Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| Phocaeicola dorei CL03T12C01 | ABI39_RS01800 | | type I restriction endonuclease subunit R | insig. | 100 | 100 |
| Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.3936.1 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | insig. | 36 | 69 |
| Rhodanobacter denitrificans MT42 | LRK55_RS00325 | | type I restriction endonuclease | strong | 35 | 69 |
| Marinobacter adhaerens HP15 | HP15_1582 | | type III restriction enzyme, res subunit | insig. | 35 | 66 |
| Caulobacter crescentus NA1000 | CCNA_00659 | | type I restriction-modification system restriction subunit | insig. | 35 | 68 |
| Caulobacter crescentus NA1000 Δfur | CCNA_00659 | | type I restriction-modification system restriction subunit | cofit | 35 | 68 |
| Vibrio cholerae E7946 ATCC 55056 | CSW01_08855 | | type I restriction endonuclease subunit R | insig. | 33 | 72 |
| Synechococcus elongatus PCC 7942 | Synpcc7942_1065 | | DEAD/DEAH box helicase-like | insig. | 34 | 68 |
| Acinetobacter radioresistens SK82 | MPMX26_02867 | | hypothetical protein | insig. | 34 | 61 |
| Pseudomonas stutzeri RCH2 | Psest_3407 | | Type I site-specific restriction-modification system, R (restriction) subunit and related helicases | insig. | 32 | 67 |
| Pseudomonas stutzeri RCH2 | Psest_0876 | | Type III restriction enzyme, res subunit./Type I restriction enzyme R protein N terminus (HSDR_N). | insig. | 32 | 61 |
| Methanococcus maripaludis JJ | MMJJ_RS02745 | | type I restriction endonuclease subunit R | no data | 23 | 50 |
| Rhodanobacter denitrificans FW104-10B01 | LRK54_RS08925 | | type I restriction endonuclease subunit R | insig. | 26 | 44 |
| Shewanella sp. ANA-3 | Shewana3_4244 | | HsdR family type I site-specific deoxyribonuclease (RefSeq) | insig. | 24 | 49 |
| Pontibacter actiniarum KMM 6156, DSM 19842 | CA264_06660 | | type I restriction-modification system endonuclease | insig. | 23 | 43 |
| Azospirillum sp. SherDot2 | MPMX19_00137 | | hypothetical protein | cofit | 23 | 46 |
| Kangiella aquimarina DSM 16071 | B158DRAFT_1641 | | type I site-specific deoxyribonuclease, HsdR family | insig. | 24 | 45 |
| Paraburkholderia bryophila 376MFSha3.1 | H281DRAFT_02139 | | type I restriction enzyme, R subunit | insig. | 22 | 44 |
| Alteromonas macleodii MIT1002 | MIT1002_04087 | | Type-1 restriction enzyme R protein | insig. | 22 | 46 |
| Castellaniella sp019104865 MT123 | ABCV34_RS11910 | | type I restriction endonuclease subunit R | insig. | 23 | 43 |
| Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.1523.1 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | strong | 21 | 48 |
| Sinorhizobium meliloti 1021 | SMc02292 | | type I restriction enzyme R protein | insig. | 22 | 44 |
| Shewanella sp. ANA-3 | Shewana3_3790 | | HsdR family type I site-specific deoxyribonuclease (RefSeq) | cofit | 22 | 41 |
| Shewanella oneidensis MR-1 | SO0380 | hsdR-1 | type I restriction-modification system, R subunit (NCBI ptt file) | insig. | 21 | 44 |
| Desulfovibrio vulgaris Hildenborough JW710 | DVU1703 | | type I restriction-modification enzyme, R subunit (TIGR) | insig. | 21 | 34 |
| Cupriavidus basilensis FW507-4G11 | RR42_RS18675 | | restriction endonuclease subunit R | insig. | 22 | 44 |
| Rhodanobacter sp. FW510-T8 | OKGIIK_15915 | | Type I restriction enzyme endonuclease subunit | insig. | 20 | 44 |
| Rhodanobacter sp. FW510-T8 | OKGIIK_13425 | | DEAD/DEAH box helicase | cofit | 21 | 44 |
