Conservation of cofitness between BWI76_RS02510 and BWI76_RS00890 in Klebsiella michiganensis M5al

60 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS02510 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 1.0 BWI76_RS00890 vitamin B12/cobalamin outer membrane transporter 0.26 5
Enterobacter asburiae PDN3 0.80 EX28DRAFT_3364 yjeF C-terminal region, hydroxyethylthiazole kinase-related/yjeF N-terminal region 0.51 EX28DRAFT_4429 TonB-dependent vitamin B12 receptor low > 76
Escherichia coli Nissle 1917 0.79 ECOLIN_RS24205 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.52 ECOLIN_RS22905 TonB-dependent vitamin B12 receptor BtuB low > 55
Enterobacter sp. TBS_079 0.79 MPMX20_00448 Bifunctional NAD(P)H-hydrate repair enzyme Nnr 0.53 MPMX20_04514 Vitamin B12 transporter BtuB low > 85
Escherichia coli BW25113 0.79 b4167 yjeF predicted carbohydrate kinase (NCBI) 0.52 b3966 btuB vitamin B12/cobalamin outer membrane transporter (NCBI) low > 76
Escherichia coli ECRC102 0.78 NIAGMN_10130 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.52 NIAGMN_11280 btuB TonB-dependent vitamin B12 receptor BtuB — —
Escherichia coli ECRC100 0.78 OKFHMN_12280 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.52 OKFHMN_13530 btuB TonB-dependent vitamin B12 receptor BtuB low > 80
Escherichia coli ECRC98 0.78 JDDGAC_15920 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.52 JDDGAC_17155 btuB TonB-dependent vitamin B12 receptor BtuB low > 86
Escherichia coli ECRC101 0.78 MCAODC_02795 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.52 MCAODC_04030 btuB TonB-dependent vitamin B12 receptor BtuB low > 87
Escherichia coli ECRC99 0.78 KEDOAH_15875 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.52 KEDOAH_14630 btuB TonB-dependent vitamin B12 receptor BtuB — —
Escherichia fergusonii Becca 0.78 EFB2_04368 Bifunctional NAD(P)H-hydrate repair enzyme Nnr 0.68 EFB2_04644 Vitamin B12 transporter BtuB low > 86
Escherichia coli ECRC62 0.78 BNILDI_06945 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.52 BNILDI_05850 btuB TonB-dependent vitamin B12 receptor BtuB low > 75
Escherichia coli HS(pFamp)R (ATCC 700891) 0.78 OHPLBJKB_03875 Bifunctional NAD(P)H-hydrate repair enzyme Nnr 0.52 OHPLBJKB_04084 Vitamin B12 transporter BtuB 0.41 23
Escherichia coli ECOR27 0.78 NOLOHH_04545 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.52 NOLOHH_05675 btuB TonB-dependent vitamin B12 receptor BtuB low > 75
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.78 GFF820 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.53 GFF2352 Outer membrane vitamin B12 receptor BtuB low > 78
Escherichia coli ECOR38 0.78 HEPCGN_10510 nnr bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.52 HEPCGN_12185 btuB TonB-dependent vitamin B12 receptor BtuB low > 87
Rahnella sp. WP5 0.65 EX31_RS08845 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.53 EX31_RS14135 TonB-dependent vitamin B12 receptor BtuB low > 89
Pantoea sp. MT58 0.64 IAI47_02565 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.50 IAI47_00955 TonB-dependent vitamin B12 receptor BtuB low > 76
Dickeya dianthicola 67-19 0.64 HGI48_RS18570 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.49 HGI48_RS20380 TonB-dependent vitamin B12 receptor BtuB low > 71
