| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Alteromonas macleodii MIT1002 | MIT1002_01203 | | putative diguanylate cyclase YcdT | insig. | 100 | 100 |
| o | Vibrio cholerae E7946 ATCC 55056 | CSW01_06815 | | GGDEF domain-containing protein | insig. | 38 | 97 |
| o | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.3367.1 | | GGDEF family protein | insig. | 33 | 99 |
| o | Lysobacter sp. OAE881 | ABIE51_RS07485 | | ligand-binding sensor domain-containing diguanylate cyclase | insig. | 35 | 97 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.1047.1 | | GGDEF family protein | insig. | 29 | 98 |
| | Rhodanobacter denitrificans MT42 | LRK55_RS17540 | | ligand-binding sensor domain-containing diguanylate cyclase | cofit | 25 | 96 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS17315 | | ligand-binding sensor domain-containing diguanylate cyclase | insig. | 25 | 96 |
| | Alteromonas macleodii MIT1002 | MIT1002_01743 | | putative diguanylate cyclase YdaM | insig. | 23 | 96 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_16885 | | GGDEF domain-containing protein | insig. | 24 | 96 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_19195 | | hypothetical protein | insig. | 23 | 80 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.2824.1 | | GGDEF family protein | insig. | 24 | 96 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.2825.1 | | hypothetical protein | insig. | 23 | 94 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02182 | | response regulator receiver domain protein | cofit | 22 | 93 |
| | Shewanella amazonensis SB2B | Sama_0993 | | ligand-binding sensor domain-containing protein (RefSeq) | insig. | 24 | 79 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS03150 | | two-component regulator propeller domain-containing protein | insig. | 24 | 73 |
| | Sphingomonas koreensis DSMZ 15582 | Ga0059261_3916 | | Histidine kinase/Y_Y_Y domain/Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | insig. | 22 | 77 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_3754 | | Signal transduction histidine kinase | insig. | 23 | 82 |
| | Lysobacter sp. OAE881 | ABIE51_RS02660 | | sensor histidine kinase | insig. | 23 | 79 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_01894 | | transcriptional regulator, AraC family | strong | 22 | 79 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4663 | | two-component system sensor histidine kinase/response (NCBI ptt file) | strong | 24 | 79 |
| | Cellulophaga baltica 18 | M666_RS09795 | | two-component regulator propeller domain-containing protein | insig. | 23 | 76 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02800 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 23 | 79 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02667 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 21 | 80 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS06690 | | response regulator | sig. | 23 | 83 |
| o | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS21280 | | hypothetical protein | insig. | 21 | 83 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02857 | | conserved hypothetical protein TIGR03982 | insig. | 22 | 82 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_2760 | | Signal transduction histidine kinase | insig. | 21 | 80 |
| | Shewanella sp. ANA-3 | Shewana3_0269 | | diguanylate cyclase (RefSeq) | cofit | 40 | 17 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1537 | | diguanylate cyclase (RefSeq) | insig. | 37 | 22 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_4346 | | Signal transduction histidine kinase | insig. | 23 | 80 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04483 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | cofit | 24 | 79 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS06050 | | hypothetical protein | insig. | 20 | 81 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS08780 | | hybrid sensor histidine kinase/response regulator transcription factor | insig. | 23 | 92 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS02675 | | response regulator | insig. | 22 | 80 |
| | Cellulophaga baltica 18 | M666_RS00005 | | two-component regulator propeller domain-containing protein | insig. | 22 | 76 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_05479 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 22 | 79 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS08450 | | response regulator | strong | 22 | 80 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2897 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 23 | 79 |
| | Shewanella oneidensis MR-1 | SO4457 | | GGDEF domain protein (NCBI ptt file) | insig. | 40 | 17 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT3049 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | cofit | 23 | 81 |
| | Lysobacter sp. OAE881 | ABIE51_RS10315 | | triple tyrosine motif-containing protein | insig. | 22 | 78 |
| | Marinobacter adhaerens HP15 | HP15_3345 | | GGDEF domain protein | insig. | 36 | 23 |
| | Marinobacter adhaerens HP15 | HP15_611 | | diguanylate cyclase | insig. | 39 | 19 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS11130 | | two-component regulator propeller domain-containing protein | cofit | 25 | 80 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS10925 | | response regulator | insig. | 21 | 81 |
| | Shewanella loihica PV-4 | Shew_2791 | | PAS/PAC sensor signal transduction histidine kinase (RefSeq) | insig. | 23 | 79 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS15170 | | response regulator | insig. | 21 | 81 |
