Conservation of cofitness between Atu3290 and Atu3731 in Agrobacterium fabrum C58

78 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Agrobacterium fabrum C58 1.0 Atu3290 phosphomethylpyrimidine kinase 1.0 Atu3731 5-formyltetrahydrofolate cyclo-ligase 0.79 11
Sinorhizobium meliloti 1021 0.59 SM_b20962 phoshomethylpyrimidine kinase 0.56 SMc03974 hypothetical protein low > 103
Xanthobacter sp. DMC5 0.55 GFF1029 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.29 GFF85 5-formyltetrahydrofolate cyclo-ligase — —
Rhodopseudomonas palustris CGA009 0.53 TX73_020570 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.33 TX73_023120 5-formyltetrahydrofolate cyclo-ligase — —
Enterobacter asburiae PDN3 0.51 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 EX28DRAFT_2964 5,10-methenyltetrahydrofolate synthetase low > 76
Pectobacterium carotovorum WPP14 0.50 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 HER17_RS19095 5-formyltetrahydrofolate cyclo-ligase low > 75
Escherichia coli ECRC100 0.50 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 OKFHMN_19485 ygfA 5-formyltetrahydrofolate cyclo-ligase low > 79
Escherichia coli ECOR27 0.50 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 NOLOHH_11395 ygfA 5-formyltetrahydrofolate cyclo-ligase low > 76
Klebsiella michiganensis M5al 0.50 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.21 BWI76_RS23915 5-formyltetrahydrofolate cyclo-ligase low > 92
Escherichia coli ECRC62 0.50 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 BNILDI_09930 ygfA 5-formyltetrahydrofolate cyclo-ligase low > 75
Escherichia coli HS(pFamp)R (ATCC 700891) 0.50 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.22 OHPLBJKB_00804 5-formyltetrahydrofolate cyclo-ligase low > 74
Escherichia coli ECRC102 0.50 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 NIAGMN_17250 ygfA 5-formyltetrahydrofolate cyclo-ligase low > 80
Escherichia coli ECRC101 0.50 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 MCAODC_10005 ygfA 5-formyltetrahydrofolate cyclo-ligase low > 88
Escherichia coli ECRC98 0.50 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 JDDGAC_23125 ygfA 5-formyltetrahydrofolate cyclo-ligase low > 87
Escherichia coli BW25113 0.50 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.22 b2912 ygfA putative ligase (VIMSS) low > 76
Escherichia coli ECRC99 0.50 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 KEDOAH_08655 ygfA 5-formyltetrahydrofolate cyclo-ligase — —
Enterobacter sp. TBS_079 0.50 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.22 MPMX20_03770 5-formyltetrahydrofolate cyclo-ligase low > 85
Escherichia coli ECOR38 0.50 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 HEPCGN_18775 ygfA 5-formyltetrahydrofolate cyclo-ligase low > 88
Escherichia fergusonii Becca 0.50 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.22 EFB2_00991 5-formyltetrahydrofolate cyclo-ligase low > 86
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.50 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.20 GFF3012 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) low > 78
Rahnella sp. WP5 0.50 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 EX31_RS21480 5-formyltetrahydrofolate cyclo-ligase low > 89
Escherichia coli BL21 0.50 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.22 ECD_02743 5-formyltetrahydrofolate cyclo-ligase family protein low > 61
Serratia liquefaciens MT49 0.50 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.25 IAI46_20895 5-formyltetrahydrofolate cyclo-ligase low > 86
Erwinia tracheiphila HP pepo 2.2 0.50 IJEDHG_18705 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.21 IJEDHG_03315 5-formyltetrahydrofolate cyclo-ligase — —
Erwinia tracheiphila SCR3 0.49 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.21 LU632_RS05860 5-formyltetrahydrofolate cyclo-ligase — —
Klebsiella pneumoniae MKP103 0.49 KDGMDA_26425 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.20 KDGMDA_04415 5-formyltetrahydrofolate cyclo-ligase low > 95
Escherichia coli Nissle 1917 0.49 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 ECOLIN_RS16205 5-formyltetrahydrofolate cyclo-ligase — —
