| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Klebsiella michiganensis M5al | BWI76_RS03875 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | sig. | 100 | 100 |
| o | Klebsiella pneumoniae MKP103 | KDGMDA_12125 | | 2-hydroxyhepta-2 4-diene-1 7-dioate isomerase | insig. | 91 | 100 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF3278 | | 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-) | insig. | 84 | 100 |
| | Escherichia coli ECRC62 | BNILDI_07885 | hpaG | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase | insig. | 83 | 100 |
| | Escherichia coli ECOR27 | NOLOHH_03715 | hpaG | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase | insig. | 83 | 100 |
| | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_03710 | | Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase | cofit | 83 | 100 |
| | Escherichia coli BL21 | ECD_04230 | | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase | insig. | 82 | 100 |
| | Enterobacter sp. TBS_079 | MPMX20_00642 | | Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase | insig. | 80 | 100 |
| | Enterobacter asburiae PDN3 | EX28DRAFT_3547 | | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit/4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit | insig. | 81 | 98 |
| o | Serratia liquefaciens MT49 | IAI46_02725 | | fumarylacetoacetate hydrolase family protein | insig. | 68 | 100 |
| | Pseudomonas sp. SVBP6 | COO64_RS13795 | | fumarylacetoacetate hydrolase family protein | insig. | 45 | 98 |
| | Pseudomonas simiae WCS417 | PS417_17830 | | 4-hydroxyphenylacetate isomerase | insig. | 44 | 97 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_21225 | | 4-hydroxyphenylacetate isomerase | insig. | 43 | 97 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_25595 | | 4-hydroxyphenylacetate isomerase | insig. | 44 | 97 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_02388 | | Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase | cofit | 44 | 97 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_1307 | | 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-) | insig. | 43 | 97 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS15920 | | 4-hydroxyphenylacetate isomerase | insig. | 43 | 97 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS15920 | | 4-hydroxyphenylacetate isomerase | strong | 43 | 97 |
| o | Paraburkholderia sabiae LMG 24235 | QEN71_RS12025 | | fumarylacetoacetate hydrolase family protein | insig. | 37 | 99 |
| o | Acidovorax sp. GW101-3H11 | Ac3H11_1488 | | 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-) | insig. | 36 | 99 |
| o | Paraburkholderia graminis OAS925 | ABIE53_005229 | | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | insig. | 39 | 95 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS34375 | | fumarylacetoacetate hydrolase family protein | insig. | 37 | 95 |
| o | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_03258 | | 5-carboxy-2-oxohept-3-enedioate decarboxylase HpaG1 subunit (EC 4.1.1.68) | insig. | 39 | 100 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS27825 | | 4-hydroxyphenylacetate isomerase | insig. | 36 | 100 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS28875 | | 5-oxo-1,2,5-tricarboxylic-3-penten acid decarboxylase | insig. | 37 | 95 |
| | Ralstonia sp. UNC404CL21Col | ABZR87_RS13535 | | fumarylacetoacetate hydrolase family protein | insig. | 41 | 91 |
| o | Variovorax sp. SCN45 | GFF7104 | | 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) | insig. | 37 | 98 |
| o | Azospirillum sp. SherDot2 | MPMX19_06800 | | Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase | insig. | 36 | 99 |
| o | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF1829 | | 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-) | insig. | 37 | 92 |
| | Klebsiella michiganensis M5al | BWI76_RS03870 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | insig. | 39 | 98 |
| | Serratia liquefaciens MT49 | IAI46_02730 | | fumarylacetoacetate hydrolase family protein | insig. | 35 | 99 |
| o | Magnetospirillum magneticum AMB-1 | AMB_RS04125 | | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase | cofit | 33 | 98 |
| | Klebsiella pneumoniae MKP103 | KDGMDA_12120 | | 2-hydroxyhepta-2 4-diene-1 7-dioate isomerase | insig. | 35 | 98 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF3278 | | 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-) | insig. | 40 | 83 |
| | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_03710 | | Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase | cofit | 38 | 84 |
| | Enterobacter sp. TBS_079 | MPMX20_00642 | | Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase | insig. | 39 | 98 |
| | Escherichia coli ECOR27 | NOLOHH_03715 | hpaG | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase | insig. | 38 | 84 |
| | Escherichia coli ECRC62 | BNILDI_07885 | hpaG | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase | insig. | 38 | 84 |
| o | Castellaniella sp019104865 MT123 | ABCV34_RS09315 | | fumarylacetoacetate hydrolase family protein | insig. | 35 | 96 |
| o | Variovorax sp. OAS795 | ABID97_RS03760 | | fumarylacetoacetate hydrolase family protein | sig. | 33 | 97 |
| | Escherichia coli BL21 | ECD_04230 | | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase | insig. | 38 | 84 |
| | Variovorax sp. OAS795 | ABID97_RS28035 | | fumarylacetoacetate hydrolase family protein | insig. | 36 | 85 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS15925 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | insig. | 35 | 97 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS15925 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | strong | 35 | 97 |
| | Enterobacter asburiae PDN3 | EX28DRAFT_3547 | | 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit/4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit | insig. | 37 | 84 |
| | Azospirillum sp. SherDot2 | MPMX19_06799 | | Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase | insig. | 34 | 96 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS04120 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | cofit | 34 | 97 |
| | Ralstonia sp. UNC404CL21Col | ABZR87_RS13530 | | fumarylacetoacetate hydrolase family protein | insig. | 34 | 97 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS28880 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | insig. | 33 | 99 |