| Escherichia coli ECOR38 | HEPCGN_10720 | | type I restriction endonuclease | cofit | 24 | 44 |
| Bacteroides ovatus ATCC 8483 | BACOVA_04167 | | type I site-specific deoxyribonuclease, HsdR family | insig. | 22 | 44 |
| Escherichia fergusonii Becca | EFB2_04103 | | hypothetical protein | insig. | 24 | 44 |
| Escherichia coli Nissle 1917 | ECOLIN_RS24950 | | HsdR family type I site-specific deoxyribonuclease | insig. | 23 | 44 |
| Dyella japonica UNC79MFTsu3.2 | ABZR86_RS15095 | | type I restriction endonuclease subunit R | no data | 22 | 41 |
| Dyella japonica UNC79MFTsu3.2 | ABZR86_RS05380 | | HsdR family type I site-specific deoxyribonuclease | insig. | 21 | 48 |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF2633 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | no data | 21 | 46 |
| Phaeobacter inhibens DSM 17395 | PGA1_c30690 | | putative type I restriction-modification system, R subunit | insig. | 19 | 43 |
| Rhodanobacter denitrificans FW104-10B01 | LRK54_RS10495 | | type I restriction endonuclease subunit R | cofit | 22 | 43 |
| Alteromonas macleodii MIT1002 | MIT1002_00593 | | Type I restriction enzyme EcoR124II R protein | cofit | 21 | 41 |
| Escherichia coli ECRC62 | BNILDI_07600 | hsdR | Type I restriction enzyme EcoR124II endonuclease subunit | insig. | 21 | 45 |
| Dickeya dianthicola ME23 | DZA65_RS04740 | | HsdR family type I site-specific deoxyribonuclease | insig. | 23 | 39 |
| Rhodanobacter sp. FW510-T8 | OKGIIK_06705 | | Type I restriction enzyme endonuclease subunit | cofit | 21 | 43 |
| Escherichia coli ECRC101 | OKFHMN_05715 | | restriction endonuclease subunit R | insig. | 21 | 44 |
| Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.611.1 | | Type I restriction-modification system, restriction subunit R (EC 3.1.21.3) | insig. | 24 | 22 |
| Rhodanobacter denitrificans MT42 | LRK55_RS10135 | | type I restriction endonuclease subunit R | cofit | 21 | 43 |
| Pseudomonas stutzeri RCH2 | Psest_4044 | | type I site-specific deoxyribonuclease, HsdR family | strong | 32 | 6 |
| Fusobacterium nucleatum SB010 | HUW76_08985 | | type I restriction endonuclease subunit R | strong | 22 | 42 |
| Rhodanobacter denitrificans FW104-10B01 | LRK54_RS02835 | | type I restriction endonuclease subunit R | insig. | 25 | 20 |
| Pseudomonas stutzeri RCH2 | Psest_4044 | | type I site-specific deoxyribonuclease, HsdR family | strong | 27 | 21 |
| Bacteroides ovatus ATCC 8483 | BACOVA_05330 | | type I site-specific deoxyribonuclease, HsdR family | insig. | 26 | 21 |
| Paraburkholderia graminis OAS925 | ABIE53_000533 | | type I restriction enzyme R subunit | insig. | 22 | 43 |
| Parabacteroides merdae CL09T00C40 | HMPREF1078_RS03160 | | type I restriction endonuclease subunit R | insig. | 27 | 20 |
| Bacteroides thetaiotaomicron VPI-5482 | BT4535 | | Type I restriction enzyme EcoR124II R protein (NCBI ptt file) | cofit | 27 | 20 |
| Klebsiella michiganensis M5al | BWI76_RS03670 | | type I restriction-modification system subunit R | insig. | 33 | 5 |
| Alteromonas macleodii MIT1002 | MIT1002_03210 | | Type-1 restriction enzyme R protein | insig. | 22 | 23 |
| Rhodanobacter sp. FW510-T8 | OKGIIK_08955 | | Type I restriction enzyme endonuclease subunit | insig. | 30 | 6 |
| Shewanella sp. ANA-3 | Shewana3_4164 | | HsdR family type I site-specific deoxyribonuclease (RefSeq) | insig. | 21 | 43 |