Conservation of cofitness between BWI76_RS06780 and BWI76_RS20925 in Klebsiella michiganensis M5al

58 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS06780 MexE family multidrug efflux RND transporter periplasmic adaptor subunit 1.0 BWI76_RS20925 peptidase M48 0.40 14
Enterobacter sp. TBS_079 0.87 MPMX20_01065 Multidrug efflux pump subunit AcrA 0.86 MPMX20_03344 Beta-barrel assembly-enhancing protease 0.32 82
Enterobacter asburiae PDN3 0.84 EX28DRAFT_2495 RND family efflux transporter, MFP subunit 0.87 EX28DRAFT_0178 Putative Zn-dependent protease, contains TPR repeats low > 76
Escherichia coli ECRC62 0.83 BNILDI_22550 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.86 BNILDI_12295 bepA beta-barrel assembly-enhancing protease low > 75
Escherichia coli HS(pFamp)R (ATCC 700891) 0.83 OHPLBJKB_03211 Multidrug efflux pump subunit AcrA 0.86 OHPLBJKB_01232 Beta-barrel assembly-enhancing protease 0.61 6
Escherichia coli ECRC100 0.83 OKFHMN_08200 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.86 OKFHMN_21835 bepA beta-barrel assembly-enhancing protease low > 80
Escherichia coli BL21 0.83 ECD_00414 multidrug efflux system 0.86 ECD_02386 OM protein maintenance and assembly metalloprotease and chaperone, periplasmic
Escherichia coli BW25113 0.83 b0463 acrA multidrug efflux system (NCBI) 0.86 b2494 yfgC predicted peptidase (NCBI) 0.49 3
Escherichia coli ECRC99 0.83 KEDOAH_19765 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.86 KEDOAH_06385 bepA beta-barrel assembly-enhancing protease
Escherichia coli ECRC102 0.83 NIAGMN_06255 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.86 NIAGMN_19605 bepA beta-barrel assembly-enhancing protease
Escherichia coli ECRC101 0.83 MCAODC_27425 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.86 MCAODC_12365 bepA beta-barrel assembly-enhancing protease low > 87
Escherichia coli ECRC98 0.83 JDDGAC_11850 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.86 JDDGAC_25780 bepA beta-barrel assembly-enhancing protease low > 86
Escherichia coli ECOR27 0.83 NOLOHH_01135 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.86 NOLOHH_13485 bepA beta-barrel assembly-enhancing protease low > 75
Escherichia coli Nissle 1917 0.82 ECOLIN_RS02755 multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.86 ECOLIN_RS14165 beta-barrel assembly-enhancing protease
Escherichia fergusonii Becca 0.82 EFB2_03595 Multidrug efflux pump subunit AcrA 0.86 EFB2_01404 Beta-barrel assembly-enhancing protease low > 86
Escherichia coli ECOR38 0.82 HEPCGN_06815 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.85 HEPCGN_21000 bepA beta-barrel assembly-enhancing protease low > 87
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.78 GFF4380 Membrane fusion protein of RND family multidrug efflux pump 0.86 GFF2175 Exported zinc metalloprotease YfgC precursor low > 78
Pantoea sp. MT58 0.74 IAI47_14510 efflux RND transporter periplasmic adaptor subunit 0.72 IAI47_05205 M48 family metallopeptidase low > 76
Rahnella sp. WP5 0.74 EX31_RS22475 efflux RND transporter periplasmic adaptor subunit 0.68 EX31_RS22720 M48 family metallopeptidase low > 89
