| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Dickeya dianthicola ME23 | DZA65_RS03370 | | type I restriction endonuclease subunit R | insig. | 100 | 100 |
| o | Pantoea agglomerans CFBP13505 P0401 | PagCFBP13516_RS04590 | | type I restriction endonuclease subunit R | cofit | 83 | 100 |
| o | Pseudomonas orientalis W4I3 | QF045_RS26425 | | type I restriction endonuclease | insig. | 75 | 100 |
| | Shewanella sp. ANA-3 | Shewana3_3790 | | HsdR family type I site-specific deoxyribonuclease (RefSeq) | cofit | 26 | 67 |
| | Shewanella oneidensis MR-1 | SO0380 | hsdR-1 | type I restriction-modification system, R subunit (NCBI ptt file) | insig. | 24 | 67 |
| | Alteromonas macleodii MIT1002 | MIT1002_04087 | | Type-1 restriction enzyme R protein | insig. | 27 | 60 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU1703 | | type I restriction-modification enzyme, R subunit (TIGR) | insig. | 25 | 72 |
| | Dickeya dianthicola ME23 | DZA65_RS04740 | | HsdR family type I site-specific deoxyribonuclease | insig. | 24 | 66 |
| | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_14280 | | DEAD/DEAH box helicase | no data | 26 | 58 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.1523.1 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | strong | 24 | 68 |
| | Cellulophaga baltica 18 | M666_RS02045 | | type I restriction endonuclease subunit R | cofit | 26 | 60 |
| | Sinorhizobium meliloti 1021 | SMc02292 | | type I restriction enzyme R protein | insig. | 24 | 67 |
| | Alteromonas macleodii MIT1002 | MIT1002_00593 | | Type I restriction enzyme EcoR124II R protein | cofit | 26 | 59 |
| | Escherichia coli ECRC100 | OKFHMN_05715 | | restriction endonuclease subunit R | cofit | 24 | 66 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS05380 | | HsdR family type I site-specific deoxyribonuclease | insig. | 24 | 76 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_13425 | | DEAD/DEAH box helicase | insig. | 23 | 70 |
| | Escherichia coli ECRC62 | BNILDI_07600 | hsdR | Type I restriction enzyme EcoR124II endonuclease subunit | insig. | 26 | 60 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS01835 | | type I restriction endonuclease subunit R | cofit | 25 | 67 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF2633 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | no data | 25 | 59 |
| | Paraburkholderia graminis OAS925 | ABIE53_000533 | | type I restriction enzyme R subunit | insig. | 25 | 59 |
| | Shewanella sp. ANA-3 | Shewana3_4244 | | HsdR family type I site-specific deoxyribonuclease (RefSeq) | insig. | 25 | 61 |
| | Azospirillum sp. SherDot2 | MPMX19_00137 | | hypothetical protein | cofit | 25 | 63 |
| | Alteromonas macleodii MIT1002 | MIT1002_03210 | | Type-1 restriction enzyme R protein | insig. | 25 | 62 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS09190 | | type I restriction endonuclease subunit R | insig. | 24 | 64 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS15095 | | type I restriction endonuclease subunit R | no data | 25 | 59 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS08925 | | type I restriction endonuclease subunit R | insig. | 25 | 59 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04167 | | type I site-specific deoxyribonuclease, HsdR family | insig. | 26 | 47 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_02139 | | type I restriction enzyme, R subunit | insig. | 26 | 40 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_05330 | | type I site-specific deoxyribonuclease, HsdR family | cofit | 25 | 41 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_4436 | | type I site-specific deoxyribonuclease, HsdR family | insig. | 24 | 60 |
| | Pseudomonas segetis P6 | ACVTMO_RS09885 | | type I restriction endonuclease subunit R | insig. | 24 | 74 |
| | Xanthobacter sp. DMC5 | GFF2200 | | hypothetical protein | insig. | 25 | 47 |
| | Herbaspirillum seropedicae SmR1 | HSERO_RS22780 | | DEAD/DEAH box helicase | insig. | 25 | 44 |
| | Escherichia fergusonii Becca | EFB2_04103 | | hypothetical protein | insig. | 23 | 63 |
| | Escherichia coli Nissle 1917 | ECOLIN_RS24950 | | HsdR family type I site-specific deoxyribonuclease | insig. | 23 | 63 |
| | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS08640 | | HsdR family type I site-specific deoxyribonuclease | insig. | 24 | 67 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_1641 | | type I site-specific deoxyribonuclease, HsdR family | insig. | 25 | 46 |
| | Escherichia coli ECOR38 | HEPCGN_10720 | | type I restriction endonuclease | insig. | 23 | 63 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_06705 | | Type I restriction enzyme endonuclease subunit | insig. | 26 | 39 |
| | Pseudomonas stutzeri RCH2 | Psest_4044 | | type I site-specific deoxyribonuclease, HsdR family | strong | 26 | 40 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c30690 | | putative type I restriction-modification system, R subunit | insig. | 25 | 39 |
| | Klebsiella michiganensis M5al | BWI76_RS03670 | | type I restriction-modification system subunit R | insig. | 23 | 63 |
