| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_09720 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 1.0 | CSW01_13635 | | thiol:disulfide interchange protein DsbD | 0.79 | 14 |
| Rahnella sp. WP5 | 0.69 | EX31_RS22835 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.46 | EX31_RS08975 | | protein-disulfide reductase DsbD | — | — |
| Klebsiella michiganensis M5al | 0.68 | BWI76_RS07100 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.47 | BWI76_RS02315 | | protein-disulfide reductase DsbD | — | — |
| Serratia liquefaciens MT49 | 0.68 | IAI46_05400 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.45 | IAI46_01465 | | protein-disulfide reductase DsbD | — | — |
| Klebsiella pneumoniae MKP103 | 0.68 | KDGMDA_15035 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.45 | KDGMDA_10805 | | Thiol:disulfide interchange protein DsbD | — | — |
| Klebsiella pneumoniae MRSN742743 | 0.68 | KFA93_RS03235 | folD;go_function=methylenetetrahydrofolate | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.46 | KFA93_RS21290 | | protein-disulfide reductase DsbD | — | — |
| Enterobacter asburiae PDN3 | 0.68 | EX28DRAFT_2449 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.46 | EX28DRAFT_3333 | | Thiol:disulfide interchange protein | — | — |
| Pantoea sp. MT58 | 0.68 | IAI47_14320 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.43 | IAI47_17335 | | protein-disulfide reductase DsbD | — | — |
| Shewanella amazonensis SB2B | 0.68 | Sama_1222 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | 0.42 | Sama_0538 | dipZ | thiol:disulfide interchange protein precursor (RefSeq) | — | — |
| Enterobacter sp. TBS_079 | 0.68 | MPMX20_01107 | | Bifunctional protein FolD protein | 0.45 | MPMX20_00416 | | Thiol:disulfide interchange protein DsbD | — | — |
| Shewanella sp. ANA-3 | 0.68 | Shewana3_2663 | | methenyltetrahydrofolate cyclohydrolase (RefSeq) | 0.43 | Shewana3_3576 | dipZ | thiol:disulfide interchange protein precursor (RefSeq) | — | — |
| Escherichia fergusonii Becca | 0.68 | EFB2_03532 | | Bifunctional protein FolD protein | 0.47 | EFB2_04399 | | Thiol:disulfide interchange protein DsbD | — | — |
| Escherichia coli ECOR27 | 0.68 | NOLOHH_00795 | | Bifunctional protein FolD | 0.47 | NOLOHH_04715 | dsbD | protein-disulfide reductase DsbD | — | — |
| Escherichia coli BW25113 | 0.68 | b0529 | folD | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase (NCBI) | 0.47 | b4136 | dipZ | thiol:disulfide interchange protein precursor (NCBI) | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.68 | OHPLBJKB_03152 | | Bifunctional protein FolD protein | 0.47 | OHPLBJKB_03907 | | Thiol:disulfide interchange protein DsbD | — | — |
| Escherichia coli BL21 | 0.68 | ECD_00479 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.47 | ECD_04006 | | thiol:disulfide interchange protein and activator of DsbC | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.68 | GFF4447 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.46 | GFF2016 | | Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) | — | — |
| Escherichia coli ECRC101 | 0.68 | MCAODC_27025 | | Bifunctional protein FolD | 0.46 | MCAODC_02960 | dsbD | protein-disulfide reductase DsbD | — | — |
| Escherichia coli Nissle 1917 | 0.68 | ECOLIN_RS03065 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.47 | ECOLIN_RS24030 | | protein-disulfide reductase DsbD | — | — |
| Escherichia coli ECRC100 | 0.68 | OKFHMN_07805 | | Bifunctional protein FolD | 0.47 | OKFHMN_12450 | dsbD | protein-disulfide reductase DsbD | — | — |
| Pantoea agglomerans CFBP13505 P0401 | 0.68 | PagCFBP13516_RS14565 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.44 | PagCFBP13516_RS17630 | | protein-disulfide reductase DsbD | — | — |
| Escherichia coli ECRC99 | 0.68 | KEDOAH_20165 | | Bifunctional protein FolD | 0.47 | KEDOAH_15715 | dsbD | protein-disulfide reductase DsbD | — | — |