Erwinia tracheiphila SCR3 0.74 LU632_RS18180 efflux RND transporter periplasmic adaptor subunit 0.70 LU632_RS08305 M48 family metallopeptidase
Serratia liquefaciens MT49 0.74 IAI46_05190 multidrug efflux RND transporter periplasmic adaptor subunit SdeX 0.69 IAI46_18840 M48 family metallopeptidase low > 86
Dickeya dadantii 3937 0.71 DDA3937_RS05740 efflux RND transporter periplasmic adaptor subunit 0.67 DDA3937_RS06050 M48 family metallopeptidase low > 74
Dickeya dianthicola 67-19 0.69 HGI48_RS05795 efflux RND transporter periplasmic adaptor subunit 0.67 HGI48_RS06095 M48 family metallopeptidase low > 71
Dickeya dianthicola ME23 0.69 DZA65_RS06120 efflux RND transporter periplasmic adaptor subunit 0.67 DZA65_RS06445 M48 family metallopeptidase low > 75
Pectobacterium carotovorum WPP14 0.68 HER17_RS15735 efflux RND transporter periplasmic adaptor subunit 0.69 HER17_RS15440 M48 family metallopeptidase low > 75
Pseudomonas fluorescens FW300-N2E2 0.51 Pf6N2E2_2823 Multidrug efflux RND membrane fusion protein MexC 0.23 Pf6N2E2_2752 Exported zinc metalloprotease YfgC precursor low > 103
Pseudomonas fluorescens FW300-N2C3 0.51 AO356_04875 antibiotic transporter 0.22 AO356_04555 peptidase M48 0.43 39
Pseudomonas syringae pv. syringae B728a 0.51 Psyr_4007 Secretion protein HlyD 0.22 Psyr_1543 Peptidase M48, Ste24p 0.45 11
Pseudomonas sp. RS175 0.51 PFR28_00632 putative efflux pump periplasmic linker TtgA 0.23 PFR28_00694 Beta-barrel assembly-enhancing protease 0.21 43
Pseudomonas syringae pv. syringae B728a ΔmexB 0.51 Psyr_4007 Secretion protein HlyD 0.22 Psyr_1543 Peptidase M48, Ste24p low > 86
Pseudomonas sp. S08-1 0.50 OH686_16045 Multidrug efflux system, membrane fusion component 0.22 OH686_19195 Exported zinc metalloprotease YfgC precursor low > 80
Pseudomonas stutzeri RCH2 0.48 Psest_0309 RND family efflux transporter, MFP subunit 0.22 Psest_1510 Putative Zn-dependent protease, contains TPR repeats 0.42 3
Pseudomonas fluorescens GW456-L13 0.48 PfGW456L13_4580 Multidrug efflux RND membrane fusion protein MexC 0.21 PfGW456L13_4512 Exported zinc metalloprotease YfgC precursor low > 87
Pseudomonas fluorescens SBW25 0.48 PFLU_RS06810 efflux RND transporter periplasmic adaptor subunit 0.21 PFLU_RS07250 M48 family metallopeptidase low > 109
Pseudomonas fluorescens SBW25-INTG 0.48 PFLU_RS06810 efflux RND transporter periplasmic adaptor subunit 0.21 PFLU_RS07250 M48 family metallopeptidase 0.47 15
Pseudomonas simiae WCS417 0.48 PS417_06775 antibiotic transporter 0.21 PS417_07140 peptidase M48 0.39 51
Pseudomonas putida KT2440 0.48 PP_1386 Probable efflux pump periplasmic linker TtgA 0.23 PP_1232 conserved exported protein of unknown function 0.40 12
Pseudomonas fluorescens FW300-N1B4 0.48 Pf1N1B4_3247 Multidrug efflux RND membrane fusion protein MexC 0.21 Pf1N1B4_3327 Exported zinc metalloprotease YfgC precursor
Herbaspirillum seropedicae SmR1 0.47 HSERO_RS06810 hemolysin D 0.19 HSERO_RS03305 peptidase M48 low > 78
