| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Azospirillum sp. SherDot2 | MPMX19_03715 | | Response regulator ArlR | insig. | 100 | 100 |
| o | Synechococcus elongatus PCC 7942 | Synpcc7942_1817 | ltnA | response regulator receiver domain protein (CheY-like) | insig. | 61 | 95 |
| o | Sinorhizobium meliloti 1021 | SM_b20357 | | histidine kinase | insig. | 60 | 91 |
| o | Magnetospirillum magneticum AMB-1 | AMB_RS05670 | | response regulator | insig. | 58 | 95 |
| o | Synechocystis sp000284455 PCC 6803 | SGL_RS10410 | | response regulator | insig. | 59 | 91 |
| o | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF4457 | | Signal transduction response regulator | no data | 58 | 91 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_03091 | | Polar-differentiation response regulator DivK | insig. | 46 | 94 |
| | Rhodospirillum rubrum S1H | Rru_A3206 | | Response regulator receiver domain protein (CheY) (NCBI) | cofit | 43 | 90 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_07720 | | hybrid sensor histidine kinase/response regulator | strong | 42 | 98 |
| | Pseudomonas orientalis W4I3 | QF045_RS16395 | | response regulator | insig. | 44 | 95 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_1099 | | Response regulator receiver | insig. | 41 | 97 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_1099 | | Response regulator receiver | insig. | 41 | 97 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS04720 | | response regulator | cofit | 39 | 88 |
| | Pseudomonas aeruginosa MRSN321 | DY961_RS19705 | | ATP-binding protein | sig. | 41 | 98 |
| | Pseudomonas aeruginosa PUPa3 | DQ20_RS53815 | | ATP-binding protein | sig. | 41 | 98 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS15260 | | response regulator | insig. | 45 | 95 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS15260 | | response regulator | sig. | 45 | 95 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS15020 | | response regulator | insig. | 36 | 93 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT1264 | | two-component system sensor histidine kinase (NCBI ptt file) | insig. | 35 | 93 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_03846 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | strong | 35 | 93 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_2693 | | histidine kinase (RefSeq) | strong | 38 | 94 |
| | Xanthobacter sp. DMC5 | GFF1825 | | Sensor histidine kinase RcsC | insig. | 44 | 94 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_13900 | | transcriptional regulator | sig. | 41 | 95 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS18065 | | response regulator | cofit | 38 | 90 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_2324 | | PAS/PAC sensor hybrid histidine kinase (RefSeq) | cofit | 43 | 93 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS13965 | | response regulator | insig. | 35 | 93 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS17750 | | response regulator | insig. | 35 | 93 |
| | Pseudomonas sp. SVBP6 | COO64_RS18980 | | response regulator | insig. | 42 | 93 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS06795 | | response regulator | insig. | 44 | 83 |
| | Shewanella loihica PV-4 | Shew_0459 | | PAS/PAC sensor hybrid histidine kinase (RefSeq) | strong | 40 | 87 |
| | Shewanella oneidensis MR-1 | SO0577 | | sensory box histidine kinase/response regulator (NCBI ptt file) | strong | 43 | 85 |
| | Xanthobacter sp. DMC5 | GFF593 | | Polar-differentiation response regulator DivK | no data | 38 | 88 |
| | Pseudomonas putida KT2440 | PP_1438 | | response regulator | insig. | 40 | 95 |
| | Pseudomonas segetis P6 | MPMX49_02274 | | Sensor histidine kinase RcsC | cofit | 36 | 95 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS20590 | | response regulator | insig. | 43 | 83 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_2543 | | response regulator receiver protein (RefSeq) | sig. | 40 | 91 |
| | Pseudomonas sp. BP01 | JOY50_RS14720 | | heavy metal response regulator transcription factor | insig. | 40 | 95 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2391 | | two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) | insig. | 39 | 93 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS01350 | | transcriptional regulator | insig. | 35 | 98 |
| | Caulobacter crescentus NA1000 | CCNA_02547 | | response regulator receiver protein DivK | no data | 35 | 95 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_02547 | | response regulator receiver protein DivK | no data | 35 | 95 |
| | Shewanella sp. ANA-3 | Shewana3_0576 | | multi-sensor hybrid histidine kinase (RefSeq) | strong | 40 | 93 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT3800 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 39 | 93 |
| | Pseudomonas sp. S08-1 | OH686_06285 | | Two-component system sensor histidine kinase | insig. | 45 | 88 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_20505 | | Histidine kinase | sig. | 42 | 86 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_01420 | | Histidine kinase | sig. | 41 | 94 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_03646 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 39 | 95 |
| | Pseudomonas sp. SVBP6 | COO64_RS16580 | | heavy metal response regulator transcription factor | insig. | 39 | 95 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS30960 | | transcriptional regulator | strong | 40 | 98 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF1107 | | DNA-binding heavy metal response regulator | insig. | 39 | 96 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02667 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 36 | 95 |
