| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_17130 | | Zn-dependent protease | 1.0 | CSW01_06585 | | fumarate hydratase | 0.46 | 10 |
| Shewanella loihica PV-4 | 0.56 | Shew_2842 | | peptidase M48, Ste24p (RefSeq) | 0.81 | Shew_1904 | | tartrate/fumarate subfamily Fe-S type hydro-lyase alpha subunit (RefSeq) | — | — |
| Shewanella amazonensis SB2B | 0.56 | Sama_2507 | | hypothetical protein (RefSeq) | 0.81 | Sama_1688 | | fumarate hydratase, class I, anaerobic, putative (RefSeq) | — | — |
| Shewanella sp. ANA-3 | 0.54 | Shewana3_0964 | | peptidase M48, Ste24p (RefSeq) | 0.81 | Shewana3_2302 | | fumarase (RefSeq) | — | — |
| Shewanella oneidensis MR-1 | 0.54 | SO1137 | | conserved hypothetical protein (NCBI ptt file) | 0.81 | SO2222 | | fumarate hydratase, class I, anaerobic, putative (NCBI ptt file) | — | — |
| Alteromonas macleodii MIT1002 | 0.51 | MIT1002_03052 | | TPR repeat-containing protein YfgC precursor | 0.84 | MIT1002_02009 | | Fumarate hydratase class I, anaerobic | — | — |
| Kangiella aquimarina DSM 16071 | 0.47 | B158DRAFT_0072 | | Peptidase family M48. | 0.73 | B158DRAFT_1342 | | fumarase, class I, homodimeric (EC 4.2.1.2) | — | — |
| Marinobacter adhaerens HP15 | 0.44 | HP15_2664 | | peptidase M48, Ste24p | 0.71 | HP15_1143 | | hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit | — | — |
| Xanthomonas campestris pv. campestris strain 8004 | 0.40 | Xcc-8004.9.1 | | Zn-dependent protease with chaperone function | 0.71 | Xcc-8004.3506.1 | | Fumarate hydratase class I, aerobic (EC 4.2.1.2) | — | — |
| Rhodanobacter sp000427505 FW510-R12 | 0.39 | LRK53_RS13345 | | M48 family metallopeptidase | 0.72 | LRK53_RS15950 | | fumarate hydratase | low | > 59 |
| Rhodanobacter denitrificans MT42 | 0.39 | LRK55_RS15010 | | M48 family metallopeptidase | 0.73 | LRK55_RS12360 | | fumarate hydratase | low | > 63 |
| Rhodanobacter sp. FW510-T8 | 0.39 | OKGIIK_04060 | bepA | peptidase | 0.72 | OKGIIK_02115 | ttdA | fumarate hydratase | low | > 53 |
| Rhodanobacter denitrificans FW104-10B01 | 0.39 | LRK54_RS15295 | | M48 family metallopeptidase | 0.72 | LRK54_RS12620 | | fumarate hydratase | low | > 59 |
| Lysobacter sp. OAE881 | 0.39 | ABIE51_RS00775 | | M48 family metallopeptidase | 0.72 | ABIE51_RS12620 | | fumarate hydratase | low | > 62 |
| Rhodospirillum rubrum S1H | 0.34 | Rru_A2450 | | Peptidase M48, Ste24p (NCBI) | 0.19 | Rru_A2206 | | tartrate dehydrogenase (NCBI) | — | — |
| Variovorax sp. SCN45 | 0.34 | GFF7455 | | Zn-dependent protease with chaperone function PA4632 | 0.66 | GFF483 | | Fumarate hydratase class I, aerobic (EC 4.2.1.2) | — | — |
| Dyella japonica UNC79MFTsu3.2 | 0.33 | ABZR86_RS20450 | | M48 family metallopeptidase | 0.72 | ABZR86_RS19555 | | fumarate hydratase | low | > 74 |
| Phocaeicola vulgatus CL09T03C04 | 0.32 | HMPREF1058_RS19010 | | M48 family metallopeptidase | 0.19 | HMPREF1058_RS13805 | | fumarate hydratase | — | — |
| Parabacteroides merdae CL09T00C40 | 0.31 | HMPREF1078_RS10560 | | M48 family metallopeptidase | 0.19 | HMPREF1078_RS17710 | | fumarate hydratase | — | — |
| Azospirillum brasilense Sp245 | 0.31 | AZOBR_RS23595 | | peptidase M48 Ste24p | 0.19 | AZOBR_RS10315 | | fumarate hydratase | low | > 97 |
| Methylophilus sp. DMC18 | 0.30 | GFF900 | | Beta-barrel assembly-enhancing protease | 0.69 | GFF482 | | Fumarate hydratase class I, anaerobic | — | — |
| Pseudomonas sp. BP01 | 0.28 | JOY50_RS19455 | | M48 family metallopeptidase | 0.74 | JOY50_RS14310 | | fumarate hydratase | — | — |
| Castellaniella sp019104865 MT123 | 0.28 | ABCV34_RS04295 | | M48 family metallopeptidase | 0.70 | ABCV34_RS09450 | | fumarate hydratase | low | > 48 |
| Pseudomonas sp. SVBP6 | 0.28 | COO64_RS03365 | | M48 family metallopeptidase | 0.74 | COO64_RS12175 | | fumarate hydratase | — | — |