| Escherichia coli ECRC98 | 0.68 | JDDGAC_11455 | | Bifunctional protein FolD | 0.47 | JDDGAC_16085 | dsbD | protein-disulfide reductase DsbD | — | — |
| Escherichia coli ECRC102 | 0.68 | NIAGMN_05860 | | Bifunctional protein FolD | 0.47 | NIAGMN_10295 | dsbD | protein-disulfide reductase DsbD | — | — |
| Escherichia coli ECOR38 | 0.67 | HEPCGN_06445 | | Bifunctional protein FolD | 0.46 | HEPCGN_10675 | dsbD | protein-disulfide reductase DsbD | — | — |
| Escherichia coli ECRC62 | 0.67 | BNILDI_22225 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.47 | BNILDI_06775 | dsbD | protein-disulfide reductase DsbD | — | — |
| Erwinia amylovora T8 | 0.67 | OLJFJH_17600 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.42 | OLJFJH_02625 | | protein-disulfide reductase DsbD | — | — |
| Pectobacterium carotovorum WPP14 | 0.67 | HER17_RS06505 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.47 | HER17_RS18850 | | protein-disulfide reductase DsbD | — | — |
| Shewanella loihica PV-4 | 0.67 | Shew_2510 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | 0.42 | Shew_3266 | dipZ | thiol:disulfide interchange protein precursor (RefSeq) | — | — |
| Dickeya dadantii 3937 | 0.67 | DDA3937_RS15075 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.43 | DDA3937_RS02705 | | protein-disulfide reductase DsbD | — | — |
| Alteromonas macleodii MIT1002 | 0.66 | MIT1002_02770 | | hypothetical protein | 0.38 | MIT1002_03939 | | Thiol:disulfide interchange protein DsbD precursor | — | — |
| Erwinia tracheiphila SCR3 | 0.66 | LU632_RS15195 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.40 | LU632_RS01840 | | protein-disulfide reductase DsbD | — | — |
| Shewanella oneidensis MR-1 | 0.66 | SO1792 | folD | methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase (NCBI ptt file) | 0.44 | SO0696 | dsbD | thiol:disulfide interchange protein DsbD (NCBI ptt file) | — | — |
| Dickeya dianthicola 67-19 | 0.66 | HGI48_RS15155 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.42 | HGI48_RS02680 | | protein-disulfide reductase DsbD | — | — |
| Dickeya dianthicola ME23 | 0.66 | DZA65_RS15960 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.42 | DZA65_RS02835 | | protein-disulfide reductase DsbD | — | — |
| Erwinia tracheiphila HP pepo 2.2 | 0.66 | IJEDHG_00975 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.40 | IJEDHG_07065 | | Thiol:disulfide interchange protein DsbD | — | — |
| Pseudomonas simiae WCS417 | 0.62 | PS417_17265 | | methenyltetrahydrofolate cyclohydrolase | 0.26 | PS417_19525 | | thiol:disulfide interchange protein | — | — |
| Pseudomonas orientalis W4I3 | 0.62 | QF045_RS18930 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.26 | QF045_RS21665 | | protein-disulfide reductase DsbD | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.62 | PfGW456L13_2550 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.28 | PfGW456L13_2298 | | Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.61 | AO356_01775 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.28 | AO356_02870 | | thiol:disulfide interchange protein | — | — |
| Marinobacter adhaerens HP15 | 0.61 | HP15_2187 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.30 | HP15_2101 | | membrane protein containing cytochrome c assembly protein, transmembrane region domain | — | — |
| Pseudomonas sp. RS175 | 0.61 | PFR28_01223 | | Bifunctional protein FolD protein | 0.27 | PFR28_01029 | | Thiol:disulfide interchange protein DsbD | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.61 | Pf6N2E2_2221 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.28 | Pf6N2E2_2398 | | Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) | — | — |
| Pseudomonas fluorescens SBW25 | 0.61 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.25 | PFLU_RS21490 | | protein-disulfide reductase DsbD | — | — |
