Conservation of cofitness between ECD_04103 and ECD_02354 in Escherichia coli BL21

64 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BL21 1.0 ECD_04103 putative antibiotic peptide MccB17 maturation peptidase 1.0 ECD_02354 malic enzyme: putative oxidoreductase/phosphotransacetylase low > 61
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_03800 Metalloprotease PmbA 1.00 OHPLBJKB_01268 NADP-dependent malic enzyme low > 73
Escherichia coli ECRC99 1.00 KEDOAH_16230 pmbA metalloprotease PmbA 0.99 KEDOAH_06215 maeB NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase — —
Escherichia coli BW25113 1.00 b4235 pmbA predicted peptidase required for the maturation and secretion of the antibiotic peptide MccB17 (NCBI) 1.00 b2463 maeB malic enzyme (NCBI) low > 76
Escherichia coli ECRC62 1.00 BNILDI_07325 pmbA metalloprotease PmbA 0.99 BNILDI_12495 maeB NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 75
Escherichia coli ECRC98 1.00 JDDGAC_15565 pmbA metalloprotease PmbA 1.00 JDDGAC_25950 maeB NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 86
Escherichia coli ECRC102 1.00 NIAGMN_09775 pmbA metalloprotease PmbA 1.00 NIAGMN_19775 maeB NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase — —
Escherichia coli ECRC101 1.00 MCAODC_02430 pmbA metalloprotease PmbA 1.00 MCAODC_12535 maeB NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 87
Escherichia coli ECOR27 1.00 NOLOHH_04185 pmbA metalloprotease PmbA 0.99 NOLOHH_13685 maeB NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 75
Escherichia coli ECRC100 1.00 OKFHMN_11925 pmbA metalloprotease PmbA 1.00 OKFHMN_22005 maeB NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 80
Escherichia coli ECOR38 1.00 HEPCGN_10125 pmbA metalloprotease PmbA 1.00 HEPCGN_21175 maeB NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 87
Escherichia fergusonii Becca 0.99 EFB2_04298 Metalloprotease PmbA 1.00 EFB2_01425 NADP-dependent malic enzyme low > 86
Escherichia coli Nissle 1917 0.99 ECOLIN_RS24570 metalloprotease PmbA 1.00 ECOLIN_RS14055 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 55
Enterobacter sp. TBS_079 0.96 MPMX20_00517 Metalloprotease PmbA 0.93 MPMX20_03324 NADP-dependent malic enzyme low > 85
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.96 GFF904 TldE protein, part of TldE/TldD proteolytic complex 0.95 GFF2198 NADP-dependent malic enzyme (EC 1.1.1.40) low > 78
Enterobacter asburiae PDN3 0.96 EX28DRAFT_3422 Predicted Zn-dependent proteases and their inactivated homologs 0.93 EX28DRAFT_0198 Malic enzyme low > 76
Klebsiella michiganensis M5al 0.94 BWI76_RS02850 metalloprotease PmbA 0.94 BWI76_RS20830 bifunctional malic enzyme oxidoreductase/phosphotransacetylase low > 92
Serratia liquefaciens MT49 0.86 IAI46_22575 metalloprotease PmbA 0.87 IAI46_18585 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 86
Rahnella sp. WP5 0.85 EX31_RS12320 metalloprotease PmbA 0.86 EX31_RS20275 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 89
Pectobacterium carotovorum WPP14 0.84 HER17_RS20090 metalloprotease PmbA 0.86 HER17_RS17280 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 75
