Conservation of cofitness between AZOBR_RS10580 and AZOBR_RS19970 in Azospirillum brasilense Sp245

69 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Azospirillum brasilense Sp245 1.0 AZOBR_RS10580 protoheme IX farnesyltransferase 1.0 AZOBR_RS19970 multidrug transporter 0.30 19
Azospirillum sp. SherDot2 0.76 MPMX19_00886 Protoheme IX farnesyltransferase 0.78 MPMX19_04288 Colistin resistance protein EmrA — —
Rhizobium sp. OAE497 0.57 ABIE40_RS04070 heme o synthase 0.41 ABIE40_RS16835 HlyD family secretion protein low > 107
Sinorhizobium meliloti 1021 0.57 SMc00450 protoheme IX farnesyltransferase 0.37 SMc03168 multidrug efflux system protein low > 103
Bosea sp. OAE506 0.52 ABIE41_RS22955 heme o synthase 0.34 ABIE41_RS08460 HlyD family secretion protein low > 77
Caulobacter crescentus NA1000 0.52 CCNA_03516 protoheme IX farnesyltransferase coxE 0.36 CCNA_03830 multidrug resistance protein A, efflux pump low > 66
Rhodopseudomonas palustris CGA009 0.52 TX73_004295 heme o synthase 0.36 TX73_018365 HlyD family secretion protein low > 86
Caulobacter crescentus NA1000 Δfur 0.52 CCNA_03516 protoheme IX farnesyltransferase coxE 0.36 CCNA_03830 multidrug resistance protein A, efflux pump low > 67
Brevundimonas sp. GW460-12-10-14-LB2 0.49 A4249_RS00115 heme o synthase 0.36 A4249_RS14990 HlyD family secretion protein low > 48
Sphingomonas koreensis DSMZ 15582 0.47 Ga0059261_2005 protoheme IX farnesyltransferase 0.30 Ga0059261_1225 Multidrug resistance efflux pump low > 68
Pseudomonas fluorescens FW300-N1B4 0.36 Pf1N1B4_1862 Cytochrome oxidase biogenesis protein Sco1/SenC/PrrC, putative copper metallochaperone 0.39 Pf1N1B4_121 Membrane fusion component of tripartite multidrug resistance system low > 87
Lysobacter sp. OAE881 0.36 ABIE51_RS19165 heme o synthase 0.36 ABIE51_RS02575 HlyD family secretion protein low > 62
Pseudomonas fluorescens GW456-L13 0.36 PfGW456L13_606 Cytochrome oxidase biogenesis protein Sco1/SenC/PrrC, putative copper metallochaperone 0.41 PfGW456L13_2410 Membrane fusion component of tripartite multidrug resistance system low > 87
Hydrogenophaga sp. GW460-11-11-14-LB1 0.35 GFF698 Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB 0.27 GFF4171 Membrane fusion component of tripartite multidrug resistance system low > 90
Dyella japonica UNC79MFTsu3.2 0.35 ABZR86_RS12895 heme o synthase 0.30 ABZR86_RS03380 HlyD family secretion protein low > 74
Paraburkholderia sabiae LMG 24235 0.34 QEN71_RS01545 heme o synthase 0.36 QEN71_RS18305 HlyD family secretion protein low > 153
Pseudomonas sp. RS175 0.34 PFR28_04683 Protoheme IX farnesyltransferase 0.31 PFR28_04797 Colistin resistance protein EmrA low > 88
Shewanella sp. ANA-3 0.34 Shewana3_3998 protoheme IX farnesyltransferase (RefSeq) 0.40 Shewana3_0522 secretion protein HlyD family protein (RefSeq) low > 73
Pseudomonas fluorescens FW300-N2E3 0.34 AO353_10870 protoheme IX farnesyltransferase 0.42 AO353_19720 hemolysin D low > 101
Burkholderia phytofirmans PsJN 0.33 BPHYT_RS02690 protoheme IX farnesyltransferase 0.36 BPHYT_RS21940 hemolysin D low > 109
Rhodanobacter denitrificans MT42 0.33 LRK55_RS06825 heme o synthase 0.23 LRK55_RS07515 HlyD family efflux transporter periplasmic adaptor subunit low > 63
Rhodanobacter denitrificans FW104-10B01 0.33 LRK54_RS07085 heme o synthase 0.23 LRK54_RS07785 HlyD family efflux transporter periplasmic adaptor subunit low > 59
Ralstonia solanacearum UW163 0.33 UW163_RS02590 protoheme IX farnesyltransferase 0.27 UW163_RS07875 HlyD family secretion protein — —
