Conservation of cofitness between BWI76_RS19375 and BWI76_RS01550 in Klebsiella michiganensis M5al

65 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 1.0 BWI76_RS01550 thiamine phosphate synthase 0.36 2
Escherichia coli ECRC100 0.93 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 OKFHMN_13380 thiE thiamine phosphate synthase 0.94 1
Escherichia coli ECRC98 0.93 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 JDDGAC_17005 thiE thiamine phosphate synthase low > 86
Escherichia coli ECRC99 0.93 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 KEDOAH_14780 thiE thiamine phosphate synthase — —
Escherichia coli ECRC101 0.93 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 MCAODC_03880 thiE thiamine phosphate synthase 0.77 15
Escherichia coli ECRC102 0.93 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 NIAGMN_11130 thiE thiamine phosphate synthase — —
Escherichia coli ECRC62 0.93 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 BNILDI_06000 thiE thiamine phosphate synthase 0.79 9
Escherichia coli BW25113 0.93 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.91 b3993 thiE thiamine-phosphate pyrophosphorylase (NCBI) 0.90 2
Escherichia coli ECOR27 0.93 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 NOLOHH_05525 thiE thiamine phosphate synthase 0.95 1
Escherichia coli HS(pFamp)R (ATCC 700891) 0.93 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.91 OHPLBJKB_04057 Thiamine-phosphate synthase low > 73
Escherichia fergusonii Becca 0.92 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.91 EFB2_04618 Thiamine-phosphate synthase low > 86
Escherichia coli BL21 0.92 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.91 ECD_03870 thiamine phosphate synthase (thiamine phosphate pyrophosphorylase) low > 61
Escherichia coli ECOR38 0.92 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 HEPCGN_12015 thiE thiamine phosphate synthase 0.79 32
Escherichia coli Nissle 1917 0.91 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.91 ECOLIN_RS23035 thiamine phosphate synthase — —
Enterobacter sp. TBS_079 0.90 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.88 MPMX20_00216 Thiamine-phosphate synthase 0.66 1
Enterobacter asburiae PDN3 0.90 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.90 EX28DRAFT_4535 thiamine-phosphate diphosphorylase low > 76
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.91 GFF4199 Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) low > 78
Pectobacterium carotovorum WPP14 0.79 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.70 HER17_RS20385 thiamine phosphate synthase 0.94 2
Serratia liquefaciens MT49 0.77 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.73 IAI46_01315 thiamine phosphate synthase low > 86
Rahnella sp. WP5 0.77 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.72 EX31_RS16810 thiamine phosphate synthase low > 89
Dickeya dianthicola 67-19 0.76 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.69 HGI48_RS01165 thiamine phosphate synthase 0.75 42
Dickeya dadantii 3937 0.76 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.71 DDA3937_RS01170 thiamine phosphate synthase 0.88 1
Dickeya dianthicola ME23 0.76 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.66 DZA65_RS01210 thiamine phosphate synthase 0.90 3
Erwinia tracheiphila SCR3 0.75 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.70 LU632_RS00965 thiE thiamine phosphate synthase low > 74
Pantoea sp. MT58 0.75 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.70 IAI47_18090 thiamine phosphate synthase 0.74 2
Burkholderia phytofirmans PsJN 0.52 BPHYT_RS12250 phosphomethylpyrimidine kinase 0.45 BPHYT_RS17770 thiamine-phosphate pyrophosphorylase — —
Rhizobium sp. OAE497 0.50 ABIE40_RS25930 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.16 ABIE40_RS25925 thiamine phosphate synthase low > 107
Rhodopseudomonas palustris CGA009 0.48 TX73_020570 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.43 TX73_018535 thiamine phosphate synthase — —
Castellaniella sp019104865 MT123 0.44 ABCV34_RS14505 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.17 ABCV34_RS10745 thiamine phosphate synthase — —
Bosea sp. OAE506 0.44 ABIE41_RS21620 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.42 ABIE41_RS20180 thiamine phosphate synthase — —
Parabacteroides merdae CL09T00C40 0.43 HMPREF1078_RS03470 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.15 HMPREF1078_RS03480 thiamine phosphate synthase low > 61
Sinorhizobium meliloti 1021 0.42 SM_b20962 phoshomethylpyrimidine kinase 0.39 SM_b20618 thiamine-phosphate pyrophosphorylase low > 103
Phocaeicola vulgatus CL09T03C04 0.39 HMPREF1058_RS06820 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.21 HMPREF1058_RS03290 thiamine phosphate synthase 0.85 8
Phocaeicola dorei CL03T12C01 0.39 ABI39_RS20615 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.21 ABI39_RS17750 thiamine phosphate synthase 0.94 3
