| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.1607.1 | | Histidine kinase/response regulator hybrid protein | insig. | 100 | 100 |
| | Lysobacter sp. OAE881 | ABIE51_RS16115 | | hybrid sensor histidine kinase/response regulator | cofit | 42 | 97 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.1608.1 | | Histidine kinase/response regulator hybrid protein | insig. | 41 | 99 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.1609.1 | | Histidine kinase/response regulator hybrid protein | insig. | 41 | 99 |
| o | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS19095 | | hybrid sensor histidine kinase/response regulator | insig. | 37 | 97 |
| o | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS12365 | | ATP-binding protein | insig. | 39 | 98 |
| o | Rhodanobacter denitrificans MT42 | LRK55_RS12100 | | hybrid sensor histidine kinase/response regulator | strong | 39 | 98 |
| | Rhodanobacter denitrificans MT42 | LRK55_RS12095 | | hybrid sensor histidine kinase/response regulator | cofit | 37 | 97 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS12360 | | ATP-binding protein | insig. | 37 | 97 |
| o | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS16135 | | hybrid sensor histidine kinase/response regulator | insig. | 37 | 98 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS19275 | | hybrid sensor histidine kinase/response regulator | insig. | 36 | 98 |
| o | Rhodanobacter sp. FW510-T8 | OKGIIK_11570 | | Histidine kinase | insig. | 35 | 97 |
| o | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS11200 | | hybrid sensor histidine kinase/response regulator transcription factor | insig. | 23 | 97 |
| o | Bacteroides ovatus ATCC 8483 | BACOVA_01840 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | cofit | 23 | 99 |
| o | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS11205 | | hybrid sensor histidine kinase/response regulator | insig. | 23 | 99 |
| o | Bacteroides thetaiotaomicron VPI-5482 | BT4663 | | two-component system sensor histidine kinase/response (NCBI ptt file) | strong | 23 | 99 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_05479 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 23 | 99 |
| | Alteromonas macleodii MIT1002 | MIT1002_02557 | | Sensor kinase protein RcsC | cofit | 25 | 89 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS03345 | | hypothetical protein | insig. | 26 | 98 |
| o | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_3754 | | Signal transduction histidine kinase | insig. | 23 | 98 |
| o | Bacteroides stercoris CC31F | HMPREF1181_RS08545 | | response regulator | insig. | 23 | 99 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04483 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | cofit | 23 | 99 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02857 | | conserved hypothetical protein TIGR03982 | insig. | 22 | 99 |
| o | Phocaeicola dorei CL03T12C01 | ABI39_RS00165 | | response regulator | strong | 23 | 99 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS08430 | | response regulator | insig. | 23 | 99 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS08780 | | hybrid sensor histidine kinase/response regulator transcription factor | insig. | 24 | 98 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS06690 | | response regulator | sig. | 22 | 98 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04394 | | response regulator receiver domain protein | strong | 22 | 99 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS06780 | | hybrid sensor histidine kinase/response regulator | insig. | 24 | 97 |
| o | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS15170 | | response regulator | insig. | 22 | 99 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_4346 | | Signal transduction histidine kinase | insig. | 22 | 99 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT3049 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | cofit | 23 | 96 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS10925 | | response regulator | insig. | 22 | 99 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_3643 | | Sensory box histidine kinase/response regulator | insig. | 41 | 33 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_2760 | | Signal transduction histidine kinase | insig. | 22 | 97 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2897 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 22 | 99 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02667 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 21 | 99 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_1645 | | Signal transduction histidine kinase | insig. | 24 | 85 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT3465 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 22 | 97 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS14215 | | hypothetical protein | insig. | 22 | 96 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2923 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 21 | 100 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS23235 | | DUF3369 domain-containing protein | insig. | 43 | 32 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT2860 | | two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) | insig. | 23 | 100 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_17725 | | TMAO reductase system sensor histidine kinase/response regulator TorS | insig. | 40 | 32 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c11790 | | two-component regulatory system, sensory/regulatory protein | insig. | 38 | 33 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS03955 | | response regulator | insig. | 23 | 96 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS09500 | | response regulator | insig. | 23 | 96 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS10265 | | hypothetical protein | insig. | 22 | 95 |