Dickeya dadantii 3937 0.81 DDA3937_RS01500 metalloprotease PmbA 0.86 DDA3937_RS04355 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 74
Dickeya dianthicola 67-19 0.81 HGI48_RS01415 metalloprotease PmbA 0.84 HGI48_RS04345 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 71
Dickeya dianthicola ME23 0.81 DZA65_RS01480 metalloprotease PmbA 0.84 DZA65_RS04265 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase low > 75
Herbaspirillum seropedicae SmR1 0.45 HSERO_RS09265 peptidase C69 0.62 HSERO_RS16825 NADP-dependent malic enzyme oxidoreductase low > 78
Xanthomonas campestris pv. campestris strain 8004 0.45 Xcc-8004.1885.1 TldE protein, part of TldE/TldD proteolytic complex 0.58 Xcc-8004.1035.1 NADP-dependent malic enzyme (EC 1.1.1.40) — —
Variovorax sp. OAS795 0.45 ABID97_RS20695 metalloprotease PmbA 0.61 ABID97_RS22340 NADP-dependent malic enzyme low > 91
Dyella japonica UNC79MFTsu3.2 0.45 ABZR86_RS21700 metalloprotease PmbA 0.58 ABZR86_RS12415 NADP-dependent malic enzyme low > 74
Rhodanobacter sp. FW510-T8 0.45 OKGIIK_10260 pmbA metalloprotease PmbA 0.58 OKGIIK_12705 pta NADP-dependent malic enzyme low > 52
Variovorax sp. SCN45 0.45 GFF4697 TldE protein, part of TldE/TldD proteolytic complex 0.61 GFF1796 NADP-dependent malic enzyme (EC 1.1.1.40) low > 127
Rhodanobacter denitrificans FW104-10B01 0.44 LRK54_RS03375 metalloprotease PmbA 0.59 LRK54_RS11170 NADP-dependent malic enzyme low > 59
Rhodanobacter denitrificans MT42 0.44 LRK55_RS03125 metalloprotease PmbA 0.59 LRK55_RS10875 NADP-dependent malic enzyme — —
Dechlorosoma suillum PS 0.44 Dsui_1234 putative Zn-dependent protease-like protein 0.63 Dsui_0543 malic enzyme low > 51
Acidovorax sp. GW101-3H11 0.44 Ac3H11_3262 TldE protein, part of TldE/TldD proteolytic complex 0.59 Ac3H11_1079 NADP-dependent malic enzyme (EC 1.1.1.40) low > 79
Ralstonia solanacearum IBSBF1503 0.43 RALBFv3_RS13965 metalloprotease PmbA 0.62 RALBFv3_RS03260 NADP-dependent malic enzyme low > 76
Ralstonia solanacearum UW163 0.43 UW163_RS15845 metalloprotease PmbA 0.62 UW163_RS10465 NADP-dependent malic enzyme — —
Ralstonia sp. UNC404CL21Col 0.43 ABZR87_RS09660 metalloprotease PmbA 0.61 ABZR87_RS15110 NADP-dependent malic enzyme low > 80
Paraburkholderia graminis OAS925 0.43 ABIE53_003116 PmbA protein 0.63 ABIE53_000015 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) low > 113
Paraburkholderia bryophila 376MFSha3.1 0.43 H281DRAFT_04304 microcin-processing peptidase 1. Unknown type peptidase. MEROPS family U62 0.63 H281DRAFT_05846 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) 0.24 79
Ralstonia solanacearum PSI07 0.43 RPSI07_RS19505 metalloprotease PmbA 0.62 RPSI07_RS14050 NADP-dependent malic enzyme low > 81
Paraburkholderia sabiae LMG 24235 0.43 QEN71_RS04270 metalloprotease PmbA 0.63 QEN71_RS28455 NADP-dependent malic enzyme low > 153
Burkholderia phytofirmans PsJN 0.43 BPHYT_RS14705 peptidase C69 0.63 BPHYT_RS18310 malic enzyme low > 109
Castellaniella sp019104865 MT123 0.42 ABCV34_RS10610 metalloprotease PmbA 0.60 ABCV34_RS01715 NADP-dependent malic enzyme low > 48