| | Bosea sp. OAE506 | ABIE41_RS18175 | | response regulator | no data | 35 | 88 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04368 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 40 | 88 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_0187 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | strong | 35 | 93 |
| | Rhizobium sp. OAE497 | ABIE40_RS07325 | | response regulator | no data | 34 | 91 |
| | Brevundimonas sp. GW460-12-10-14-LB2 | A4249_RS08355 | | response regulator | cofit | 38 | 88 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS15805 | | two component system response regulator RpaA | strong | 36 | 98 |
| | Pseudomonas aeruginosa MRSN321 | DY961_RS12980 | ladS;inference=COORDINATES | hybrid sensor histidine kinase/response regulator LadS | strong | 39 | 95 |
| | Pseudomonas aeruginosa PUPa3 | DQ20_RS48305 | ladS;inference=COORDINATES | hybrid sensor histidine kinase/response regulator LadS | strong | 39 | 95 |
| | Dechlorosoma suillum PS | Dsui_1068 | | heavy metal response regulator | cofit | 43 | 93 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU1563 | | sensory box histidine kinase/response regulator (TIGR) | insig. | 39 | 93 |
| | Sphingomonas koreensis DSMZ 15582 | Ga0059261_3651 | | phosphate regulon transcriptional regulatory protein PhoB | no data | 38 | 99 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS15305 | | heavy metal response regulator transcription factor | insig. | 37 | 98 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_2021 | | Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal | sig. | 43 | 85 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_2021 | | Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal | insig. | 43 | 85 |
| | Agrobacterium fabrum C58 | Atu1296 | | two component response regulator | no data | 34 | 91 |
| | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS04615 | | response regulator | insig. | 44 | 85 |
| | Shewanella amazonensis SB2B | Sama_3129 | | sensory box histidine kinase/response regulator (RefSeq) | strong | 42 | 85 |
| | Rhodanobacter denitrificans MT42 | LRK55_RS17160 | | heavy metal response regulator transcription factor | insig. | 40 | 95 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS17690 | | heavy metal response regulator transcription factor | insig. | 40 | 95 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_2622 | | Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | strong | 34 | 99 |
| | Pseudomonas sp. RS175 | PFR28_03079 | | Sensor histidine kinase RcsC | strong | 40 | 85 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS25955 | | transcriptional regulator | insig. | 39 | 98 |
| | Cellulophaga baltica 18 | M666_RS17625 | | response regulator transcription factor | no data | 37 | 97 |
| | Azospirillum sp. SherDot2 | MPMX19_01523 | | Polar-differentiation response regulator DivK | insig. | 37 | 88 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1860 | ycf29 | two component transcriptional regulator, LuxR family | no data | 33 | 97 |
| | Dechlorosoma suillum PS | Dsui_2382 | | PAS domain S-box | cofit | 41 | 94 |
| | Azospirillum brasilense Sp245 | AZOBR_RS16185 | | chemotaxis protein CheY | sig. | 37 | 88 |
| | Sinorhizobium meliloti 1021 | SMc01371 | | 2-component receiver domain-containing protein | no data | 33 | 91 |
| | Azospirillum sp. SherDot2 | MPMX19_06088 | | Sensor histidine kinase RcsC | insig. | 42 | 90 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1251 | | multi-sensor hybrid histidine kinase (RefSeq) | insig. | 42 | 86 |
| | Pseudomonas sp. BP01 | JOY50_RS19155 | | ATP-binding protein | insig. | 41 | 81 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1875 | | multi-sensor hybrid histidine kinase (RefSeq) | insig. | 38 | 94 |
| | Dinoroseobacter shibae DFL-12 | Dshi_1538 | | two component transcriptional regulator, winged helix family (RefSeq) | no data | 38 | 98 |
| | Variovorax sp. SCN45 | GFF4042 | | Copper-sensing two-component system response regulator CusR | insig. | 40 | 92 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_5872 | | Sensor histidine kinase/response regulator | strong | 44 | 80 |
| | Escherichia fergusonii Becca | EFB2_03523 | | Transcriptional regulatory protein CusR | insig. | 39 | 93 |
| | Escherichia coli ECOR38 | HEPCGN_00585 | cusR | copper response regulator transcription factor CusR | insig. | 39 | 93 |
| | Escherichia coli ECRC100 | OKFHMN_07705 | cusR | copper response regulator transcription factor CusR | cofit | 39 | 93 |
| | Escherichia coli ECRC101 | MCAODC_26920 | cusR | copper response regulator transcription factor CusR | insig. | 39 | 93 |
| | Escherichia coli ECRC102 | NIAGMN_05760 | cusR | copper response regulator transcription factor CusR | insig. | 39 | 93 |
| | Escherichia coli ECRC62 | BNILDI_22095 | cusR | copper response regulator transcription factor CusR | insig. | 39 | 93 |
| | Escherichia coli ECRC98 | JDDGAC_11350 | cusR | copper response regulator transcription factor CusR | insig. | 39 | 93 |
| | Escherichia coli ECRC99 | KEDOAH_20265 | cusR | copper response regulator transcription factor CusR | no data | 39 | 93 |
| | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_03138 | | Transcriptional regulatory protein CusR | insig. | 39 | 93 |
| | Escherichia coli Nissle 1917 | ECOLIN_RS03125 | | copper response regulator transcription factor CusR | no data | 39 | 93 |
| | Escherichia coli BW25113 | b0571 | cusR | DNA-binding response regulator in two-component regulatory system with CusS (NCBI) | insig. | 39 | 93 |
| | Ralstonia solanacearum PSI07 | RPSI07_RS02355 | | DNA-binding response regulator | insig. | 39 | 93 |
| | Sphingobium sp. HT1-2 | GFF2657 | | Phosphate regulon transcriptional regulatory protein PhoB (SphR) | cofit | 38 | 99 |
| | Pseudomonas fluorescens FW300-N2E3 | AO353_01750 | | histidine kinase | insig. | 45 | 80 |