Homologs of Rv0939 from Mycobacterium tuberculosis H37Rv

Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase
SEED: Fumarylacetoacetase (EC 3.7.1.2)

Top 100 hits from BLASTp (E < 0.01)

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Orth Species Gene Name Description Fitness %Id Cov
  Mycobacterium tuberculosis H37Rv Rv0939 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase insig. 100 100
  Hydrogenophaga sp. GW460-11-11-14-LB1 GFF5259 Fumarylacetoacetase (EC 3.7.1.2) insig. 41 48
  Mucilaginibacter yixingensis YX-36 DSM 26809 ABZR88_RS04235 fumarylacetoacetate hydrolase family protein insig. 35 48
  Pedobacter sp. GW460-11-11-14-LB5 CA265_RS03145 fumarylacetoacetate hydrolase insig. 35 48
  Pseudomonas fluorescens GW456-L13 PfGW456L13_3405 Fumarylacetoacetate hydrolase family protein insig. 39 43
  Hydrogenophaga sp. GW460-11-11-14-LB1 GFF5254 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) insig. 37 46
  Acidovorax sp. GW101-3H11 Ac3H11_2765 Fumarylacetoacetate hydrolase family protein insig. 37 42
  Marinobacter adhaerens HP15 HP15_38 fumarylacetoacetate (FAA) hydrolase insig. 39 39
  Sphingomonas koreensis DSMZ 15582 Ga0059261_1678 Fumarylacetoacetate (FAA) hydrolase family insig. 35 46
  Rhodopseudomonas palustris CGA009 TX73_017820 fumarylacetoacetate hydrolase family protein insig. 33 46
  Variovorax sp. OAS795 ABID97_RS13435 fumarylacetoacetate hydrolase family protein insig. 35 44
  Hydrogenophaga sp. GW460-11-11-14-LB1 GFF3721 Fumarylacetoacetate hydrolase family protein insig. 33 47
  Variovorax sp. OAS795 ABID97_RS27265 fumarylacetoacetate hydrolase family protein insig. 33 45
  Herbaspirillum seropedicae SmR1 HSERO_RS05065 2-keto-4-pentenoate hydratase insig. 32 36
  Pedobacter sp. GW460-11-11-14-LB5 CA265_RS08350 ureidoglycolate lyase insig. 31 47
  Variovorax sp. OAS795 ABID97_RS01285 fumarylacetoacetate hydrolase family protein no data 34 38
  Xanthomonas campestris pv. campestris strain 8004 Xcc-8004.5166.1 hypothetical protein insig. 35 31
  Dyella japonica UNC79MFTsu3.2 ABZR86_RS01325 fumarylacetoacetate hydrolase family protein insig. 35 30
  Rhodopseudomonas palustris CGA009 TX73_022935 fumarylacetoacetate hydrolase family protein insig. 35 30
  Pseudomonas fluorescens FW300-N2E3 AO353_24305 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase insig. 36 30
  Azospirillum brasilense Sp245 AZOBR_RS26375 hypothetical protein insig. 30 45
  Variovorax sp. SCN45 GFF4615 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase insig. 35 32
  Variovorax sp. OAS795 ABID97_RS05835 fumarylacetoacetate hydrolase family protein strong 36 32
  Magnetospirillum magneticum AMB-1 AMB_RS14215 FAA hydrolase family protein cofit 30 42
  Hydrogenophaga sp. GW460-11-11-14-LB1 GFF5465 Fumarylacetoacetate hydrolase family protein insig. 33 39
  Mucilaginibacter yixingensis YX-36 DSM 26809 ABZR88_RS19960 fumarylacetoacetate hydrolase family protein insig. 29 47
  Hydrogenophaga sp. GW460-11-11-14-LB1 GFF1773 SoxH protein, homolog insig. 31 38
  Azospirillum sp. SherDot2 MPMX19_06074 Ureidoglycolate lyase insig. 36 30
  Phaeobacter inhibens DSM 17395 PGA1_c04530 ureidoglycolate lyase insig. 35 30
  Dinoroseobacter shibae DFL-12 Dshi_2542 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase (RefSeq) insig. 31 42
  Azospirillum sp. SherDot2 MPMX19_03313 Ureidoglycolate lyase insig. 35 30
  Cupriavidus basilensis FW507-4G11 RR42_RS00385 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase insig. 35 30
