| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS08650 | | restriction endonuclease subunit S | insig. | 100 | 100 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_4442 | | Restriction endonuclease S subunits | insig. | 45 | 43 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS05385 | | restriction endonuclease subunit S | insig. | 34 | 67 |
| | Erwinia tracheiphila HP pepo 2.2 | IJEDHG_14265 | | Restriction endonuclease subunit S | no data | 28 | 85 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_15905 | | hypothetical protein | insig. | 27 | 72 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF1000 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | insig. | 27 | 81 |
| | Alteromonas macleodii MIT1002 | MIT1002_00591 | | Type I restriction enzyme specificity protein MPN_089 | insig. | 30 | 54 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.3938.1 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | insig. | 29 | 56 |
| | Escherichia fergusonii Becca | EFB2_04102 | | hypothetical protein | insig. | 30 | 45 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.1524.1 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | insig. | 35 | 37 |
| | Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS20485 | | hypothetical protein | cofit | 32 | 37 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_05328 | | type I restriction modification DNA specificity domain protein | insig. | 33 | 36 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU1705 | | type I restriction-modification enzyme, S subunit (TIGR) | insig. | 27 | 61 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_1064 | | type I restriction-modification | insig. | 32 | 46 |
| | Shewanella sp. ANA-3 | Shewana3_3793 | | restriction modification system DNA specificity subunit (RefSeq) | insig. | 26 | 72 |
| | Escherichia coli ECOR38 | HEPCGN_09460 | | type I restriction endonuclease subunit S | insig. | 29 | 45 |
| | Pseudomonas fluorescens FW300-N2E3 | AO353_11440 | | hypothetical protein | insig. | 26 | 76 |
| | Alteromonas macleodii MIT1002 | MIT1002_03393 | | Type I restriction enzyme EcoKI specificity protein | insig. | 25 | 78 |
| | Alteromonas macleodii MIT1002 | MIT1002_00591 | | Type I restriction enzyme specificity protein MPN_089 | insig. | 32 | 30 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS13600 | | restriction endonuclease subunit S | insig. | 30 | 41 |
| | Paraburkholderia graminis OAS925 | ABIE53_005411 | | type I restriction enzyme S subunit | strong | 25 | 53 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS02840 | | restriction endonuclease subunit S | sig. | 29 | 54 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS01815 | | restriction endonuclease subunit S | cofit | 22 | 63 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS01155 | | restriction endonuclease subunit S | sig. | 23 | 75 |
| | Xanthobacter sp. DMC5 | GFF2199 | | hypothetical protein | insig. | 25 | 61 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS21415 | | restriction endonuclease subunit S | insig. | 29 | 35 |
| | Dickeya dianthicola 67-19 | HGI48_RS21690 | | restriction endonuclease subunit S | insig. | 23 | 72 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS11945 | | restriction endonuclease subunit S | sig. | 23 | 62 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04168 | | type I restriction modification DNA specificity domain protein | insig. | 32 | 33 |
| | Rhodanobacter sp000427505 FW510-R12 | LRK53_RS01060 | | restriction endonuclease subunit S | insig. | 33 | 33 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_14000 | | restriction endonuclease subunit S | insig. | 31 | 40 |
| | Shewanella oneidensis MR-1 | SO0382 | hsdS-1 | type I restriction-modification system, S subunit (NCBI ptt file) | insig. | 23 | 62 |
| | Shewanella sp. ANA-3 | Shewana3_4163 | | restriction modification system DNA specificity subunit (RefSeq) | cofit | 23 | 55 |
| | Dyella japonica UNC79MFTsu3.2 | ABZR86_RS05385 | | restriction endonuclease subunit S | insig. | 28 | 41 |
| | Klebsiella michiganensis M5al | BWI76_RS03675 | | restriction modification system DNA specificity domain-containing protein | cofit | 27 | 45 |