| | Variovorax sp. SCN45 | GFF5091 | | 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) | insig. | 34 | 97 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS12030 | | fumarylacetoacetate hydrolase family protein | insig. | 33 | 99 |
| | Variovorax sp. SCN45 | GFF7103 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-) | insig. | 35 | 95 |
| | Variovorax sp. SCN45 | GFF5092 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-) | insig. | 34 | 95 |
| | Paraburkholderia graminis OAS925 | ABIE53_005228 | | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | sig. | 33 | 99 |
| | Variovorax sp. OAS795 | ABID97_RS03755 | | fumarylacetoacetate hydrolase family protein | sig. | 34 | 95 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS09310 | | fumarylacetoacetate hydrolase family protein | insig. | 34 | 97 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS34380 | | fumarylacetoacetate hydrolase family protein | insig. | 32 | 99 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_03257 | | 5-carboxy-2-oxohept-3-enedioate decarboxylase HpaG2 subunit | no data | 32 | 99 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU0875 | | fumarylacetoacetate hydrolase family protein (TIGR) | insig. | 36 | 84 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_2925 | | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (RefSeq) | insig. | 35 | 82 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_1487 | | 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-) | insig. | 31 | 97 |
| | Pseudomonas sp. SVBP6 | COO64_RS13790 | | fumarylacetoacetate hydrolase family protein | insig. | 35 | 83 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS27830 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | insig. | 33 | 98 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_1308 | | 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-) | insig. | 34 | 83 |
| | Methanococcus maripaludis JJ | MMJJ_RS04665 | | fumarylacetoacetate hydrolase family protein | insig. | 31 | 95 |
| | Bosea sp. OAE506 | ABIE41_RS22825 | | fumarylacetoacetate hydrolase family protein | insig. | 31 | 95 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF1828 | | 5-carboxymethyl-2-oxo-hex-3- ene-1,7-dioate decarboxylase (EC 4.1.1.68) / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC 5.3.3.-) | insig. | 31 | 95 |
| | Pseudomonas fluorescens FW300-N2C3 | AO356_25590 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | insig. | 34 | 83 |
| | Bifidobacterium breve UCC2003 | BBR_RS19710 | | FAA hydrolase family protein | sig. | 31 | 95 |
| | Methanococcus maripaludis S2 | MMP_RS00825 | | fumarylacetoacetate hydrolase family protein | insig. | 31 | 95 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c04530 | | ureidoglycolate lyase | insig. | 29 | 97 |
| | Pseudomonas simiae WCS417 | PS417_17835 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | sig. | 35 | 83 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.5166.1 | | hypothetical protein | insig. | 33 | 83 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS07600 | | fumarylacetoacetate hydrolase family protein | strong | 35 | 83 |
| | Azospirillum brasilense Sp245 | AZOBR_RS26375 | | hypothetical protein | insig. | 30 | 94 |
| | Pseudomonas lactucae CFBP13502 | GEMAOFIL_02387 | | Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase | cofit | 34 | 83 |
| | Variovorax sp. SCN45 | GFF3754 | | Fumarylacetoacetate hydrolase family protein | insig. | 32 | 96 |
| | Variovorax sp. OAS795 | ABID97_RS25485 | | fumarylacetoacetate hydrolase family protein | insig. | 33 | 96 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS01325 | | fumarylacetoacetate hydrolase family protein | insig. | 31 | 79 |
| | Variovorax sp. OAS795 | ABID97_RS26355 | | fumarylacetoacetate hydrolase family protein | insig. | 33 | 80 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_21230 | | 2-hydroxyhepta-2 4-diene-1 7-dioate isomerase | insig. | 32 | 83 |
| | Azospirillum brasilense Sp245 | AZOBR_RS15905 | | 2-hydroxyhepta-2 4-diene-1 7-dioate isomerase | insig. | 32 | 79 |
| | Xanthobacter sp. DMC5 | GFF3305 | | Ureidoglycolate lyase | insig. | 34 | 95 |
| | Mycobacterium tuberculosis H37Rv | Rv2993c | | Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) | sig. | 32 | 85 |
| | Variovorax sp. OAS795 | ABID97_RS24465 | | fumarylacetoacetate hydrolase family protein | cofit | 31 | 81 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS07330 | | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase | insig. | 32 | 96 |
| | Paraburkholderia graminis OAS925 | ABIE53_006289 | | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase in catechol pathway | insig. | 29 | 95 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS29905 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | insig. | 32 | 82 |
| | Ralstonia solanacearum GMI1000 | RS_RS09200 | | FAA hydrolase family protein | sig. | 31 | 100 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS05150 | | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase | insig. | 32 | 97 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS31355 | | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase | insig. | 31 | 82 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS19960 | | fumarylacetoacetate hydrolase family protein | insig. | 33 | 79 |
| | Cellulophaga baltica 18 | M666_RS00130 | | fumarylacetoacetate hydrolase family protein | insig. | 34 | 79 |
| | Xanthobacter sp. DMC5 | GFF2957 | | Ureidoglycolate lyase | insig. | 31 | 90 |
| | Rhodopseudomonas palustris CGA009 | TX73_022935 | | fumarylacetoacetate hydrolase family protein | insig. | 32 | 83 |
| | Erwinia amylovora T8 | OLJFJH_13135 | | fumarylacetoacetate hydrolase family protein | insig. | 31 | 76 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_02528 | | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) | insig. | 29 | 92 |
| | Azospirillum sp. SherDot2 | MPMX19_03313 | | Ureidoglycolate lyase | insig. | 31 | 80 |
| | Variovorax sp. SCN45 | GFF1928 | | Fumarylacetoacetate hydrolase family protein | insig. | 29 | 95 |
| | Ralstonia solanacearum PSI07 | RPSI07_RS21875 | | FAA hydrolase family protein | insig. | 32 | 97 |