Conservation of cofitness between BWI76_RS19375 and BWI76_RS01275 in Klebsiella michiganensis M5al

58 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 1.0 BWI76_RS01275 LysR family transcriptional regulator 0.28 7
Escherichia coli ECRC100 0.93 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 OKFHMN_14330 metR HTH-type transcriptional regulator MetR low > 80
Escherichia coli ECRC99 0.93 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 KEDOAH_13820 metR HTH-type transcriptional regulator MetR — —
Escherichia coli ECRC98 0.93 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 JDDGAC_17955 metR HTH-type transcriptional regulator MetR low > 86
Escherichia coli ECRC101 0.93 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 MCAODC_04835 metR HTH-type transcriptional regulator MetR low > 87
Escherichia coli ECRC102 0.93 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 NIAGMN_12085 metR HTH-type transcriptional regulator MetR — —
Escherichia coli ECOR27 0.93 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 NOLOHH_06460 metR HTH-type transcriptional regulator MetR low > 75
Escherichia coli BW25113 0.93 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.92 b3828 metR DNA-binding transcriptional activator, homocysteine-binding (NCBI) 0.69 8
Escherichia coli HS(pFamp)R (ATCC 700891) 0.93 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.92 OHPLBJKB_04223 HTH-type transcriptional regulator MetR low > 73
Escherichia coli ECRC62 0.93 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 BNILDI_05070 metR HTH-type transcriptional regulator MetR low > 75
Escherichia fergusonii Becca 0.92 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.92 EFB2_04809 HTH-type transcriptional regulator MetR low > 86
Escherichia coli BL21 0.92 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.92 ECD_03707 methionine biosynthesis regulon transcriptional regulator low > 61
Escherichia coli ECOR38 0.92 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 HEPCGN_13030 metR HTH-type transcriptional regulator MetR 0.69 55
Escherichia coli Nissle 1917 0.91 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 ECOLIN_RS30005 HTH-type transcriptional regulator MetR — —
Enterobacter sp. TBS_079 0.90 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.92 MPMX20_04452 HTH-type transcriptional regulator MetR low > 85
Enterobacter asburiae PDN3 0.90 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.92 EX28DRAFT_4493 Transcriptional regulator low > 76
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.90 GFF253 Transcriptional activator MetR low > 78
Pectobacterium carotovorum WPP14 0.79 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.81 HER17_RS20690 HTH-type transcriptional regulator MetR 0.80 32
Serratia liquefaciens MT49 0.77 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 IAI46_01030 HTH-type transcriptional regulator MetR 0.42 86
Rahnella sp. WP5 0.77 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.85 EX31_RS25370 HTH-type transcriptional regulator MetR 0.38 47
Dickeya dianthicola 67-19 0.76 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 HGI48_RS00815 HTH-type transcriptional regulator MetR 0.82 7
Dickeya dadantii 3937 0.76 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 DDA3937_RS20385 HTH-type transcriptional regulator MetR 0.82 4
Dickeya dianthicola ME23 0.76 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 DZA65_RS00870 HTH-type transcriptional regulator MetR 0.83 11
Erwinia tracheiphila SCR3 0.75 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.77 LU632_RS24035 metR HTH-type transcriptional regulator MetR low > 74
Pantoea sp. MT58 0.75 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.78 IAI47_18315 HTH-type transcriptional regulator MetR 0.45 25
Paraburkholderia sabiae LMG 24235 0.54 QEN71_RS06305 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.31 QEN71_RS19730 LysR family transcriptional regulator — —
Burkholderia phytofirmans PsJN 0.52 BPHYT_RS12250 phosphomethylpyrimidine kinase 0.37 BPHYT_RS26650 LysR family transcriptional regulator — —
Agrobacterium fabrum C58 0.46 Atu3290 phosphomethylpyrimidine kinase 0.29 Atu3827 LysR family transcriptional regulator low > 89
Castellaniella sp019104865 MT123 0.44 ABCV34_RS14505 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.38 ABCV34_RS04450 LysR substrate-binding domain-containing protein — —
Vibrio cholerae E7946 ATCC 55056 0.40 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.55 CSW01_08580 HTH-type transcriptional regulator MetR low > 62
