| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_13560 | | methylenetetrahydrofolate reductase | 1.0 | CSW01_03175 | | penicillin-binding protein 1B | 0.71 | 3 |
| Dickeya dianthicola 67-19 | 0.80 | HGI48_RS20415 | | methylenetetrahydrofolate reductase | 0.48 | HGI48_RS16030 | | bifunctional glycosyl transferase/transpeptidase | low | > 71 |
| Dickeya dianthicola ME23 | 0.79 | DZA65_RS21460 | | methylenetetrahydrofolate reductase | 0.48 | DZA65_RS17115 | | bifunctional glycosyl transferase/transpeptidase | low | > 75 |
| Dickeya dadantii 3937 | 0.79 | DDA3937_RS00960 | | methylenetetrahydrofolate reductase | 0.48 | DDA3937_RS15915 | | bifunctional glycosyl transferase/transpeptidase | low | > 74 |
| Enterobacter sp. TBS_079 | 0.79 | MPMX20_04529 | | 5,10-methylenetetrahydrofolate reductase | 0.45 | MPMX20_00835 | | Penicillin-binding protein 1B | low | > 85 |
| Escherichia coli ECRC62 | 0.79 | BNILDI_05725 | metF | methylenetetrahydrofolate reductase | 0.45 | BNILDI_09000 | mrcB | bifunctional glycosyl transferase/transpeptidase | low | > 75 |
| Escherichia coli ECRC100 | 0.79 | OKFHMN_13665 | metF | methylenetetrahydrofolate reductase | 0.45 | OKFHMN_10325 | mrcB | bifunctional glycosyl transferase/transpeptidase | low | > 79 |
| Escherichia coli ECOR27 | 0.79 | NOLOHH_05810 | metF | methylenetetrahydrofolate reductase | 0.45 | NOLOHH_02670 | mrcB | bifunctional glycosyl transferase/transpeptidase | low | > 76 |
| Escherichia coli BW25113 | 0.79 | b3941 | metF | 5,10-methylenetetrahydrofolate reductase (NCBI) | 0.45 | b0149 | mrcB | penicillin-binding protein 1b (NCBI) | low | > 76 |
| Escherichia coli BL21 | 0.79 | ECD_03827 | | 5,10-methylenetetrahydrofolate reductase | 0.45 | ECD_00148 | | fused glycosyl transferase and transpeptidase | 0.71 | 55 |
| Enterobacter asburiae PDN3 | 0.79 | EX28DRAFT_4413 | | 5,10-methylenetetrahydrofolate reductase, prokaryotic form | 0.45 | EX28DRAFT_3738 | | penicillin-binding protein 1B | low | > 76 |
| Escherichia coli ECRC99 | 0.79 | KEDOAH_14495 | metF | methylenetetrahydrofolate reductase | 0.45 | KEDOAH_17830 | mrcB | bifunctional glycosyl transferase/transpeptidase | — | — |
| Escherichia coli ECRC101 | 0.79 | MCAODC_04165 | metF | methylenetetrahydrofolate reductase | 0.45 | MCAODC_00840 | mrcB | bifunctional glycosyl transferase/transpeptidase | low | > 87 |
| Escherichia coli ECRC102 | 0.79 | NIAGMN_11420 | metF | methylenetetrahydrofolate reductase | 0.45 | NIAGMN_08175 | mrcB | bifunctional glycosyl transferase/transpeptidase | low | > 80 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.79 | OHPLBJKB_04109 | | 5,10-methylenetetrahydrofolate reductase | 0.45 | OHPLBJKB_03513 | | Penicillin-binding protein 1B | low | > 74 |
| Escherichia coli ECRC98 | 0.79 | JDDGAC_17290 | metF | methylenetetrahydrofolate reductase | 0.45 | JDDGAC_13920 | mrcB | bifunctional glycosyl transferase/transpeptidase | low | > 87 |
| Pantoea agglomerans CFBP13505 P0401 | 0.78 | PagCFBP13505_RS18450 | | methylenetetrahydrofolate reductase | 0.46 | PagCFBP13505_RS13390 | | bifunctional glycosyl transferase/transpeptidase | low | > 74 |
