| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
|---|
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_09720 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 1.0 | CSW01_12320 | | 3',5'-cyclic-AMP phosphodiesterase | 0.78 | 19 |
| Rahnella sp. WP5 | 0.69 | EX31_RS22835 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.53 | EX31_RS25975 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Serratia liquefaciens MT49 | 0.68 | IAI46_05400 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.51 | IAI46_21930 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Klebsiella michiganensis M5al | 0.68 | BWI76_RS07100 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.52 | BWI76_RS24385 | | phosphodiesterase | — | — |
| Klebsiella pneumoniae MKP103 | 0.68 | KDGMDA_15035 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.48 | KDGMDA_05210 | | 3' 5'-cyclic-AMP phosphodiesterase | — | — |
| Pantoea sp. MT58 | 0.68 | IAI47_14320 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.53 | IAI47_03150 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Enterobacter asburiae PDN3 | 0.68 | EX28DRAFT_2449 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.48 | EX28DRAFT_3070 | | Predicted phosphohydrolases | — | — |
| Shewanella amazonensis SB2B | 0.68 | Sama_1222 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | 0.43 | Sama_3045 | | lacZ expression regulator (RefSeq) | — | — |
| Enterobacter sp. TBS_079 | 0.68 | MPMX20_01107 | | Bifunctional protein FolD protein | 0.48 | MPMX20_03879 | | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA | — | — |
| Escherichia coli ECRC102 | 0.68 | NIAGMN_05860 | | Bifunctional protein FolD | 0.50 | NIAGMN_16585 | cpdA | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Escherichia fergusonii Becca | 0.68 | EFB2_03532 | | Bifunctional protein FolD protein | 0.50 | EFB2_00776 | | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA | — | — |
| Pantoea agglomerans CFBP13505 P0401 | 0.68 | PagCFBP13505_RS10890 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.53 | PagCFBP13505_RS11970 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Escherichia coli ECRC98 | 0.68 | JDDGAC_11455 | | Bifunctional protein FolD | 0.50 | JDDGAC_22455 | cpdA | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Escherichia coli ECRC101 | 0.68 | MCAODC_27025 | | Bifunctional protein FolD | 0.50 | MCAODC_09335 | cpdA | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Escherichia coli BW25113 | 0.68 | b0529 | folD | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase (NCBI) | 0.50 | b3032 | cpdA | cyclic 3',5'-adenosine monophosphate phosphodiesterase (NCBI) | — | — |
| Escherichia coli Nissle 1917 | 0.68 | ECOLIN_RS03065 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.50 | ECOLIN_RS17500 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.68 | OHPLBJKB_03152 | | Bifunctional protein FolD protein | 0.50 | OHPLBJKB_00671 | | '3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA' transl_table=11 | — | — |
| Escherichia coli BL21 | 0.68 | ECD_00479 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.49 | ECD_02904 | | 3',5' cAMP phosphodiesterase | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.68 | GFF4447 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.49 | GFF3146 | | '3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17)' transl_table=11 | — | — |
| Escherichia coli ECRC99 | 0.68 | KEDOAH_20165 | | Bifunctional protein FolD | 0.50 | KEDOAH_09325 | cpdA | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Escherichia coli ECOR27 | 0.68 | NOLOHH_00795 | | Bifunctional protein FolD | 0.50 | NOLOHH_10625 | cpdA | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Escherichia coli ECRC100 | 0.68 | OKFHMN_07805 | | Bifunctional protein FolD | 0.50 | OKFHMN_18820 | cpdA | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Shewanella sp. ANA-3 | 0.68 | Shewana3_2663 | | methenyltetrahydrofolate cyclohydrolase (RefSeq) | 0.44 | Shewana3_0728 | | calcineurin phosphoesterase C-terminal domain-containing protein (RefSeq) | — | — |
| Escherichia coli ECOR38 | 0.67 | HEPCGN_06445 | | Bifunctional protein FolD | 0.50 | HEPCGN_17695 | cpdA | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Escherichia coli ECRC62 | 0.67 | BNILDI_22225 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.50 | BNILDI_00890 | cpdA | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Erwinia amylovora T8 | 0.67 | OLJFJH_17600 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.53 | OLJFJH_07690 | | 3' 5'-cyclic-AMP phosphodiesterase | — | — |