Hydrogenophaga sp. GW460-11-11-14-LB1 0.41 GFF3655 TldE protein, part of TldE/TldD proteolytic complex 0.60 GFF3306 NADP-dependent malic enzyme (EC 1.1.1.40) low > 90
Lysobacter sp. OAE881 0.41 ABIE51_RS06805 metalloprotease PmbA 0.60 ABIE51_RS18820 NADP-dependent malic enzyme low > 62
Ralstonia solanacearum GMI1000 0.41 RS_RS04700 metalloprotease PmbA 0.62 RS_RS10650 NADP-dependent malic enzyme low > 80
Cupriavidus basilensis FW507-4G11 0.41 RR42_RS14750 peptidase PMbA 0.63 RR42_RS05210 malic enzyme low > 128
Azospirillum brasilense Sp245 0.34 AZOBR_RS11930 modulator protein 0.57 AZOBR_RS21145 NADP-dependent malic enzyme low > 97
Azospirillum sp. SherDot2 0.34 MPMX19_01886 Metalloprotease PmbA 0.59 MPMX19_04254 NADP-dependent malic enzyme low > 112
Sphingomonas koreensis DSMZ 15582 0.30 Ga0059261_0810 Predicted Zn-dependent proteases and their inactivated homologs 0.43 Ga0059261_3786 Malic enzyme low > 68
Magnetospirillum magneticum AMB-1 0.29 AMB_RS22120 TldD/PmbA family protein 0.60 AMB_RS03695 NADP-dependent malic enzyme low > 64
Rhodopseudomonas palustris CGA009 0.29 TX73_005930 TldD/PmbA family protein 0.51 TX73_015740 NADP-dependent malic enzyme low > 86
Rhodospirillum rubrum S1H 0.29 Rru_A0575 Peptidase U62, modulator of DNA gyrase (NCBI) 0.42 Rru_A3542 malate dehydrogenase (NCBI) low > 58
Caulobacter crescentus NA1000 0.28 CCNA_00311 Zn-dependent protease family protein 0.57 CCNA_02704 NADP-dependent malic enzyme — —
Caulobacter crescentus NA1000 Δfur 0.28 CCNA_00311 Zn-dependent protease family protein 0.57 CCNA_02704 NADP-dependent malic enzyme low > 67
Sinorhizobium meliloti 1021 0.28 SMc00897 PMBA protein 0.56 SMc00169 malic enzyme low > 103
Brevundimonas sp. GW460-12-10-14-LB2 0.28 A4249_RS09195 TldD/PmbA family protein 0.41 A4249_RS13295 NADP-dependent malic enzyme — —
Agrobacterium fabrum C58 0.27 Atu0693 PmbA/TldD related protein 0.54 Atu1652 NADP-dependent malic enzyme — —
Phaeobacter inhibens DSM 17395 0.27 PGA1_c33480 protein PmbA 0.54 PGA1_c11910 Malate dehydrogenase (decarboxylating) (EC 1.1.1.39) (from data) — —
Rhizobium sp. OAE497 0.27 ABIE40_RS03780 TldD/PmbA family protein 0.56 ABIE40_RS10450 NADP-dependent malic enzyme low > 107
Dinoroseobacter shibae DFL-12 0.26 Dshi_0064 peptidase U62 modulator of DNA gyrase (RefSeq) 0.51 Dshi_0826 malic protein NAD-binding (RefSeq) low > 64
Bacteroides thetaiotaomicron VPI-5482 0.20 BT3649 putative modulator of DNA gyrase (NCBI ptt file) 0.46 BT1969 NADP-dependent malate dehydrogenase (NCBI ptt file) low > 81
Bacteroides stercoris CC31F 0.17 HMPREF1181_RS03170 TldD/PmbA family protein 0.46 HMPREF1181_RS07830 NADP-dependent malic enzyme low > 56
Parabacteroides merdae CL09T00C40 0.16 HMPREF1078_RS03625 TldD/PmbA family protein 0.45 HMPREF1078_RS07665 NADP-dependent malic enzyme low > 61
Pedobacter sp. GW460-11-11-14-LB5 0.06 CA265_RS02445 peptidase C69 0.46 CA265_RS19000 NADP-dependent malic enzyme low > 88
Pontibacter actiniarum KMM 6156, DSM 19842 0.06 CA264_16645 peptidase C69 0.45 CA264_14540 NADP-dependent malic enzyme low > 74

Not shown: 24 genomes with orthologs for ECD_04103 only; 7 genomes with orthologs for ECD_02354 only