Conservation of cofitness between BWI76_RS19375 and BWI76_RS04525 in Klebsiella michiganensis M5al

68 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 1.0 BWI76_RS04525 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 0.21 15
Escherichia coli ECRC100 0.93 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.84 OKFHMN_10830 pdxA 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 0.89 14
Escherichia coli ECRC102 0.93 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.84 NIAGMN_08680 pdxA 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Escherichia coli ECRC101 0.93 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.84 MCAODC_01345 pdxA 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 0.74 19
Escherichia coli ECRC98 0.93 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.84 JDDGAC_14425 pdxA 4-hydroxythreonine-4-phosphate dehydrogenase PdxA low > 86
Escherichia coli ECRC99 0.93 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.84 KEDOAH_17325 pdxA 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Escherichia coli ECRC62 0.93 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.84 BNILDI_08430 pdxA 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 0.77 19
Escherichia coli ECOR27 0.93 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.84 NOLOHH_03175 pdxA 4-hydroxythreonine-4-phosphate dehydrogenase PdxA low > 75
Escherichia coli BW25113 0.93 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.85 b0052 pdxA 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) 0.70 7
Escherichia coli HS(pFamp)R (ATCC 700891) 0.93 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.84 OHPLBJKB_03604 4-hydroxythreonine-4-phosphate dehydrogenase low > 73
Escherichia coli BL21 0.92 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.85 ECD_00056 4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent low > 61
Escherichia fergusonii Becca 0.92 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.84 EFB2_03991 4-hydroxythreonine-4-phosphate dehydrogenase low > 86
Escherichia coli ECOR38 0.92 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.85 HEPCGN_08820 pdxA 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 0.88 5
Escherichia coli Nissle 1917 0.91 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.84 ECOLIN_RS00290 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Enterobacter sp. TBS_079 0.90 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.85 MPMX20_00748 4-hydroxythreonine-4-phosphate dehydrogenase 0.48 8
Enterobacter asburiae PDN3 0.90 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.84 EX28DRAFT_3646 4-hydroxythreonine-4-phosphate dehydrogenase 0.64 5
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.86 GFF189 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) low > 78
Pectobacterium carotovorum WPP14 0.79 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.71 HER17_RS02965 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 0.74 73
Serratia liquefaciens MT49 0.77 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.75 IAI46_03250 4-hydroxythreonine-4-phosphate dehydrogenase PdxA low > 86
Rahnella sp. WP5 0.77 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.71 EX31_RS03775 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 0.36 67
Dickeya dianthicola 67-19 0.76 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.74 HGI48_RS18195 4-hydroxythreonine-4-phosphate dehydrogenase PdxA low > 71
Dickeya dadantii 3937 0.76 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.74 DDA3937_RS18260 4-hydroxythreonine-4-phosphate dehydrogenase PdxA low > 74
Dickeya dianthicola ME23 0.76 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.74 DZA65_RS19335 4-hydroxythreonine-4-phosphate dehydrogenase PdxA low > 75
Erwinia tracheiphila SCR3 0.75 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.73 LU632_RS02725 pdxA 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Pantoea sp. MT58 0.75 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.74 IAI47_16080 4-hydroxythreonine-4-phosphate dehydrogenase PdxA low > 76
Paraburkholderia sabiae LMG 24235 0.54 QEN71_RS06305 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.46 QEN71_RS02125 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Paraburkholderia bryophila 376MFSha3.1 0.54 H281DRAFT_00587 hydroxymethylpyrimidine kinase /phosphomethylpyrimidine kinase 0.49 H281DRAFT_04639 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) — —
Burkholderia phytofirmans PsJN 0.52 BPHYT_RS12250 phosphomethylpyrimidine kinase 0.50 BPHYT_RS03300 4-hydroxythreonine-4-phosphate dehydrogenase — —
Paraburkholderia graminis OAS925 0.50 ABIE53_002529 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.49 ABIE53_000799 4-hydroxythreonine-4-phosphate dehydrogenase — —
Rhizobium sp. OAE497 0.50 ABIE40_RS25930 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.30 ABIE40_RS06395 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Agrobacterium fabrum C58 0.46 Atu3290 phosphomethylpyrimidine kinase 0.33 Atu1104 pyridoxal phosphate biosynthesis protein — —
Parabacteroides merdae CL09T00C40 0.43 HMPREF1078_RS03470 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.24 HMPREF1078_RS14540 4-hydroxythreonine-4-phosphate dehydrogenase PdxA low > 61
Sinorhizobium meliloti 1021 0.42 SM_b20962 phoshomethylpyrimidine kinase 0.33 SMc00580 4-hydroxythreonine-4-phosphate dehydrogenase low > 103
Vibrio cholerae E7946 ATCC 55056 0.40 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 CSW01_02330 4-hydroxythreonine-4-phosphate dehydrogenase — —
