2
Shewanella sp. ANA-3 0.72 Shewana3_0371 acriflavin resistance protein (RefSeq) 0.47 Shewana3_0725 tolC outer membrane channel protein (RefSeq) low > 73
Shewanella amazonensis SB2B 0.71 Sama_3269 putative multidrug resistance protein (RefSeq) 0.44 Sama_3048 tolC outer membrane channel protein (RefSeq) 0.39 46
Pseudomonas segetis P6 0.48 MPMX49_03771 Multidrug efflux pump subunit AcrB 0.29 MPMX49_04185 Outer membrane protein TolC 0.37 73
Pseudomonas simiae WCS417 0.47 PS417_22755 acriflavine resistance protein B 0.28 PS417_02350 channel protein TolC low > 88
Pseudomonas fluorescens SBW25-INTG 0.47 PFLU_RS24405 multidrug efflux RND transporter permease subunit 0.28 PFLU_RS02425 TolC family outer membrane protein low > 109
Pseudomonas fluorescens SBW25 0.47 PFLU_RS24405 multidrug efflux RND transporter permease subunit 0.28 PFLU_RS02425 TolC family outer membrane protein low > 109
Pseudomonas sp. RS175 0.47 PFR28_03330 Multidrug efflux pump subunit AcrB 0.28 PFR28_05090 Outer membrane protein TolC low > 88
Pseudomonas fluorescens FW300-N2C3 0.47 AO356_18440 acriflavine resistance protein B 0.29 AO356_08815 channel protein TolC low > 104
Pseudomonas sp. S08-1 0.47 OH686_17360 Multidrug efflux system, inner membrane proton/drug antiporter (RND type) 0.28 OH686_15890 Outer membrane channel TolC (OpmH) low > 80
Pseudomonas fluorescens FW300-N2E2 0.47 Pf6N2E2_5614 RND multidrug efflux transporter; Acriflavin resistance protein 0.29 Pf6N2E2_3645 Type I secretion outer membrane protein, TolC precursor low > 103
Pseudomonas sp. BP01 0.47 JOY50_RS14955 multidrug efflux RND transporter permease subunit 0.28 JOY50_RS10060 TolC family outer membrane protein 0.37 10
Pseudomonas fluorescens FW300-N1B4 0.47 Pf1N1B4_720 RND multidrug efflux transporter; Acriflavin resistance protein 0.28 Pf1N1B4_1448 Type I secretion outer membrane protein, TolC precursor low > 87
Pseudomonas putida KT2440 0.46 PP_0906 putative Multidrug efflux RND transporter 0.28 PP_4923 Outer membrane efflux protein low > 96
Pseudomonas sp. SVBP6 0.46 COO64_RS12055 multidrug efflux RND transporter permease subunit 0.27 COO64_RS17750 TolC family outer membrane protein low > 93
Pseudomonas fluorescens FW300-N2E3 0.46 AO353_04000 acriflavine resistance protein B 0.28 AO353_13005 channel protein TolC low > 101
Pseudomonas aeruginosa PA14 0.46 IKLFDK_02225 multidrug efflux RND transporter permease subunit MexW 0.29 IKLFDK_28670 efflux transporter outer membrane subunit OpmH low > 98
Pseudomonas aeruginosa PUPa3 0.46 DQ20_RS57065 mexW;inference=COORDINATES multidrug efflux RND transporter permease subunit MexW 0.29 DQ20_RS51395 opmH;inference=COORDINATES efflux transporter outer membrane subunit OpmH low > 101
Pseudomonas aeruginosa MRSN321 0.46 DY961_RS24615 mexW;inference=COORDINATES multidrug efflux RND transporter permease subunit MexW 0.29 DY961_RS10665 opmH;inference=COORDINATES efflux transporter outer membrane subunit OpmH low > 100
Pseudomonas sp. DMC3 0.46 GFF5069 Multidrug efflux pump subunit AcrB 0.26 GFF3182 Outer membrane protein TolC low > 89
Marinobacter adhaerens HP15 0.46 HP15_3262 multidrug resistance protein 0.26 HP15_451 type I secretion outer membrane protein, TolC family — —
