| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
|---|
| Bacteroides thetaiotaomicron VPI-5482 | 1.0 | BT1607 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase (NCBI ptt file) | 1.0 | BT0700 | | GTP pyrophosphokinase (NCBI ptt file) | 0.76 | 11 |
| Bacteroides stercoris CC31F | 0.97 | HMPREF1181_RS11305 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.82 | HMPREF1181_RS16240 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | low | > 56 |
| Bacteroides ovatus ATCC 8483 | 0.97 | BACOVA_04344 | | tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein | 0.96 | BACOVA_02404 | | RelA/SpoT family protein | low | > 94 |
| Phocaeicola vulgatus CL09T03C04 | 0.96 | HMPREF1058_RS15075 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.78 | HMPREF1058_RS17885 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | low | > 67 |
| Phocaeicola dorei CL03T12C01 | 0.96 | ABI39_RS10870 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.78 | ABI39_RS14150 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | low | > 72 |
| Parabacteroides merdae CL09T00C40 | 0.84 | HMPREF1078_RS14700 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.61 | HMPREF1078_RS16595 | | HD domain-containing protein | low | > 61 |
| Pedobacter sp. GW460-11-11-14-LB5 | 0.65 | CA265_RS08950 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.46 | CA265_RS14485 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Mucilaginibacter yixingensis YX-36 DSM 26809 | 0.64 | ABZR88_RS09400 | | bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase | 0.47 | ABZR88_RS15610 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.44 | RR42_RS07345 | | methenyltetrahydrofolate cyclohydrolase | 0.23 | RR42_RS06585 | | GTP pyrophosphokinase | — | — |
| Variovorax sp. SCN45 | 0.44 | GFF964 | | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) / Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) | 0.20 | GFF403 | | Inactive (p)ppGpp 3'-pyrophosphohydrolase domain / GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I | — | — |
| Acidovorax sp. GW101-3H11 | 0.44 | Ac3H11_4096 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.21 | Ac3H11_362 | | GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I | — | — |
| Erwinia tracheiphila SCR3 | 0.44 | LU632_RS15195 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.25 | LU632_RS06350 | relA | GTP diphosphokinase | — | — |
| Vibrio cholerae E7946 ATCC 55056 | 0.44 | CSW01_09720 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.24 | CSW01_12405 | | GTP diphosphokinase | low | > 62 |
| Dickeya dianthicola ME23 | 0.43 | DZA65_RS15960 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.24 | DZA65_RS18145 | | GTP diphosphokinase | — | — |
| Dickeya dianthicola 67-19 | 0.43 | HGI48_RS15155 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.25 | HGI48_RS17070 | | GTP diphosphokinase | — | — |
| Dickeya dadantii 3937 | 0.43 | DDA3937_RS15075 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.25 | DDA3937_RS17015 | | GTP diphosphokinase | — | — |
| Rahnella sp. WP5 | 0.43 | EX31_RS22835 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.24 | EX31_RS07955 | | GTP diphosphokinase | — | — |
| Shewanella sp. ANA-3 | 0.43 | Shewana3_2663 | | methenyltetrahydrofolate cyclohydrolase (RefSeq) | 0.23 | Shewana3_1111 | | (p)ppGpp synthetase I, SpoT/RelA (RefSeq) | — | — |
| Alteromonas macleodii MIT1002 | 0.43 | MIT1002_02770 | | hypothetical protein | 0.23 | MIT1002_00794 | | GTP pyrophosphokinase | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.43 | GFF4447 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.24 | GFF4837 | | 'GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)' transl_table=11 | — | — |
| Shewanella oneidensis MR-1 | 0.43 | SO1792 | folD | methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase (NCBI ptt file) | 0.23 | SO3455 | relA | GTP pyrophosphokinase (NCBI ptt file) | — | — |
