| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_08555 | | intracellular septation protein A | 1.0 | CSW01_00595 | | heme biosynthesis protein HemY | 0.54 | 19 |
| Shewanella sp. ANA-3 | 0.66 | Shewana3_1505 | | intracellular septation protein A (RefSeq) | 0.11 | Shewana3_0383 | | HemY domain-containing protein (RefSeq) | — | — |
| Shewanella oneidensis MR-1 | 0.65 | SO3035 | ispZ | intracellular septation protein A (NCBI ptt file) | 0.12 | SO4316 | | hemY protein, putative (NCBI ptt file) | low | > 76 |
| Shewanella amazonensis SB2B | 0.64 | Sama_2137 | | intracellular septation protein A (RefSeq) | 0.12 | Sama_3257 | | HemY protein (RefSeq) | low | > 62 |
| Serratia liquefaciens MT49 | 0.64 | IAI46_14080 | | septation protein A | 0.26 | IAI46_00680 | | protoheme IX biogenesis protein HemY | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.63 | GFF2734 | | Intracellular septation protein IspA | 0.24 | GFF226 | | Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives) | — | — |
| Pectobacterium carotovorum WPP14 | 0.63 | HER17_RS10960 | | septation protein A | 0.24 | HER17_RS01300 | | protoheme IX biogenesis protein HemY | — | — |
| Shewanella loihica PV-4 | 0.63 | Shew_2260 | | intracellular septation protein A (RefSeq) | 0.12 | Shew_0315 | | HemY domain-containing protein (RefSeq) | — | — |
| Escherichia coli Nissle 1917 | 0.62 | ECOLIN_RS07570 | | septation protein A | 0.27 | ECOLIN_RS21820 | | protoheme IX biogenesis protein HemY | — | — |
| Enterobacter sp. TBS_079 | 0.62 | MPMX20_02574 | | putative intracellular septation protein A | 0.26 | MPMX20_04473 | | Protein HemY | low | > 85 |
| Escherichia coli ECOR38 | 0.62 | HEPCGN_25150 | yciB | septation protein A | 0.27 | HEPCGN_13185 | hemY | protoheme IX biogenesis protein HemY | — | — |
| Klebsiella michiganensis M5al | 0.62 | BWI76_RS11800 | | intracellular septation protein A | 0.26 | BWI76_RS01165 | | protoheme IX biogenesis protein HemY | — | — |
| Escherichia coli ECRC99 | 0.62 | KEDOAH_25680 | yciB | septation protein A | 0.27 | KEDOAH_13685 | hemY | protoheme IX biogenesis protein HemY | — | — |
| Escherichia coli ECRC102 | 0.62 | NIAGMN_27550 | yciB | septation protein A | 0.27 | NIAGMN_12220 | hemY | protoheme IX biogenesis protein HemY | — | — |
| Escherichia coli ECRC101 | 0.62 | MCAODC_21575 | yciB | septation protein A | 0.27 | MCAODC_04970 | hemY | protoheme IX biogenesis protein HemY | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.62 | OHPLBJKB_02429 | | putative intracellular septation protein A | 0.27 | OHPLBJKB_04251 | | Protein HemY | — | — |
| Enterobacter asburiae PDN3 | 0.62 | EX28DRAFT_0924 | | intracellular septation protein A | 0.26 | EX28DRAFT_4471 | | heme biosynthesis-associated TPR protein | — | — |
| Escherichia coli BL21 | 0.62 | ECD_01228 | | IspA family inner membrane protein | 0.27 | ECD_03677 | | putative protoheme IX synthesis protein | — | — |
| Escherichia coli ECOR27 | 0.62 | NOLOHH_20365 | yciB | septation protein A | 0.27 | NOLOHH_06610 | hemY | protoheme IX biogenesis protein HemY | — | — |
| Escherichia fergusonii Becca | 0.62 | EFB2_02671 | | putative intracellular septation protein A | 0.27 | EFB2_04836 | | Protein HemY | — | — |
| Escherichia coli ECRC62 | 0.62 | BNILDI_18510 | yciB | septation protein A | 0.27 | BNILDI_04925 | hemY | protoheme IX biogenesis protein HemY | low | > 75 |