| Escherichia coli ECOR38 | 0.78 | HEPCGN_12310 | metF | methylenetetrahydrofolate reductase | 0.45 | HEPCGN_08275 | mrcB | bifunctional glycosyl transferase/transpeptidase | low | > 88 |
| Pantoea sp. MT58 | 0.78 | IAI47_00890 | | methylenetetrahydrofolate reductase | 0.46 | IAI47_15615 | | bifunctional glycosyl transferase/transpeptidase | low | > 76 |
| Rahnella sp. WP5 | 0.78 | EX31_RS14205 | | methylenetetrahydrofolate reductase | 0.45 | EX31_RS03230 | | bifunctional glycosyl transferase/transpeptidase | low | > 89 |
| Klebsiella michiganensis M5al | 0.78 | BWI76_RS00805 | | 5,10-methylenetetrahydrofolate reductase | 0.45 | BWI76_RS05120 | | bifunctional glycosyl transferase/transpeptidase | low | > 92 |
| Escherichia fergusonii Becca | 0.78 | EFB2_04672 | | 5,10-methylenetetrahydrofolate reductase | 0.45 | EFB2_03895 | | Penicillin-binding protein 1B | low | > 86 |
| Klebsiella pneumoniae MKP103 | 0.78 | KDGMDA_09325 | | methylenetetrahydrofolate reductase | 0.45 | KDGMDA_13365 | | bifunctional glycosyl transferase/transpeptidase | low | > 95 |
| Escherichia coli Nissle 1917 | 0.78 | ECOLIN_RS22760 | | methylenetetrahydrofolate reductase | 0.45 | ECOLIN_RS00835 | | bifunctional glycosyl transferase/transpeptidase | low | > 55 |
| Erwinia amylovora T8 | 0.77 | OLJFJH_06105 | | methylenetetrahydrofolate reductase | 0.45 | OLJFJH_00745 | | bifunctional glycosyl transferase/transpeptidase | low | > 58 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.77 | GFF2329 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.45 | GFF83 | | Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) | low | > 78 |
| Pectobacterium carotovorum WPP14 | 0.76 | HER17_RS00950 | | methylenetetrahydrofolate reductase | 0.48 | HER17_RS05600 | | bifunctional glycosyl transferase/transpeptidase | low | > 75 |
| Serratia liquefaciens MT49 | 0.76 | IAI46_24530 | | methylenetetrahydrofolate reductase | 0.49 | IAI46_21190 | | bifunctional glycosyl transferase/transpeptidase | low | > 87 |
| Shewanella amazonensis SB2B | 0.76 | Sama_3169 | metF | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.43 | Sama_2971 | | peptidoglycan glycosyltransferase (RefSeq) | low | > 62 |
| Erwinia tracheiphila HP pepo 2.2 | 0.75 | IJEDHG_13030 | metF | methylenetetrahydrofolate reductase | 0.46 | IJEDHG_15080 | | Penicillin-binding protein 1B | low | > 61 |
| Erwinia tracheiphila SCR3 | 0.75 | LU632_RS19630 | metF | methylenetetrahydrofolate reductase | 0.46 | LU632_RS20060 | mrcB | bifunctional glycosyl transferase/transpeptidase | low | > 73 |
| Shewanella loihica PV-4 | 0.74 | Shew_0522 | metF | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.43 | Shew_3123 | | penicillin-binding protein 1B (RefSeq) | low | > 60 |
| Shewanella oneidensis MR-1 | 0.73 | SO4054 | metF | 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) | 0.43 | SO0633 | mrcB | penicillin-binding protein 1B (NCBI ptt file) | low | > 76 |
| Shewanella sp. ANA-3 | 0.73 | Shewana3_3612 | metF | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.43 | Shewana3_0623 | | penicillin-binding protein 1B (RefSeq) | low | > 73 |
| Alteromonas macleodii MIT1002 | 0.66 | MIT1002_03670 | | 5,10-methylenetetrahydrofolate reductase | 0.41 | MIT1002_00409 | | Murein polymerase | low | > 70 |