| Shewanella loihica PV-4 | 0.42 | Shew_2510 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | 0.23 | Shew_1202 | | (p)ppGpp synthetase I, SpoT/RelA (RefSeq) | — | — |
| Pectobacterium carotovorum WPP14 | 0.42 | HER17_RS06505 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.24 | HER17_RS04115 | | GTP diphosphokinase | — | — |
| Herbaspirillum seropedicae SmR1 | 0.42 | HSERO_RS07295 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.22 | HSERO_RS09855 | | GTP pyrophosphokinase | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.42 | RALBFv3_RS01685 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.22 | RALBFv3_RS01805 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Ralstonia solanacearum UW163 | 0.42 | UW163_RS14995 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.22 | UW163_RS15115 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Pseudomonas putida KT2440 | 0.42 | PP_1945 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.24 | PP_1656 | | ATP:GTP 3'-pyrophosphotransferase | low | > 96 |
| Ralstonia solanacearum GMI1000 | 0.42 | RS_RS08040 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.22 | RS_RS07930 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Pantoea sp. MT58 | 0.42 | IAI47_14320 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.25 | IAI47_04120 | | GTP diphosphokinase | — | — |
| Ralstonia solanacearum PSI07 | 0.42 | RPSI07_RS15800 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.23 | RPSI07_RS15685 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.42 | Psyr_2225 | | methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | 0.24 | Psyr_3695 | | RelA/SpoT protein | low | > 86 |
| Pseudomonas syringae pv. syringae B728a | 0.42 | Psyr_2225 | | methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | 0.24 | Psyr_3695 | | RelA/SpoT protein | low | > 86 |
| Escherichia coli ECOR38 | 0.41 | HEPCGN_06445 | | Bifunctional protein FolD | 0.24 | HEPCGN_19500 | relA | GTP diphosphokinase | — | — |
| Escherichia coli BL21 | 0.41 | ECD_00479 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.24 | ECD_02629 | | (p)ppGpp synthetase I/GTP pyrophosphokinase | — | — |
| Escherichia coli ECRC101 | 0.41 | MCAODC_27025 | | Bifunctional protein FolD | 0.24 | MCAODC_10775 | relA | GTP diphosphokinase | — | — |
| Escherichia coli ECRC62 | 0.41 | BNILDI_22225 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.24 | BNILDI_10630 | relA | GTP diphosphokinase | — | — |
| Escherichia coli ECRC99 | 0.41 | KEDOAH_20165 | | Bifunctional protein FolD | 0.24 | KEDOAH_07880 | relA | GTP diphosphokinase | — | — |
| Escherichia coli ECOR27 | 0.41 | NOLOHH_00795 | | Bifunctional protein FolD | 0.24 | NOLOHH_12125 | relA | GTP diphosphokinase | — | — |
| Escherichia coli Nissle 1917 | 0.41 | ECOLIN_RS03065 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.24 | ECOLIN_RS15515 | | GTP diphosphokinase | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.41 | OHPLBJKB_03152 | | Bifunctional protein FolD protein | 0.24 | OHPLBJKB_00947 | | GTP pyrophosphokinase | — | — |
| Escherichia coli ECRC102 | 0.41 | NIAGMN_05860 | | Bifunctional protein FolD | 0.24 | NIAGMN_18020 | relA | GTP diphosphokinase | — | — |
| Escherichia coli ECRC98 | 0.41 | JDDGAC_11455 | | Bifunctional protein FolD | 0.24 | JDDGAC_23915 | relA | GTP diphosphokinase | — | — |
| Klebsiella michiganensis M5al | 0.41 | BWI76_RS07100 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.24 | BWI76_RS22805 | | GTP diphosphokinase | — | — |
| Escherichia coli BW25113 | 0.41 | b0529 | folD | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase (NCBI) | 0.24 | b2784 | relA | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | — | — |
| Escherichia coli ECRC101 | 0.41 | OKFHMN_07805 | | Bifunctional protein FolD | 0.24 | OKFHMN_20250 | relA | GTP diphosphokinase | — | — |