  Echinicola vietnamensis KMM 6221, DSM 17526 Echvi_2939 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) insig. 32 37
  Ralstonia solanacearum PSI07 RPSI07_RS21875 FAA hydrolase family protein insig. 35 30
  Acidovorax sp. GW101-3H11 Ac3H11_3715 Fumarylacetoacetate hydrolase family protein insig. 33 40
  Serratia liquefaciens MT49 IAI46_02795 fumarylacetoacetate hydrolase family protein insig. 33 30
  Rahnella sp. WP5 EX31_RS02090 fumarylacetoacetate hydrolase family protein insig. 35 30
  Rhodospirillum rubrum S1H Rru_A2126 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase (NCBI) insig. 36 30
  Azospirillum brasilense Sp245 AZOBR_RS15905 2-hydroxyhepta-2 4-diene-1 7-dioate isomerase insig. 34 30
  Pseudomonas fluorescens FW300-N2C3 AO356_28735 ureidoglycolate lyase no data 35 30
  Bosea sp. OAE506 ABIE41_RS19195 fumarylacetoacetate hydrolase family protein insig. 32 30
  Paraburkholderia sabiae LMG 24235 QEN71_RS13990 fumarylacetoacetate hydrolase family protein insig. 37 30
  Ralstonia solanacearum GMI1000 RS_RS09200 FAA hydrolase family protein sig. 32 38
  Hydrogenophaga sp. GW460-11-11-14-LB1 GFF2290 Fumarylacetoacetate hydrolase family protein insig. 30 41
  Pseudomonas fluorescens FW300-N2E2 Pf6N2E2_1662 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase. insig. 35 30
  Ralstonia sp. UNC404CL21Col ABZR87_RS12045 ureidoglycolate lyase insig. 34 30
  Acidovorax sp. GW101-3H11 Ac3H11_2742 Fumarylacetoacetate hydrolase family protein insig. 32 40
  Variovorax sp. OAS795 ABID97_RS29380 fumarylacetoacetate hydrolase family protein insig. 29 46
  Agrobacterium fabrum C58 Atu0014 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase strong 35 30
  Bosea sp. OAE506 ABIE41_RS20235 fumarylacetoacetate hydrolase family protein insig. 31 46
  Paraburkholderia graminis OAS925 ABIE53_006289 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase in catechol pathway insig. 31 37
  Pseudomonas sp. S08-1 OH686_23315 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) insig. 30 36
  Paraburkholderia sabiae LMG 24235 QEN71_RS31015 ureidoglycolate lyase cofit 34 30
  Mycobacterium tuberculosis H37Rv Rv2993c Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) insig. 33 38
  Paraburkholderia bryophila 376MFSha3.1 H281DRAFT_05461 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) insig. 33 42
  Rhizobium sp. OAE497 ABIE40_RS19310 fumarylacetoacetate hydrolase family protein strong 35 30
  Sphingomonas koreensis DSMZ 15582 Ga0059261_2636 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) insig. 34 30
  Sinorhizobium meliloti 1021 SM_b21112 L-2,4-diketo-3-deoxyrhamnonate hydrolase; 2,4-dioxopentanoate hydrolase (from data) strong 33 30
  Sinorhizobium meliloti 1021 SM_b20168 hypothetical protein insig. 31 39
  Rhizobium sp. OAE497 ABIE40_RS19950 fumarylacetoacetate hydrolase family protein insig. 35 30
  Ralstonia solanacearum IBSBF1503 RALBFv3_RS20210 MBL fold hydrolase sig. 29 37
  Ralstonia solanacearum UW163 UW163_RS18965 MBL fold hydrolase insig. 29 37
  Desulfovibrio vulgaris Hildenborough JW710 DVU0875 fumarylacetoacetate hydrolase family protein (TIGR) insig. 34 29
  Pseudomonas fluorescens GW456-L13 PfGW456L13_3396 Fumarylacetoacetate hydrolase family protein insig. 35 30
  Ralstonia sp. UNC404CL21Col ABZR87_RS20775 MBL fold metallo-hydrolase insig. 28 37
  Pseudomonas fluorescens FW300-N2C3 AO356_29975 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase insig. 28 45
