| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_13640 | | DNA-binding response regulator | 1.0 | CSW01_06870 | | 7-carboxy-7-deazaguanine synthase QueE | 0.46 | 11 |
| Shewanella amazonensis SB2B | 0.54 | Sama_2076 | | response regulator receiver protein (RefSeq) | 0.55 | Sama_1825 | | radical activating enzyme (RefSeq) | low | > 62 |
| Shewanella sp. ANA-3 | 0.52 | Shewana3_1732 | | two component LuxR family transcriptional regulator (RefSeq) | 0.59 | Shewana3_2163 | | radical activating enzyme (RefSeq) | low | > 73 |
| Shewanella loihica PV-4 | 0.52 | Shew_1545 | | two component LuxR family transcriptional regulator (RefSeq) | 0.56 | Shew_2061 | | radical SAM domain-containing protein (RefSeq) | — | — |
| Shewanella oneidensis MR-1 | 0.52 | SO2648 | | DNA-binding response regulator, LuxR family (NCBI ptt file) | 0.60 | SO2501 | | radical activating enzyme (NCBI ptt file) | low | > 76 |
| Pseudomonas putida KT2440 | 0.52 | PP_1635 | | DNA-binding response regulator | 0.12 | PP_1225 | | 7-carboxy-7-deazaguanine synthase | low | > 96 |
| Pseudomonas sp. S08-1 | 0.52 | OH686_18240 | | Two-component transcriptional response regulator, LuxR family | 0.12 | OH686_19175 | | 7-carboxy-7-deazaguanine synthase | low | > 80 |
| Pseudomonas sp. BP01 | 0.51 | JOY50_RS23810 | erdR | response regulator transcription factor ErdR | 0.12 | JOY50_RS01775 | queE | 7-carboxy-7-deazaguanine synthase QueE | low | > 84 |
| Pseudomonas lactucae CFBP13502 | 0.51 | GEMAOFIL_01339 | | Transcriptional regulatory protein LnrK | 0.13 | GEMAOFIL_04633 | | 7-carboxy-7-deazaguanine synthase | low | > 96 |
| Pseudomonas simiae WCS417 | 0.51 | PS417_05840 | | LuxR family transcriptional regulator | 0.13 | PS417_22405 | | 7-carboxy-7-deazaguanine synthase | low | > 88 |
| Pseudomonas segetis P6 | 0.51 | MPMX49_03324 | | Transcriptional regulatory protein DegU | 0.12 | MPMX49_01693 | | 7-carboxy-7-deazaguanine synthase | low | > 75 |
| Pseudomonas orientalis W4I3 | 0.50 | QF045_RS08755 | | response regulator transcription factor ErdR | 0.13 | QF045_RS24570 | | 7-carboxy-7-deazaguanine synthase QueE | low | > 93 |
| Pseudomonas fluorescens SBW25 | 0.50 | PFLU_RS05910 | | response regulator transcription factor | 0.13 | PFLU_RS24045 | | 7-carboxy-7-deazaguanine synthase QueE | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.50 | Pf1N1B4_3150 | | Transcriptional regulator, LuxR family | 0.12 | Pf1N1B4_629 | | Queuosine Biosynthesis QueE Radical SAM | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.50 | PFLU_RS05910 | | response regulator transcription factor | 0.13 | PFLU_RS24045 | | 7-carboxy-7-deazaguanine synthase QueE | low | > 109 |
| Pseudomonas fluorescens FW300-N2E2 | 0.50 | Pf6N2E2_2986 | | Transcriptional regulator, LuxR family | 0.13 | Pf6N2E2_5545 | | Queuosine Biosynthesis QueE Radical SAM | low | > 103 |
| Pseudomonas aeruginosa PUPa3 | 0.50 | DQ20_RS42170 | erdR;inference=COORDINATES | response regulator transcription factor ErdR | 0.12 | DQ20_RS45235 | queE;go_function=4 | 7-carboxy-7-deazaguanine synthase QueE | low | > 101 |
