Conservation of cofitness between BWI76_RS06780 and BWI76_RS19805 in Klebsiella michiganensis M5al

56 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS06780 MexE family multidrug efflux RND transporter periplasmic adaptor subunit 1.0 BWI76_RS19805 Bcr/CflA family multidrug efflux MFS transporter 0.43 12
Enterobacter sp. TBS_079 0.87 MPMX20_01065 Multidrug efflux pump subunit AcrA 0.85 MPMX20_03148 Bicyclomycin resistance protein low > 85
Enterobacter asburiae PDN3 0.84 EX28DRAFT_2495 RND family efflux transporter, MFP subunit 0.86 EX28DRAFT_0379 drug resistance transporter, Bcr/CflA subfamily low > 76
Escherichia coli ECRC62 0.83 BNILDI_22550 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.81 BNILDI_13860 bcr multidrug efflux MFS transporter Bcr low > 75
Escherichia coli ECRC101 0.83 MCAODC_27425 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.84 MCAODC_14415 bcr multidrug efflux MFS transporter Bcr low > 87
Escherichia coli ECOR27 0.83 NOLOHH_01135 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.81 NOLOHH_14940 bcr multidrug efflux MFS transporter Bcr low > 75
Escherichia coli ECRC102 0.83 NIAGMN_06255 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.84 NIAGMN_21130 bcr multidrug efflux MFS transporter Bcr
Escherichia coli HS(pFamp)R (ATCC 700891) 0.83 OHPLBJKB_03211 Multidrug efflux pump subunit AcrA 0.82 OHPLBJKB_01527 Bicyclomycin resistance protein low > 73
Escherichia coli ECRC98 0.83 JDDGAC_11850 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.84 JDDGAC_27325 bcr multidrug efflux MFS transporter Bcr low > 86
Escherichia coli BW25113 0.83 b0463 acrA multidrug efflux system (NCBI) 0.82 b2182 bcr bicyclomycin/multidrug efflux system (NCBI) low > 76
Escherichia coli ECRC100 0.83 OKFHMN_08200 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.83 OKFHMN_23365 bcr multidrug efflux MFS transporter Bcr low > 80
Escherichia coli BL21 0.83 ECD_00414 multidrug efflux system 0.82 ECD_02112 bicyclomycin/cysteine/sulfonamide efflux transporter low > 61
Escherichia coli ECRC99 0.83 KEDOAH_19765 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.84 KEDOAH_04820 bcr multidrug efflux MFS transporter Bcr
Escherichia fergusonii Becca 0.82 EFB2_03595 Multidrug efflux pump subunit AcrA 0.84 EFB2_01674 Bicyclomycin resistance protein low > 86
Escherichia coli Nissle 1917 0.82 ECOLIN_RS02755 multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.84 ECOLIN_RS12755 multidrug efflux MFS transporter Bcr
Escherichia coli ECOR38 0.82 HEPCGN_06815 acrA multidrug efflux RND transporter periplasmic adaptor subunit AcrA 0.84 HEPCGN_22630 bcr multidrug efflux MFS transporter Bcr low > 87
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.78 GFF4380 Membrane fusion protein of RND family multidrug efflux pump 0.84 GFF3754 MFS family multidrug transport protein, bicyclomycin resistance protein low > 78
Pantoea sp. MT58 0.74 IAI47_14510 efflux RND transporter periplasmic adaptor subunit 0.71 IAI47_06590 Bcr/CflA family multidrug efflux MFS transporter low > 76
