| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Xanthobacter sp. DMC5 | GFF2199 | | hypothetical protein | insig. | 100 | 100 |
| | Azospirillum sp. SherDot2 | MPMX19_00136 | | hypothetical protein | cofit | 32 | 76 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS01815 | | restriction endonuclease subunit S | cofit | 38 | 45 |
| | Klebsiella michiganensis M5al | BWI76_RS03675 | | restriction modification system DNA specificity domain-containing protein | insig. | 40 | 32 |
| | Pseudomonas segetis P6 | ACVTMO_RS09865 | | restriction endonuclease subunit S | insig. | 35 | 42 |
| | Escherichia fergusonii Becca | EFB2_04102 | | hypothetical protein | insig. | 44 | 32 |
| | Shewanella sp. ANA-3 | Shewana3_3793 | | restriction modification system DNA specificity subunit (RefSeq) | insig. | 26 | 82 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_4441 | | Restriction endonuclease S subunits | insig. | 26 | 67 |
| | Shewanella oneidensis MR-1 | SO0382 | hsdS-1 | type I restriction-modification system, S subunit (NCBI ptt file) | insig. | 28 | 72 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_1643 | | Restriction endonuclease S subunits | insig. | 37 | 36 |
| | Fusobacterium nucleatum SB010 | HUW76_09000 | | restriction endonuclease subunit S | insig. | 26 | 70 |
| | Alteromonas macleodii MIT1002 | MIT1002_04091 | | EcoKI restriction-modification system protein HsdS | insig. | 23 | 75 |
| | Sphingobium sp. HT1-2 | GFF5345 | | Type I restriction-modification system, specificity subunit S | cofit | 35 | 29 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_15905 | | hypothetical protein | insig. | 26 | 69 |
| | Mycobacterium tuberculosis H37Rv | Rv2755c | | Possible type I restriction/modification system specificity determinant (fragment) HsdS.1 (S protein) | insig. | 43 | 24 |
| | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS08650 | | restriction endonuclease subunit S | insig. | 25 | 66 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS01815 | | restriction endonuclease subunit S | cofit | 27 | 62 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU1705 | | type I restriction-modification enzyme, S subunit (TIGR) | insig. | 26 | 64 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS00030 | | restriction endonuclease subunit S | no data | 25 | 40 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.1524.1 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | insig. | 27 | 67 |
| | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_14265 | | Restriction endonuclease subunit S | no data | 25 | 64 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS18680 | | hypothetical protein | insig. | 25 | 63 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS02840 | | restriction endonuclease subunit S | sig. | 23 | 90 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS19490 | | restriction endonuclease subunit S | insig. | 23 | 58 |
| | Shewanella sp. ANA-3 | Shewana3_2960 | | restriction modification system DNA specificity subunit (RefSeq) | cofit | 26 | 38 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1064 | | type I restriction-modification | insig. | 26 | 64 |
| | Paraburkholderia graminis OAS925 | ABIE53_000532 | | type I restriction enzyme S subunit | insig. | 26 | 65 |
| | Rhodanobacter denitrificans MT42 | LRK55_RS00335 | | restriction endonuclease subunit S | cofit | 22 | 84 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4541 | | putative Type I restriction modification DNA specificity protein (NCBI ptt file) | cofit | 29 | 24 |
| | Shewanella oneidensis MR-1 | SO4264 | hsdS-2 | type I restriction-modification system, S subunit (NCBI ptt file) | insig. | 24 | 38 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS01155 | | restriction endonuclease subunit S | sig. | 21 | 93 |
| | Acinetobacter radioresistens SK82 | MPMX26_02869 | | hypothetical protein | strong | 20 | 98 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS05385 | | restriction endonuclease subunit S | insig. | 25 | 64 |
| | Escherichia coli ECRC100 | OKFHMN_05700 | | restriction endonuclease | insig. | 24 | 66 |
| | Mycobacterium tuberculosis H37Rv | Rv2761c | | Possible type I restriction/modification system specificity determinant HsdS (S protein) | insig. | 22 | 36 |
| | Pseudomonas orientalis W4I3 | QF045_RS26415 | | restriction endonuclease subunit S | cofit | 26 | 40 |
| | Dickeya dianthicola ME23 | DZA65_RS04765 | | restriction endonuclease subunit S | insig. | 23 | 64 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS11945 | | restriction endonuclease subunit S | insig. | 29 | 22 |
| | Cellulophaga baltica 18 | M666_RS14695 | | restriction endonuclease subunit S | insig. | 28 | 35 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_02138 | | type I restriction enzyme, S subunit | insig. | 26 | 73 |
| | Vibrio cholerae E7946 ATCC 55056 | CSW01_08870 | | restriction endonuclease subunit S | insig. | 26 | 44 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4543 | | putative type I restriction enzyme specificity protein (NCBI ptt file) | sig. | 23 | 65 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c30700 | | putative type I restriction-modification system, S subunit | insig. | 34 | 17 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_05325 | | type I restriction modification DNA specificity domain protein | cofit | 24 | 63 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS03195 | | restriction endonuclease subunit S | insig. | 22 | 68 |
| | Cellulophaga baltica 18 | M666_RS14695 | | restriction endonuclease subunit S | insig. | 21 | 81 |
| | Shewanella oneidensis MR-1 | SO0382 | hsdS-1 | type I restriction-modification system, S subunit (NCBI ptt file) | insig. | 27 | 28 |
| | Pseudomonas stutzeri RCH2 | Psest_3406 | | Restriction endonuclease S subunits | sig. | 23 | 86 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF1000 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | insig. | 26 | 35 |
| | Cellulophaga baltica 18 | M666_RS02035 | | restriction endonuclease subunit S | cofit | 37 | 13 |
| | Methanococcus maripaludis JJ | MMJJ_RS02750 | | restriction endonuclease subunit S | no data | 31 | 29 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_06655 | | hypothetical protein | insig. | 20 | 40 |
| | Marinobacter adhaerens HP15 | HP15_1579 | | type I site-specific restriction-modification system, S subunit | sig. | 23 | 66 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS05385 | | restriction endonuclease subunit S | insig. | 33 | 20 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS10480 | | restriction endonuclease subunit S | cofit | 22 | 38 |