| Pseudomonas aeruginosa MRSN321 | 0.50 | DY961_RS14960 | erdR;inference=COORDINATES | response regulator transcription factor ErdR | 0.12 | DY961_RS07555 | queE;go_function=4 | 7-carboxy-7-deazaguanine synthase QueE | low | > 100 |
| Pseudomonas aeruginosa PA14 | 0.50 | IKLFDK_18400 | | DNA-binding response regulator | 0.12 | IKLFDK_04415 | | 7-carboxy-7-deazaguanine synthase QueE | low | > 98 |
| Pseudomonas sp. RS175 | 0.50 | PFR28_00478 | | Transcriptional regulatory protein DegU | 0.14 | PFR28_03404 | | 7-carboxy-7-deazaguanine synthase | low | > 88 |
| Pseudomonas sp. DMC3 | 0.50 | GFF2117 | | Transcriptional regulatory protein DegU | 0.14 | GFF5176 | | 7-carboxy-7-deazaguanine synthase | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.50 | PfGW456L13_4662 | | Transcriptional regulator, LuxR family | 0.12 | PfGW456L13_1861 | | Queuosine Biosynthesis QueE Radical SAM | low | > 87 |
| Pseudomonas fluorescens FW300-N2C3 | 0.49 | AO356_05640 | | LuxR family transcriptional regulator | 0.13 | AO356_18065 | | 7-carboxy-7-deazaguanine synthase | low | > 104 |
| Dyella japonica UNC79MFTsu3.2 | 0.49 | ABZR86_RS15195 | | response regulator transcription factor | 0.13 | ABZR86_RS10790 | | 7-carboxy-7-deazaguanine synthase QueE | low | > 74 |
| Lysobacter sp. OAE881 | 0.47 | ABIE51_RS01665 | | response regulator transcription factor | 0.11 | ABIE51_RS05100 | | 7-carboxy-7-deazaguanine synthase QueE | — | — |
| Rhodanobacter sp000427505 FW510-R12 | 0.47 | LRK53_RS00075 | | response regulator transcription factor | 0.13 | LRK53_RS05170 | | 7-carboxy-7-deazaguanine synthase QueE | low | > 59 |
| Rhodanobacter sp. FW510-T8 | 0.46 | OKGIIK_15195 | | LuxR family transcriptional regulator | 0.14 | OKGIIK_01890 | | 7-carboxy-7-deazaguanine synthase | low | > 53 |
| Xanthobacter sp. DMC5 | 0.46 | GFF134 | | Transcriptional regulatory protein DegU | 0.14 | GFF3476 | | 7-carboxy-7-deazaguanine synthase | — | — |
| Acidovorax sp. GW101-3H11 | 0.43 | Ac3H11_716 | | Transcriptional regulator, LuxR family | 0.14 | Ac3H11_3825 | | Queuosine Biosynthesis QueE Radical SAM | — | — |
| Rhodopseudomonas palustris CGA009 | 0.43 | TX73_004390 | | response regulator transcription factor | 0.14 | TX73_006110 | | 7-carboxy-7-deazaguanine synthase | low | > 86 |
| Alteromonas macleodii MIT1002 | 0.43 | MIT1002_03515 | | Protease production enhancer protein | 0.51 | MIT1002_01264 | | 7-carboxy-7-deazaguanine synthase | low | > 70 |
| Sinorhizobium meliloti 1021 | 0.42 | SMc02248 | | transcriptional regulator | 0.14 | SM_b20938 | | hypothetical protein | low | > 103 |
| Azospirillum brasilense Sp245 | 0.41 | AZOBR_RS12735 | | transcriptional regulator | 0.15 | AZOBR_RS04155 | | radical SAM protein | low | > 97 |
| Brevundimonas sp. GW460-12-10-14-LB2 | 0.39 | A4249_RS15200 | | response regulator transcription factor | 0.14 | A4249_RS08695 | | 7-carboxy-7-deazaguanine synthase | — | — |
