| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS15415 | | response regulator | insig. | 100 | 100 |
| | Rhodospirillum rubrum S1H | Rru_A3293 | | two-component response regulator (NarL subfamily) (NCBI) | insig. | 31 | 79 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS07235 | | signal transduction histidine kinase | insig. | 30 | 49 |
| | Pantoea agglomerans CFBP13505 P0401 | PagCFBP13505_RS16725 | | two-component system response regulator NarL | insig. | 34 | 42 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS03925 | | diguanylate cyclase | insig. | 34 | 34 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_3852 | | DNA-binding response regulator, LuxR family | no data | 36 | 23 |
| | Pantoea sp. MT58 | IAI47_04245 | | two-component system response regulator NarL | sig. | 32 | 39 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS02865 | | response regulator | insig. | 25 | 58 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS09645 | | ATP-binding protein | insig. | 29 | 50 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS15005 | | two-component system response regulator | insig. | 27 | 40 |
| | Rhodospirillum rubrum S1H | Rru_A1653 | | guanylate cyclase (GGDEF domain) with PAS/PAC sensor and Response Regulator Receiver modulation (NCBI) | insig. | 33 | 29 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF5823 | | Nitrate/nitrite response regulator protein | no data | 28 | 42 |
| | Serratia liquefaciens MT49 | IAI46_15610 | | two-component system response regulator NarL | insig. | 32 | 41 |
| | Dechlorosoma suillum PS | Dsui_2158 | | response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain | cofit | 32 | 27 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_12485 | | two-component system response regulator | strong | 30 | 36 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU2114 | atoC | sigma-54 dependent transcriptional regulator/response regulator (TIGR) | insig. | 27 | 54 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_19985 | | two-component system response regulator NarL | insig. | 30 | 38 |
| | Pseudomonas stutzeri RCH2 | Psest_3491 | | Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain | no data | 30 | 28 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS01790 | | LuxR family transcriptional regulator | strong | 28 | 26 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF3581 | | Secretion system regulator of DegU/UvrY/BvgA type | insig. | 27 | 35 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_2748 | | two component, sigma54 specific, transcriptional regulator, Fis family (RefSeq) | insig. | 25 | 49 |
| | Caulobacter crescentus NA1000 | CCNA_03130 | | cell cycle response regulator CtrA | no data | 32 | 35 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_03130 | | cell cycle response regulator CtrA | no data | 32 | 35 |
| | Paraburkholderia graminis OAS925 | ABIE53_000448 | | two-component system invasion response regulator UvrY | strong | 30 | 26 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_2541 | | multi-sensor signal transduction histidine kinase (RefSeq) | insig. | 27 | 53 |
| | Variovorax sp. SCN45 | GFF1411 | | Two-component transcriptional response regulator, LuxR family | insig. | 32 | 39 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS34855 | | LuxR family transcriptional regulator | insig. | 31 | 35 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_02179 | | two component transcriptional regulator, LuxR family | cofit | 28 | 26 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS05870 | | PglZ domain-containing protein | strong | 21 | 43 |
| | Bosea sp. OAE506 | ABIE41_RS15410 | | response regulator transcription factor | insig. | 33 | 35 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_04126 | | Transcriptional regulatory protein DegU | cofit | 32 | 36 |
| | Variovorax sp. SCN45 | GFF5597 | | Two-component transcriptional response regulator, LuxR family | insig. | 32 | 21 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS08905 | | XRE family transcriptional regulator | insig. | 27 | 41 |