| Pectobacterium carotovorum WPP14 | 0.67 | HER17_RS06505 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.48 | HER17_RS19810 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Shewanella loihica PV-4 | 0.67 | Shew_2510 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | 0.41 | Shew_0547 | | calcineurin phosphoesterase C-terminal domain-containing protein (RefSeq) | — | — |
| Dickeya dadantii 3937 | 0.67 | DDA3937_RS15075 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.54 | DDA3937_RS01755 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Alteromonas macleodii MIT1002 | 0.66 | MIT1002_02770 | | hypothetical protein | 0.21 | MIT1002_00673 | | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA | — | — |
| Erwinia tracheiphila SCR3 | 0.66 | LU632_RS15195 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.51 | LU632_RS20620 | cpdA | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Shewanella oneidensis MR-1 | 0.66 | SO1792 | folD | methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase (NCBI ptt file) | 0.44 | SO3901 | icc | lacZ expression regulator (NCBI ptt file) | — | — |
| Dickeya dianthicola 67-19 | 0.66 | HGI48_RS15155 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.53 | HGI48_RS01650 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Dickeya dianthicola ME23 | 0.66 | DZA65_RS15960 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.53 | DZA65_RS01725 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Erwinia tracheiphila HP pepo 2.2 | 0.66 | IJEDHG_00975 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.51 | IJEDHG_14450 | cpdA | 3' 5'-cyclic-AMP phosphodiesterase | — | — |
| Pseudomonas simiae WCS417 | 0.62 | PS417_17265 | | methenyltetrahydrofolate cyclohydrolase | 0.41 | PS417_02380 | | serine/threonine protein phosphatase | — | — |
| Pseudomonas sp. S08-1 | 0.62 | OH686_03670 | | Methenyltetrahydrofolate cyclohydrolase / Methylenetetrahydrofolate dehydrogenase (NADP+) | 0.41 | OH686_15825 | | 3',5'-cyclic-nucleotide phosphodiesterase | — | — |
| Pseudomonas aeruginosa PA14 | 0.62 | IKLFDK_08690 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.38 | IKLFDK_28695 | | 3' 5'-cyclic-AMP phosphodiesterase | — | — |
| Pseudomonas aeruginosa PUPa3 | 0.62 | DQ20_RS54755 | folD;go_function=methylenetetrahydrofolate | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.39 | DQ20_RS51420 | cpdA;go_function=3'%2C5'-cyclic-AMP | 3' 5'-cyclic-AMP phosphodiesterase | — | — |
| Pseudomonas aeruginosa MRSN321 | 0.62 | DY961_RS20675 | folD;go_function=methylenetetrahydrofolate | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.39 | DY961_RS10640 | cpdA;go_function=3'%2C5'-cyclic-AMP | 3' 5'-cyclic-AMP phosphodiesterase | — | — |
| Pseudomonas orientalis W4I3 | 0.62 | QF045_RS18930 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.37 | QF045_RS05440 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.62 | PfGW456L13_2550 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.40 | PfGW456L13_180 | | 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17) | — | — |
| Pseudomonas sp. RS175 | 0.61 | PFR28_01223 | | Bifunctional protein FolD protein | 0.39 | PFR28_05096 | | '3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA' transl_table=11 | — | — |
| Marinobacter adhaerens HP15 | 0.61 | HP15_2187 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.34 | HP15_456 | | phosphohydrolase | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.61 | AO356_01775 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.41 | AO356_08785 | | serine/threonine protein phosphatase | — | — |
| Pseudomonas fluorescens SBW25 | 0.61 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.41 | PFLU_RS02455 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Pseudomonas lactucae CFBP13502 | 0.61 | GEMAOFIL_03749 | | Bifunctional protein FolD protein | 0.40 | GEMAOFIL_00713 | | '3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA' transl_table=11 | — | — |
