| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_12260 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 1.0 | CSW01_12405 | | GTP diphosphokinase | 0.67 | 3 |
| Escherichia coli ECOR38 | 0.62 | HEPCGN_08505 | ampD | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | HEPCGN_19500 | relA | GTP diphosphokinase | low | > 88 |
| Escherichia fergusonii Becca | 0.62 | EFB2_03939 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | EFB2_01133 | | GTP pyrophosphokinase | low | > 86 |
| Escherichia coli Nissle 1917 | 0.62 | ECOLIN_RS00590 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | ECOLIN_RS15515 | | GTP diphosphokinase | low | > 55 |
| Enterobacter sp. TBS_079 | 0.62 | MPMX20_00801 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.66 | MPMX20_03653 | | GTP pyrophosphokinase | low | > 85 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.61 | GFF129 | | N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) AmpD | 0.67 | GFF4837 | | 'GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)' transl_table=11 | low | > 78 |
| Escherichia coli ECRC101 | 0.61 | MCAODC_01040 | ampD | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | MCAODC_10775 | relA | GTP diphosphokinase | low | > 87 |
| Escherichia coli ECRC100 | 0.61 | OKFHMN_10525 | ampD | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | OKFHMN_20250 | relA | GTP diphosphokinase | low | > 79 |
| Escherichia coli ECRC98 | 0.61 | JDDGAC_14120 | ampD | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | JDDGAC_23915 | relA | GTP diphosphokinase | low | > 87 |
| Enterobacter asburiae PDN3 | 0.61 | EX28DRAFT_3703 | | N-acetylmuramoyl-L-alanine amidase | 0.66 | EX28DRAFT_2864 | | (p)ppGpp synthetase, RelA/SpoT family | — | — |
| Escherichia coli ECRC99 | 0.61 | KEDOAH_17630 | ampD | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | KEDOAH_07880 | relA | GTP diphosphokinase | — | — |
| Erwinia amylovora T8 | 0.61 | OLJFJH_01045 | | 1 6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.66 | OLJFJH_09245 | | GTP diphosphokinase | low | > 58 |
| Escherichia coli ECRC102 | 0.61 | NIAGMN_08375 | ampD | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | NIAGMN_18020 | relA | GTP diphosphokinase | low | > 80 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.61 | OHPLBJKB_03551 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | OHPLBJKB_00947 | | GTP pyrophosphokinase | low | > 74 |
| Alteromonas macleodii MIT1002 | 0.61 | MIT1002_03006 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.53 | MIT1002_00794 | | GTP pyrophosphokinase | low | > 70 |
| Escherichia coli BW25113 | 0.61 | b0110 | ampD | N-acetyl-anhydromuranmyl-L-alanine amidase (NCBI) | 0.67 | b2784 | relA | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | low | > 76 |
| Escherichia coli ECOR27 | 0.61 | NOLOHH_02870 | ampD | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | NOLOHH_12125 | relA | GTP diphosphokinase | low | > 76 |
| Escherichia coli ECRC62 | 0.61 | BNILDI_08740 | ampD | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | BNILDI_10630 | relA | GTP diphosphokinase | low | > 75 |
| Escherichia coli BL21 | 0.61 | ECD_00109 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase, Zn-dependent; murein amidase | 0.67 | ECD_02629 | | (p)ppGpp synthetase I/GTP pyrophosphokinase | low | > 61 |
| Klebsiella michiganensis M5al | 0.61 | BWI76_RS04850 | | N-acetylmuramoyl-L-alanine amidase | 0.67 | BWI76_RS22805 | | GTP diphosphokinase | low | > 92 |
| Klebsiella pneumoniae MKP103 | 0.60 | KDGMDA_13085 | | 1 6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | KDGMDA_03335 | | GTP diphosphokinase | 0.73 | 18 |
| Kangiella aquimarina DSM 16071 | 0.60 | B158DRAFT_2134 | | Negative regulator of beta-lactamase expression | 0.43 | B158DRAFT_2277 | | (p)ppGpp synthetase, RelA/SpoT family | low | > 40 |
| Rahnella sp. WP5 | 0.59 | EX31_RS03510 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.66 | EX31_RS07955 | | GTP diphosphokinase | 0.60 | 7 |
| Herbaspirillum seropedicae SmR1 | 0.59 | HSERO_RS01880 | | N-acetyl-anhydromuranmyl-L-alanine amidase | 0.35 | HSERO_RS09855 | | GTP pyrophosphokinase | low | > 78 |
| Pantoea sp. MT58 | 0.58 | IAI47_15840 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.66 | IAI47_04120 | | GTP diphosphokinase | low | > 76 |
| Pantoea agglomerans CFBP13505 P0401 | 0.58 | PagCFBP13505_RS13160 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.66 | PagCFBP13505_RS16850 | | GTP diphosphokinase | low | > 74 |
