| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_09215 | | tol-pal system-associated acyl-CoA thioesterase | 1.0 | CSW01_09720 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.78 | 1 |
| Serratia liquefaciens MT49 | 0.49 | IAI46_06315 | | tol-pal system-associated acyl-CoA thioesterase | 0.68 | IAI46_05400 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Pantoea agglomerans CFBP13505 P0401 | 0.49 | PagCFBP13516_RS13815 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.68 | PagCFBP13516_RS14565 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Pantoea sp. MT58 | 0.48 | IAI47_13705 | | tol-pal system-associated acyl-CoA thioesterase | 0.68 | IAI47_14320 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Pectobacterium carotovorum WPP14 | 0.47 | HER17_RS14885 | | tol-pal system-associated acyl-CoA thioesterase | 0.67 | HER17_RS06505 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Rahnella sp. WP5 | 0.47 | EX31_RS23475 | | tol-pal system-associated acyl-CoA thioesterase | 0.69 | EX31_RS22835 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Enterobacter asburiae PDN3 | 0.46 | EX28DRAFT_2255 | | tol-pal system-associated acyl-CoA thioesterase | 0.68 | EX28DRAFT_2449 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | — | — |
| Escherichia coli Nissle 1917 | 0.46 | ECOLIN_RS03920 | | tol-pal system-associated acyl-CoA thioesterase | 0.68 | ECOLIN_RS03065 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Klebsiella pneumoniae MRSN742743 | 0.46 | GJGHJB_03506 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.68 | GJGHJB_03782 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Escherichia coli BL21 | 0.46 | ECD_00696 | | acyl-CoA thioester hydrolase | 0.68 | ECD_00479 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | — | — |
| Escherichia coli BW25113 | 0.46 | b0736 | ybgC | predicted acyl-CoA thioesterase (NCBI) | 0.68 | b0529 | folD | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase (NCBI) | — | — |
| Shewanella sp. ANA-3 | 0.46 | Shewana3_2535 | | 4-hydroxybenzoyl-CoA thioesterase (RefSeq) | 0.68 | Shewana3_2663 | | methenyltetrahydrofolate cyclohydrolase (RefSeq) | — | — |
| Enterobacter sp. TBS_079 | 0.46 | MPMX20_01365 | | Acyl-CoA thioester hydrolase YbgC | 0.68 | MPMX20_01107 | | Bifunctional protein FolD protein | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.46 | OHPLBJKB_02977 | | Acyl-CoA thioester hydrolase YbgC | 0.68 | OHPLBJKB_03152 | | Bifunctional protein FolD protein | — | — |
| Klebsiella pneumoniae MKP103 | 0.46 | KDGMDA_16770 | | tol-pal system-associated acyl-CoA thioesterase | 0.68 | KDGMDA_15035 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Escherichia fergusonii Becca | 0.46 | EFB2_03370 | | Acyl-CoA thioester hydrolase YbgC | 0.68 | EFB2_03532 | | Bifunctional protein FolD protein | — | — |
| Dickeya dadantii 3937 | 0.46 | DDA3937_RS06495 | | tol-pal system-associated acyl-CoA thioesterase | 0.67 | DDA3937_RS15075 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Escherichia coli ECRC62 | 0.46 | BNILDI_21255 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.67 | BNILDI_22225 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Escherichia coli ECRC100 | 0.46 | OKFHMN_06825 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.68 | OKFHMN_07805 | | Bifunctional protein FolD | — | — |
| Escherichia coli ECOR27 | 0.46 | NOLOHH_23260 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.68 | NOLOHH_00795 | | Bifunctional protein FolD | — | — |
| Escherichia coli ECRC98 | 0.46 | JDDGAC_10480 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.68 | JDDGAC_11455 | | Bifunctional protein FolD | — | — |
| Escherichia coli ECRC99 | 0.46 | KEDOAH_21140 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.68 | KEDOAH_20165 | | Bifunctional protein FolD | — | — |