| Pseudomonas putida KT2440 | 0.61 | PP_2265 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.37 | PP_4917 | | 3',5'-cyclic-nucleotide phosphodiesterase | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.61 | Pf6N2E2_2221 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.41 | Pf6N2E2_3639 | | 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17) | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.61 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.41 | PFLU_RS02455 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.61 | Pf1N1B4_3943 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.39 | Pf1N1B4_1442 | | 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17) | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.61 | AO353_20145 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.40 | AO353_13035 | | serine/threonine protein phosphatase | — | — |
| Pseudomonas sp. BP01 | 0.61 | JOY50_RS25950 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.38 | JOY50_RS17115 | cpdA | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Pseudomonas sp. DMC3 | 0.61 | GFF1441 | | Bifunctional protein FolD protein | 0.38 | GFF3188 | | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA | — | — |
| Pseudomonas sp. SVBP6 | 0.61 | COO64_RS19115 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.36 | COO64_RS17780 | cpdA | 3',5'-cyclic-AMP phosphodiesterase | — | — |
| Pseudomonas segetis P6 | 0.60 | MPMX49_02256 | | Bifunctional protein FolD protein | 0.39 | MPMX49_04179 | | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.60 | Psyr_1743 | | methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | 0.39 | Psyr_0549 | | Metallophosphoesterase | — | — |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.60 | Psyr_1743 | | methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | 0.39 | Psyr_0549 | | Metallophosphoesterase | — | — |
| Pseudomonas stutzeri RCH2 | 0.58 | Psest_2301 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.38 | Psest_0481 | | Predicted phosphohydrolases | — | — |
| Kangiella aquimarina DSM 16071 | 0.57 | B158DRAFT_1028 | | methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)/5,10-methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) | 0.31 | B158DRAFT_0977 | | Predicted phosphohydrolases | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.46 | RR42_RS07345 | | methenyltetrahydrofolate cyclohydrolase | 0.18 | RR42_RS27795 | | metallophosphatase | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.45 | RALBFv3_RS01685 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.21 | RALBFv3_RS21090 | | phosphohydrolase | — | — |
| Ralstonia solanacearum UW163 | 0.45 | UW163_RS14995 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.21 | UW163_RS22230 | | phosphohydrolase | — | — |
| Ralstonia solanacearum GMI1000 | 0.45 | RS_RS08040 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.20 | RS_RS19730 | | phosphohydrolase | — | — |
| Variovorax sp. SCN45 | 0.44 | GFF964 | | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) / Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) | 0.15 | GFF6061 | | 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17) | — | — |
| Synechococcus elongatus PCC 7942 | 0.43 | Synpcc7942_0777 | folD | Methenyltetrahydrofolate cyclohydrolase | 0.17 | Synpcc7942_0586 | | hypothetical protein | — | — |
| Paraburkholderia sabiae LMG 24235 | 0.43 | QEN71_RS05700 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.15 | QEN71_RS05540 | | phosphodiesterase | — | — |
| Paraburkholderia graminis OAS925 | 0.42 | ABIE53_002796 | | methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase | 0.15 | ABIE53_002840 | | Icc protein | — | — |
| Xanthobacter sp. DMC5 | 0.42 | GFF1063 | | Bifunctional protein FolD protein | 0.16 | GFF4007 | | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA | — | — |
| Azospirillum sp. SherDot2 | 0.40 | MPMX19_02743 | | Bifunctional protein FolD protein | 0.18 | MPMX19_04066 | | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA | — | — |
| Acinetobacter radioresistens SK82 | 0.35 | MPMX26_00777 | | Bifunctional protein FolD protein | 0.31 | MPMX26_00178 | | 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA | — | — |
| Acinetobacter baumannii LAC-4 | 0.35 | RR41_RS04225 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.33 | RR41_RS17725 | | 3',5'-cyclic-AMP phosphodiesterase | — | — |
Not shown: 49 genomes with orthologs for CSW01_09720 only; 0 genomes with orthologs for CSW01_12320 only