| Serratia liquefaciens MT49 | 0.57 | IAI46_03535 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.66 | IAI46_03600 | | GTP diphosphokinase | low | > 87 |
| Pseudomonas segetis P6 | 0.56 | MPMX49_03899 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.44 | MPMX49_01654 | | GTP pyrophosphokinase | low | > 75 |
| Dickeya dianthicola ME23 | 0.56 | DZA65_RS19020 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | DZA65_RS18145 | | GTP diphosphokinase | 0.56 | 2 |
| Dickeya dianthicola 67-19 | 0.56 | HGI48_RS17875 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | HGI48_RS17070 | | GTP diphosphokinase | low | > 71 |
| Pectobacterium carotovorum WPP14 | 0.56 | HER17_RS03260 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.66 | HER17_RS04115 | | GTP diphosphokinase | low | > 75 |
| Dickeya dadantii 3937 | 0.56 | DDA3937_RS17945 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.67 | DDA3937_RS17015 | | GTP diphosphokinase | low | > 74 |
| Pseudomonas sp. SVBP6 | 0.56 | COO64_RS03530 | ampD | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.45 | COO64_RS07325 | relA | GTP diphosphokinase | — | — |
| Pseudomonas aeruginosa PA14 | 0.55 | IKLFDK_01470 | | beta-lactamase expression regulator AmpD | 0.45 | IKLFDK_04200 | | GTP diphosphokinase | low | > 98 |
| Pseudomonas aeruginosa PUPa3 | 0.55 | DQ20_RS56325 | ampD;go_function=N-acetylmuramoyl-L-alanine | 1 6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.45 | DQ20_RS45020 | relA;go_process=guanosine | GTP diphosphokinase | low | > 101 |
| Shewanella sp. ANA-3 | 0.55 | Shewana3_0423 | | N-acetyl-anhydromuranmyl-L-alanine amidase (RefSeq) | 0.56 | Shewana3_1111 | | (p)ppGpp synthetase I, SpoT/RelA (RefSeq) | low | > 73 |
| Pseudomonas lactucae CFBP13502 | 0.53 | GEMAOFIL_00991 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.45 | GEMAOFIL_04223 | | GTP pyrophosphokinase | low | > 96 |
| Shewanella oneidensis MR-1 | 0.53 | SO0421 | ampD | AmpD protein (NCBI ptt file) | 0.56 | SO3455 | relA | GTP pyrophosphokinase (NCBI ptt file) | low | > 76 |
| Pseudomonas simiae WCS417 | 0.53 | PS417_03935 | | N-acetyl-anhydromuranmyl-L-alanine amidase | 0.45 | PS417_20150 | | (p)ppGpp synthetase | — | — |
| Pseudomonas sp. RS175 | 0.53 | PFR28_00100 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.45 | PFR28_03223 | | GTP pyrophosphokinase | low | > 88 |
| Marinobacter adhaerens HP15 | 0.53 | HP15_1307 | | N-acetyl-anhydromuranmyl-L-alanine amidase | 0.43 | HP15_791 | | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.53 | Pf1N1B4_1151 | | N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) AmpD | 0.45 | Pf1N1B4_3508 | | GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.53 | PFLU_RS03980 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.45 | PFLU_RS22095 | | GTP diphosphokinase | low | > 109 |
| Pseudomonas sp. S08-1 | 0.53 | OH686_16530 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase | 0.45 | OH686_18960 | | Inactive (p)ppGpp 3'-pyrophosphohydrolase domain / GTP pyrophosphokinase , (p)ppGpp synthetase I | low | > 80 |
| Pseudomonas fluorescens SBW25 | 0.53 | PFLU_RS03980 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.45 | PFLU_RS22095 | | GTP diphosphokinase | 0.81 | 30 |
| Shewanella amazonensis SB2B | 0.53 | Sama_0372 | | N-acetyl-anhydromuranmyl-L-alanine amidase (RefSeq) | 0.57 | Sama_1033 | | GTP diphosphokinase (RefSeq) | low | > 62 |
| Pseudomonas sp. DMC3 | 0.53 | GFF4998 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.45 | GFF4818 | | GTP pyrophosphokinase | low | > 89 |
| Shewanella loihica PV-4 | 0.53 | Shew_3434 | | N-acetyl-anhydromuranmyl-L-alanine amidase (RefSeq) | 0.56 | Shew_1202 | | (p)ppGpp synthetase I, SpoT/RelA (RefSeq) | low | > 60 |
| Pseudomonas fluorescens GW456-L13 | 0.52 | PfGW456L13_5081 | | N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) AmpD | 0.45 | PfGW456L13_2035 | | GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) | — | — |
| Pseudomonas stutzeri RCH2 | 0.52 | Psest_0725 | | Negative regulator of beta-lactamase expression | 0.44 | Psest_1640 | | (p)ppGpp synthetase, RelA/SpoT family | low | > 67 |
| Pseudomonas fluorescens FW300-N2C3 | 0.52 | AO356_07360 | | N-acetyl-anhydromuranmyl-L-alanine amidase | 0.45 | AO356_19060 | | (p)ppGpp synthetase | low | > 104 |