Pseudomonas fluorescens GW456-L13 0.45 PfGW456L13_1771 RND multidrug efflux transporter; Acriflavin resistance protein 0.27 PfGW456L13_188 Type I secretion outer membrane protein, TolC precursor low > 87
Pseudomonas stutzeri RCH2 0.45 Psest_1153 Cation/multidrug efflux pump 0.29 Psest_0476 type I secretion outer membrane protein, TolC family 0.87 2
Variovorax sp. SCN45 0.45 GFF3509 Multidrug efflux system, inner membrane proton/drug antiporter (RND type) => MexI of MexHI-OpmD system 0.24 GFF6530 Type I secretion outer membrane protein, TolC family low > 127
Dechlorosoma suillum PS 0.35 Dsui_1555 cation/multidrug efflux pump 0.24 Dsui_0405 type I secretion outer membrane protein, TolC family low > 51
Hydrogenophaga sp. GW460-11-11-14-LB1 0.34 GFF4261 RND multidrug efflux transporter; Acriflavin resistance protein 0.24 GFF5765 Type I secretion outer membrane protein, TolC precursor low > 90
Acidovorax sp. GW101-3H11 0.34 Ac3H11_482 RND multidrug efflux transporter; Acriflavin resistance protein 0.24 Ac3H11_2219 Type I secretion outer membrane protein, TolC precursor low > 79
Desulfovibrio vulgaris Hildenborough JW710 0.25 DVU0061 multidrug resistance protein, putative (TIGR) 0.10 DVU3097 outer membrane efflux protein (TIGR) low > 55
Acinetobacter baumannii LAC-4 0.25 RR41_RS03865 multidrug efflux RND transporter permease subunit AdeJ 0.16 RR41_RS17695 TolC family outer membrane protein — —
Acinetobacter radioresistens SK82 0.24 MPMX26_00689 Multidrug resistance protein MexB 0.16 MPMX26_00182 Outer membrane protein TolC low > 36
Methylophilus sp. DMC18 0.24 GFF1649 Efflux pump membrane transporter BepE 0.26 GFF2824 Outer membrane protein TolC low > 43
Enterobacter asburiae PDN3 0.24 EX28DRAFT_2496 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family 0.43 EX28DRAFT_3073 type I secretion outer membrane protein, TolC family 0.82 2
Klebsiella michiganensis M5al 0.24 BWI76_RS06775 multidrug efflux RND transporter permease subunit 0.43 BWI76_RS24400 outer membrane channel protein TolC 0.75 2
Escherichia coli HS(pFamp)R (ATCC 700891) 0.24 OHPLBJKB_01261 Multidrug efflux pump subunit AcrB 0.42 OHPLBJKB_00668 Outer membrane protein TolC low > 74
Escherichia fergusonii Becca 0.24 EFB2_01418 Multidrug efflux pump subunit AcrB 0.42 EFB2_00773 Outer membrane protein TolC low > 86
Escherichia coli BW25113 0.24 b2470 acrD aminoglycoside/multidrug efflux system (NCBI) 0.42 b3035 tolC outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) low > 76
Escherichia coli BL21 0.24 ECD_02361 aminoglycoside/multidrug efflux system 0.42 ECD_02907 transport channel low > 61
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.24 GFF4246 RND efflux system, inner membrane transporter CmeB 0.43 GFF3149 Type I secretion outer membrane protein, TolC precursor low > 78
Escherichia coli ECOR38 0.24 HEPCGN_21140 acrD multidrug efflux RND transporter permease AcrD 0.42 HEPCGN_17680 tolC outer membrane channel protein TolC low > 88
Escherichia coli ECRC62 0.24 BNILDI_12460 acrD multidrug efflux RND transporter permease AcrD 0.42 BNILDI_00905 tolC outer membrane channel protein TolC low > 75
Escherichia coli ECRC99 0.24 KEDOAH_06250 acrD multidrug efflux RND transporter permease AcrD 0.42 KEDOAH_09340 tolC outer membrane channel protein TolC — —