| o | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS17305 | | hybrid sensor histidine kinase/response regulator transcription factor | insig. | 21 | 97 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_4351 | | sensor histidine kinase/response regulator | insig. | 40 | 32 |
| o | Cellulophaga baltica 18 | M666_RS09795 | | two-component regulator propeller domain-containing protein | insig. | 23 | 97 |
| | Dechlorosoma suillum PS | Dsui_2885 | | PAS domain S-box | cofit | 40 | 34 |
| | Pseudomonas segetis P6 | MPMX49_04005 | | Sensor histidine kinase RcsC | insig. | 40 | 32 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_01996 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | strong | 22 | 99 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS00710 | | hypothetical protein | insig. | 21 | 97 |
| | Cellulophaga baltica 18 | M666_RS00005 | | two-component regulator propeller domain-containing protein | insig. | 22 | 97 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02182 | | response regulator receiver domain protein | cofit | 21 | 100 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS09220 | | ATP-binding protein | insig. | 38 | 32 |
| | Rhodospirillum rubrum S1H | Rru_A2033 | | PAS/PAC Sensor Hybrid Histidine Kinase (NCBI) | insig. | 42 | 32 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_03437 | | response regulator receiver domain protein | strong | 20 | 96 |
| | Dechlorosoma suillum PS | Dsui_1009 | | PAS domain S-box | insig. | 40 | 32 |
| | Pseudomonas sp. S08-1 | OH686_07460 | | hypothetical protein | insig. | 39 | 35 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS11185 | | response regulator | insig. | 20 | 97 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_02648 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | cofit | 22 | 98 |
| | Dinoroseobacter shibae DFL-12 | Dshi_2708 | | PAS/PAC sensor hybrid histidine kinase (RefSeq) | sig. | 38 | 32 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS05860 | | response regulator | insig. | 20 | 97 |
| | Cellulophaga baltica 18 | M666_RS19625 | | two-component regulator propeller domain-containing protein | insig. | 22 | 98 |
| | Azospirillum sp. SherDot2 | MPMX19_02061 | | Sensor histidine kinase RcsC | insig. | 40 | 31 |
| | Shewanella sp. ANA-3 | Shewana3_3419 | | multi-sensor hybrid histidine kinase (RefSeq) | cofit | 35 | 32 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_00239 | | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein | insig. | 22 | 95 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT3334 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | strong | 22 | 99 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS32070 | | ATP-binding protein | insig. | 40 | 32 |
| | Shewanella loihica PV-4 | Shew_3200 | | multi-sensor hybrid histidine kinase (RefSeq) | insig. | 36 | 32 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS24635 | | PAS domain S-box protein | cofit | 38 | 31 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_2683 | | multi-sensor hybrid histidine kinase (RefSeq) | insig. | 39 | 33 |
| | Azospirillum sp. SherDot2 | MPMX19_06077 | | Sensor histidine kinase RcsC | insig. | 41 | 33 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS09870 | | hybrid sensor histidine kinase/response regulator | insig. | 38 | 33 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS12625 | | hybrid sensor histidine kinase/response regulator transcription factor | strong | 22 | 98 |
| | Shewanella amazonensis SB2B | Sama_2952 | | sensory box histidine kinase/response regulator (RefSeq) | strong | 34 | 34 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS14910 | | helix-turn-helix domain-containing protein | insig. | 23 | 87 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS03030 | | response regulator | insig. | 22 | 97 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS34705 | | hypothetical protein | insig. | 39 | 31 |
| | Shewanella oneidensis MR-1 | SO0859 | | sensory box histidine kinase/response regulator (NCBI ptt file) | insig. | 35 | 32 |
| | Azospirillum sp. SherDot2 | MPMX19_04098 | | Sensor histidine kinase RcsC | insig. | 37 | 32 |
| | Rhodospirillum rubrum S1H | Rru_A3492 | | Periplasmic Sensor Hybrid Histidine Kinase (NCBI) | cofit | 39 | 33 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS23595 | | hypothetical protein | cofit | 36 | 33 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_01673 | | response regulator receiver domain protein | insig. | 22 | 99 |
| | Rhodopseudomonas palustris CGA009 | TX73_022895 | | ATP-binding protein | sig. | 36 | 33 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS15175 | | response regulator | insig. | 37 | 33 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS08910 | | response regulator | insig. | 22 | 97 |
| | Burkholderia phytofirmans PsJN | BPHYT_RS30910 | | histidine kinase | insig. | 38 | 35 |
| | Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS13565 | | hybrid sensor histidine kinase/response regulator transcription factor | insig. | 22 | 99 |
| | Acidovorax sp. GW101-3H11 | Ac3H11_2618 | | sensory box histidine kinase/response regulator | insig. | 38 | 32 |
| | Pseudomonas aeruginosa PA14 | IKLFDK_28630 | | hybrid sensor histidine kinase/response regulator | insig. | 40 | 32 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS07235 | | signal transduction histidine kinase | insig. | 37 | 33 |
| | Cellulophaga baltica 18 | M666_RS18760 | | sensor histidine kinase | insig. | 22 | 87 |
| | Dechlorosoma suillum PS | Dsui_2382 | | PAS domain S-box | cofit | 37 | 33 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT3678 | | two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) | insig. | 22 | 97 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS06050 | | hypothetical protein | insig. | 21 | 98 |
| | Variovorax sp. SCN45 | GFF7915 | | Histidine kinase/response regulator hybrid protein | no data | 67 | 15 |