| Pseudomonas lactucae CFBP13502 | 0.61 | GEMAOFIL_03749 | | Bifunctional protein FolD protein | 0.25 | GEMAOFIL_04105 | | Thiol:disulfide interchange protein DsbD | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.61 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.25 | PFLU_RS21490 | | protein-disulfide reductase DsbD | — | — |
| Pseudomonas putida KT2440 | 0.61 | PP_2265 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.25 | PP_0561 | | thiol/disulfide interchange protein 1 | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.61 | Pf1N1B4_3943 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.27 | Pf1N1B4_210 | | Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8) | — | — |
| Pseudomonas sp. BP01 | 0.61 | JOY50_RS25950 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.26 | JOY50_RS23140 | | protein-disulfide reductase DsbD | — | — |
| Pseudomonas protegens RBAN4 | 0.61 | FABNJH_20635 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.27 | FABNJH_21580 | dsbD | Thiol:disulfide interchange protein DsbD | — | — |
| Pseudomonas sp. DMC3 | 0.61 | GFF1441 | | Bifunctional protein FolD protein | 0.29 | GFF4549 | | Thiol:disulfide interchange protein DsbD | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.61 | AO353_20145 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.25 | AO353_19365 | | thiol:disulfide interchange protein | — | — |
| Pseudomonas segetis P6 | 0.60 | ACVTMO_RS11215 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.26 | ACVTMO_RS20330 | | protein-disulfide reductase DsbD | — | — |
| Pseudomonas stutzeri RCH2 | 0.58 | Psest_2301 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.27 | Psest_1603 | | Thiol:disulfide interchange protein | — | — |
| Kangiella aquimarina DSM 16071 | 0.57 | B158DRAFT_1028 | | methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)/5,10-methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) | 0.32 | B158DRAFT_0153 | | Thiol:disulfide interchange protein | — | — |
| Castellaniella sp019104865 MT123 | 0.48 | ABCV34_RS04175 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.27 | ABCV34_RS03205 | | protein-disulfide reductase DsbD | — | — |
| Herbaspirillum seropedicae SmR1 | 0.46 | HSERO_RS07295 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.29 | HSERO_RS00715 | | thiol:disulfide interchange protein | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.46 | RR42_RS07345 | | methenyltetrahydrofolate cyclohydrolase | 0.29 | RR42_RS19110 | | thiol:disulfide interchange protein | — | — |
| Dechlorosoma suillum PS | 0.46 | Dsui_0093 | | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase | 0.31 | Dsui_0718 | | thiol:disulfide interchange protein | — | — |
| Ralstonia solanacearum PSI07 | 0.45 | RPSI07_RS15800 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.28 | RPSI07_RS10195 | | protein-disulfide reductase DsbD | — | — |
| Ralstonia solanacearum UW163 | 0.45 | UW163_RS14995 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.27 | UW163_RS06570 | | protein-disulfide reductase DsbD | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.45 | RALBFv3_RS01685 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.27 | RALBFv3_RS07045 | | protein-disulfide reductase DsbD | — | — |
| Ralstonia sp. UNC404CL21Col | 0.45 | ABZR87_RS13485 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.28 | ABZR87_RS02695 | | protein-disulfide reductase DsbD | — | — |
| Ralstonia solanacearum GMI1000 | 0.45 | RS_RS08040 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.27 | RS_RS14985 | | thiol:disulfide interchange protein DsbD | — | — |
| Paraburkholderia graminis OAS925 | 0.42 | ABIE53_002796 | | methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase | 0.26 | ABIE53_000167 | | thiol:disulfide interchange protein DsbD | — | — |
Not shown: 58 genomes with orthologs for CSW01_09720 only; 1 genomes with orthologs for CSW01_13635 only