| | Agrobacterium fabrum C58 | Atu1988 | | two component sensor kinase | insig. | 26 | 57 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_3084 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | insig. | 26 | 68 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_3084 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | insig. | 26 | 68 |
| | Variovorax sp. OAS795 | ABID97_RS19555 | | response regulator transcription factor | insig. | 32 | 44 |
| | Sphingobium sp. HT1-2 | GFF1825 | | Two-component transcriptional response regulator, NarL/FixJ family | cofit | 38 | 21 |
| | Mycobacterium tuberculosis H37Rv | Rv1027c | | Probable transcriptional regulatory protein KdpE | no data | 29 | 46 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_2264 | | Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains | strong | 27 | 26 |
| | Variovorax sp. OAS795 | ABID97_RS07360 | | response regulator transcription factor | strong | 34 | 21 |
| | Variovorax sp. SCN45 | GFF2564 | | Two-component transcriptional response regulator, LuxR family | cofit | 34 | 21 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_00410 | | two component transcriptional regulator, LuxR family | insig. | 32 | 21 |
| | Pseudomonas putida KT2440 | PP_1651 | | two-component response regulator | insig. | 32 | 35 |
| | Xanthobacter sp. DMC5 | GFF221 | | Cell cycle response regulator CtrA | no data | 31 | 35 |
| | Shewanella loihica PV-4 | Shew_3200 | | multi-sensor hybrid histidine kinase (RefSeq) | insig. | 28 | 47 |
| | Azospirillum brasilense Sp245 | AZOBR_RS26130 | | ATPase AAA | insig. | 27 | 49 |
| | Pseudomonas sp. S08-1 | OH686_08925 | | Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB | cofit | 25 | 56 |
| | Shewanella loihica PV-4 | Shew_3317 | | two component transcriptional regulator (RefSeq) | insig. | 23 | 66 |
| | Paraburkholderia graminis OAS925 | ABIE53_002843 | | DNA-binding NarL/FixJ family response regulator | sig. | 32 | 21 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF2765 | | Nitrate/nitrite response regulator protein | insig. | 35 | 38 |
| | Variovorax sp. SCN45 | GFF69 | | Two-component transcriptional response regulator, LuxR family | insig. | 32 | 39 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU0140 | cheYI | response regulator (TIGR) | insig. | 26 | 39 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS34135 | | two-component system response regulator NarL | insig. | 29 | 42 |
| | Enterobacter asburiae PDN3 | EX28DRAFT_0848 | | two component transcriptional regulator, LuxR family | insig. | 35 | 38 |
| | Pseudomonas sp. DMC3 | GFF4822 | | Transcriptional regulatory protein OmpR | insig. | 33 | 35 |
| | Variovorax sp. SCN45 | GFF1180 | | hypothetical protein | insig. | 30 | 35 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_1932 | | Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain | strong | 29 | 35 |
| | Azospirillum sp. SherDot2 | MPMX19_01591 | | Sensor histidine kinase RcsC | insig. | 25 | 34 |
| | Pseudomonas sp. SVBP6 | COO64_RS07345 | | response regulator transcription factor | insig. | 31 | 35 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS13150 | | hisitidine kinase | no data | 31 | 21 |
| | Pseudomonas sp. RS175 | PFR28_01009 | | Transcriptional regulatory protein DegU | insig. | 31 | 30 |
| | Serratia liquefaciens MT49 | IAI46_18680 | | two-component system response regulator NarL | insig. | 29 | 37 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS12850 | | LuxR family transcriptional regulator | strong | 29 | 30 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_2418 | | DNA-binding response regulator, LuxR family | insig. | 29 | 30 |
| | Pseudomonas sp. DMC3 | GFF4570 | | Transcriptional regulatory protein DegU | insig. | 28 | 30 |
| | Rhodospirillum rubrum S1H | Rru_A2158 | | Two Component, Sigma54 Specific, Transcriptional Regulator, Fis family (NCBI) | insig. | 26 | 54 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_05195 | | sigma-54-dependent Fis family transcriptional regulator | sig. | 23 | 62 |