Dickeya dianthicola ME23 0.63 DZA65_RS19705 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.63 DZA65_RS21425 TonB-dependent vitamin B12 receptor BtuB low > 75
Serratia liquefaciens MT49 0.63 IAI46_01600 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.52 IAI46_24450 TonB-dependent vitamin B12 receptor BtuB low > 86
Pectobacterium carotovorum WPP14 0.62 HER17_RS02560 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.52 HER17_RS00980 TonB-dependent vitamin B12 receptor BtuB low > 75
Dickeya dadantii 3937 0.60 DDA3937_RS18635 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.50 DDA3937_RS00995 TonB-dependent vitamin B12 receptor BtuB low > 74
Vibrio cholerae E7946 ATCC 55056 0.39 CSW01_14940 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.28 CSW01_00790 vitamin B12 transporter BtuB low > 62
Alteromonas macleodii MIT1002 0.38 MIT1002_03793 Nicotinamide nucleotide repair protein 0.14 MIT1002_00716 Outer membrane cobalamin translocator low > 70
Rhodanobacter denitrificans FW104-10B01 0.34 LRK54_RS15135 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.17 LRK54_RS07830 TonB-dependent vitamin B12 receptor low > 59
Rhodanobacter denitrificans MT42 0.34 LRK55_RS14850 NAD(P)H-hydrate dehydratase 0.17 LRK55_RS07560 TonB-dependent vitamin B12 receptor low > 63
Lysobacter sp. OAE881 0.34 ABIE51_RS08050 NAD(P)H-hydrate dehydratase 0.21 ABIE51_RS04930 TonB-dependent vitamin B12 receptor low > 62
Dyella japonica UNC79MFTsu3.2 0.33 ABZR86_RS00840 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.21 ABZR86_RS14720 TonB-dependent vitamin B12 receptor low > 74
Marinobacter adhaerens HP15 0.31 HP15_2504 carbohydrate kinase, YjeF related protein 0.16 HP15_3953 outer membrane receptor for transport of vitamin B low > 73
Xanthomonas campestris pv. campestris strain 8004 0.31 Xcc-8004.2253.1 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.19 Xcc-8004.1388.1 Outer membrane vitamin B12 receptor BtuB low > 74
Pseudomonas stutzeri RCH2 0.31 Psest_0678 yjeF C-terminal region, hydroxyethylthiazole kinase-related/yjeF N-terminal region 0.18 Psest_3016 TonB-dependent vitamin B12 receptor 0.25 10
Pseudomonas fluorescens FW300-N1B4 0.31 Pf1N1B4_1417 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.16 Pf1N1B4_2660 Outer membrane vitamin B12 receptor BtuB low > 87
Rhodanobacter sp. FW510-T8 0.31 OKGIIK_03905 Bifunctional NAD(P)H-hydrate repair enzyme 0.20 OKGIIK_05465 btuB TonB-dependent vitamin B12 receptor low > 52
Pseudomonas sp. RS175 0.30 PFR28_05116 Bifunctional NAD(P)H-hydrate repair enzyme Nnr 0.16 PFR28_03938 Vitamin B12 transporter BtuB low > 88
Pseudomonas fluorescens FW300-N2E2 0.30 Pf6N2E2_3619 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.16 Pf6N2E2_4930 Outer membrane vitamin B12 receptor BtuB low > 103
Pseudomonas fluorescens GW456-L13 0.30 PfGW456L13_159 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.16 PfGW456L13_1324 Outer membrane vitamin B12 receptor BtuB low > 87
Pseudomonas fluorescens FW300-N2C3 0.30 AO356_08680 carbohydrate kinase 0.15 AO356_14985 TonB-dependent receptor low > 104
Pseudomonas fluorescens FW300-N2E3 0.30 AO353_13120 carbohydrate kinase 0.15 AO353_06660 TonB-dependent receptor low > 101