  Agrobacterium fabrum C58 Atu4593 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase insig. 35 31
  Bosea sp. OAE506 ABIE41_RS22825 fumarylacetoacetate hydrolase family protein insig. 31 38
  Pseudomonas syringae pv. syringae B728a Psyr_4479 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase insig. 31 34
  Pseudomonas syringae pv. syringae B728a ΔmexB Psyr_4479 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase insig. 31 34
  Cupriavidus basilensis FW507-4G11 RR42_RS24410 5-carboxymethyl-2-hydroxymuconate isomerase insig. 29 47
  Paraburkholderia bryophila 376MFSha3.1 H281DRAFT_02528 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) insig. 35 30
  Hydrogenophaga sp. GW460-11-11-14-LB1 GFF2985 Fumarylacetoacetate hydrolase family protein insig. 31 36
  Castellaniella sp019104865 MT123 ABCV34_RS12070 fumarylacetoacetate hydrolase family protein insig. 32 34
  Dinoroseobacter shibae DFL-12 Dshi_0967 fumarylacetoacetate (FAA) hydrolase (RefSeq) insig. 31 36
  Burkholderia phytofirmans PsJN BPHYT_RS35700 beta-lactamase domain-containing protein insig. 27 40
  Herbaspirillum seropedicae SmR1 HSERO_RS06355 2,4-diketo-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) (from data) strong 32 30
  Hydrogenophaga sp. GW460-11-11-14-LB1 GFF1560 Fumarylacetoacetate hydrolase family protein insig. 31 32
  Ralstonia solanacearum GMI1000 RS_RS20495 MBL fold metallo-hydrolase insig. 27 41
  Ralstonia solanacearum PSI07 RPSI07_RS02650 MBL fold metallo-hydrolase insig. 28 37
  Pseudomonas fluorescens FW300-N2E2 Pf6N2E2_865 Fumarylacetoacetate hydrolase family protein insig. 37 30
  Cupriavidus basilensis FW507-4G11 RR42_RS22485 MBL fold metallo-hydrolase sig. 27 39
  Marinobacter adhaerens HP15 HP15_47 fumarylacetoacetate (FAA) hydrolase insig. 31 40
  Ralstonia sp. UNC404CL21Col ABZR87_RS20835 ureidoglycolate lyase insig. 34 30
  Hydrogenophaga sp. GW460-11-11-14-LB1 GFF421 Fumarylacetoacetate hydrolase family protein insig. 31 45
  Paraburkholderia bryophila 376MFSha3.1 H281DRAFT_03753 Glyoxylase, beta-lactamase superfamily II insig. 27 38
  Brevundimonas sp. GW460-12-10-14-LB2 A4249_RS07700 fumarylacetoacetate hydrolase family protein insig. 33 30
  Serratia liquefaciens MT49 IAI46_12460 fumarylacetoacetate hydrolase family protein insig. 30 46
  Pseudomonas fluorescens SBW25 PFLU_RS15575 fumarylacetoacetate hydrolase family protein insig. 37 29
  Pseudomonas fluorescens SBW25-INTG PFLU_RS15575 fumarylacetoacetate hydrolase family protein insig. 37 29
  Burkholderia phytofirmans PsJN BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) (from data) strong 32 30
  Paraburkholderia bryophila 376MFSha3.1 H281DRAFT_03528 ureidoglycolate lyase sig. 32 30
  Herbaspirillum seropedicae SmR1 HSERO_RS02710 Zn-dependent hydrolase insig. 25 39
  Variovorax sp. SCN45 GFF3754 Fumarylacetoacetate hydrolase family protein insig. 32 32
  Acidovorax sp. GW101-3H11 Ac3H11_4136 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase. insig. 32 30
  Paraburkholderia sabiae LMG 24235 QEN71_RS17220 ureidoglycolate lyase insig. 30 31
  Variovorax sp. OAS795 ABID97_RS01790 MBL fold metallo-hydrolase insig. 28 43
  Ralstonia solanacearum GMI1000 RS_RS23490 MBL fold metallo-hydrolase no data 28 38
  Ralstonia solanacearum GMI1000 RS_RS23620 MBL fold metallo-hydrolase no data 28 38
  Paraburkholderia graminis OAS925 ABIE53_004732 ureidoglycolate lyase strong 32 30