| Magnetospirillum magneticum AMB-1 | 0.35 | AMB_RS13915 | | DNA-binding response regulator | 0.17 | AMB_RS01255 | | 7-carboxy-7-deazaguanine synthase | low | > 64 |
| Dechlorosoma suillum PS | 0.30 | Dsui_0382 | | response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain | 0.13 | Dsui_0476 | | organic radical activating enzyme | low | > 51 |
| Variovorax sp. OAS795 | 0.29 | ABID97_RS05205 | | response regulator transcription factor | 0.15 | ABID97_RS07425 | | 7-carboxy-7-deazaguanine synthase | — | — |
| Herbaspirillum seropedicae SmR1 | 0.27 | HSERO_RS06185 | | response regulator protein | 0.17 | HSERO_RS11035 | | 7-cyano-7-deazaguanine reductase | low | > 78 |
| Variovorax sp. SCN45 | 0.27 | GFF5786 | | Transcriptional regulator, LuxR family | 0.16 | GFF2577 | | 7-carboxy-7-deazaguanine synthase (EC 4.3.99.3) | — | — |
| Paraburkholderia bryophila 376MFSha3.1 | 0.27 | H281DRAFT_05306 | | two component transcriptional regulator, LuxR family | 0.16 | H281DRAFT_02231 | | 7-carboxy-7-deazaguanine synthase, Cx14CxxC type | low | > 103 |
| Paraburkholderia graminis OAS925 | 0.26 | ABIE53_006519 | | DNA-binding NarL/FixJ family response regulator | 0.16 | ABIE53_000397 | | 7-carboxy-7-deazaguanine synthase | low | > 113 |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.25 | GFF107 | | Transcriptional regulator, LuxR family | 0.13 | GFF4633 | | Queuosine Biosynthesis QueE Radical SAM | low | > 90 |
| Paraburkholderia sabiae LMG 24235 | 0.25 | QEN71_RS07810 | | response regulator transcription factor | 0.42 | QEN71_RS41925 | | 7-carboxy-7-deazaguanine synthase QueE | low | > 153 |
| Ralstonia sp. UNC404CL21Col | 0.25 | ABZR87_RS00385 | | response regulator transcription factor | 0.15 | ABZR87_RS12145 | | 7-carboxy-7-deazaguanine synthase | low | > 80 |
| Ralstonia solanacearum PSI07 | 0.24 | RPSI07_RS12620 | | DNA-binding response regulator | 0.15 | RPSI07_RS16890 | | 7-carboxy-7-deazaguanine synthase | — | — |
| Burkholderia phytofirmans PsJN | 0.24 | BPHYT_RS24080 | | LuxR family transcriptional regulator | 0.16 | BPHYT_RS01505 | | 7-cyano-7-deazaguanine reductase | — | — |
| Serratia liquefaciens MT49 | 0.24 | IAI46_06400 | | response regulator transcription factor | 0.58 | IAI46_03675 | | 7-carboxy-7-deazaguanine synthase QueE | low | > 87 |
| Ralstonia solanacearum IBSBF1503 | 0.24 | RALBFv3_RS04765 | | DNA-binding response regulator | 0.13 | RALBFv3_RS00615 | | 7-carboxy-7-deazaguanine synthase | — | — |
| Ralstonia solanacearum UW163 | 0.24 | UW163_RS08905 | | DNA-binding response regulator | 0.13 | UW163_RS13945 | | 7-carboxy-7-deazaguanine synthase | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.24 | RR42_RS27790 | | LuxR family transcriptional regulator | 0.13 | RR42_RS11390 | | 7-cyano-7-deazaguanine reductase | — | — |
| Enterobacter sp. TBS_079 | 0.22 | MPMX20_01186 | | Transcriptional activator protein ExaE | 0.56 | MPMX20_03645 | | 7-carboxy-7-deazaguanine synthase | low | > 85 |
Not shown: 17 genomes with orthologs for CSW01_13640 only; 48 genomes with orthologs for CSW01_06870 only