| | Pseudomonas segetis P6 | MPMX49_00520 | | hypothetical protein | strong | 37 | 20 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_4259 | | His Kinase A (phosphoacceptor) domain./Response regulator receiver domain./Y_Y_Y domain./Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase./Two component regulator propeller./Bacterial regulatory helix-turn-helix proteins, AraC family. | insig. | 24 | 79 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT3465 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 23 | 92 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS00710 | | hypothetical protein | insig. | 22 | 78 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS02485 | | hypothetical protein | insig. | 22 | 79 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_24210 | | diguanylate cyclase | sig. | 38 | 20 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2923 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 22 | 80 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS08430 | | response regulator | insig. | 22 | 83 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS08545 | | response regulator | insig. | 24 | 80 |
| | Acinetobacter radioresistens SK82 | MPMX26_02261 | | hypothetical protein | no data | 40 | 16 |
| | Marinobacter adhaerens HP15 | HP15_3763 | | response regulator receiver domain protein (CheY) | insig. | 39 | 20 |
| | Pseudomonas sp. S08-1 | OH686_05940 | | GGDEF domain protein | cofit | 40 | 17 |
| | Rhodopseudomonas palustris CGA009 | TX73_008830 | | diguanylate cyclase | insig. | 39 | 19 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS03465 | | response regulator | sig. | 22 | 82 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_11340 | | GGDEF domain-containing protein | insig. | 42 | 17 |
| | Shewanella sp. ANA-3 | Shewana3_4330 | | diguanylate cyclase with GAF sensor (RefSeq) | insig. | 42 | 16 |
| | Shewanella amazonensis SB2B | Sama_2970 | | diguanylate cyclase (RefSeq) | insig. | 40 | 19 |
| | Pseudomonas sp. DMC3 | GFF1559 | | hypothetical protein | insig. | 39 | 19 |
| | Pseudomonas putida KT2440 | PP_1411 | | GGDEF domain protein | insig. | 42 | 17 |
| | Pseudomonas sp. SVBP6 | COO64_RS16430 | | sensor domain-containing diguanylate cyclase | insig. | 39 | 17 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS07185 | | two-component regulator propeller domain-containing protein | insig. | 23 | 83 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS15155 | | hybrid sensor histidine kinase/response regulator transcription factor | cofit | 22 | 80 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_3970 | | Two-component response regulator | insig. | 37 | 23 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_0723 | | diguanylate cyclase (GGDEF) domain | insig. | 33 | 20 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS01485 | | hypothetical protein | insig. | 24 | 82 |
| | Pseudomonas sp. BP01 | JOY50_RS14585 | | sensor domain-containing diguanylate cyclase | insig. | 41 | 17 |
| | Pseudomonas fluorescens GW456-L13 | PfGW456L13_4533 | | hypothetical protein | insig. | 36 | 18 |
| | Marinobacter adhaerens HP15 | HP15_p187g173 | | protein containing diguanylate cyclase, predicted domains | insig. | 43 | 17 |
| | Dechlorosoma suillum PS | Dsui_0789 | | diguanylate cyclase (GGDEF) domain-containing protein | insig. | 39 | 20 |
| | Pseudomonas syringae pv. syringae B728a | Psyr_2281 | | GGDEF domain protein | insig. | 39 | 19 |
| | Pseudomonas syringae pv. syringae B728a ΔmexB | Psyr_2281 | | GGDEF domain protein | insig. | 39 | 19 |
| | Azospirillum brasilense Sp245 | AZOBR_RS09565 | | diguanylate cyclase | insig. | 43 | 17 |
| | Pseudomonas stutzeri RCH2 | Psest_3437 | | diguanylate cyclase (GGDEF) domain | insig. | 36 | 19 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS25885 | | diguanylate cyclase | insig. | 42 | 18 |
| | Klebsiella pneumoniae MKP103 | KDGMDA_22435 | | sensor domain-containing diguanylate cyclase | insig. | 41 | 17 |
| | Rhodopseudomonas palustris CGA009 | TX73_021305 | | diguanylate cyclase | insig. | 33 | 24 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS10265 | | hypothetical protein | insig. | 22 | 77 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_1490 | | diguanylate cyclase (GGDEF) domain | strong | 22 | 81 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_00976 | | response regulator receiver domain protein | insig. | 21 | 76 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS10630 | | helix-turn-helix domain-containing protein | insig. | 21 | 75 |
| | Pseudomonas sp. DMC3 | GFF2253 | | hypothetical protein | insig. | 37 | 17 |
| | Shewanella sp. ANA-3 | Shewana3_0308 | | diguanylate cyclase (RefSeq) | insig. | 40 | 17 |
| | Xanthobacter sp. DMC5 | GFF2622 | | hypothetical protein | insig. | 35 | 21 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU1805 | | GGDEF domain protein (TIGR) | insig. | 40 | 17 |
| | Pseudomonas sp. S08-1 | OH686_21285 | | hypothetical protein | cofit | 35 | 23 |
| | Rhodopseudomonas palustris CGA009 | TX73_012800 | | GGDEF domain-containing protein | insig. | 34 | 20 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS04050 | | helix-turn-helix domain-containing protein | insig. | 23 | 79 |
| | Pseudomonas fluorescens FW300-N1B4 | Pf1N1B4_40 | | diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) | insig. | 40 | 19 |
| | Shewanella loihica PV-4 | Shew_1681 | | diguanylate cyclase with PAS/PAC sensor (RefSeq) | cofit | 39 | 17 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_1120 | | Diguanylate cyclase/phosphodiesterase domain 1 (GGDEF) | insig. | 36 | 20 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS13495 | | hybrid sensor histidine kinase/response regulator transcription factor | insig. | 23 | 79 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS03345 | | hypothetical protein | insig. | 22 | 77 |
| | Serratia liquefaciens MT49 | IAI46_05820 | | diguanylate cyclase | insig. | 37 | 17 |