| Kangiella aquimarina DSM 16071 | 0.57 | B158DRAFT_2461 | | 5,10-methylenetetrahydrofolate reductase (NAD(P)) (EC 1.5.1.20) | 0.33 | B158DRAFT_0038 | | penicillin-binding protein 1B | low | > 40 |
| Marinobacter adhaerens HP15 | 0.36 | HP15_2917 | | 5,10-methylenetetrahydrofolate reductase-like protein | 0.36 | HP15_338 | | penicillin-binding protein 1B | low | > 73 |
| Pseudomonas sp. BP01 | 0.35 | JOY50_RS09810 | metF | methylenetetrahydrofolate reductase [NAD(P)H] | 0.38 | JOY50_RS27745 | mrcB | penicillin-binding protein 1B | low | > 84 |
| Pseudomonas putida KT2440 | 0.35 | PP_4977 | | 5,10-methylenetetrahydrofolate reductase | 0.38 | PP_4683 | | transglycosylase/transpeptidase | low | > 96 |
| Pseudomonas sp. RS175 | 0.35 | PFR28_04202 | | 5,10-methylenetetrahydrofolate reductase | 0.38 | PFR28_03703 | | Penicillin-binding protein 1B | low | > 88 |
| Pseudomonas fluorescens FW300-N1B4 | 0.35 | Pf1N1B4_2384 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.38 | Pf1N1B4_2874 | | Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) | low | > 87 |
| Pseudomonas sp. DMC3 | 0.35 | GFF171 | | 5,10-methylenetetrahydrofolate reductase | 0.38 | GFF4046 | | Penicillin-binding protein 1B | low | > 89 |
| Pseudomonas fluorescens FW300-N2E2 | 0.35 | Pf6N2E2_4638 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.37 | Pf6N2E2_5171 | | Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) | low | > 103 |
| Pseudomonas orientalis W4I3 | 0.35 | QF045_RS00905 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.38 | QF045_RS26085 | | penicillin-binding protein 1B | low | > 93 |
| Pseudomonas simiae WCS417 | 0.35 | PS417_26510 | | 5,10-methylenetetrahydrofolate reductase | 0.38 | PS417_23825 | | penicillin-binding protein | low | > 88 |
| Pseudomonas sp. S08-1 | 0.35 | OH686_10820 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.37 | OH686_08150 | | penicillin-binding protein 1B | low | > 80 |
| Xanthomonas campestris pv. campestris strain 8004 | 0.35 | Xcc-8004.4336.1 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.28 | Xcc-8004.1494.1 | | Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) | low | > 74 |
| Pseudomonas fluorescens SBW25-INTG | 0.34 | PFLU_RS28165 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.38 | PFLU_RS25665 | | penicillin-binding protein 1B | low | > 109 |
| Pseudomonas fluorescens FW300-N2C3 | 0.34 | AO356_13605 | | 5,10-methylenetetrahydrofolate reductase | 0.38 | AO356_16150 | | penicillin-binding protein 1B | low | > 104 |
| Pseudomonas segetis P6 | 0.34 | MPMX49_00645 | | 5,10-methylenetetrahydrofolate reductase | 0.37 | MPMX49_01270 | | Penicillin-binding protein 1B | low | > 75 |
| Pseudomonas stutzeri RCH2 | 0.34 | Psest_0313 | | 5,10-methylenetetrahydrofolate reductase, prokaryotic form | 0.38 | Psest_1032 | | penicillin-binding protein 1B | — | — |
| Pseudomonas fluorescens SBW25 | 0.34 | PFLU_RS28165 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.38 | PFLU_RS25665 | | penicillin-binding protein 1B | low | > 109 |
| Pseudomonas fluorescens FW300-N2E3 | 0.34 | AO353_08015 | | 5,10-methylenetetrahydrofolate reductase | 0.38 | AO353_14475 | | penicillin-binding protein 1B | low | > 101 |