Pantoea agglomerans CFBP13505 P0401 0.48 PagCFBP13505_RS00915 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.24 PagCFBP13505_RS15970 5-formyltetrahydrofolate cyclo-ligase low > 74
Bosea sp. OAE506 0.48 ABIE41_RS21620 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.29 ABIE41_RS09445 5-formyltetrahydrofolate cyclo-ligase — —
Pantoea sp. MT58 0.47 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.20 IAI47_03730 5-formyltetrahydrofolate cyclo-ligase low > 76
Paraburkholderia sabiae LMG 24235 0.46 QEN71_RS06305 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.14 QEN71_RS28640 5-formyltetrahydrofolate cyclo-ligase — —
Erwinia amylovora T8 0.46 OLJFJH_11930 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.21 OLJFJH_08740 5-formyltetrahydrofolate cyclo-ligase low > 58
Echinicola vietnamensis KMM 6221, DSM 17526 0.45 Echvi_0215 phosphomethylpyrimidine kinase 0.18 Echvi_1511 5,10-methenyltetrahydrofolate synthetase low > 79
Vibrio cholerae E7946 ATCC 55056 0.44 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 CSW01_12545 5-formyltetrahydrofolate cyclo-ligase low > 62
Rhizobium sp. OAE497 0.43 ABIE40_RS25930 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.62 ABIE40_RS15645 5-formyltetrahydrofolate cyclo-ligase low > 107
Bacteroides ovatus ATCC 8483 0.42 BACOVA_02530 phosphomethylpyrimidine kinase 0.14 BACOVA_05091 5-formyltetrahydrofolate cyclo-ligase 0.59 34
Bacteroides stercoris CC31F 0.42 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.15 HMPREF1181_RS06170 5-formyltetrahydrofolate cyclo-ligase low > 56
Hydrogenophaga sp. GW460-11-11-14-LB1 0.41 GFF249 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.16 GFF1613 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) low > 90
Rhodanobacter sp000427505 FW510-R12 0.38 LRK53_RS03825 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.15 LRK53_RS16890 5-formyltetrahydrofolate cyclo-ligase low > 59
Dyella japonica UNC79MFTsu3.2 0.36 ABZR86_RS00760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.17 ABZR86_RS11995 5-formyltetrahydrofolate cyclo-ligase — —
Variovorax sp. OAS795 0.35 ABID97_RS15330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.15 ABID97_RS06600 5-formyltetrahydrofolate cyclo-ligase — —
Ralstonia solanacearum UW163 0.35 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 UW163_RS03715 5-formyltetrahydrofolate cyclo-ligase — —
Ralstonia solanacearum IBSBF1503 0.35 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 RALBFv3_RS09865 5-formyltetrahydrofolate cyclo-ligase — —
Ralstonia sp. UNC404CL21Col 0.35 ABZR87_RS04830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 ABZR87_RS04880 5-formyltetrahydrofolate cyclo-ligase — —
Ralstonia solanacearum GMI1000 0.34 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 RS_RS00450 5-formyltetrahydrofolate cyclo-ligase — —
Xanthomonas campestris pv. campestris strain 8004 0.34 Xcc-8004.3091.1 hypothetical protein 0.17 Xcc-8004.1138.1 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) low > 74
Ralstonia solanacearum PSI07 0.34 RPSI07_RS23455 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.25 RPSI07_RS23505 5-formyltetrahydrofolate cyclo-ligase — —
Lysobacter sp. OAE881 0.33 ABIE51_RS07970 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.19 ABIE51_RS17355 5-formyltetrahydrofolate cyclo-ligase — —
Brevundimonas sp. GW460-12-10-14-LB2 0.33 A4249_RS15985 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.18 A4249_RS00800 5-formyltetrahydrofolate cyclo-ligase — —
Sphingobium sp. HT1-2 0.33 GFF2573 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.19 GFF2137 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) low > 95
Cupriavidus basilensis FW507-4G11 0.31 RR42_RS01370 phosphomethylpyrimidine kinase 0.16 RR42_RS01400 5-formyltetrahydrofolate cyclo-ligase — —
Synechococcus elongatus PCC 7942 0.30 Synpcc7942_2379 thiD phosphomethylpyrimidine kinase 0.17 Synpcc7942_1300 hypothetical protein low > 38
Rhodanobacter sp. FW510-T8 0.29 OKGIIK_03835 Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.19 OKGIIK_12225 5-formyltetrahydrofolate cyclo-ligase 0.45 43