Ralstonia solanacearum IBSBF1503 0.33 RALBFv3_RS10990 protoheme IX farnesyltransferase 0.27 RALBFv3_RS05750 HlyD family secretion protein low > 76
Ralstonia solanacearum GMI1000 0.33 RS_RS01830 protoheme IX farnesyltransferase 0.29 RS_RS19270 HlyD family secretion protein low > 80
Paraburkholderia bryophila 376MFSha3.1 0.33 H281DRAFT_01985 protoheme IX farnesyltransferase 0.36 H281DRAFT_04938 membrane fusion protein, multidrug efflux system low > 103
Ralstonia solanacearum PSI07 0.32 RPSI07_RS22315 protoheme IX farnesyltransferase 0.28 RPSI07_RS11550 HlyD family secretion protein — —
Herbaspirillum seropedicae SmR1 0.32 HSERO_RS20745 protoheme IX farnesyltransferase 0.27 HSERO_RS16350 hemolysin D — —
Pseudomonas sp. S08-1 0.32 OH686_12285 protoheme IX farnesyltransferase 0.33 OH686_04565 Membrane fusion component of MSF-type tripartite multidrug efflux system low > 80
Cupriavidus basilensis FW507-4G11 0.32 RR42_RS01920 protoheme IX farnesyltransferase 0.40 RR42_RS27150 hemolysin D low > 128
Pseudomonas simiae WCS417 0.32 PS417_00340 protoheme IX farnesyltransferase 0.33 PS417_00660 DSBA oxidoreductase low > 88
Shewanella loihica PV-4 0.32 Shew_0117 protoheme IX farnesyltransferase (RefSeq) 0.38 Shew_3406 secretion protein HlyD family protein (RefSeq) low > 60
Pseudomonas putida KT2440 0.31 PP_0110 CyoE like protoheme IX farnesyltransferase 0.35 PP_1976 HlyD family secretion protein low > 96
Paraburkholderia graminis OAS925 0.31 ABIE53_000683 protoheme IX farnesyltransferase 0.36 ABIE53_005461 membrane fusion protein (multidrug efflux system) low > 113
Pseudomonas fluorescens SBW25 0.31 PFLU_RS00330 protoheme IX farnesyltransferase 0.33 PFLU_RS00670 HlyD family secretion protein low > 109
Pseudomonas fluorescens SBW25-INTG 0.31 PFLU_RS00330 protoheme IX farnesyltransferase 0.33 PFLU_RS00670 HlyD family secretion protein low > 109
Castellaniella sp019104865 MT123 0.30 ABCV34_RS13230 heme o synthase 0.22 ABCV34_RS05945 HlyD family efflux transporter periplasmic adaptor subunit low > 48
Shewanella amazonensis SB2B 0.28 Sama_3491 protoheme IX farnesyltransferase (RefSeq) 0.38 Sama_0402 HlyD family secretion protein (RefSeq) low > 62
Magnetospirillum magneticum AMB-1 0.28 AMB_RS03800 protoheme IX farnesyltransferase 1 0.44 AMB_RS20235 HlyD family secretion protein low > 64
Pontibacter actiniarum KMM 6156, DSM 19842 0.24 CA264_01325 protoheme IX farnesyltransferase 0.27 CA264_07175 secretion protein HlyD — —
Rahnella sp. WP5 0.22 EX31_RS22200 protoheme IX farnesyltransferase 0.31 EX31_RS10770 HlyD family secretion protein low > 89
Klebsiella michiganensis M5al 0.22 BWI76_RS06475 protoheme IX farnesyltransferase 0.29 BWI76_RS13180 multidrug transporter EmrA low > 92
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.21 GFF4342 Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB 0.20 GFF1592 Multidrug resistance protein A low > 78
Escherichia coli ECOR27 0.21 NOLOHH_01315 cyoE heme o synthase 0.21 NOLOHH_14120 emrK multidrug efflux MFS transporter periplasmic adaptor subunit EmrK low > 75
Escherichia coli ECRC62 0.21 BNILDI_22730 cyoE heme o synthase 0.21 BNILDI_12975 emrK multidrug efflux MFS transporter periplasmic adaptor subunit EmrK low > 75
Escherichia coli BW25113 0.21 b0428 cyoE protoheme IX farnesyltransferase (NCBI) 0.21 b2368 emrK EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component (NCBI) low > 76
Escherichia coli ECOR38 0.21 HEPCGN_06995 cyoE heme o synthase 0.21 HEPCGN_21645 emrK multidrug efflux MFS transporter periplasmic adaptor subunit EmrK low > 87