| Escherichia coli ECRC100 | 0.62 | OKFHMN_28685 | yciB | septation protein A | 0.27 | OKFHMN_14465 | hemY | protoheme IX biogenesis protein HemY | — | — |
| Escherichia coli BW25113 | 0.62 | b1254 | yciB | intracellular septation protein A (NCBI) | 0.27 | b3802 | hemY | predicted protoheme IX synthesis protein (NCBI) | — | — |
| Escherichia coli ECRC98 | 0.61 | JDDGAC_05890 | | Inner membrane-spanning protein YciB | 0.27 | JDDGAC_18090 | hemY | protoheme IX biogenesis protein HemY | — | — |
| Klebsiella pneumoniae MKP103 | 0.61 | KDGMDA_19470 | | septation protein A | 0.27 | KDGMDA_09655 | | protoheme IX biogenesis protein HemY | low | > 95 |
| Rahnella sp. WP5 | 0.60 | EX31_RS10005 | | septation protein A | 0.28 | EX31_RS15130 | | protoheme IX biogenesis protein HemY | — | — |
| Dickeya dianthicola ME23 | 0.58 | DZA65_RS10915 | | septation protein A | 0.24 | DZA65_RS21135 | | protoheme IX biogenesis protein HemY | low | > 75 |
| Dickeya dianthicola 67-19 | 0.58 | HGI48_RS10440 | | septation protein A | 0.24 | HGI48_RS20090 | | protoheme IX biogenesis protein HemY | — | — |
| Dickeya dadantii 3937 | 0.57 | DDA3937_RS10435 | | septation protein A | 0.25 | DDA3937_RS19935 | | protoheme IX biogenesis protein HemY | low | > 74 |
| Pantoea sp. MT58 | 0.57 | IAI47_09140 | | septation protein A | 0.26 | IAI47_18440 | | protoheme IX biogenesis protein HemY | — | — |
| Erwinia amylovora T8 | 0.57 | OLJFJH_13450 | | septation protein A | 0.24 | OLJFJH_06375 | | protoheme IX biogenesis protein HemY | — | — |
| Pantoea agglomerans CFBP13505 P0401 | 0.57 | PagCFBP13505_RS02980 | | septation protein A | 0.26 | PagCFBP13505_RS15420 | | protoheme IX biogenesis protein HemY | — | — |
| Erwinia tracheiphila HP pepo 2.2 | 0.54 | IJEDHG_23450 | ispZ | septation protein A | 0.24 | IJEDHG_08815 | hemY | protoheme IX biogenesis protein HemY | — | — |
| Erwinia tracheiphila SCR3 | 0.54 | LU632_RS12805 | | septation protein A | 0.24 | LU632_RS24175 | hemY | protoheme IX biogenesis protein HemY | — | — |
| Pseudomonas sp. BP01 | 0.40 | JOY50_RS01080 | | septation protein A | 0.15 | JOY50_RS18735 | | heme biosynthesis protein HemY | — | — |
| Pseudomonas putida KT2440 | 0.40 | PP_4501 | | Probable intracellular septation protein A | 0.15 | PP_0189 | | putative heme biosynthesis protein | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.38 | Psyr_3587 | | Intracellular septation protein A | 0.14 | Psyr_0059 | | HemY, N-terminal:HemY, N-terminal:HemY, N-terminal | — | — |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.38 | Psyr_3587 | | Intracellular septation protein A | 0.14 | Psyr_0059 | | HemY, N-terminal:HemY, N-terminal:HemY, N-terminal | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.38 | PFLU_RS23920 | | septation protein A | 0.15 | PFLU_RS29195 | | heme biosynthesis protein HemY | low | > 109 |
| Pseudomonas fluorescens SBW25 | 0.38 | PFLU_RS23920 | | septation protein A | 0.15 | PFLU_RS29195 | | heme biosynthesis protein HemY | low | > 109 |
| Pseudomonas simiae WCS417 | 0.38 | PS417_22280 | | septation protein A | 0.15 | PS417_27515 | | heme biosynthesis protein HemY | — | — |
| Paraburkholderia graminis OAS925 | 0.37 | ABIE53_002147 | | intracellular septation protein | 0.08 | ABIE53_001317 | | HemY protein | — | — |