| Pseudomonas syringae pv. syringae B728a | 0.52 | Psyr_0817 | | N-acetylmuramoyl-L-alanine amidase, family 2 | 0.45 | Psyr_3695 | | RelA/SpoT protein | low | > 86 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.52 | Psyr_0817 | | N-acetylmuramoyl-L-alanine amidase, family 2 | 0.45 | Psyr_3695 | | RelA/SpoT protein | low | > 86 |
| Pseudomonas fluorescens FW300-N2E2 | 0.52 | Pf6N2E2_3344 | | N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) AmpD | 0.45 | Pf6N2E2_5723 | | GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) | low | > 103 |
| Pseudomonas fluorescens FW300-N2E3 | 0.51 | AO353_05510 | | N-acetyl-anhydromuranmyl-L-alanine amidase | 0.45 | AO353_02710 | | (p)ppGpp synthetase | low | > 101 |
| Pseudomonas putida KT2440 | 0.51 | PP_0789 | | N-acetyl-anhydromuramyl-L-alanine-amidase | 0.45 | PP_1656 | | ATP:GTP 3'-pyrophosphotransferase | low | > 96 |
| Pseudomonas sp. BP01 | 0.51 | JOY50_RS19335 | ampD | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.45 | JOY50_RS23910 | relA | GTP diphosphokinase | low | > 84 |
| Acinetobacter radioresistens SK82 | 0.50 | MPMX26_00043 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.35 | MPMX26_00539 | | GTP pyrophosphokinase | low | > 36 |
| Castellaniella sp019104865 MT123 | 0.50 | ABCV34_RS09025 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.34 | ABCV34_RS08440 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | low | > 48 |
| Acinetobacter baumannii LAC-4 | 0.49 | RR41_RS18675 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.35 | RR41_RS16080 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | low | > 55 |
| Burkholderia phytofirmans PsJN | 0.48 | BPHYT_RS17065 | | N-acetyl-anhydromuranmyl-L-alanine amidase | 0.35 | BPHYT_RS13655 | | GTP pyrophosphokinase | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.48 | RR42_RS17865 | | N-acetyl-anhydromuranmyl-L-alanine amidase | 0.37 | RR42_RS06585 | | GTP pyrophosphokinase | low | > 128 |
| Dechlorosoma suillum PS | 0.47 | Dsui_0134 | | negative regulator of beta-lactamase expression | 0.38 | Dsui_2816 | | (p)ppGpp synthetase, RelA/SpoT family | low | > 51 |
| Paraburkholderia bryophila 376MFSha3.1 | 0.47 | H281DRAFT_06273 | | AmpD protein | 0.35 | H281DRAFT_04499 | | GTP pyrophosphokinase | low | > 103 |
| Paraburkholderia sabiae LMG 24235 | 0.47 | QEN71_RS27225 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.37 | QEN71_RS05265 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | low | > 153 |
| Paraburkholderia graminis OAS925 | 0.47 | ABIE53_003579 | | AmpD protein | 0.35 | ABIE53_002905 | | GTP pyrophosphokinase | low | > 113 |
| Methylophilus sp. DMC18 | 0.47 | GFF2302 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.37 | GFF2658 | | GTP pyrophosphokinase | — | — |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.47 | GFF594 | | N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) AmpD | 0.34 | GFF4925 | | GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I | — | — |
| Ralstonia solanacearum GMI1000 | 0.46 | RS_RS14030 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.38 | RS_RS07930 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Ralstonia solanacearum PSI07 | 0.45 | RPSI07_RS11160 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.38 | RPSI07_RS15685 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Ralstonia solanacearum UW163 | 0.45 | UW163_RS07545 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.38 | UW163_RS15115 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.45 | RALBFv3_RS06080 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.38 | RALBFv3_RS01805 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Variovorax sp. SCN45 | 0.45 | GFF4433 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase | 0.32 | GFF403 | | Inactive (p)ppGpp 3'-pyrophosphohydrolase domain / GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I | low | > 127 |
| Ralstonia sp. UNC404CL21Col | 0.44 | ABZR87_RS01745 | | 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD | 0.38 | ABZR87_RS13745 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | low | > 80 |
| Acidovorax sp. GW101-3H11 | 0.37 | Ac3H11_4020 | | N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) AmpD | 0.34 | Ac3H11_362 | | GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I | — | — |
Not shown: 1 genomes with orthologs for CSW01_12260 only; 16 genomes with orthologs for CSW01_12405 only