Escherichia coli ECRC101 0.24 MCAODC_12500 acrD multidrug efflux RND transporter permease AcrD 0.42 MCAODC_09320 tolC outer membrane channel protein TolC low > 87
Escherichia coli ECRC102 0.24 NIAGMN_19740 acrD multidrug efflux RND transporter permease AcrD 0.42 NIAGMN_16570 tolC outer membrane channel protein TolC low > 80
Enterobacter sp. TBS_079 0.24 MPMX20_01064 Multidrug efflux pump subunit AcrB 0.43 MPMX20_03882 Outer membrane protein TolC 0.66 2
Escherichia coli ECRC98 0.24 JDDGAC_25915 acrD multidrug efflux RND transporter permease AcrD 0.42 JDDGAC_22440 tolC outer membrane channel protein TolC low > 87
Escherichia coli Nissle 1917 0.24 ECOLIN_RS14090 multidrug efflux RND transporter permease AcrD 0.42 ECOLIN_RS17515 outer membrane channel protein TolC low > 55
Escherichia coli ECRC100 0.24 OKFHMN_21970 acrD multidrug efflux RND transporter permease AcrD 0.42 OKFHMN_18805 tolC outer membrane channel protein TolC low > 79
Escherichia coli ECOR27 0.24 NOLOHH_13650 acrD multidrug efflux RND transporter permease AcrD 0.42 NOLOHH_10610 tolC outer membrane channel protein TolC low > 76
Klebsiella pneumoniae MKP103 0.24 KDGMDA_14835 acriflavine resistance protein B 0.43 KDGMDA_05225 outer membrane channel protein TolC low > 95
Pseudomonas orientalis W4I3 0.24 QF045_RS16760 efflux RND transporter permease subunit 0.28 QF045_RS05410 TolC family outer membrane protein low > 93
Desulfovibrio vulgaris Miyazaki F 0.24 DvMF_2163 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family (RefSeq) 0.06 DvMF_2365 outer membrane efflux protein (RefSeq) low > 51
Pseudomonas syringae pv. syringae B728a ΔmexB 0.23 Psyr_2968 Hydrophobe/amphiphile efflux-1 HAE1 0.29 Psyr_0543 Type I secretion outer membrane protein, TolC low > 86
Pseudomonas syringae pv. syringae B728a 0.23 Psyr_2968 Hydrophobe/amphiphile efflux-1 HAE1 0.29 Psyr_0543 Type I secretion outer membrane protein, TolC low > 86
Rhodanobacter sp. FW510-T8 0.23 OKGIIK_11990 acrB acriflavine resistance protein B 0.25 OKGIIK_16950 tolC Outer membrane protein TolC low > 53
Caulobacter crescentus NA1000 0.23 CCNA_00850 cation/multidrug efflux pump acrB2 0.12 CCNA_01379 type I secretion outer membrane protein rsaFb low > 66
Caulobacter crescentus NA1000 Δfur 0.23 CCNA_00850 cation/multidrug efflux pump acrB2 0.12 CCNA_01379 type I secretion outer membrane protein rsaFb low > 67
Dyella japonica UNC79MFTsu3.2 0.23 ABZR86_RS11745 efflux RND transporter permease subunit 0.26 ABZR86_RS17210 TolC family outer membrane protein low > 74
Pseudomonas lactucae CFBP13502 0.23 GEMAOFIL_03223 multidrug efflux RND transporter permease subunit OqxB9 0.28 GEMAOFIL_00707 Outer membrane protein TolC low > 96
Serratia liquefaciens MT49 0.23 IAI46_18690 multidrug efflux RND transporter permease AcrD 0.42 IAI46_21945 outer membrane channel protein TolC low > 87
Rahnella sp. WP5 0.23 EX31_RS22470 multidrug efflux RND transporter permease subunit 0.42 EX31_RS08100 outer membrane channel protein TolC 0.67 6
Rhodanobacter denitrificans MT42 0.23 LRK55_RS11630 efflux RND transporter permease subunit 0.25 LRK55_RS06430 TolC family outer membrane protein low > 63