| Paraburkholderia bryophila 376MFSha3.1 | 0.37 | H281DRAFT_00912 | | intracellular septation protein | 0.08 | H281DRAFT_00200 | | HemY protein | — | — |
| Burkholderia phytofirmans PsJN | 0.37 | BPHYT_RS09540 | | intracellular septation protein A | 0.08 | BPHYT_RS05240 | | heme biosynthesis protein HemY | — | — |
| Pseudomonas sp. SVBP6 | 0.37 | COO64_RS21760 | | septation protein A | 0.16 | COO64_RS01180 | | heme biosynthesis protein HemY | — | — |
| Pseudomonas lactucae CFBP13502 | 0.37 | GEMAOFIL_04593 | | putative intracellular septation protein A | 0.16 | GEMAOFIL_05641 | | Protein HemY | — | — |
| Dechlorosoma suillum PS | 0.36 | Dsui_2886 | | intracellular septation protein A | 0.07 | Dsui_1599 | | putative enzyme of heme biosynthesis | — | — |
| Pseudomonas orientalis W4I3 | 0.36 | QF045_RS24410 | | septation protein A | 0.15 | QF045_RS01875 | | heme biosynthesis protein HemY | low | > 93 |
| Pseudomonas fluorescens FW300-N2C3 | 0.35 | AO356_18490 | | septation protein A | 0.15 | AO356_12800 | | heme biosynthesis protein HemY | — | — |
| Pseudomonas sp. S08-1 | 0.35 | OH686_20790 | | intracellular septation protein A | 0.11 | OH686_13915 | | Uncharacterized protein EC-HemY in Proteobacteria (unrelated to HemY-type PPO in GramPositives) | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.35 | Pf6N2E2_5624 | | Intracellular septation protein IspA | 0.15 | Pf6N2E2_4433 | | Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives) | — | — |
| Pseudomonas sp. RS175 | 0.35 | PFR28_03320 | | putative intracellular septation protein A | 0.14 | PFR28_04363 | | Protein HemY | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.35 | AO353_18515 | | septation protein A | 0.15 | AO353_08975 | | heme biosynthesis protein HemY | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.35 | Pf1N1B4_3550 | | Intracellular septation protein IspA | 0.13 | Pf1N1B4_2188 | | Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives) | — | — |
| Pseudomonas sp. DMC3 | 0.35 | GFF2398 | | putative intracellular septation protein A | 0.15 | GFF355 | | Protein HemY | — | — |
| Pseudomonas aeruginosa PUPa3 | 0.35 | DQ20_RS40130 | | septation protein A | 0.13 | DQ20_RS49955 | | heme biosynthesis protein HemY | — | — |
| Pseudomonas aeruginosa PA14 | 0.35 | IKLFDK_16270 | | septation protein A | 0.13 | IKLFDK_27170 | | heme biosynthesis protein HemY | — | — |
| Paraburkholderia sabiae LMG 24235 | 0.35 | QEN71_RS21905 | | septation protein A | 0.08 | QEN71_RS24940 | | heme biosynthesis protein HemY | — | — |
| Pseudomonas aeruginosa MRSN321 | 0.35 | DY961_RS00910 | | septation protein A | 0.13 | DY961_RS12165 | | heme biosynthesis protein HemY | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.34 | PfGW456L13_4406 | | Intracellular septation protein IspA | 0.14 | PfGW456L13_859 | | Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives) | — | — |
| Herbaspirillum seropedicae SmR1 | 0.33 | HSERO_RS11210 | | septation protein A | 0.08 | HSERO_RS14650 | | porphyrin biosynthesis protein | — | — |
| Kangiella aquimarina DSM 16071 | 0.22 | B158DRAFT_2303 | | Intracellular septation protein A | 0.21 | B158DRAFT_0255 | | Uncharacterized enzyme of heme biosynthesis | low | > 40 |
Not shown: 26 genomes with orthologs for CSW01_08555 only; 4 genomes with orthologs for CSW01_00595 only