| Pseudomonas aeruginosa MRSN321 | 0.34 | DY961_RS22135 | metF;go_function=methylenetetrahydrofolate | methylenetetrahydrofolate reductase [NAD(P)H] | 0.39 | DY961_RS09235 | mrcB;go_component=peptidoglycan-based | penicillin-binding protein 1B | low | > 100 |
| Pseudomonas sp. SVBP6 | 0.34 | COO64_RS17485 | metF | methylenetetrahydrofolate reductase [NAD(P)H] | 0.38 | COO64_RS15020 | mrcB | penicillin-binding protein 1B | low | > 93 |
| Pseudomonas aeruginosa PA14 | 0.34 | IKLFDK_23270 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.39 | IKLFDK_30125 | | penicillin-binding protein 1B | low | > 98 |
| Pseudomonas aeruginosa PUPa3 | 0.34 | DQ20_RS37170 | metF;go_function=methylenetetrahydrofolate | methylenetetrahydrofolate reductase [NAD(P)H] | 0.39 | DQ20_RS52795 | mrcB;go_component=peptidoglycan-based | penicillin-binding protein 1B | low | > 101 |
| Dyella japonica UNC79MFTsu3.2 | 0.34 | ABZR86_RS11570 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.31 | ABZR86_RS19740 | | penicillin-binding protein 1B | low | > 74 |
| Rhodanobacter denitrificans FW104-10B01 | 0.34 | LRK54_RS12030 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.32 | LRK54_RS12740 | | penicillin-binding protein 1B | low | > 59 |
| Pseudomonas lactucae CFBP13502 | 0.34 | GEMAOFIL_05433 | | 5,10-methylenetetrahydrofolate reductase | 0.38 | GEMAOFIL_04916 | | Penicillin-binding protein 1B | low | > 96 |
| Rhodanobacter denitrificans MT42 | 0.34 | LRK55_RS11765 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.32 | LRK55_RS12445 | | penicillin-binding protein 1B | low | > 63 |
| Pseudomonas fluorescens GW456-L13 | 0.34 | PfGW456L13_1050 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.37 | PfGW456L13_1535 | | Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-) | low | > 87 |
| Lysobacter sp. OAE881 | 0.34 | ABIE51_RS16490 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.28 | ABIE51_RS05185 | | penicillin-binding protein 1B | low | > 62 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.33 | Psyr_0459 | | 5,10-methylenetetrahydrofolate reductase | 0.37 | Psyr_0842 | | Peptidoglycan glycosyltransferase | low | > 86 |
| Pseudomonas syringae pv. syringae B728a | 0.33 | Psyr_0459 | | 5,10-methylenetetrahydrofolate reductase | 0.37 | Psyr_0842 | | Peptidoglycan glycosyltransferase | low | > 86 |
| Rhodanobacter sp. FW510-T8 | 0.33 | OKGIIK_11830 | metF | methylenetetrahydrofolate reductase [NAD(P)H] | 0.31 | OKGIIK_02185 | | Penicillin-binding protein 1B | low | > 53 |
| Rhodanobacter sp000427505 FW510-R12 | 0.33 | LRK53_RS16505 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.31 | LRK53_RS15845 | | penicillin-binding protein 1B | low | > 59 |
| Acinetobacter baumannii LAC-4 | 0.32 | RR41_RS05725 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.31 | RR41_RS06175 | | penicillin-binding protein 1B | low | > 55 |
| Acinetobacter radioresistens SK82 | 0.32 | MPMX26_01002 | | 5,10-methylenetetrahydrofolate reductase | 0.31 | MPMX26_02029 | | Penicillin-binding protein 1B | low | > 36 |
Not shown: 50 genomes with orthologs for CSW01_13560 only; 0 genomes with orthologs for CSW01_03175 only