| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_13560 | | methylenetetrahydrofolate reductase | 1.0 | CSW01_04650 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | 0.64 | 14 |
| Dickeya dianthicola 67-19 | 0.80 | HGI48_RS20415 | | methylenetetrahydrofolate reductase | 0.66 | HGI48_RS16910 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Dickeya dianthicola ME23 | 0.79 | DZA65_RS21460 | | methylenetetrahydrofolate reductase | 0.66 | DZA65_RS17985 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | low | > 75 |
| Enterobacter sp. TBS_079 | 0.79 | MPMX20_04529 | | 5,10-methylenetetrahydrofolate reductase | 0.66 | MPMX20_00884 | | D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase | — | — |
| Escherichia coli ECRC101 | 0.79 | MCAODC_04165 | metF | methylenetetrahydrofolate reductase | 0.64 | MCAODC_00560 | gmhB | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Escherichia coli ECRC102 | 0.79 | NIAGMN_11420 | metF | methylenetetrahydrofolate reductase | 0.64 | NIAGMN_07895 | gmhB | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | low | > 80 |
| Escherichia coli BL21 | 0.79 | ECD_03827 | | 5,10-methylenetetrahydrofolate reductase | 0.64 | ECD_00199 | | D,D-heptose 1,7-bisphosphate phosphatase | — | — |
| Escherichia coli ECRC98 | 0.79 | JDDGAC_17290 | metF | methylenetetrahydrofolate reductase | 0.64 | JDDGAC_13640 | gmhB | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | low | > 87 |
| Escherichia coli ECRC100 | 0.79 | OKFHMN_13665 | metF | methylenetetrahydrofolate reductase | 0.64 | OKFHMN_10045 | gmhB | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | low | > 79 |
| Escherichia coli BW25113 | 0.79 | b3941 | metF | 5,10-methylenetetrahydrofolate reductase (NCBI) | 0.64 | b0200 | gmhB | hypothetical protein (NCBI) | low | > 76 |
| Escherichia coli ECOR27 | 0.79 | NOLOHH_05810 | metF | methylenetetrahydrofolate reductase | 0.64 | NOLOHH_02390 | gmhB | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | low | > 76 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.79 | OHPLBJKB_04109 | | 5,10-methylenetetrahydrofolate reductase | 0.64 | OHPLBJKB_03461 | | D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase | low | > 74 |
| Enterobacter asburiae PDN3 | 0.79 | EX28DRAFT_4413 | | 5,10-methylenetetrahydrofolate reductase, prokaryotic form | 0.65 | EX28DRAFT_3788 | | D,D-heptose 1,7-bisphosphate phosphatase | — | — |
| Escherichia coli ECRC99 | 0.79 | KEDOAH_14495 | metF | methylenetetrahydrofolate reductase | 0.64 | KEDOAH_18110 | gmhB | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Escherichia coli ECRC62 | 0.79 | BNILDI_05725 | metF | methylenetetrahydrofolate reductase | 0.64 | BNILDI_09280 | gmhB | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Pantoea agglomerans CFBP13505 P0401 | 0.78 | PagCFBP13505_RS18450 | | methylenetetrahydrofolate reductase | 0.63 | PagCFBP13505_RS13625 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Escherichia coli ECOR38 | 0.78 | HEPCGN_12310 | metF | methylenetetrahydrofolate reductase | 0.64 | HEPCGN_07985 | gmhB | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | low | > 88 |
| Pantoea sp. MT58 | 0.78 | IAI47_00890 | | methylenetetrahydrofolate reductase | 0.63 | IAI47_15380 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Rahnella sp. WP5 | 0.78 | EX31_RS14205 | | methylenetetrahydrofolate reductase | 0.65 | EX31_RS12875 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | low | > 89 |
| Klebsiella michiganensis M5al | 0.78 | BWI76_RS00805 | | 5,10-methylenetetrahydrofolate reductase | 0.66 | BWI76_RS05370 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Escherichia fergusonii Becca | 0.78 | EFB2_04672 | | 5,10-methylenetetrahydrofolate reductase | 0.65 | EFB2_03843 | | D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase | — | — |
| Klebsiella pneumoniae MKP103 | 0.78 | KDGMDA_09325 | | methylenetetrahydrofolate reductase | 0.66 | KDGMDA_13620 | | D-glycero-beta-D-manno-heptose 1 7-bisphosphate 7-phosphatase | low | > 95 |