Acinetobacter radioresistens SK82 0.28 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.15 MPMX26_02298 5-formyltetrahydrofolate cyclo-ligase — —
Pseudomonas aeruginosa PA14 0.27 IKLFDK_20515 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.17 IKLFDK_27325 5-formyltetrahydrofolate cyclo-ligase low > 100
Dechlorosoma suillum PS 0.27 Dsui_0662 phosphomethylpyrimidine kinase 0.22 Dsui_0682 5,10-methenyltetrahydrofolate synthetase — —
Pseudomonas putida KT2440 0.27 PP_4782 Phosphomethylpyrimidine kinase 0.16 PP_5203 5-formyltetrahydrofolate cyclo-ligase 0.36 72
Pseudomonas fluorescens FW300-N2C3 0.27 AO356_15435 hydrogenase 0.15 AO356_12990 5-formyltetrahydrofolate cyclo-ligase low > 104
Pseudomonas simiae WCS417 0.27 PS417_24600 hydrogenase 0.16 PS417_27305 5-formyltetrahydrofolate cyclo-ligase low > 88
Pseudomonas sp. BP01 0.27 JOY50_RS21745 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.15 JOY50_RS22470 5-formyltetrahydrofolate cyclo-ligase low > 84
Pseudomonas sp. SVBP6 0.26 COO64_RS15485 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.13 COO64_RS01015 5-formyltetrahydrofolate cyclo-ligase low > 93
Pseudomonas sp. S08-1 0.26 OH686_09185 Hydroxymethylpyrimidine phosphate kinase ThiD 0.16 OH686_11225 5-formyltetrahydrofolate cyclo-ligase low > 80
Pseudomonas fluorescens FW300-N2E3 0.26 AO353_06350 hydrogenase 0.15 AO353_08780 5-formyltetrahydrofolate cyclo-ligase low > 101
Pseudomonas fluorescens SBW25 0.26 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.16 PFLU_RS28965 5-formyltetrahydrofolate cyclo-ligase low > 109
Pseudomonas fluorescens SBW25-INTG 0.26 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.16 PFLU_RS28965 5-formyltetrahydrofolate cyclo-ligase low > 109
Mycobacterium tuberculosis H37Rv 0.26 Rv0422c Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) 0.14 Rv0992c Conserved hypothetical protein — —
Pseudomonas fluorescens GW456-L13 0.26 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.17 PfGW456L13_892 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) low > 87
Pseudomonas sp. DMC3 0.26 GFF3905 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.14 GFF320 5-formyltetrahydrofolate cyclo-ligase low > 89
Pseudomonas syringae pv. syringae B728a ΔmexB 0.26 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.16 Psyr_0317 5-formyltetrahydrofolate cyclo-ligase low > 86
Pseudomonas stutzeri RCH2 0.26 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.19 Psest_0170 5,10-methenyltetrahydrofolate synthetase 0.23 58
Pseudomonas syringae pv. syringae B728a 0.26 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.16 Psyr_0317 5-formyltetrahydrofolate cyclo-ligase low > 86
Pseudomonas segetis P6 0.25 MPMX49_01077 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.16 MPMX49_04492 5-formyltetrahydrofolate cyclo-ligase low > 75
Pseudomonas sp. RS175 0.24 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.15 PFR28_04325 5-formyltetrahydrofolate cyclo-ligase low > 88
Herbaspirillum seropedicae SmR1 0.24 HSERO_RS02135 phosphomethylpyrimidine kinase 0.20 HSERO_RS21420 5-formyltetrahydrofolate cyclo-ligase low > 78
Pseudomonas fluorescens FW300-N1B4 0.23 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.16 Pf1N1B4_2225 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) low > 87
Pseudomonas fluorescens FW300-N2E2 0.23 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.14 Pf6N2E2_4476 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) low > 103
Pontibacter actiniarum KMM 6156, DSM 19842 0.23 CA264_20430 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.18 CA264_15880 5-formyltetrahydrofolate cyclo-ligase low > 74
Pseudomonas lactucae CFBP13502 0.23 GEMAOFIL_05068 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.16 GEMAOFIL_05599 5-formyltetrahydrofolate cyclo-ligase low > 93
Phaeobacter inhibens DSM 17395 0.19 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.21 PGA1_c21820 5-formyltetrahydrofolate cycloligase-like protein low > 62

Not shown: 29 genomes with orthologs for Atu3290 only; 8 genomes with orthologs for Atu3731 only