Dinoroseobacter shibae DFL-12 0.38 Dshi_0915 phosphomethylpyrimidine kinase (RefSeq) 0.41 Dshi_0911 Thiamine-phosphate diphosphorylase (RefSeq) low > 64
Bacteroides stercoris CC31F 0.38 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.17 HMPREF1181_RS14675 thiamine phosphate synthase low > 56
Rhodospirillum rubrum S1H 0.37 Rru_A1102 Phosphomethylpyrimidine kinase (NCBI) 0.19 Rru_A1080 Thiamine-phosphate diphosphorylase (NCBI) — —
Bacteroides thetaiotaomicron VPI-5482 0.36 BT0790 phosphomethylpyrimidine kinase (NCBI ptt file) 0.18 BT0652 putative thiamine-phosphate pyrophosphorylase (NCBI ptt file) 0.38 56
Azospirillum brasilense Sp245 0.36 AZOBR_RS07045 phosphomethylpyrimidine kinase 0.17 AZOBR_RS10400 thiamine-phosphate synthase — —
Echinicola vietnamensis KMM 6221, DSM 17526 0.36 Echvi_0215 phosphomethylpyrimidine kinase 0.17 Echvi_0216 thiamine-phosphate pyrophosphorylase low > 79
Bacteroides ovatus ATCC 8483 0.35 BACOVA_02530 phosphomethylpyrimidine kinase 0.17 BACOVA_02360 thiamine-phosphate diphosphorylase 0.90 5
Pedobacter sp. GW460-11-11-14-LB5 0.34 CA265_RS24160 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 CA265_RS20175 thiamine-phosphate diphosphorylase low > 88
Azospirillum sp. SherDot2 0.34 MPMX19_06182 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.18 MPMX19_00683 Thiamine-phosphate synthase — —
Mucilaginibacter yixingensis YX-36 DSM 26809 0.31 ABZR88_RS08810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.21 ABZR88_RS08830 thiamine phosphate synthase 0.55 21
Fusobacterium nucleatum SB010 0.30 HUW76_10300 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.15 HUW76_10295 thiamine phosphate synthase low > 35
Magnetospirillum magneticum AMB-1 0.30 AMB_RS16155 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.15 AMB_RS14385 thiamine phosphate synthase — —
Dyella japonica UNC79MFTsu3.2 0.29 ABZR86_RS00760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.18 ABZR86_RS17410 thiamine phosphate synthase — —
Brevundimonas sp. GW460-12-10-14-LB2 0.28 A4249_RS15985 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.16 A4249_RS08810 thiamine phosphate synthase — —
Dechlorosoma suillum PS 0.24 Dsui_0662 phosphomethylpyrimidine kinase 0.17 Dsui_0663 thiamine-phosphate pyrophosphorylase — —
Mycobacterium tuberculosis H37Rv 0.24 Rv0422c Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) 0.17 Rv0414c Thiamine-phosphate pyrophosphorylase ThiE (TMP pyrophosphorylase) (TMP-PPASE) (thiamine-phosphate synthase) — —
Pseudomonas fluorescens SBW25 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.19 PFLU_RS26535 thiamine phosphate synthase 0.83 25
Pseudomonas fluorescens SBW25-INTG 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.19 PFLU_RS26535 thiamine phosphate synthase 0.93 2
Pseudomonas simiae WCS417 0.23 PS417_24600 hydrogenase 0.19 PS417_24605 thiamine-phosphate pyrophosphorylase 0.59 8
Pseudomonas putida KT2440 0.22 PP_4782 Phosphomethylpyrimidine kinase 0.16 PP_4783 Thiamine-phosphate synthase — —
Pseudomonas fluorescens GW456-L13 0.22 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.18 PfGW456L13_1384 Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) 0.39 32
Pseudomonas fluorescens FW300-N2E3 0.22 AO353_06350 hydrogenase 0.19 AO353_06355 thiamine-phosphate pyrophosphorylase 0.58 7
Pseudomonas fluorescens FW300-N2C3 0.22 AO356_15435 hydrogenase 0.18 AO356_15430 thiamine-phosphate pyrophosphorylase 0.32 15
Pseudomonas stutzeri RCH2 0.21 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.19 Psest_0536 thiamine-phosphate pyrophosphorylase 0.60 4
Pseudomonas syringae pv. syringae B728a ΔmexB 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.20 Psyr_4341 thiamine-phosphate diphosphorylase 0.88 2
Pseudomonas syringae pv. syringae B728a 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.20 Psyr_4341 thiamine-phosphate diphosphorylase 0.92 2
Acinetobacter radioresistens SK82 0.21 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.14 MPMX26_01022 Thiamine-phosphate synthase — —
Pseudomonas sp. RS175 0.20 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.19 PFR28_03844 Thiamine-phosphate synthase 0.91 3
Pontibacter actiniarum KMM 6156, DSM 19842 0.20 CA264_20430 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.16 CA264_20425 thiamine phosphate synthase 0.87 1
Pseudomonas fluorescens FW300-N1B4 0.18 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.18 Pf1N1B4_2717 Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) — —
Pseudomonas fluorescens FW300-N2E2 0.18 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.19 Pf6N2E2_5023 Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) 0.41 2
Phaeobacter inhibens DSM 17395 0.17 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.35 PGA1_c09050 thiamine-phosphate pyrophosphorylase ThiE 0.84 5

Not shown: 23 genomes with orthologs for BWI76_RS19375 only; 7 genomes with orthologs for BWI76_RS01550 only