Rahnella sp. WP5 0.74 EX31_RS22475 efflux RND transporter periplasmic adaptor subunit 0.67 EX31_RS19190 Bcr/CflA family multidrug efflux MFS transporter low > 89
Erwinia tracheiphila SCR3 0.74 LU632_RS18180 efflux RND transporter periplasmic adaptor subunit 0.61 LU632_RS17590 Bcr/CflA family multidrug efflux MFS transporter
Serratia liquefaciens MT49 0.74 IAI46_05190 multidrug efflux RND transporter periplasmic adaptor subunit SdeX 0.73 IAI46_17340 Bcr/CflA family multidrug efflux MFS transporter low > 86
Dickeya dadantii 3937 0.71 DDA3937_RS05740 efflux RND transporter periplasmic adaptor subunit 0.71 DDA3937_RS09165 Bcr/CflA family multidrug efflux MFS transporter low > 74
Dickeya dianthicola 67-19 0.69 HGI48_RS05795 efflux RND transporter periplasmic adaptor subunit 0.70 HGI48_RS09205 Bcr/CflA family multidrug efflux MFS transporter low > 71
Dickeya dianthicola ME23 0.69 DZA65_RS06120 efflux RND transporter periplasmic adaptor subunit 0.70 DZA65_RS09505 Bcr/CflA family multidrug efflux MFS transporter low > 75
Pectobacterium carotovorum WPP14 0.68 HER17_RS15735 efflux RND transporter periplasmic adaptor subunit 0.73 HER17_RS12945 Bcr/CflA family multidrug efflux MFS transporter low > 75
Pseudomonas syringae pv. syringae B728a 0.51 Psyr_4007 Secretion protein HlyD 0.26 Psyr_0657 Drug resistance transporter Bcr/CflA subfamily low > 86
Pseudomonas syringae pv. syringae B728a ΔmexB 0.51 Psyr_4007 Secretion protein HlyD 0.26 Psyr_0657 Drug resistance transporter Bcr/CflA subfamily low > 86
Pseudomonas sp. RS175 0.51 PFR28_00632 putative efflux pump periplasmic linker TtgA 0.23 PFR28_05247 Bicyclomycin resistance protein low > 88
Pseudomonas sp. S08-1 0.50 OH686_16045 Multidrug efflux system, membrane fusion component 0.26 OH686_07365 Multidrug resistance transporter, Bcr/CflA family low > 80
Pseudomonas stutzeri RCH2 0.48 Psest_0309 RND family efflux transporter, MFP subunit 0.25 Psest_0741 drug resistance transporter, Bcr/CflA subfamily low > 67
Xanthomonas campestris pv. campestris strain 8004 0.47 Xcc-8004.1793.1 RND efflux system, membrane fusion protein CmeA 0.18 Xcc-8004.3876.1 MFS transporter low > 74
Herbaspirillum seropedicae SmR1 0.47 HSERO_RS06810 hemolysin D 0.28 HSERO_RS23560 MFS transporter low > 78
Azospirillum brasilense Sp245 0.46 AZOBR_RS30180 hemolysin D 0.24 AZOBR_RS00095 MFS transporter permease low > 97
Paraburkholderia sabiae LMG 24235 0.46 QEN71_RS29870 efflux RND transporter periplasmic adaptor subunit 0.29 QEN71_RS03315 Bcr/CflA family multidrug efflux MFS transporter low > 153
Burkholderia phytofirmans PsJN 0.46 BPHYT_RS34600 hemolysin D 0.29 BPHYT_RS15365 Bcr/CflA family drug resistance efflux transporter low > 109
Azospirillum sp. SherDot2 0.46 MPMX19_05883 Multidrug resistance protein MexA 0.30 MPMX19_06022 Bicyclomycin resistance protein low > 112
Dyella japonica UNC79MFTsu3.2 0.45 ABZR86_RS18280 efflux RND transporter periplasmic adaptor subunit 0.26 ABZR86_RS00225 multidrug effflux MFS transporter low > 74
Cupriavidus basilensis FW507-4G11 0.45 RR42_RS32415 hemolysin D 0.29 RR42_RS28940 Bcr/CflA family drug resistance efflux transporter low > 128