Pseudomonas sp. S08-1 0.28 OH686_09495 NAD(P)H-hydrate epimerase / ADP-dependent (S)-NAD(P)H-hydrate dehydratase 0.16 OH686_15755 Outer membrane vitamin B12 receptor BtuB low > 80
Burkholderia phytofirmans PsJN 0.26 BPHYT_RS09505 carbohydrate kinase 0.14 BPHYT_RS04850 TonB-denpendent receptor low > 109
Ralstonia sp. UNC404CL21Col 0.24 ABZR87_RS12740 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.14 ABZR87_RS00095 TonB-dependent receptor 0.31 67
Ralstonia solanacearum UW163 0.24 UW163_RS14605 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.14 UW163_RS09175 TonB-dependent receptor — —
Ralstonia solanacearum IBSBF1503 0.24 RALBFv3_RS01295 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.14 RALBFv3_RS04495 TonB-dependent receptor low > 76
Paraburkholderia graminis OAS925 0.24 ABIE53_002139 hydroxyethylthiazole kinase-like uncharacterized protein yjeF 0.15 ABIE53_001246 vitamin B12 transporter low > 113
Paraburkholderia bryophila 376MFSha3.1 0.23 H281DRAFT_00907 yjeF C-terminal region, hydroxyethylthiazole kinase-related/yjeF N-terminal region 0.15 H281DRAFT_00136 vitamin B12 transporter low > 103
Ralstonia solanacearum GMI1000 0.23 RS_RS08700 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.13 RS_RS12050 TonB-dependent receptor low > 80
Ralstonia solanacearum PSI07 0.23 RPSI07_RS16180 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.13 RPSI07_RS12875 TonB-dependent receptor low > 81
Paraburkholderia sabiae LMG 24235 0.22 QEN71_RS21930 NAD(P)H-hydrate dehydratase 0.14 QEN71_RS25145 TonB-dependent receptor low > 153
Acinetobacter radioresistens SK82 0.21 MPMX26_01782 Bifunctional NAD(P)H-hydrate repair enzyme Nnr 0.10 MPMX26_02619 Vitamin B12 transporter BtuB — —
Cupriavidus basilensis FW507-4G11 0.21 RR42_RS09070 carbohydrate kinase 0.14 RR42_RS16140 TonB-dependent receptor low > 128
Castellaniella sp019104865 MT123 0.20 ABCV34_RS02980 NAD(P)H-hydrate dehydratase 0.15 ABCV34_RS14545 TonB-dependent receptor low > 48
Pedobacter sp. GW460-11-11-14-LB5 0.18 CA265_RS24885 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase 0.11 CA265_RS09235 hypothetical protein low > 88
Acidovorax sp. GW101-3H11 0.18 Ac3H11_415 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.16 Ac3H11_985 Outer membrane vitamin B12 receptor BtuB low > 79
Azospirillum brasilense Sp245 0.18 AZOBR_RS07115 hypothetical protein 0.14 AZOBR_RS19160 outer membrane cobalamin receptor protein BtuB low > 97
Variovorax sp. SCN45 0.17 GFF397 NAD(P)H-hydrate epimerase (EC 5.1.99.6) / ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) 0.17 GFF450 Outer membrane vitamin B12 receptor BtuB low > 127
Variovorax sp. OAS795 0.17 ABID97_RS17190 NAD(P)H-hydrate dehydratase 0.18 ABID97_RS17425 TonB-dependent receptor low > 91
Hydrogenophaga sp. GW460-11-11-14-LB1 0.16 GFF4918 NAD(P)HX epimerase / NAD(P)HX dehydratase 0.18 GFF3976 Outer membrane vitamin B12 receptor BtuB — —
Caulobacter crescentus NA1000 0.14 CCNA_02043 sugar kinase 0.14 CCNA_01826 vitamin B12 receptor low > 66
Caulobacter crescentus NA1000 Δfur 0.14 CCNA_02043 sugar kinase 0.14 CCNA_01826 vitamin B12 receptor low > 67
Rhodospirillum rubrum S1H 0.11 Rru_A1547 hypothetical protein (NCBI) 0.12 Rru_A0488 TonB-dependent receptor (NCBI) low > 58

Not shown: 34 genomes with orthologs for BWI76_RS02510 only; 5 genomes with orthologs for BWI76_RS00890 only