| Ralstonia sp. UNC404CL21Col | 0.41 | ABZR87_RS13485 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.23 | ABZR87_RS13745 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Escherichia fergusonii Becca | 0.41 | EFB2_03532 | | Bifunctional protein FolD protein | 0.24 | EFB2_01133 | | GTP pyrophosphokinase | — | — |
| Serratia liquefaciens MT49 | 0.41 | IAI46_05400 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.23 | IAI46_03600 | | GTP diphosphokinase | — | — |
| Shewanella amazonensis SB2B | 0.41 | Sama_1222 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | 0.25 | Sama_1033 | | GTP diphosphokinase (RefSeq) | — | — |
| Pseudomonas sp. S08-1 | 0.41 | OH686_03670 | | Methenyltetrahydrofolate cyclohydrolase / Methylenetetrahydrofolate dehydrogenase (NADP+) | 0.24 | OH686_18960 | | Inactive (p)ppGpp 3'-pyrophosphohydrolase domain / GTP pyrophosphokinase , (p)ppGpp synthetase I | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.41 | AO353_20145 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.24 | AO353_02710 | | (p)ppGpp synthetase | — | — |
| Enterobacter sp. TBS_079 | 0.41 | MPMX20_01107 | | Bifunctional protein FolD protein | 0.24 | MPMX20_03653 | | GTP pyrophosphokinase | — | — |
| Enterobacter asburiae PDN3 | 0.41 | EX28DRAFT_2449 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.24 | EX28DRAFT_2864 | | (p)ppGpp synthetase, RelA/SpoT family | — | — |
| Pseudomonas stutzeri RCH2 | 0.41 | Psest_2301 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.25 | Psest_1640 | | (p)ppGpp synthetase, RelA/SpoT family | — | — |
| Pseudomonas simiae WCS417 | 0.40 | PS417_17265 | | methenyltetrahydrofolate cyclohydrolase | 0.24 | PS417_20150 | | (p)ppGpp synthetase | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.40 | Pf6N2E2_2221 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.24 | Pf6N2E2_5723 | | GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) | — | — |
| Pseudomonas sp. RS175 | 0.40 | PFR28_01223 | | Bifunctional protein FolD protein | 0.24 | PFR28_03223 | | GTP pyrophosphokinase | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.40 | PfGW456L13_2550 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.24 | PfGW456L13_2035 | | GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.40 | Pf1N1B4_3943 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.24 | Pf1N1B4_3508 | | GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.40 | AO356_01775 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.24 | AO356_19060 | | (p)ppGpp synthetase | — | — |
| Marinobacter adhaerens HP15 | 0.40 | HP15_2187 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.24 | HP15_791 | | (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA | — | — |
| Pseudomonas fluorescens SBW25 | 0.40 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.24 | PFLU_RS22095 | | GTP diphosphokinase | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.40 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.24 | PFLU_RS22095 | | GTP diphosphokinase | — | — |
| Rhodanobacter denitrificans FW104-10B01 | 0.38 | LRK54_RS00100 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.22 | LRK54_RS12725 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Rhodanobacter denitrificans MT42 | 0.38 | LRK55_RS18095 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.22 | LRK55_RS12430 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Acinetobacter radioresistens SK82 | 0.38 | MPMX26_00777 | | Bifunctional protein FolD protein | 0.20 | MPMX26_00539 | | GTP pyrophosphokinase | — | — |
| Fusobacterium nucleatum SB010 | 0.37 | HUW76_09060 | | bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase | 0.26 | HUW76_09030 | | bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase | — | — |
| Xanthomonas campestris pv. campestris strain 8004 | 0.34 | Xcc-8004.2390.1 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.23 | Xcc-8004.1489.1 | | GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I | — | — |
Not shown: 34 genomes with orthologs for BT1607 only; 0 genomes with orthologs for BT0700 only