| Escherichia coli Nissle 1917 | 0.78 | ECOLIN_RS22760 | | methylenetetrahydrofolate reductase | 0.65 | ECOLIN_RS26745 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Erwinia amylovora T8 | 0.77 | OLJFJH_06105 | | methylenetetrahydrofolate reductase | 0.60 | OLJFJH_00475 | | D-glycero-beta-D-manno-heptose 1 7-bisphosphate 7-phosphatase | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.77 | GFF2329 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.64 | GFF20 | | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase (EC 3.1.1.-) | low | > 78 |
| Pectobacterium carotovorum WPP14 | 0.76 | HER17_RS00950 | | methylenetetrahydrofolate reductase | 0.67 | HER17_RS04385 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | low | > 75 |
| Serratia liquefaciens MT49 | 0.76 | IAI46_24530 | | methylenetetrahydrofolate reductase | 0.66 | IAI46_20070 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Shewanella amazonensis SB2B | 0.76 | Sama_3169 | metF | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.71 | Sama_1535 | | D,D-heptose 1,7-bisphosphate phosphatase (RefSeq) | — | — |
| Erwinia tracheiphila SCR3 | 0.75 | LU632_RS19630 | metF | methylenetetrahydrofolate reductase | 0.61 | LU632_RS19815 | gmhB | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | low | > 73 |
| Erwinia tracheiphila HP pepo 2.2 | 0.75 | IJEDHG_13030 | metF | methylenetetrahydrofolate reductase | 0.62 | IJEDHG_15330 | gmhB | D-glycero-beta-D-manno-heptose 1 7-bisphosphate 7-phosphatase | — | — |
| Shewanella loihica PV-4 | 0.74 | Shew_0522 | metF | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.71 | Shew_2357 | | D,D-heptose 1,7-bisphosphate phosphatase (RefSeq) | low | > 60 |
| Shewanella sp. ANA-3 | 0.73 | Shewana3_3612 | metF | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.68 | Shewana3_1583 | | D,D-heptose 1,7-bisphosphate phosphatase (RefSeq) | low | > 73 |
| Shewanella oneidensis MR-1 | 0.73 | SO4054 | metF | 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) | 0.67 | SO2851 | | histidinol phosphatase domain protein (NCBI ptt file) | low | > 76 |
| Azospirillum brasilense Sp245 | 0.51 | AZOBR_RS09540 | | 5 10-methylenetetrahydrofolate reductase | 0.38 | AZOBR_RS33755 | | D-glycero-D-manno-heptose 1 7-bisphosphate phosphatase | low | > 97 |
| Burkholderia phytofirmans PsJN | 0.35 | BPHYT_RS18705 | | 5,10-methylenetetrahydrofolate reductase | 0.26 | BPHYT_RS03340 | | D,D-heptose 1,7-bisphosphate phosphatase | — | — |
| Pseudomonas sp. BP01 | 0.35 | JOY50_RS09810 | metF | methylenetetrahydrofolate reductase [NAD(P)H] | 0.26 | JOY50_RS08285 | gmhB | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas putida KT2440 | 0.35 | PP_4977 | | 5,10-methylenetetrahydrofolate reductase | 0.26 | PP_0059 | | D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.35 | RR42_RS01385 | | 5,10-methylenetetrahydrofolate reductase | 0.29 | RR42_RS02815 | | D,D-heptose 1,7-bisphosphate phosphatase | — | — |
| Dechlorosoma suillum PS | 0.35 | Dsui_0640 | | 5,10-methylenetetrahydrofolate reductase | 0.29 | Dsui_1201 | | histidinol-phosphate phosphatase family protein | — | — |
| Pseudomonas sp. RS175 | 0.35 | PFR28_04202 | | 5,10-methylenetetrahydrofolate reductase | 0.25 | PFR28_04599 | | D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.35 | Pf1N1B4_2384 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.27 | Pf1N1B4_1921 | | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase (EC 3.1.1.-); Histidinol-phosphatase (EC 3.1.3.15) | — | — |
| Pseudomonas sp. DMC3 | 0.35 | GFF171 | | 5,10-methylenetetrahydrofolate reductase | 0.26 | GFF583 | | D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas simiae WCS417 | 0.35 | PS417_26510 | | 5,10-methylenetetrahydrofolate reductase | 0.26 | PS417_00050 | | histidinol phosphatase | — | — |