Pseudomonas fluorescens FW300-N2E3 0.47 AO353_17300 antibiotic transporter 0.22 AO353_17645 peptidase M48 0.38 52
Paraburkholderia sabiae LMG 24235 0.46 QEN71_RS29870 efflux RND transporter periplasmic adaptor subunit 0.14 QEN71_RS02380 M48 family metalloprotease low > 153
Burkholderia phytofirmans PsJN 0.46 BPHYT_RS34600 hemolysin D 0.14 BPHYT_RS16315 peptidase M48 Ste24p low > 109
Dyella japonica UNC79MFTsu3.2 0.45 ABZR86_RS18280 efflux RND transporter periplasmic adaptor subunit 0.19 ABZR86_RS00725 M48 family metalloprotease low > 74
Shewanella amazonensis SB2B 0.44 Sama_3553 multidrug resistance protein AcrA/AcrE family (RefSeq) 0.37 Sama_1913 peptidase M48, Ste24p (RefSeq) 0.48 30
Ralstonia solanacearum IBSBF1503 0.44 RALBFv3_RS19790 efflux RND transporter periplasmic adaptor subunit 0.16 RALBFv3_RS12125 peptidase M48 low > 76
Ralstonia solanacearum UW163 0.44 UW163_RS19385 efflux RND transporter periplasmic adaptor subunit 0.16 UW163_RS01485 peptidase M48
Ralstonia sp. UNC404CL21Col 0.44 ABZR87_RS05310 efflux RND transporter periplasmic adaptor subunit 0.16 ABZR87_RS08020 M48 family metalloprotease low > 80
Ralstonia solanacearum GMI1000 0.44 RS_RS21035 efflux RND transporter periplasmic adaptor subunit 0.16 RS_RS02810 peptidase M48 low > 80
Shewanella oneidensis MR-1 0.44 SO4693 multidrug resistance protein, AcrA/AcrE family (NCBI ptt file) 0.39 SO2869 conserved hypothetical protein (NCBI ptt file) 0.35 41
Shewanella sp. ANA-3 0.44 Shewana3_4046 RND family efflux transporter MFP subunit (RefSeq) 0.39 Shewana3_1649 peptidase M48, Ste24p (RefSeq) 0.49 9
Ralstonia solanacearum PSI07 0.44 RPSI07_RS23900 efflux RND transporter periplasmic adaptor subunit 0.16 RPSI07_RS21205 peptidase M48 low > 81
Acinetobacter radioresistens SK82 0.40 MPMX26_00690 Multidrug efflux pump subunit AcrA 0.18 MPMX26_01126 Beta-barrel assembly-enhancing protease
Variovorax sp. OAS795 0.38 ABID97_RS00320 efflux RND transporter periplasmic adaptor subunit 0.13 ABID97_RS02095 M48 family metalloprotease low > 91
Acidovorax sp. GW101-3H11 0.34 Ac3H11_4449 RND efflux system, membrane fusion protein CmeA 0.12 Ac3H11_1239 Peptidase M48, Ste24p precursor 0.53 3
Rhodanobacter sp. FW510-T8 0.34 OKGIIK_09165 acrA efflux transporter periplasmic adaptor subunit 0.18 OKGIIK_03795 Putative beta-barrel assembly-enhancing protease low > 52
Kangiella aquimarina DSM 16071 0.33 B158DRAFT_0734 RND family efflux transporter, MFP subunit 0.25 B158DRAFT_2440 Putative Zn-dependent protease, contains TPR repeats low > 40
Castellaniella sp019104865 MT123 0.33 ABCV34_RS04230 efflux RND transporter periplasmic adaptor subunit 0.14 ABCV34_RS07945 M48 family metalloprotease low > 48
Rhodanobacter denitrificans FW104-10B01 0.31 LRK54_RS02095 efflux RND transporter periplasmic adaptor subunit 0.19 LRK54_RS15035 M48 family metalloprotease low > 59
Rhodanobacter denitrificans MT42 0.31 LRK55_RS01870 efflux RND transporter periplasmic adaptor subunit 0.19 LRK55_RS14750 M48 family metalloprotease low > 63

Not shown: 15 genomes with orthologs for BWI76_RS06780 only; 7 genomes with orthologs for BWI76_RS20925 only