Escherichia coli ECRC98 0.21 JDDGAC_12035 cyoE heme o synthase 0.21 JDDGAC_26400 emrK multidrug efflux MFS transporter periplasmic adaptor subunit EmrK low > 86
Escherichia coli ECRC102 0.21 NIAGMN_06435 cyoE heme o synthase 0.21 NIAGMN_20215 emrK multidrug efflux MFS transporter periplasmic adaptor subunit EmrK — —
Escherichia coli HS(pFamp)R (ATCC 700891) 0.21 OHPLBJKB_03245 Protoheme IX farnesyltransferase 0.21 OHPLBJKB_01353 putative multidrug resistance protein EmrK low > 73
Escherichia coli Nissle 1917 0.21 ECOLIN_RS02575 heme o synthase 0.21 ECOLIN_RS13630 multidrug efflux MFS transporter periplasmic adaptor subunit EmrK — —
Escherichia fergusonii Becca 0.21 EFB2_03629 Protoheme IX farnesyltransferase 0.35 EFB2_02590 Colistin resistance protein EmrA low > 86
Escherichia coli BL21 0.21 ECD_00379 protoheme IX farnesyltransferase 0.21 ECD_02278 multidrug resistance efflux pump membrane fusion protein low > 61
Escherichia coli ECRC99 0.21 KEDOAH_19585 cyoE heme o synthase 0.21 KEDOAH_05785 emrK multidrug efflux MFS transporter periplasmic adaptor subunit EmrK — —
Escherichia coli ECRC100 0.21 OKFHMN_08380 cyoE heme o synthase 0.21 OKFHMN_22440 emrK multidrug efflux MFS transporter periplasmic adaptor subunit EmrK low > 80
Escherichia coli ECRC101 0.21 MCAODC_27605 cyoE heme o synthase 0.21 MCAODC_12970 emrK multidrug efflux MFS transporter periplasmic adaptor subunit EmrK low > 87
Erwinia tracheiphila SCR3 0.21 LU632_RS18395 cyoE heme o synthase 0.28 LU632_RS04700 HlyD family secretion protein — —
Pseudomonas syringae pv. syringae B728a 0.20 Psyr_1145 Protoheme IX farnesyltransferase 0.30 Psyr_1772 Secretion protein HlyD — —
Pseudomonas syringae pv. syringae B728a ΔmexB 0.20 Psyr_1145 Protoheme IX farnesyltransferase 0.30 Psyr_1772 Secretion protein HlyD — —
Enterobacter sp. TBS_079 0.20 MPMX20_01019 Protoheme IX farnesyltransferase 0.30 MPMX20_02192 Colistin resistance protein EmrA low > 85
Enterobacter asburiae PDN3 0.20 EX28DRAFT_2543 protoheme IX farnesyltransferase 0.30 EX28DRAFT_1354 Multidrug resistance efflux pump low > 76
Pedobacter sp. GW460-11-11-14-LB5 0.20 CA265_RS17805 protoheme IX farnesyltransferase 0.29 CA265_RS21340 secretion protein HlyD — —
Dickeya dianthicola 67-19 0.20 HGI48_RS05640 protoheme IX farnesyltransferase 0.22 HGI48_RS08130 efflux RND transporter periplasmic adaptor subunit low > 71
Dickeya dianthicola ME23 0.20 DZA65_RS05965 protoheme IX farnesyltransferase 0.22 DZA65_RS08725 HlyD family efflux transporter periplasmic adaptor subunit low > 75
Dickeya dadantii 3937 0.20 DDA3937_RS05595 protoheme IX farnesyltransferase 0.22 DDA3937_RS07310 efflux RND transporter periplasmic adaptor subunit low > 74
Serratia liquefaciens MT49 0.20 IAI46_04965 protoheme IX farnesyltransferase 0.32 IAI46_06625 HlyD family secretion protein low > 86
Pectobacterium carotovorum WPP14 0.19 HER17_RS15895 heme o synthase 0.21 HER17_RS04465 multidrug efflux MFS transporter periplasmic adaptor subunit EmrA low > 75
Pantoea sp. MT58 0.19 IAI47_14700 protoheme IX farnesyltransferase 0.30 IAI47_05585 HlyD family secretion protein low > 76
Mucilaginibacter yixingensis YX-36 DSM 26809 0.19 ABZR88_RS03670 heme o synthase 0.30 ABZR88_RS20980 HlyD family secretion protein — —
Acinetobacter radioresistens SK82 0.18 MPMX26_01158 Protoheme IX farnesyltransferase 0.24 MPMX26_02532 Colistin resistance protein EmrA low > 36

Not shown: 17 genomes with orthologs for AZOBR_RS10580 only; 5 genomes with orthologs for AZOBR_RS19970 only