Rhodanobacter denitrificans FW104-10B01 0.23 LRK54_RS11905 efflux RND transporter permease subunit 0.25 LRK54_RS06685 TolC family outer membrane protein low > 59
Pantoea agglomerans CFBP13505 P0401 0.23 PagCFBP13505_RS19855 multidrug efflux RND transporter permease AcrD 0.43 PagCFBP13505_RS11955 outer membrane channel protein TolC low > 74
Paraburkholderia bryophila 376MFSha3.1 0.23 H281DRAFT_04170 multidrug efflux pump 0.19 H281DRAFT_00100 outer membrane protein low > 103
Pectobacterium carotovorum WPP14 0.23 HER17_RS01560 multidrug efflux RND transporter permease AcrD 0.43 HER17_RS19825 outer membrane channel protein TolC low > 75
Kangiella aquimarina DSM 16071 0.23 B158DRAFT_0733 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family 0.28 B158DRAFT_0973 type I secretion outer membrane protein, TolC family 0.45 39
Dickeya dadantii 3937 0.23 DDA3937_RS05735 multidrug efflux RND transporter permease subunit 0.42 DDA3937_RS01740 outer membrane channel protein TolC low > 74
Pantoea sp. MT58 0.23 IAI47_05310 multidrug efflux RND transporter permease AcrD 0.43 IAI47_03135 outer membrane channel protein TolC 0.22 28
Erwinia amylovora T8 0.22 OLJFJH_17855 multidrug efflux RND transporter permease subunit AcrB 0.41 OLJFJH_07675 outer membrane channel protein TolC 0.85 2
Ralstonia sp. UNC404CL21Col 0.22 ABZR87_RS09795 efflux RND transporter permease subunit 0.22 ABZR87_RS08765 TolC family outer membrane protein low > 80
Variovorax sp. OAS795 0.22 ABID97_RS17350 efflux RND transporter permease subunit 0.26 ABID97_RS21375 TolC family outer membrane protein low > 91
Dickeya dianthicola 67-19 0.22 HGI48_RS05790 multidrug efflux RND transporter permease subunit 0.42 HGI48_RS01635 outer membrane channel protein TolC low > 71
Dickeya dianthicola ME23 0.22 DZA65_RS06115 multidrug efflux RND transporter permease subunit 0.42 DZA65_RS01710 outer membrane channel protein TolC low > 75
Ralstonia solanacearum GMI1000 0.22 RS_RS00045 multidrug efflux RND transporter permease subunit 0.23 RS_RS03495 channel protein TolC low > 80
Cupriavidus basilensis FW507-4G11 0.22 RR42_RS32420 multidrug efflux RND transporter permease subunit 0.25 RR42_RS15670 channel protein TolC low > 128
Ralstonia solanacearum UW163 0.22 UW163_RS04135 multidrug efflux RND transporter permease subunit 0.22 UW163_RS00850 channel protein TolC — —
Ralstonia solanacearum IBSBF1503 0.22 RALBFv3_RS09445 multidrug efflux RND transporter permease subunit 0.22 RALBFv3_RS12715 channel protein TolC low > 76
Rhodanobacter sp000427505 FW510-R12 0.22 LRK53_RS07935 multidrug efflux RND transporter permease subunit 0.25 LRK53_RS01735 TolC family outer membrane protein low > 59
Ralstonia solanacearum PSI07 0.22 RPSI07_RS23905 hydrophobe/amphiphile efflux-1 family RND transporter 0.23 RPSI07_RS20545 channel protein TolC low > 81
Erwinia tracheiphila SCR3 0.22 LU632_RS18185 efflux RND transporter permease subunit 0.41 LU632_RS20635 tolC outer membrane channel protein TolC — —
Erwinia tracheiphila HP pepo 2.2 0.21 IJEDHG_16580 adeB hydrophobe/amphiphile efflux-1 family RND transporter 0.41 IJEDHG_14425 tolC outer membrane channel protein TolC — —

Not shown: 14 genomes with orthologs for CSW01_00850 only; 12 genomes with orthologs for CSW01_12335 only