| | Dickeya dianthicola ME23 | DZA65_RS04765 | | restriction endonuclease subunit S | insig. | 20 | 86 |
| | Caulobacter crescentus NA1000 | CCNA_00657 | | type I restriction-modification system specificity subunit | insig. | 29 | 43 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_00657 | | type I restriction-modification system specificity subunit | cofit | 29 | 43 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_04168 | | type I restriction modification DNA specificity domain protein | insig. | 26 | 34 |
| | Bacteroides thetaiotaomicron VPI-5482 | BT4540 | | putative Type I restriction enzyme MjaXP specificity protein (NCBI ptt file) | insig. | 26 | 39 |
| | Paraburkholderia graminis OAS925 | ABIE53_000532 | | type I restriction enzyme S subunit | insig. | 24 | 85 |
| | Cupriavidus basilensis FW507-4G11 | RR42_RS18680 | | hypothetical protein | insig. | 23 | 74 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS09050 | | restriction endonuclease subunit S | insig. | 27 | 41 |
| | Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_02138 | | type I restriction enzyme, S subunit | insig. | 34 | 34 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS09200 | | restriction endonuclease subunit S | cofit | 22 | 93 |
| | Escherichia coli ECRC100 | OKFHMN_05700 | | restriction endonuclease | insig. | 26 | 43 |
| | Sphingobium sp. HT1-2 | GFF5345 | | Type I restriction-modification system, specificity subunit S | cofit | 27 | 32 |
| | Shewanella sp. ANA-3 | Shewana3_4241 | | restriction modification system DNA specificity subunit (RefSeq) | sig. | 23 | 39 |
| | Escherichia coli ECOR38 | HEPCGN_10725 | | restriction endonuclease subunit S | insig. | 28 | 32 |
| | Pseudomonas stutzeri RCH2 | Psest_4047 | | Restriction endonuclease S subunits | sig. | 27 | 43 |
| | Rhodanobacter denitrificans FW104-10B01 | LRK54_RS10480 | | restriction endonuclease subunit S | cofit | 25 | 39 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.612.1 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | insig. | 24 | 78 |
| | Rhodanobacter sp. FW510-T8 | OKGIIK_06685 | | Restriction endonuclease subunit S | insig. | 25 | 54 |
| | Bacteroides ovatus ATCC 8483 | BACOVA_05327 | | type I restriction modification DNA specificity domain protein | insig. | 27 | 35 |
| | Sinorhizobium meliloti 1021 | SMc02295 | | specificity protein S | insig. | 27 | 30 |
| | Pseudomonas stutzeri RCH2 | Psest_1098 | | Restriction endonuclease S subunits | strong | 24 | 40 |
| | Caulobacter crescentus NA1000 | CCNA_00657 | | type I restriction-modification system specificity subunit | insig. | 25 | 61 |
| | Caulobacter crescentus NA1000 Δfur | CCNA_00657 | | type I restriction-modification system specificity subunit | cofit | 25 | 61 |
| | Shewanella sp. ANA-3 | Shewana3_4241 | | restriction modification system DNA specificity subunit (RefSeq) | sig. | 24 | 40 |
| | Shewanella sp. ANA-3 | Shewana3_2028 | | restriction modification system DNA specificity subunit (RefSeq) | insig. | 24 | 38 |
| | Castellaniella sp019104865 MT123 | ABCV34_RS09200 | | restriction endonuclease subunit S | cofit | 26 | 47 |
| | Cellulophaga baltica 18 | M666_RS02035 | | restriction endonuclease subunit S | cofit | 24 | 50 |
| | Paraburkholderia graminis OAS925 | ABIE53_000532 | | type I restriction enzyme S subunit | insig. | 26 | 48 |
| | Methanococcus maripaludis JJ | MMJJ_RS02750 | | restriction endonuclease subunit S | no data | 24 | 40 |
| | Escherichia coli Nissle 1917 | ECOLIN_RS24955 | | restriction endonuclease subunit S | insig. | 24 | 45 |
| | Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_06655 | | hypothetical protein | insig. | 21 | 63 |
| | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.1524.1 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | insig. | 24 | 55 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_4441 | | Restriction endonuclease S subunits | insig. | 23 | 69 |
| | Alteromonas macleodii MIT1002 | MIT1002_03211 | | Type I restriction-modification system methyltransferase subunit | insig. | 20 | 70 |
| | Phaeobacter inhibens DSM 17395 | PGA1_c30700 | | putative type I restriction-modification system, S subunit | insig. | 22 | 80 |
| | Methanococcus maripaludis JJ | MMJJ_RS02750 | | restriction endonuclease subunit S | no data | 27 | 35 |