| | Escherichia coli BL21 | ECD_01199 | | response regulator in two-component regulatory system with NarX | no data | 34 | 38 |
| | Escherichia fergusonii Becca | EFB2_02705 | | Nitrate/nitrite response regulator protein NarL | insig. | 34 | 38 |
| | Escherichia coli ECOR27 | NOLOHH_20535 | narX | nitrate/nitrite two-component system sensor histidine kinase NarX | no data | 34 | 38 |
| | Escherichia coli ECOR38 | HEPCGN_24980 | narX | nitrate/nitrite two-component system sensor histidine kinase NarX | sig. | 34 | 38 |
| | Escherichia coli ECRC100 | OKFHMN_28520 | narX | nitrate/nitrite two-component system sensor histidine kinase NarX | no data | 34 | 38 |
| | Escherichia coli ECRC101 | MCAODC_21740 | narX | nitrate/nitrite two-component system sensor histidine kinase NarX | sig. | 34 | 38 |
| | Escherichia coli ECRC102 | NIAGMN_27715 | narX | nitrate/nitrite two-component system sensor histidine kinase NarX | insig. | 34 | 38 |
| | Escherichia coli ECRC62 | BNILDI_18685 | narX | nitrate/nitrite two-component system sensor histidine kinase NarX | cofit | 34 | 38 |
| | Escherichia coli ECRC98 | JDDGAC_06055 | narX | nitrate/nitrite two-component system sensor histidine kinase NarX | insig. | 34 | 38 |
| | Escherichia coli ECRC99 | KEDOAH_25515 | narX | nitrate/nitrite two-component system sensor histidine kinase NarX | no data | 34 | 38 |
| | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_02463 | | Nitrate/nitrite response regulator protein NarL | sig. | 34 | 38 |
| | Escherichia coli Nissle 1917 | ECOLIN_RS07375 | | two-component system response regulator NarL | insig. | 34 | 38 |
| | Enterobacter sp. TBS_079 | MPMX20_02618 | | Nitrate/nitrite response regulator protein NarL | strong | 34 | 38 |
| | Escherichia coli BW25113 | b1221 | narL | DNA-binding response regulator in two-component regulatory system with NarX (or NarQ) (NCBI) | strong | 34 | 38 |
| | Pseudomonas fluorescens FW300-N2E3 | AO353_02730 | | transcriptional regulator | insig. | 29 | 36 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_02965 | | LuxR family transcriptional regulator | insig. | 28 | 30 |
| | Marinobacter adhaerens HP15 | HP15_185 | | two component transcriptional regulator, winged helix family | insig. | 27 | 35 |
| | Serratia liquefaciens MT49 | IAI46_06400 | | response regulator transcription factor | insig. | 33 | 19 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF2789 | | DNA-binding response regulator, LuxR family | insig. | 32 | 26 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS24135 | | DNA-binding response regulator | insig. | 30 | 22 |
| | Methylophilus sp. DMC18 | GFF88 | | Response regulator UvrY | insig. | 29 | 27 |
| | Pseudomonas sp. RS175 | PFR28_04634 | | Alginate biosynthesis transcriptional regulatory protein AlgB | strong | 28 | 37 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_25 | | DNA-binding response regulator, LuxR family | insig. | 25 | 39 |
| | Dinoroseobacter shibae DFL-12 | Dshi_1508 | | two component transcriptional regulator, winged helix family (RefSeq) | strong | 25 | 54 |
| | Alteromonas macleodii MIT1002 | MIT1002_03317 | | Transcriptional regulatory protein DevR (DosR) | strong | 25 | 35 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS13915 | | DNA-binding response regulator | cofit | 31 | 30 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS21600 | | response regulator transcription factor | insig. | 30 | 36 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS21600 | | response regulator transcription factor | sig. | 30 | 36 |
| | Pseudomonas simiae WCS417 | PS417_19630 | | LuxR family transcriptional regulator | cofit | 30 | 36 |
| | Variovorax sp. OAS795 | ABID97_RS19165 | | response regulator transcription factor | no data | 29 | 36 |
| | Escherichia coli BW25113 | b2193 | narP | DNA-binding response regulator in two-component regulatory system with NarQ or NarX (NCBI) | insig. | 29 | 39 |
| | Rhizobium sp. OAE497 | ABIE40_RS11240 | | response regulator | cofit | 28 | 49 |