| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS00270 | | response regulator | cofit | 100 | 100 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS04350 | | PleD family two-component system response regulator | sig. | 45 | 55 |
| | Pseudomonas sp. S08-1 | OH686_16560 | | Two-component transcriptional response regulator, LuxR family | insig. | 38 | 49 |
| | Pseudomonas segetis P6 | MPMX49_00466 | | Sensor histidine kinase RcsC | insig. | 41 | 42 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS15805 | | two component system response regulator RpaA | strong | 40 | 45 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04496 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | strong | 29 | 89 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS12170 | | response regulator | insig. | 32 | 69 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_0095 | rpaA | two component transcriptional regulator, winged helix family | strong | 39 | 45 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT1754 | | two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) | strong | 30 | 75 |
| | Shewanella amazonensis SB2B | Sama_3111 | | response regulator receiver protein (RefSeq) | insig. | 42 | 41 |
| | Azospirillum sp. SherDot2 | MPMX19_01958 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | insig. | 42 | 42 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS12370 | | response regulator transcription factor | insig. | 38 | 43 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS12370 | | response regulator transcription factor | insig. | 38 | 43 |
| | Pseudomonas simiae WCS417 | PS417_11585 | | LuxR family transcriptional regulator | insig. | 38 | 43 |
| | Dinoroseobacter shibae DFL-12 | Dshi_2820 | | response regulator receiver modulated diguanylate cyclase (RefSeq) | sig. | 40 | 39 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_03275 | | hybrid sensor histidine kinase/response regulator | insig. | 36 | 49 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS06935 | | phosphate regulon transcriptional regulatory protein PhoB | insig. | 37 | 42 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS10730 | | response regulator | insig. | 39 | 45 |
| | Caulobacter crescentus NA1000 | CCNA_02546 | | GGDEF/response regulator protein PleD | strong | 43 | 39 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_02546 | | GGDEF/response regulator protein PleD | cofit | 43 | 39 |
| | Azospirillum brasilense Sp245 | AZOBR_RS14285 | | transcriptional regulator | strong | 40 | 44 |
| | Bifidobacterium breve UCC2003 | BBR_RS17455 | | DNA-binding response regulator | strong | 36 | 40 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_181 | | Two-component response regulator | insig. | 37 | 41 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_1645 | | Signal transduction histidine kinase | insig. | 39 | 42 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS08635 | | response regulator | sig. | 36 | 51 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1453 | rpaB | two component transcriptional regulator, winged helix family | no data | 39 | 44 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS06370 | | response regulator | insig. | 39 | 45 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02648 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | cofit | 36 | 46 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_1098 | | response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) | insig. | 41 | 43 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_1098 | | response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) | insig. | 41 | 43 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF2878 | | Two-component response regulator | insig. | 40 | 39 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_03092 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | insig. | 35 | 54 |
| | Rhizobium sp. OAE497 | ABIE40_RS14675 | | response regulator transcription factor | insig. | 32 | 46 |
| | Cellulophaga baltica 18 | M666_RS00005 | | two-component regulator propeller domain-containing protein | insig. | 37 | 45 |
| | Agrobacterium fabrum C58 | Atu2419 | | transcriptional regulator, LuxR family | insig. | 33 | 46 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS09900 | | two-component regulator propeller domain-containing protein | insig. | 37 | 41 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS14895 | | response regulator | insig. | 35 | 45 |
| | Sinorhizobium meliloti 1021 | SM_b20610 | | two-component response regulator protein | insig. | 33 | 46 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS11370 | | response regulator transcription factor | no data | 41 | 38 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS13215 | | response regulator | insig. | 39 | 44 |
| | Pseudomonas sp. BP01 | JOY50_RS19685 | | response regulator transcription factor | no data | 38 | 46 |
| | Alteromonas macleodii MIT1002 | MIT1002_01768 | | Cyclic di-GMP phosphodiesterase response regulator RpfG | insig. | 39 | 41 |
| | Paraburkholderia graminis OAS925 | ABIE53_004192 | | PAS domain S-box-containing protein | strong | 30 | 50 |
| | Azospirillum sp. SherDot2 | MPMX19_01957 | | Sensor histidine kinase RcsC | insig. | 39 | 45 |
| | Shewanella loihica PV-4 | Shew_3199 | | response regulator receiver modulated metal dependent phosphohydrolase (RefSeq) | insig. | 40 | 39 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_03106 | | PAS domain S-box-containing protein | insig. | 30 | 50 |
| | Azospirillum sp. SherDot2 | MPMX19_04589 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | insig. | 36 | 40 |
| | Variovorax sp. SCN45 | GFF2488 | | Two-component transcriptional response regulator, LuxR family | insig. | 37 | 48 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS02130 | | hybrid sensor histidine kinase/response regulator | strong | 37 | 41 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4236 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 36 | 41 |
| | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS05185 | | response regulator | insig. | 39 | 42 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS03105 | | response regulator transcription factor | strong | 33 | 49 |
| | Rhodospirillum rubrum S1H | Rru_A0603 | | Two component Transcriptional regulator, Winged helix family (NCBI) | cofit | 38 | 40 |
| | Azospirillum brasilense Sp245 | AZOBR_RS16180 | | diguanylate cyclase | strong | 40 | 39 |
| | Pseudomonas putida KT2440 | PP_3454 | | putative transcriptional regulatory protein | strong | 38 | 46 |
| | Shewanella sp. ANA-3 | Shewana3_3418 | | response regulator receiver modulated metal dependent phosphohydrolase (RefSeq) | insig. | 35 | 55 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_0556 | srrB | two component transcriptional regulator, winged helix family | strong | 35 | 44 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_3695 | | Two-component response regulator | sig. | 35 | 46 |
| | Ralstonia sp. UNC404CL21Col | ABZR87_RS22750 | | response regulator transcription factor | insig. | 35 | 41 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF3270 | | Two-component response regulator | insig. | 34 | 44 |
| | Azospirillum brasilense Sp245 | AZOBR_RS14200 | | chemotaxis protein CheY | strong | 41 | 39 |
| | Cellulophaga baltica 18 | M666_RS02930 | | response regulator transcription factor | no data | 38 | 47 |
| | Shewanella oneidensis MR-1 | SO0860 | | response regulator (NCBI ptt file) | insig. | 34 | 55 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS00635 | | substrate-binding domain-containing protein | strong | 31 | 61 |
| | Azospirillum sp. SherDot2 | MPMX19_04108 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | insig. | 35 | 40 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_00787 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 35 | 52 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS08885 | | response regulator | strong | 40 | 41 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_03437 | | response regulator receiver domain protein | strong | 33 | 45 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS06700 | | response regulator | insig. | 35 | 45 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS20605 | | response regulator | insig. | 33 | 52 |
| | Variovorax sp. OAS795 | ABID97_RS23505 | | response regulator transcription factor | insig. | 36 | 48 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS09180 | | DNA-binding response regulator | no data | 32 | 47 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS17305 | | hybrid sensor histidine kinase/response regulator transcription factor | insig. | 39 | 39 |
| | Azospirillum brasilense Sp245 | AZOBR_RS14305 | | transcriptional regulator | cofit | 37 | 46 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT3738 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | strong | 38 | 41 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS10050 | | response regulator | insig. | 35 | 45 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_00976 | | response regulator receiver domain protein | insig. | 33 | 43 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS05670 | | substrate-binding domain-containing protein | strong | 27 | 77 |
| | Dechlorosoma suillum PS | Dsui_0331 | | PAS domain S-box | insig. | 34 | 49 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS06810 | | response regulator | insig. | 33 | 52 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS00165 | | response regulator | strong | 34 | 43 |
| | Azospirillum sp. SherDot2 | MPMX19_01522 | | Response regulator PleD | insig. | 38 | 39 |
| | Rhodopseudomonas palustris CGA009 | TX73_016195 | | PleD family two-component system response regulator | insig. | 42 | 39 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS00410 | | response regulator | strong | 36 | 41 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS07960 | | response regulator | strong | 36 | 41 |
| | Azospirillum sp. SherDot2 | MPMX19_00501 | | Protein-glutamate methylesterase/protein-glutamine glutaminase | insig. | 36 | 45 |
| | Rhodopseudomonas palustris CGA009 | TX73_006410 | | response regulator transcription factor | insig. | 32 | 42 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS08240 | | substrate-binding domain-containing protein | strong | 30 | 62 |
| | Shewanella amazonensis SB2B | Sama_2951 | | response regulator receiver protein (RefSeq) | insig. | 38 | 39 |
| | Shewanella sp. ANA-3 | Shewana3_0479 | | response regulator receiver modulated metal dependent phosphohydrolase (RefSeq) | insig. | 37 | 47 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT3800 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 35 | 41 |
| | Rhizobium sp. OAE497 | ABIE40_RS16015 | | response regulator | insig. | 41 | 38 |
| | Mycobacterium tuberculosis H37Rv | Rv1033c | | Two component transcriptional regulator TrcR | insig. | 36 | 43 |
| | Pseudomonas sp. SVBP6 | COO64_RS25455 | | response regulator transcription factor | insig. | 36 | 49 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS13200 | | transcriptional regulator | insig. | 30 | 43 |
| | Sphingomonas koreensis DSMZ 15582 | Ga0059261_1121 | | Response regulator receiver domain | no data | 40 | 39 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_2416 | srrA | two component transcriptional regulator, winged helix family | sig. | 35 | 42 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02667 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 34 | 41 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS15245 | | response regulator | insig. | 32 | 49 |
| | Shewanella oneidensis MR-1 | SO4003 | | response regulator (NCBI ptt file) | insig. | 38 | 42 |