Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| Shewanella oneidensis MR-1 | SO1457 | | type I restriction-modification system, M subunit, putative (NCBI ptt file) | strong | 100 | 100 |
o | Phocaeicola dorei CL03T12C01 | ABI39_RS18425 | | N-6 DNA methylase | cofit | 38 | 97 |
| Rhodanobacter sp. FW510-T8 | OKGIIK_11790 | | N-6 DNA methylase | insig. | 24 | 87 |
| Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.5272.1 | | XmnI methyltransferase | insig. | 27 | 61 |
| Ralstonia solanacearum UW163 | UW163_RS05190 | | restriction endonuclease subunit M | insig. | 28 | 54 |
| Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_0382 | | Type I restriction-modification system methyltransferase subunit | sig. | 30 | 47 |
| Serratia liquefaciens MT49 | IAI46_02400 | | N-6 DNA methylase | insig. | 25 | 55 |
| Pseudomonas stutzeri RCH2 | Psest_1099 | | Type I restriction-modification system methyltransferase subunit | cofit | 26 | 44 |
| Dickeya dianthicola 67-19 | HGI48_RS21695 | | N-6 DNA methylase | insig. | 26 | 41 |
| Shewanella sp. ANA-3 | Shewana3_2027 | | N-6 DNA methylase (RefSeq) | insig. | 26 | 42 |
| Alteromonas macleodii MIT1002 | MIT1002_03394 | | Type I restriction enzyme EcoKI M protein | insig. | 25 | 58 |
| Escherichia coli ECRC101 | OKFHMN_11415 | hsdM | Type I restriction enzyme EcoEI methylase subunit | insig. | 27 | 51 |
| Escherichia coli ECRC101 | MCAODC_01930 | hsdM | Type I restriction enzyme EcoEI methylase subunit | insig. | 27 | 51 |
| Escherichia coli ECRC102 | NIAGMN_09265 | hsdM | Type I restriction enzyme EcoEI methylase subunit | insig. | 27 | 51 |
| Escherichia coli ECRC98 | JDDGAC_15010 | hsdM | Type I restriction enzyme EcoEI methylase subunit | no data | 27 | 51 |
| Escherichia coli ECRC99 | KEDOAH_16730 | hsdM | Type I restriction enzyme EcoEI methylase subunit | no data | 27 | 51 |
| Escherichia coli ECOR38 | HEPCGN_09455 | hsdM | Type I restriction enzyme EcoEI methylase subunit | cofit | 27 | 51 |
| Pseudomonas sp. RS175 | PFR28_03897 | | Type I restriction enzyme EcoKI M protein | insig. | 25 | 46 |
| Bacteroides stercoris CC31F | HMPREF1181_RS13640 | | type I restriction-modification system subunit M | insig. | 28 | 42 |
| Bacteroides thetaiotaomicron VPI-5482 | BT4518 | | Type I restriction enzyme StySJI M protein (NCBI ptt file) | insig. | 28 | 42 |
| Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS07500 | | type I restriction-modification system subunit M | insig. | 28 | 42 |
| Phocaeicola dorei CL03T12C01 | ABI39_RS21430 | | type I restriction-modification system subunit M | insig. | 27 | 42 |
| Ralstonia solanacearum PSI07 | RPSI07_RS08080 | | SAM-dependent DNA methyltransferase | insig. | 25 | 42 |
| Pseudomonas fluorescens GW456-L13 | PfGW456L13_3109 | | Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) | insig. | 27 | 56 |
| Pseudomonas putida KT2440 | PP_4741 | | Type I restriction enzyme EcoEI M protein | insig. | 28 | 45 |
| Ralstonia solanacearum IBSBF1503 | RALBFv3_RS09190 | | SAM-dependent DNA methyltransferase | insig. | 23 | 44 |
| Ralstonia solanacearum UW163 | UW163_RS04405 | | SAM-dependent DNA methyltransferase | insig. | 23 | 44 |
| Ralstonia solanacearum GMI1000 | RS_RS17020 | | SAM-dependent DNA methyltransferase | insig. | 25 | 51 |
| Pectobacterium carotovorum WPP14 | HER17_RS08020 | | N-6 DNA methylase | cofit | 38 | 16 |
| Escherichia coli ECOR38 | HEPCGN_09675 | | SAM-dependent methyltransferase | cofit | 38 | 16 |
| Escherichia coli BW25113 | b4349 | hsdM | DNA methylase M (NCBI) | sig. | 23 | 58 |
| Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_0424 | | Type I restriction-modification system methyltransferase subunit | insig. | 24 | 49 |
| Rhodanobacter sp. FW510-T8 | OKGIIK_13995 | | Site-specific DNA-methyltransferase (adenine-specific) | insig. | 26 | 42 |
| Pseudomonas fluorescens FW300-N2E3 | AO353_11435 | | SAM-dependent methyltransferase | insig. | 26 | 45 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF1001 | | Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) | insig. | 25 | 47 |
| Escherichia coli BL21 | ECD_04215 | | DNA methyltransferase M | insig. | 24 | 47 |
| Shewanella oneidensis MR-1 | SO4265 | hsdM-2 | type I restriction-modification system, M subunit (NCBI ptt file) | insig. | 25 | 45 |
| Pantoea sp. MT58 | IAI47_16550 | | N-6 DNA methylase | insig. | 25 | 47 |
