| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Alteromonas macleodii MIT1002 | MIT1002_04087 | | Type-1 restriction enzyme R protein | insig. | 100 | 100 |
| o | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_14280 | | DEAD/DEAH box helicase | no data | 82 | 87 |
| o | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_02139 | | type I restriction enzyme, R subunit | insig. | 57 | 99 |
| o | Desulfovibrio vulgaris Hildenborough JW710 | DVU1703 | | type I restriction-modification enzyme, R subunit (TIGR) | insig. | 57 | 99 |
| o | Rhodanobacter sp. FW510-T8 | OKGIIK_13425 | | DEAD/DEAH box helicase | insig. | 56 | 100 |
| o | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.1523.1 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | strong | 54 | 100 |
| o | Shewanella oneidensis MR-1 | SO0380 | hsdR-1 | type I restriction-modification system, R subunit (NCBI ptt file) | insig. | 31 | 87 |
| o | Shewanella sp. ANA-3 | Shewana3_3790 | | HsdR family type I site-specific deoxyribonuclease (RefSeq) | cofit | 31 | 86 |
| | Paraburkholderia graminis OAS925 | ABIE53_000533 | | type I restriction enzyme R subunit | insig. | 32 | 77 |
| o | Cupriavidus basilensis FW507-4G11 | RR42_RS18675 | | restriction endonuclease subunit R | insig. | 30 | 81 |
| | Escherichia coli ECRC100 | OKFHMN_05715 | | restriction endonuclease subunit R | cofit | 30 | 74 |
| o | Phaeobacter inhibens DSM 17395 | PGA1_c30690 | | putative type I restriction-modification system, R subunit | insig. | 27 | 98 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_06705 | | Type I restriction enzyme endonuclease subunit | insig. | 28 | 92 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS01835 | | type I restriction endonuclease subunit R | cofit | 30 | 75 |
| | Dickeya dianthicola ME23 | DZA65_RS04740 | | HsdR family type I site-specific deoxyribonuclease | insig. | 30 | 74 |
| o | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS05380 | | HsdR family type I site-specific deoxyribonuclease | insig. | 28 | 87 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS09190 | | type I restriction endonuclease subunit R | insig. | 29 | 73 |
| | Methanococcus maripaludis JJ | MMJJ_RS02745 | | type I restriction endonuclease subunit R | no data | 32 | 69 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_15915 | | Type I restriction enzyme endonuclease subunit | insig. | 29 | 81 |
| | Sinorhizobium meliloti 1021 | SMc02292 | | type I restriction enzyme R protein | insig. | 31 | 67 |
| o | Xanthobacter sp. DMC5 | GFF2200 | | hypothetical protein | insig. | 29 | 87 |
| | Pseudomonas segetis P6 | ACVTMO_RS09885 | | type I restriction endonuclease subunit R | insig. | 32 | 60 |
| | Rhodanobacter denitrificans MT42 | LRK55_RS10135 | | type I restriction endonuclease subunit R | cofit | 30 | 66 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS10495 | | type I restriction endonuclease subunit R | cofit | 30 | 66 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS11910 | | type I restriction endonuclease subunit R | insig. | 29 | 68 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS08925 | | type I restriction endonuclease subunit R | insig. | 29 | 71 |
| | Shewanella sp. ANA-3 | Shewana3_4244 | | HsdR family type I site-specific deoxyribonuclease (RefSeq) | insig. | 30 | 62 |
| | Azospirillum sp. SherDot2 | MPMX19_00137 | | hypothetical protein | cofit | 30 | 59 |
| | Pseudomonas stutzeri RCH2 | Psest_4044 | | type I site-specific deoxyribonuclease, HsdR family | strong | 30 | 59 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_08955 | | Type I restriction enzyme endonuclease subunit | insig. | 28 | 61 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04167 | | type I site-specific deoxyribonuclease, HsdR family | insig. | 30 | 60 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_06660 | | type I restriction-modification system endonuclease | insig. | 30 | 61 |
| | Klebsiella michiganensis M5al | BWI76_RS03670 | | type I restriction-modification system subunit R | insig. | 30 | 57 |
| | Escherichia coli ECOR38 | HEPCGN_10720 | | type I restriction endonuclease | insig. | 29 | 70 |
| | Escherichia fergusonii Becca | EFB2_04103 | | hypothetical protein | insig. | 29 | 56 |
| | Escherichia coli Nissle 1917 | ECOLIN_RS24950 | | HsdR family type I site-specific deoxyribonuclease | insig. | 29 | 56 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_1641 | | type I site-specific deoxyribonuclease, HsdR family | insig. | 26 | 72 |
| | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_14275 | | type I restriction endonuclease | no data | 70 | 12 |
| | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS08640 | | HsdR family type I site-specific deoxyribonuclease | insig. | 28 | 69 |
| | Pseudomonas sp. DMC3 | GFF4952 | | hypothetical protein | insig. | 26 | 69 |
| | Dickeya dianthicola ME23 | DZA65_RS03370 | | type I restriction endonuclease subunit R | insig. | 27 | 56 |
| | Escherichia coli ECRC62 | BNILDI_07600 | hsdR | Type I restriction enzyme EcoR124II endonuclease subunit | insig. | 27 | 58 |
| | Fusobacterium nucleatum SB010 | HUW76_08985 | | type I restriction endonuclease subunit R | strong | 28 | 56 |
| | Alteromonas macleodii MIT1002 | MIT1002_03210 | | Type-1 restriction enzyme R protein | insig. | 28 | 54 |
| | Alteromonas macleodii MIT1002 | MIT1002_00593 | | Type I restriction enzyme EcoR124II R protein | cofit | 27 | 53 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_4436 | | type I site-specific deoxyribonuclease, HsdR family | insig. | 25 | 58 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS15095 | | type I restriction endonuclease subunit R | no data | 28 | 57 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS03160 | | type I restriction endonuclease subunit R | cofit | 24 | 59 |
| | Cellulophaga baltica 18 | M666_RS02045 | | type I restriction endonuclease subunit R | cofit | 25 | 56 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF2633 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | no data | 26 | 58 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4535 | | Type I restriction enzyme EcoR124II R protein (NCBI ptt file) | cofit | 25 | 59 |
| | Pseudomonas orientalis W4I3 | QF045_RS26425 | | type I restriction endonuclease | insig. | 25 | 67 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_05330 | | type I site-specific deoxyribonuclease, HsdR family | cofit | 26 | 55 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.611.1 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | insig. | 25 | 57 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS02835 | | type I restriction endonuclease subunit R | insig. | 25 | 56 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS22780 | | DEAD/DEAH box helicase | insig. | 23 | 53 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_08855 | | type I restriction endonuclease subunit R | insig. | 26 | 53 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.3936.1 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | insig. | 25 | 52 |
| | Marinobacter adhaerens HP15 | HP15_1582 | | type III restriction enzyme, res subunit | insig. | 24 | 58 |
| | Pseudomonas stutzeri RCH2 | Psest_0876 | | Type III restriction enzyme, res subunit./Type I restriction enzyme R protein N terminus (HSDR_N). | insig. | 25 | 53 |
| | Acinetobacter radioresistens SK82 | MPMX26_02867 | | hypothetical protein | insig. | 24 | 53 |
| | Rhodanobacter denitrificans MT42 | LRK55_RS00325 | | type I restriction endonuclease | strong | 23 | 54 |
| | Cellulophaga baltica 18 | M666_RS14710 | | DEAD/DEAH box helicase family protein | insig. | 25 | 51 |
| | Shewanella sp. ANA-3 | Shewana3_4164 | | HsdR family type I site-specific deoxyribonuclease (RefSeq) | insig. | 23 | 33 |
| | Pseudomonas stutzeri RCH2 | Psest_3407 | | Type I site-specific restriction-modification system, R (restriction) subunit and related helicases | insig. | 25 | 40 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS01800 | | type I restriction endonuclease subunit R | insig. | 22 | 58 |
| | Erwinia amylovora T8 | OLJFJH_08155 | | hypothetical protein | insig. | 73 | 5 |
| | Klebsiella pneumoniae MKP103 | KDGMDA_01860 | | type I restriction endonuclease subunit R | cofit | 24 | 38 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1065 | | DEAD/DEAH box helicase-like | insig. | 24 | 39 |
| | Caulobacter crescentus NA1000 | CCNA_00659 | | type I restriction-modification system restriction subunit | insig. | 23 | 39 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_00659 | | type I restriction-modification system restriction subunit | cofit | 23 | 39 |
| | Shewanella sp. ANA-3 | Shewana3_4164 | | HsdR family type I site-specific deoxyribonuclease (RefSeq) | insig. | 50 | 6 |
| | Methylophilus sp. DMC18 | GFF1952 | | hypothetical protein | cofit | 26 | 30 |
| | Pseudomonas putida KT2440 | PP_4740 | | Type I restriction enzyme EcoAI R protein | insig. | 27 | 19 |