| | Fusobacterium nucleatum SB010 | HUW76_08985 | | type I restriction endonuclease subunit R | strong | 26 | 40 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.611.1 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | insig. | 25 | 43 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS18675 | | restriction endonuclease subunit R | insig. | 25 | 40 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS11910 | | type I restriction endonuclease subunit R | insig. | 24 | 44 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_06660 | | type I restriction-modification system endonuclease | insig. | 24 | 60 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS02835 | | type I restriction endonuclease subunit R | insig. | 23 | 60 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_15915 | | Type I restriction enzyme endonuclease subunit | insig. | 24 | 39 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS03160 | | type I restriction endonuclease subunit R | cofit | 24 | 40 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4535 | | Type I restriction enzyme EcoR124II R protein (NCBI ptt file) | cofit | 25 | 39 |
| | Shewanella sp. ANA-3 | Shewana3_4164 | | HsdR family type I site-specific deoxyribonuclease (RefSeq) | insig. | 24 | 39 |
| | Methanococcus maripaludis JJ | MMJJ_RS02745 | | type I restriction endonuclease subunit R | no data | 23 | 44 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_08955 | | Type I restriction enzyme endonuclease subunit | insig. | 31 | 20 |
| | Cellulophaga baltica 18 | M666_RS14665 | | hypothetical protein | sig. | 42 | 9 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_02139 | | type I restriction enzyme, R subunit | insig. | 36 | 10 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS10495 | | type I restriction endonuclease subunit R | cofit | 29 | 18 |
| | Rhodanobacter denitrificans MT42 | LRK55_RS10135 | | type I restriction endonuclease subunit R | cofit | 30 | 18 |
| | Fusobacterium nucleatum SB010 | HUW76_08985 | | type I restriction endonuclease subunit R | strong | 33 | 9 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS18675 | | restriction endonuclease subunit R | insig. | 43 | 7 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4535 | | Type I restriction enzyme EcoR124II R protein (NCBI ptt file) | cofit | 40 | 7 |
| | Methanococcus maripaludis JJ | MMJJ_RS02745 | | type I restriction endonuclease subunit R | no data | 36 | 8 |
| | Pseudomonas sp. DMC3 | GFF4952 | | hypothetical protein | insig. | 45 | 6 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c30690 | | putative type I restriction-modification system, R subunit | insig. | 42 | 8 |
| | Acinetobacter radioresistens SK82 | MPMX26_02867 | | hypothetical protein | insig. | 22 | 62 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS03160 | | type I restriction endonuclease subunit R | cofit | 41 | 6 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_06705 | | Type I restriction enzyme endonuclease subunit | insig. | 29 | 18 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS11910 | | type I restriction endonuclease subunit R | insig. | 25 | 14 |
| | Caulobacter crescentus NA1000 | CCNA_00659 | | type I restriction-modification system restriction subunit | insig. | 21 | 42 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_00659 | | type I restriction-modification system restriction subunit | cofit | 21 | 42 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_15915 | | Type I restriction enzyme endonuclease subunit | insig. | 45 | 6 |
| | Shewanella sp. ANA-3 | Shewana3_4164 | | HsdR family type I site-specific deoxyribonuclease (RefSeq) | insig. | 45 | 5 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_08955 | | Type I restriction enzyme endonuclease subunit | insig. | 42 | 5 |
| | Pseudomonas sp. DMC3 | GFF4952 | | hypothetical protein | insig. | 25 | 21 |
| | Pseudomonas stutzeri RCH2 | Psest_4044 | | type I site-specific deoxyribonuclease, HsdR family | strong | 28 | 9 |
| | Escherichia coli ECOR38 | HEPCGN_09450 | hsdR | DEAD/DEAH box helicase | insig. | 26 | 20 |
| | Escherichia coli ECRC100 | OKFHMN_11410 | hsdR | DEAD/DEAH box helicase | insig. | 26 | 20 |
| | Escherichia coli ECRC101 | MCAODC_01925 | hsdR | DEAD/DEAH box helicase | insig. | 26 | 20 |
| | Escherichia coli ECRC102 | NIAGMN_09260 | hsdR | DEAD/DEAH box helicase | insig. | 26 | 20 |
| | Escherichia coli ECRC98 | JDDGAC_15005 | hsdR | DEAD/DEAH box helicase | insig. | 26 | 20 |
| | Escherichia coli ECRC99 | KEDOAH_16735 | hsdR | DEAD/DEAH box helicase | no data | 26 | 20 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF1002 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | insig. | 25 | 21 |
| | Rhodanobacter denitrificans MT42 | LRK55_RS10135 | | type I restriction endonuclease subunit R | cofit | 36 | 6 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS10495 | | type I restriction endonuclease subunit R | cofit | 36 | 6 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1065 | | DEAD/DEAH box helicase-like | insig. | 32 | 7 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_05330 | | type I site-specific deoxyribonuclease, HsdR family | cofit | 29 | 11 |
| | Xanthobacter sp. DMC5 | GFF2200 | | hypothetical protein | insig. | 35 | 6 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_0384 | | Type I site-specific restriction-modification system, R (restriction) subunit and related helicases | insig. | 22 | 20 |