| Cupriavidus basilensis FW507-4G11 | RR42_RS18685 | | restriction endonuclease subunit M | insig. | 24 | 35 |
| Castellaniella sp019104865 MT123 | ABCV34_RS05465 | | class I SAM-dependent DNA methyltransferase | insig. | 23 | 46 |
| Shewanella sp. ANA-3 | Shewana3_2961 | | N-6 DNA methylase (RefSeq) | cofit | 25 | 47 |
| Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS20480 | | restriction endonuclease subunit S | cofit | 24 | 57 |
| Paraburkholderia graminis OAS925 | ABIE53_005413 | | type I restriction enzyme M protein | insig. | 24 | 43 |
| Rhodanobacter sp. FW510-T8 | OKGIIK_15900 | | Site-specific DNA-methyltransferase (adenine-specific) | insig. | 22 | 39 |
| Rahnella sp. WP5 | EX31_RS04290 | | N-6 DNA methylase | insig. | 25 | 48 |
| Phaeobacter inhibens DSM 17395 | PGA1_c30710 | | putative type I restriction-modification system, M subunit | insig. | 21 | 46 |
| Bacteroides ovatus ATCC 8483 | BACOVA_04171 | | putative type I restriction-modification system, M subunit | insig. | 23 | 28 |
| Bacteroides ovatus ATCC 8483 | BACOVA_04172 | | putative type I restriction-modification system, M subunit | insig. | 23 | 44 |
| Shewanella sp. ANA-3 | Shewana3_3794 | | type I restriction-modification system, M subunit (RefSeq) | insig. | 23 | 47 |
| Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.616.1 | | Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72) | insig. | 23 | 50 |
| Dickeya dianthicola ME23 | DZA65_RS04770 | | type I restriction-modification system subunit M | insig. | 22 | 36 |
| Bacteroides thetaiotaomicron VPI-5482 | BT4538 | | Type I restriction enzyme EcoR124II M protein (NCBI ptt file) | cofit | 22 | 43 |
| Parabacteroides merdae CL09T00C40 | HMPREF1078_RS03170 | | type I restriction-modification system subunit M | insig. | 22 | 43 |
| Shewanella oneidensis MR-1 | SO0383 | hsdM-1 | type I restriction-modification system, M subunit (NCBI ptt file) | insig. | 22 | 45 |
| Rhodanobacter denitrificans FW104-10B01 | LRK54_RS10475 | | type I restriction-modification system subunit M | cofit | 23 | 39 |
| Rhodanobacter denitrificans FW104-10B01 | LRK54_RS02855 | | type I restriction-modification system subunit M | strong | 22 | 50 |
| Rhodanobacter denitrificans MT42 | LRK55_RS10115 | | N-6 DNA methylase | cofit | 24 | 38 |
| Bacteroides stercoris CC31F | HMPREF1181_RS11430 | | N-6 DNA methylase | no data | 20 | 39 |
| Sinorhizobium meliloti 1021 | SMc02296 | | modification enzyme transmembrane protein | insig. | 25 | 25 |
| Rhodanobacter sp. FW510-T8 | OKGIIK_06680 | | Site-specific DNA-methyltransferase (adenine-specific) | cofit | 23 | 39 |
| Shewanella sp. ANA-3 | Shewana3_4240 | | N-6 DNA methylase (RefSeq) | sig. | 26 | 27 |
| Mycobacterium tuberculosis H37Rv | Rv2756c | | Possible type I restriction/modification system DNA methylase HsdM (M protein) (DNA methyltransferase) | insig. | 30 | 20 |
| Rhodanobacter denitrificans FW104-10B01 | LRK54_RS09055 | | type I restriction-modification system subunit M | insig. | 23 | 39 |
| Mucilaginibacter yixingensis YX-36 DSM 26809 | ABZR88_RS16855 | | class I SAM-dependent DNA methyltransferase | no data | 23 | 38 |
| Methanococcus maripaludis JJ | MMJJ_RS02740 | | type I restriction-modification system subunit M | no data | 22 | 46 |
| Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_06635 | | DNA methyltransferase | insig. | 31 | 12 |
| Rhodanobacter sp. FW510-T8 | OKGIIK_08965 | | Site-specific DNA-methyltransferase (adenine-specific) | insig. | 23 | 31 |
| Kangiella aquimarina DSM 16071 | B158DRAFT_1644 | | Type I restriction-modification system methyltransferase subunit | insig. | 22 | 55 |
| Pseudomonas stutzeri RCH2 | Psest_4048 | | Type I restriction-modification system methyltransferase subunit | insig. | 23 | 38 |
| Azospirillum sp. SherDot2 | MPMX19_00135 | | hypothetical protein | cofit | 22 | 41 |
| Castellaniella sp019104865 MT123 | ABCV34_RS11955 | | class I SAM-dependent DNA methyltransferase | insig. | 31 | 11 |
| Phocaeicola dorei CL03T12C01 | ABI39_RS16110 | | N-6 DNA methylase | insig. | 25 | 19 |
| Klebsiella michiganensis M5al | BWI76_RS03365 | | N-6 DNA methylase | insig. | 29 | 19 |
| Bacteroides stercoris CC31F | HMPREF1181_RS10225 | | N-6 DNA methylase | insig. | 23 | 20 |
| Methanococcus maripaludis JJ | MMJJ_RS09005 | | N-6 DNA methylase | sig. | 18 | 36 |
| Pectobacterium carotovorum WPP14 | HER17_RS08020 | | N-6 DNA methylase | cofit | 25 | 28 |