| Herbaspirillum seropedicae SmR1 | 0.28 | HSERO_RS16520 | | peptidase M48 | 0.71 | HSERO_RS07760 | | fumarate hydratase | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.28 | Pf1N1B4_2951 | | Zn-dependent protease with chaperone function | 0.73 | Pf1N1B4_683 | | Fumarate hydratase class I, aerobic (EC 4.2.1.2) | low | > 87 |
| Pseudomonas segetis P6 | 0.27 | MPMX49_03711 | | Metalloprotease LoiP | 0.72 | MPMX49_03729 | | Fumarate hydratase class I, anaerobic | — | — |
| Pseudomonas fluorescens SBW25 | 0.27 | PFLU_RS04560 | | M48 family metalloprotease | 0.73 | PFLU_RS24270 | | fumarate hydratase | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.27 | PFLU_RS04560 | | M48 family metalloprotease | 0.73 | PFLU_RS24270 | | fumarate hydratase | — | — |
| Pseudomonas sp. S08-1 | 0.27 | OH686_06365 | | Zn-dependent protease with chaperone function | 0.74 | OH686_18780 | | Fumarate hydratase class I, aerobic | — | — |
| Pseudomonas putida KT2440 | 0.27 | PP_0759 | | conserved exported protein of unknown function | 0.74 | PP_0897 | | Fumarate hydratase, class I | — | — |
| Pseudomonas lactucae CFBP13502 | 0.27 | GEMAOFIL_01106 | | Metalloprotease LoiP | 0.73 | GEMAOFIL_04680 | | Fumarate hydratase class I, aerobic | low | > 93 |
| Pseudomonas simiae WCS417 | 0.27 | PS417_04515 | | peptidase M48 | 0.73 | PS417_22635 | | fumarate hydratase | — | — |
| Pseudomonas aeruginosa PA14 | 0.27 | IKLFDK_00345 | | peptidase M48 | 0.73 | IKLFDK_02440 | | fumarate hydratase | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.27 | Pf6N2E2_3249 | | Zn-dependent protease with chaperone function | 0.73 | Pf6N2E2_5489 | | Fumarate hydratase class I, aerobic (EC 4.2.1.2) | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.26 | AO356_06950 | | peptidase M48 | 0.73 | AO356_17810 | | fumarate hydratase | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.26 | AO353_14985 | | peptidase M48 | 0.73 | AO353_03795 | | fumarate hydratase | low | > 101 |
| Pseudomonas sp. RS175 | 0.26 | PFR28_03625 | | Metalloprotease LoiP | 0.73 | PFR28_03458 | | Fumarate hydratase class I, aerobic | — | — |
| Pseudomonas sp. DMC3 | 0.26 | GFF4457 | | Metalloprotease LoiP | 0.73 | GFF5036 | | Fumarate hydratase class I, aerobic | — | — |
| Pseudomonas stutzeri RCH2 | 0.26 | Psest_3228 | | Zn-dependent protease with chaperone function | 0.74 | Psest_3193 | | hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region/hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.26 | PfGW456L13_1614 | | Zn-dependent protease with chaperone function | 0.74 | PfGW456L13_1808 | | Fumarate hydratase class I, aerobic (EC 4.2.1.2) | — | — |
| Ralstonia solanacearum GMI1000 | 0.24 | RS_RS00755 | | M48 family peptidase | 0.70 | RS_RS09830 | | fumarate hydratase | low | > 80 |
| Ralstonia solanacearum IBSBF1503 | 0.24 | RALBFv3_RS10140 | | M48 family peptidase | 0.71 | RALBFv3_RS02460 | | fumarate hydratase | low | > 76 |
| Ralstonia solanacearum UW163 | 0.24 | UW163_RS03440 | | M48 family peptidase | 0.71 | UW163_RS11265 | | fumarate hydratase | — | — |
| Acinetobacter radioresistens SK82 | 0.23 | MPMX26_01092 | | Metalloprotease LoiP | 0.69 | MPMX26_00411 | | Fumarate hydratase class I, aerobic | low | > 36 |
| Acinetobacter baumannii LAC-4 | 0.23 | RR41_RS10025 | | M48 family metallopeptidase | 0.68 | RR41_RS16545 | | fumarate hydratase | — | — |
| Bacteroides thetaiotaomicron VPI-5482 | 0.14 | BT0149 | | peptidase (NCBI ptt file) | 0.19 | BT2256 | | fumarate hydratase class I, anaerobic (NCBI ptt file) | — | — |
| Bacteroides ovatus ATCC 8483 | 0.13 | BACOVA_01288 | | peptidase, M48 family | 0.18 | BACOVA_03087 | | hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type | — | — |
Not shown: 10 genomes with orthologs for CSW01_17130 only; 51 genomes with orthologs for CSW01_06585 only