| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Phocaeicola vulgatus CL09T03C04 | 1.0 | HMPREF1058_RS01405 | | cobyrinate a,c-diamide synthase | 1.0 | HMPREF1058_RS01565 | | iron ABC transporter permease | 0.88 | 4 |
| Phocaeicola dorei CL03T12C01 | 0.98 | ABI39_RS15650 | | cobyrinate a,c-diamide synthase | 1.00 | ABI39_RS15500 | | iron ABC transporter permease | 0.88 | 12 |
| Parabacteroides merdae CL09T00C40 | 0.50 | HMPREF1078_RS09710 | | cobyrinate a,c-diamide synthase | 0.86 | HMPREF1078_RS07465 | | iron ABC transporter permease | 0.53 | 61 |
| Bacteroides stercoris CC31F | 0.40 | HMPREF1181_RS10540 | | cobyrinate a,c-diamide synthase | 0.83 | HMPREF1181_RS10605 | | iron ABC transporter permease | — | — |
| Dinoroseobacter shibae DFL-12 | 0.30 | Dshi_1693 | | cobyrinic acid a,c-diamide synthase (RefSeq) | 0.18 | Dshi_0562 | | transport system permease protein (RefSeq) | — | — |
| Azospirillum brasilense Sp245 | 0.28 | AZOBR_RS16735 | | cobyrinic acid a c-diamide synthase | 0.13 | AZOBR_RS19100 | | iron ABC transporter permease | — | — |
| Klebsiella pneumoniae MKP103 | 0.28 | KDGMDA_03655 | | cobyrinate a c-diamide synthase | 0.24 | KDGMDA_24330 | | vitamin B12 ABC transporter permease BtuC | low | > 95 |
| Methanococcus maripaludis JJ | 0.28 | MMJJ_RS06760 | | Ni-sirohydrochlorin a,c-diamide synthase | 0.19 | MMJJ_RS08265 | | iron ABC transporter permease | low | > 28 |
| Synechocystis sp000284455 PCC 6803 | 0.28 | SGL_RS04180 | | hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing) | 0.19 | SGL_RS01935 | | iron ABC transporter permease | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.28 | GFF3950 | | Cobyrinic acid A,C-diamide synthase | 0.22 | GFF3529 | | Vitamin B12 ABC transporter, permease component BtuC | low | > 78 |
| Sphingobium sp. HT1-2 | 0.27 | GFF1852 | | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing) (EC 6.3.5.9) | 0.16 | GFF312 | | Vitamin B12 ABC transporter, permease protein BtuC | low | > 95 |
| Klebsiella michiganensis M5al | 0.26 | BWI76_RS23090 | | cobyrinic acid a,c-diamide synthase | 0.24 | BWI76_RS17110 | | vitamin B12 ABC transporter permease BtuC | low | > 92 |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.26 | GFF3977 | | Cobyrinic acid A,C-diamide synthase | 0.34 | GFF5755 | | Vitamin B12 ABC transporter, permease component BtuC | — | — |
| Rhizobium sp. OAE497 | 0.26 | ABIE40_RS11105 | | cobyrinate a,c-diamide synthase | 0.21 | ABIE40_RS14430 | | iron ABC transporter permease | low | > 107 |
| Pseudomonas fluorescens SBW25-INTG | 0.26 | PFLU_RS22025 | | cobyrinate a,c-diamide synthase | 0.22 | PFLU_RS25690 | | iron ABC transporter permease | low | > 109 |
| Pseudomonas fluorescens SBW25 | 0.26 | PFLU_RS22025 | | cobyrinate a,c-diamide synthase | 0.22 | PFLU_RS25690 | | iron ABC transporter permease | low | > 109 |
| Pseudomonas simiae WCS417 | 0.26 | PS417_20060 | | cobyrinic acid a,c-diamide synthase | 0.22 | PS417_23850 | | ABC transporter permease | low | > 88 |
| Methylophilus sp. DMC18 | 0.26 | GFF1477 | | Cobyrinate a,c-diamide synthase | 0.19 | GFF2533 | | Vitamin B12 import system permease protein BtuC | low | > 43 |
| Phaeobacter inhibens DSM 17395 | 0.25 | PGA1_c08080 | | putative cobyrinic acid A,C-diamide synthase CobB | 0.20 | PGA1_c26880 | | putative iron transport system permease protein | — | — |
| Pseudomonas sp. RS175 | 0.25 | PFR28_03208 | | Cobyrinate a,c-diamide synthase | 0.21 | PFR28_03709 | | Hemin transport system permease protein HmuU | low | > 88 |
| Sinorhizobium meliloti 1021 | 0.25 | SMc04282 | | cobyrinic acid a,c-diamide synthase | 0.22 | SMc01511 | | hemin transport system permease transmembrane protein | — | — |
| Pseudomonas lactucae CFBP13502 | 0.25 | GEMAOFIL_04209 | | Cobyrinate a,c-diamide synthase | 0.20 | GEMAOFIL_02440 | | Hemin transport system permease protein HmuU | — | — |
| Pseudomonas stutzeri RCH2 | 0.25 | Psest_3013 | | cobyrinic acid a,c-diamide synthase | 0.19 | Psest_1024 | | ABC-type Fe3+-siderophore transport system, permease component | low | > 67 |
| Ralstonia solanacearum IBSBF1503 | 0.25 | RALBFv3_RS20545 | | cobyrinate a,c-diamide synthase | 0.15 | RALBFv3_RS04490 | | iron ABC transporter permease | low | > 76 |