| Escherichia coli ECRC102 | 0.46 | NIAGMN_04875 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.68 | NIAGMN_05860 | | Bifunctional protein FolD | — | — |
| Escherichia coli ECRC101 | 0.46 | MCAODC_26045 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.68 | MCAODC_27025 | | Bifunctional protein FolD | — | — |
| Escherichia coli ECOR38 | 0.46 | HEPCGN_01445 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.67 | HEPCGN_06445 | | Bifunctional protein FolD | — | — |
| Dickeya dianthicola ME23 | 0.45 | DZA65_RS06890 | | tol-pal system-associated acyl-CoA thioesterase | 0.66 | DZA65_RS15960 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Shewanella oneidensis MR-1 | 0.45 | SO2752 | | conserved hypothetical protein TIGR00051 (NCBI ptt file) | 0.66 | SO1792 | folD | methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase (NCBI ptt file) | — | — |
| Klebsiella michiganensis M5al | 0.45 | BWI76_RS08515 | | acyl-CoA thioesterase YbgC | 0.68 | BWI76_RS07100 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | — | — |
| Erwinia amylovora T8 | 0.45 | OLJFJH_16930 | | tol-pal system-associated acyl-CoA thioesterase | 0.67 | OLJFJH_17600 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Erwinia tracheiphila SCR3 | 0.45 | LU632_RS16050 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.66 | LU632_RS15195 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Shewanella loihica PV-4 | 0.45 | Shew_1523 | | 4-hydroxybenzoyl-CoA thioesterase (RefSeq) | 0.67 | Shew_2510 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | — | — |
| Erwinia tracheiphila HP pepo 2.2 | 0.45 | IJEDHG_02105 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.66 | IJEDHG_00975 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Dickeya dianthicola 67-19 | 0.44 | HGI48_RS06540 | | tol-pal system-associated acyl-CoA thioesterase | 0.66 | HGI48_RS15155 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Shewanella amazonensis SB2B | 0.43 | Sama_2090 | | hypothetical protein (RefSeq) | 0.68 | Sama_1222 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | — | — |
| Paraburkholderia sabiae LMG 24235 | 0.43 | QEN71_RS26245 | | tol-pal system-associated acyl-CoA thioesterase | 0.43 | QEN71_RS05700 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Alteromonas macleodii MIT1002 | 0.41 | MIT1002_01334 | | Acyl-CoA thioester hydrolase YbgC | 0.66 | MIT1002_02770 | | hypothetical protein | — | — |
| Kangiella aquimarina DSM 16071 | 0.40 | B158DRAFT_1137 | | tol-pal system-associated acyl-CoA thioesterase | 0.57 | B158DRAFT_1028 | | methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)/5,10-methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) | — | — |
| Ralstonia solanacearum PSI07 | 0.39 | RPSI07_RS20320 | | tol-pal system-associated acyl-CoA thioesterase | 0.45 | RPSI07_RS15800 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Ralstonia solanacearum GMI1000 | 0.38 | RS_RS03680 | | tol-pal system-associated acyl-CoA thioesterase | 0.45 | RS_RS08040 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | — | — |
| Lysobacter sp. OAE881 | 0.38 | ABIE51_RS05060 | | tol-pal system-associated acyl-CoA thioesterase | 0.52 | ABIE51_RS09470 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Rhodopseudomonas palustris CGA009 | 0.37 | TX73_005670 | | tol-pal system-associated acyl-CoA thioesterase | 0.39 | TX73_002145 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Azospirillum sp. SherDot2 | 0.35 | MPMX19_00699 | | Acyl-CoA thioesterase YbgC | 0.40 | MPMX19_02743 | | Bifunctional protein FolD protein | — | — |
| Dechlorosoma suillum PS | 0.35 | Dsui_0483 | | tol-pal system-associated acyl-CoA thioesterase | 0.46 | Dsui_0093 | | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase | — | — |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.35 | GFF5172 | | 4-hydroxybenzoyl-CoA thioesterase family active site | 0.45 | GFF4894 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.34 | Psyr_1411 | | 4-hydroxybenzoyl-CoA thioesterase | 0.60 | Psyr_1743 | | methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | — | — |
| Rhodospirillum rubrum S1H | 0.34 | Rru_A1090 | | 4-hydroxybenzoyl-CoA thioesterase (NCBI) | 0.42 | Rru_A0557 | | Methenyltetrahydrofolate cyclohydrolase (NCBI) | — | — |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.34 | Psyr_1411 | | 4-hydroxybenzoyl-CoA thioesterase | 0.60 | Psyr_1743 | | methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | — | — |
| Pseudomonas lactucae CFBP13502 | 0.34 | GEMAOFIL_04640 | | Acyl-CoA thioester hydrolase YbgC | 0.61 | GEMAOFIL_03749 | | Bifunctional protein FolD protein | — | — |
| Bosea sp. OAE506 | 0.34 | ABIE41_RS09500 | | tol-pal system-associated acyl-CoA thioesterase | 0.42 | ABIE41_RS08995 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Pseudomonas orientalis W4I3 | 0.33 | QF045_RS24605 | | tol-pal system-associated acyl-CoA thioesterase | 0.62 | QF045_RS18930 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Castellaniella sp019104865 MT123 | 0.33 | ABCV34_RS09830 | | tol-pal system-associated acyl-CoA thioesterase | 0.48 | ABCV34_RS04175 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Pseudomonas fluorescens SBW25 | 0.33 | PFLU_RS24080 | | tol-pal system-associated acyl-CoA thioesterase | 0.61 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.33 | PFLU_RS24080 | | tol-pal system-associated acyl-CoA thioesterase | 0.61 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Pseudomonas simiae WCS417 | 0.33 | PS417_22440 | | 4-hydroxybenzoyl-CoA thioesterase | 0.62 | PS417_17265 | | methenyltetrahydrofolate cyclohydrolase | — | — |
| Pseudomonas sp. RS175 | 0.33 | PFR28_03411 | | Acyl-CoA thioester hydrolase YbgC | 0.61 | PFR28_01223 | | Bifunctional protein FolD protein | — | — |
| Pseudomonas sp. DMC3 | 0.33 | GFF5183 | | Acyl-CoA thioester hydrolase YbgC | 0.61 | GFF1441 | | Bifunctional protein FolD protein | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.32 | Pf6N2E2_5538 | | 4-hydroxybenzoyl-CoA thioesterase family active site | 0.61 | Pf6N2E2_2221 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.32 | AO356_18030 | | 4-hydroxybenzoyl-CoA thioesterase | 0.61 | AO356_01775 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.32 | Pf1N1B4_636 | | 4-hydroxybenzoyl-CoA thioesterase family active site | 0.61 | Pf1N1B4_3943 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.32 | AO353_03575 | | 4-hydroxybenzoyl-CoA thioesterase | 0.61 | AO353_20145 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | — | — |
| Pseudomonas protegens RBAN4 | 0.32 | FABNJH_24085 | ybgC | tol-pal system-associated acyl-CoA thioesterase | 0.61 | FABNJH_20635 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Variovorax sp. SCN45 | 0.31 | GFF574 | | Tol-Pal system-associated acyl-CoA thioesterase | 0.44 | GFF964 | | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) / Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) | — | — |
| Variovorax sp. OAS795 | 0.30 | ABID97_RS17965 | | YbgC/FadM family acyl-CoA thioesterase | 0.44 | ABID97_RS14085 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
| Dinoroseobacter shibae DFL-12 | 0.30 | Dshi_1107 | | Pol-Pal system-associated acyl-CoA thioesterase (RefSeq) | 0.37 | Dshi_1285 | | Methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | — | — |
| Acinetobacter radioresistens SK82 | 0.29 | MPMX26_02190 | | Acyl-CoA thioesterase YbgC | 0.35 | MPMX26_00777 | | Bifunctional protein FolD protein | — | — |
| Acinetobacter baumannii LAC-4 | 0.28 | RR41_RS04675 | | tol-pal system-associated acyl-CoA thioesterase | 0.35 | RR41_RS04225 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | — | — |
Not shown: 1 genomes with orthologs for CSW01_09215 only; 57 genomes with orthologs for CSW01_09720 only