| Pseudomonas sp. S08-1 | 0.35 | OH686_10820 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.23 | OH686_12570 | | Histidinol-phosphatase | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.35 | Pf6N2E2_4638 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.25 | Pf6N2E2_4191 | | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase (EC 3.1.1.-); Histidinol-phosphatase (EC 3.1.3.15) | — | — |
| Pseudomonas orientalis W4I3 | 0.35 | QF045_RS00905 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.25 | QF045_RS02985 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas stutzeri RCH2 | 0.34 | Psest_0313 | | 5,10-methylenetetrahydrofolate reductase, prokaryotic form | 0.26 | Psest_0009 | | histidinol-phosphate phosphatase family domain/HAD-superfamily hydrolase, subfamily IIIA | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.34 | PFLU_RS28165 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.26 | PFLU_RS00045 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.34 | AO356_13605 | | 5,10-methylenetetrahydrofolate reductase | 0.25 | AO356_11605 | | histidinol phosphatase | — | — |
| Pseudomonas segetis P6 | 0.34 | MPMX49_00645 | | 5,10-methylenetetrahydrofolate reductase | 0.25 | MPMX49_00264 | | D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.34 | AO353_08015 | | 5,10-methylenetetrahydrofolate reductase | 0.25 | AO353_10590 | | histidinol phosphatase | — | — |
| Pseudomonas fluorescens SBW25 | 0.34 | PFLU_RS28165 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.26 | PFLU_RS00045 | | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas sp. SVBP6 | 0.34 | COO64_RS17485 | metF | methylenetetrahydrofolate reductase [NAD(P)H] | 0.25 | COO64_RS02180 | gmhB | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas aeruginosa PUPa3 | 0.34 | DQ20_RS37170 | metF;go_function=methylenetetrahydrofolate | methylenetetrahydrofolate reductase [NAD(P)H] | 0.26 | DQ20_RS58635 | gmhB;go_function=phosphatase | D-glycero-beta-D-manno-heptose 1 7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas aeruginosa MRSN321 | 0.34 | DY961_RS22135 | metF;go_function=methylenetetrahydrofolate | methylenetetrahydrofolate reductase [NAD(P)H] | 0.26 | DY961_RS26230 | gmhB;go_function=phosphatase | D-glycero-beta-D-manno-heptose 1 7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas aeruginosa PA14 | 0.34 | IKLFDK_23270 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.26 | IKLFDK_25530 | | D-glycero-beta-D-manno-heptose 1 7-bisphosphate 7-phosphatase | — | — |
| Methylophilus sp. DMC18 | 0.34 | GFF1492 | | 5,10-methylenetetrahydrofolate reductase | 0.26 | GFF2588 | | D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas lactucae CFBP13502 | 0.34 | GEMAOFIL_05433 | | 5,10-methylenetetrahydrofolate reductase | 0.26 | GEMAOFIL_00216 | | D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.34 | PfGW456L13_1050 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.26 | PfGW456L13_660 | | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase (EC 3.1.1.-); Histidinol-phosphatase (EC 3.1.3.15) | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.33 | Psyr_0459 | | 5,10-methylenetetrahydrofolate reductase | 0.24 | Psyr_0010 | | D-alpha,beta-D-heptose 1,7-bisphosphate phosphatase | — | — |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.33 | Psyr_0459 | | 5,10-methylenetetrahydrofolate reductase | 0.24 | Psyr_0010 | | D-alpha,beta-D-heptose 1,7-bisphosphate phosphatase | — | — |
| Herbaspirillum seropedicae SmR1 | 0.32 | HSERO_RS21425 | | 5,10-methylenetetrahydrofolate reductase | 0.33 | HSERO_RS22085 | | D,D-heptose 1,7-bisphosphate phosphatase | low | > 78 |
| Pedobacter sp. GW460-11-11-14-LB5 | 0.20 | CA265_RS23445 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.30 | CA265_RS08680 | | histidinol phosphate phosphatase | low | > 88 |
| Mucilaginibacter yixingensis YX-36 DSM 26809 | 0.20 | ABZR88_RS20935 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.34 | ABZR88_RS06900 | | HAD-IIIA family hydrolase | low | > 71 |
Not shown: 55 genomes with orthologs for CSW01_13560 only; 0 genomes with orthologs for CSW01_04650 only