Rhodospirillum rubrum S1H 0.45 Rru_A2050 Secretion protein HlyD (NCBI) 0.18 Rru_A2971 Drug resistance transporter Bcr/CflA subfamily (NCBI) low > 58
Shewanella amazonensis SB2B 0.44 Sama_3553 multidrug resistance protein AcrA/AcrE family (RefSeq) 0.24 Sama_2017 bicyclomycin resistance protein (RefSeq) low > 62
Desulfovibrio vulgaris Hildenborough JW710 0.44 DVU2817 acrA multidrug resistance protein (TIGR) 0.09 DVU1895 major facilitator superfamily protein (TIGR) low > 55
Ralstonia solanacearum UW163 0.44 UW163_RS19385 efflux RND transporter periplasmic adaptor subunit 0.27 UW163_RS23085 Bcr/CflA family drug resistance efflux transporter
Ralstonia solanacearum IBSBF1503 0.44 RALBFv3_RS19790 efflux RND transporter periplasmic adaptor subunit 0.27 RALBFv3_RS22540 Bcr/CflA family drug resistance efflux transporter low > 76
Ralstonia solanacearum GMI1000 0.44 RS_RS21035 efflux RND transporter periplasmic adaptor subunit 0.29 RS_RS01070 MFS transporter low > 80
Shewanella oneidensis MR-1 0.44 SO4693 multidrug resistance protein, AcrA/AcrE family (NCBI ptt file) 0.23 SO2280 bicyclomycin resistance protein (NCBI ptt file) low > 76
Shewanella sp. ANA-3 0.44 Shewana3_4046 RND family efflux transporter MFP subunit (RefSeq) 0.23 Shewana3_2268 Bcr/CflA subfamily drug resistance transporter (RefSeq) low > 73
Ralstonia solanacearum PSI07 0.44 RPSI07_RS23900 efflux RND transporter periplasmic adaptor subunit 0.27 RPSI07_RS00615 MFS transporter low > 81
Rhizobium sp. OAE497 0.43 ABIE40_RS24220 efflux RND transporter periplasmic adaptor subunit 0.19 ABIE40_RS09565 multidrug effflux MFS transporter low > 107
Rhodopseudomonas palustris CGA009 0.43 TX73_012250 efflux RND transporter periplasmic adaptor subunit 0.19 TX73_018225 multidrug effflux MFS transporter low > 86
Bosea sp. OAE506 0.40 ABIE41_RS01600 efflux RND transporter periplasmic adaptor subunit 0.22 ABIE41_RS02750 multidrug effflux MFS transporter low > 77
Variovorax sp. OAS795 0.38 ABID97_RS00320 efflux RND transporter periplasmic adaptor subunit 0.21 ABID97_RS10530 multidrug effflux MFS transporter low > 91
Hydrogenophaga sp. GW460-11-11-14-LB1 0.38 GFF5686 RND efflux system, membrane fusion protein CmeA 0.16 GFF5490 Multidrug resistance transporter, Bcr/CflA family low > 90
Agrobacterium fabrum C58 0.37 Atu3203 RND multidrug efflux membrane permease 0.20 Atu1855 MFS permease low > 89
Acidovorax sp. GW101-3H11 0.34 Ac3H11_4449 RND efflux system, membrane fusion protein CmeA 0.22 Ac3H11_1673 MFS transporter low > 79
Kangiella aquimarina DSM 16071 0.33 B158DRAFT_0734 RND family efflux transporter, MFP subunit 0.25 B158DRAFT_0826 drug resistance transporter, Bcr/CflA subfamily low > 40
Lysobacter sp. OAE881 0.30 ABIE51_RS17985 efflux RND transporter periplasmic adaptor subunit 0.19 ABIE51_RS14645 multidrug effflux MFS transporter low > 62
Pedobacter sp. GW460-11-11-14-LB5 0.20 CA265_RS23015 efflux transporter periplasmic adaptor subunit 0.24 CA265_RS08155 Bcr/CflA family drug resistance efflux transporter low > 88

Not shown: 17 genomes with orthologs for BWI76_RS06780 only; 14 genomes with orthologs for BWI76_RS19805 only