Phocaeicola vulgatus CL09T03C04 0.39 HMPREF1058_RS06820 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.30 HMPREF1058_RS17035 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 0.83 10
Phocaeicola dorei CL03T12C01 0.39 ABI39_RS20615 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.29 ABI39_RS12955 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 0.65 21
Dinoroseobacter shibae DFL-12 0.38 Dshi_0915 phosphomethylpyrimidine kinase (RefSeq) 0.33 Dshi_1186 4-hydroxythreonine-4-phosphate dehydrogenase (RefSeq) — —
Bacteroides stercoris CC31F 0.38 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.29 HMPREF1181_RS05765 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Bacteroides thetaiotaomicron VPI-5482 0.36 BT0790 phosphomethylpyrimidine kinase (NCBI ptt file) 0.28 BT4374 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI ptt file) — —
Ralstonia solanacearum GMI1000 0.36 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.49 RS_RS02575 4-hydroxythreonine-4-phosphate dehydrogenase — —
Ralstonia sp. UNC404CL21Col 0.36 ABZR87_RS04830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.48 ABZR87_RS07705 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Ralstonia solanacearum UW163 0.35 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.48 UW163_RS01835 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Ralstonia solanacearum IBSBF1503 0.35 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.48 RALBFv3_RS11750 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Ralstonia solanacearum PSI07 0.35 RPSI07_RS23455 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.49 RPSI07_RS21465 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Bacteroides ovatus ATCC 8483 0.35 BACOVA_02530 phosphomethylpyrimidine kinase 0.28 BACOVA_05206 4-hydroxythreonine-4-phosphate dehydrogenase — —
Pedobacter sp. GW460-11-11-14-LB5 0.34 CA265_RS24160 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.30 CA265_RS18320 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Cupriavidus basilensis FW507-4G11 0.32 RR42_RS01370 phosphomethylpyrimidine kinase 0.45 RR42_RS02780 4-hydroxythreonine-4-phosphate dehydrogenase — —
Xanthomonas campestris pv. campestris strain 8004 0.30 Xcc-8004.3091.1 hypothetical protein 0.42 Xcc-8004.4270.1 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) low > 74
Dyella japonica UNC79MFTsu3.2 0.29 ABZR86_RS00760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.48 ABZR86_RS11265 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Brevundimonas sp. GW460-12-10-14-LB2 0.28 A4249_RS15985 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.30 A4249_RS06755 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Dechlorosoma suillum PS 0.24 Dsui_0662 phosphomethylpyrimidine kinase 0.50 Dsui_1585 4-hydroxythreonine-4-phosphate dehydrogenase — —
Sphingomonas koreensis DSMZ 15582 0.24 Ga0059261_1961 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.30 Ga0059261_0878 4-hydroxythreonine-4-phosphate dehydrogenase — —
Pseudomonas fluorescens SBW25-INTG 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.57 PFLU_RS27460 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Pseudomonas fluorescens SBW25 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.57 PFLU_RS27460 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Pseudomonas simiae WCS417 0.23 PS417_24600 hydrogenase 0.57 PS417_25805 4-hydroxythreonine-4-phosphate dehydrogenase — —
Pseudomonas putida KT2440 0.22 PP_4782 Phosphomethylpyrimidine kinase 0.58 PP_0402 4-hydroxythreonine-4-phosphate dehydrogenase — —
Pseudomonas fluorescens GW456-L13 0.22 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.58 PfGW456L13_1201 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) — —
Pseudomonas fluorescens FW300-N2E3 0.22 AO353_06350 hydrogenase 0.58 AO353_07310 4-hydroxythreonine-4-phosphate dehydrogenase — —
Pseudomonas fluorescens FW300-N2C3 0.22 AO356_15435 hydrogenase 0.57 AO356_14340 4-hydroxythreonine-4-phosphate dehydrogenase — —
Pseudomonas stutzeri RCH2 0.21 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.57 Psest_3667 4-hydroxythreonine-4-phosphate dehydrogenase — —
Pseudomonas syringae pv. syringae B728a ΔmexB 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.56 Psyr_4626 4-hydroxythreonine-4-phosphate dehydrogenase — —
Pseudomonas syringae pv. syringae B728a 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.56 Psyr_4626 4-hydroxythreonine-4-phosphate dehydrogenase — —
Acinetobacter radioresistens SK82 0.21 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.52 MPMX26_00595 4-hydroxythreonine-4-phosphate dehydrogenase — —
Pseudomonas sp. RS175 0.20 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.57 PFR28_04063 4-hydroxythreonine-4-phosphate dehydrogenase — —
Pontibacter actiniarum KMM 6156, DSM 19842 0.20 CA264_20430 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.29 CA264_03840 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —
Pseudomonas fluorescens FW300-N1B4 0.18 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.58 Pf1N1B4_2529 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) — —
Pseudomonas fluorescens FW300-N2E2 0.18 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.57 Pf6N2E2_4806 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) — —
Herbaspirillum seropedicae SmR1 0.18 HSERO_RS02135 phosphomethylpyrimidine kinase 0.46 HSERO_RS03535 4-hydroxythreonine-4-phosphate dehydrogenase — —
Phaeobacter inhibens DSM 17395 0.17 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.32 PGA1_c19850 4-hydroxythreonine-4-phosphate dehydrogenase PdxA — —

Not shown: 20 genomes with orthologs for BWI76_RS19375 only; 12 genomes with orthologs for BWI76_RS04525 only