Dinoroseobacter shibae DFL-12 0.38 Dshi_0915 phosphomethylpyrimidine kinase (RefSeq) 0.37 Dshi_2079 transcriptional regulator, LysR family (RefSeq) low > 64
Azospirillum brasilense Sp245 0.36 AZOBR_RS07045 phosphomethylpyrimidine kinase 0.28 AZOBR_RS24270 LysR family transcriptional regulator — —
Ralstonia solanacearum GMI1000 0.36 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.36 RS_RS20365 LysR family transcriptional regulator — —
Ralstonia sp. UNC404CL21Col 0.36 ABZR87_RS04830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.35 ABZR87_RS20875 LysR family transcriptional regulator — —
Ralstonia solanacearum UW163 0.35 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.35 UW163_RS18860 LysR family transcriptional regulator — —
Ralstonia solanacearum IBSBF1503 0.35 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.35 RALBFv3_RS20315 LysR family transcriptional regulator — —
Ralstonia solanacearum PSI07 0.35 RPSI07_RS23455 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.36 RPSI07_RS02550 LysR family transcriptional regulator — —
Variovorax sp. OAS795 0.35 ABID97_RS15330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.34 ABID97_RS19400 LysR family transcriptional regulator — —
Azospirillum sp. SherDot2 0.34 MPMX19_06182 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.28 MPMX19_00645 HTH-type transcriptional regulator MetR — —
Acidovorax sp. GW101-3H11 0.33 Ac3H11_1063 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.35 Ac3H11_2344 Transcriptional activator MetR — —
Cupriavidus basilensis FW507-4G11 0.32 RR42_RS01370 phosphomethylpyrimidine kinase 0.35 RR42_RS30655 LysR family transcriptional regulator — —
Mucilaginibacter yixingensis YX-36 DSM 26809 0.31 ABZR88_RS08810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.21 ABZR88_RS03450 LysR family transcriptional regulator low > 71
Xanthomonas campestris pv. campestris strain 8004 0.30 Xcc-8004.3091.1 hypothetical protein 0.31 Xcc-8004.400.1 Transcriptional activator MetR low > 74
Pseudomonas fluorescens SBW25-INTG 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.42 PFLU_RS05540 LysR family transcriptional regulator low > 109
Pseudomonas fluorescens SBW25 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.42 PFLU_RS05540 LysR family transcriptional regulator low > 109
Pseudomonas simiae WCS417 0.23 PS417_24600 hydrogenase 0.42 PS417_05455 XRE family transcriptional regulator low > 88
Pseudomonas putida KT2440 0.22 PP_4782 Phosphomethylpyrimidine kinase 0.42 PP_1063 DNA-binding transcriptional regulator, homocysteine-binding low > 96
Pseudomonas fluorescens GW456-L13 0.22 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.42 PfGW456L13_4778 Transcriptional activator MetR low > 87
Pseudomonas fluorescens FW300-N2E3 0.22 AO353_06350 hydrogenase 0.42 AO353_16210 XRE family transcriptional regulator low > 101
Pseudomonas fluorescens FW300-N2C3 0.22 AO356_15435 hydrogenase 0.43 AO356_17735 XRE family transcriptional regulator low > 104
Pseudomonas stutzeri RCH2 0.21 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.43 Psest_1450 Transcriptional regulator — —
Pseudomonas syringae pv. syringae B728a ΔmexB 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.43 Psyr_3917 transcriptional regulator, LysR family low > 86
Pseudomonas syringae pv. syringae B728a 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.43 Psyr_3917 transcriptional regulator, LysR family low > 86
Acinetobacter radioresistens SK82 0.21 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.35 MPMX26_01201 HTH-type transcriptional regulator MetR — —
Pseudomonas sp. RS175 0.20 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.43 PFR28_03478 HTH-type transcriptional regulator MetR low > 88
Pseudomonas fluorescens FW300-N1B4 0.18 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.42 Pf1N1B4_784 Transcriptional activator MetR low > 87
Pseudomonas fluorescens FW300-N2E2 0.18 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.42 Pf6N2E2_5471 Transcriptional activator MetR low > 103
Herbaspirillum seropedicae SmR1 0.18 HSERO_RS02135 phosphomethylpyrimidine kinase 0.33 HSERO_RS22770 LysR family transcriptional regulator low > 78
Phaeobacter inhibens DSM 17395 0.17 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.36 PGA1_c11710 transcriptional regulator, LysR family low > 62

Not shown: 30 genomes with orthologs for BWI76_RS19375 only; 8 genomes with orthologs for BWI76_RS01275 only