| Ralstonia solanacearum UW163 | 0.25 | UW163_RS18630 | | cobyrinate a,c-diamide synthase | 0.15 | UW163_RS09180 | | iron ABC transporter permease | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.25 | AO353_02635 | | cobyrinic acid a,c-diamide synthase | 0.20 | AO353_14445 | | ABC transporter permease | low | > 101 |
| Pseudomonas aeruginosa PA14 | 0.25 | IKLFDK_06035 | | cobyrinate a c-diamide synthase | 0.18 | IKLFDK_30080 | | ABC transporter permease | low | > 100 |
| Pseudomonas fluorescens FW300-N1B4 | 0.25 | Pf1N1B4_3707 | | Cobyrinic acid A,C-diamide synthase | 0.22 | Pf1N1B4_4814 | | Iron(III) dicitrate transport system permease protein FecD (TC 3.A.1.14.1) | low | > 87 |
| Pseudomonas segetis P6 | 0.25 | MPMX49_01817 | | Cobyrinate a,c-diamide synthase | 0.23 | MPMX49_01264 | | Hemin transport system permease protein HmuU | low | > 75 |
| Pseudomonas putida KT2440 | 0.25 | PP_1673 | | cobyrinate a,c-diamide synthase | 0.17 | PP_4688 | | Heme/hemin ABC transporter, permease protein | low | > 96 |
| Paraburkholderia sabiae LMG 24235 | 0.25 | QEN71_RS08690 | | cobyrinate a,c-diamide synthase | 0.17 | QEN71_RS31160 | | iron ABC transporter permease | low | > 153 |
| Ralstonia solanacearum PSI07 | 0.25 | RPSI07_RS02195 | | cobyrinate a,c-diamide synthase | 0.18 | RPSI07_RS00910 | | iron ABC transporter permease | low | > 81 |
| Dyella japonica UNC79MFTsu3.2 | 0.25 | ABZR86_RS10915 | | cobyrinate a,c-diamide synthase | 0.17 | ABZR86_RS04590 | | iron ABC transporter permease | low | > 74 |
| Acidovorax sp. GW101-3H11 | 0.25 | Ac3H11_986 | | Cobyrinic acid A,C-diamide synthase | 0.17 | Ac3H11_227 | | Hemin ABC transporter, permease protein | low | > 79 |
| Bosea sp. OAE506 | 0.25 | ABIE41_RS01835 | | cobyrinate a,c-diamide synthase | 0.21 | ABIE41_RS02455 | | iron ABC transporter permease | — | — |
| Pseudomonas sp. SVBP6 | 0.25 | COO64_RS07245 | | cobyrinate a,c-diamide synthase | 0.21 | COO64_RS19165 | | iron ABC transporter permease | low | > 93 |
| Pseudomonas sp. BP01 | 0.24 | JOY50_RS27945 | | cobyrinate a,c-diamide synthase | 0.17 | JOY50_RS27720 | | iron ABC transporter permease | low | > 84 |
| Pseudomonas fluorescens FW300-N2C3 | 0.24 | AO356_19140 | | cobyrinic acid a,c-diamide synthase | 0.21 | AO356_28840 | | iron-siderophore ABC transporter permease | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.24 | Pf6N2E2_5738 | | Cobyrinic acid A,C-diamide synthase | 0.22 | Pf6N2E2_1686 | | Iron(III) dicitrate transport system permease protein FecD (TC 3.A.1.14.1) | — | — |
| Variovorax sp. SCN45 | 0.24 | GFF449 | | Cobyrinic acid a,c-diamide synthetase (EC 6.3.5.11) | 0.14 | GFF446 | | Iron(III) dicitrate transport system permease protein FecD (TC 3.A.1.14.1) | low | > 127 |
| Variovorax sp. OAS795 | 0.23 | ABID97_RS17420 | | cobyrinate a,c-diamide synthase | 0.12 | ABID97_RS17405 | | iron ABC transporter permease | — | — |
| Pseudomonas sp. S08-1 | 0.23 | OH686_04985 | | Cobyrinic acid a,c-diamide synthetase | 0.15 | OH686_17300 | | Heme ABC transporter, permease protein HmuU | low | > 80 |
| Rhodanobacter sp. FW510-T8 | 0.23 | OKGIIK_05485 | | cobyrinate a,c-diamide synthase | 0.17 | OKGIIK_05365 | | Fe3+-siderophore ABC transporter permease | low | > 53 |
| Xanthobacter sp. DMC5 | 0.23 | GFF3280 | | Hydrogenobyrinate a,c-diamide synthase | 0.17 | GFF2744 | | Vitamin B12 import system permease protein BtuC | — | — |
| Azospirillum sp. SherDot2 | 0.23 | MPMX19_05562 | | Hydrogenobyrinate a,c-diamide synthase | 0.15 | MPMX19_05168 | | Hemin transport system permease protein HmuU | — | — |
| Ralstonia solanacearum GMI1000 | 0.22 | RS_RS20060 | | cobyrinate a,c-diamide synthase | 0.15 | RS_RS12045 | | iron ABC transporter permease | low | > 80 |
| Desulfovibrio vulgaris Hildenborough JW710 | 0.22 | DVU0405 | cobB-1 | cobyrinic acid a,c-diamide synthase (TIGR) | 0.12 | DVU0649 | | iron compound ABC transporter, permease protein (TIGR) | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.22 | RR42_RS35070 | | cobyrinic acid a,c-diamide synthase | 0.18 | RR42_RS16135 | | ABC transporter permease | low | > 128 |
| Dechlorosoma suillum PS | 0.18 | Dsui_0533 | | cobyrinic acid a,c-diamide synthase | 0.15 | Dsui_0530 | | ABC-type Fe3+-siderophore transport system, permease component | low | > 51 |
Not shown: 18 genomes with orthologs for HMPREF1058_RS01405 only; 42 genomes with orthologs for HMPREF1058_RS01565 only