| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Azospirillum sp. SherDot2 | 1.0 | MPMX19_01364 | | O-succinylhomoserine sulfhydrylase | 1.0 | MPMX19_00635 | | 5,10-methylenetetrahydrofolate reductase | 0.97 | 2 |
| Azospirillum brasilense Sp245 | 0.84 | AZOBR_RS02140 | | O-succinylhomoserine sulfhydrylase | 0.90 | AZOBR_RS09540 | | 5 10-methylenetetrahydrofolate reductase | 0.81 | 26 |
| Magnetospirillum magneticum AMB-1 | 0.59 | AMB_RS21365 | | O-succinylhomoserine sulfhydrylase | 0.65 | AMB_RS02230 | | methylenetetrahydrofolate reductase | — | — |
| Dinoroseobacter shibae DFL-12 | 0.55 | Dshi_2410 | | O-succinylhomoserine sulfhydrylase (RefSeq) | 0.41 | Dshi_2080 | | 5,10-methylenetetrahydrofolate reductase (RefSeq) | — | — |
| Rhodospirillum rubrum S1H | 0.54 | Rru_A3214 | | O-succinylhomoserine sulfhydrylase (NCBI) | 0.62 | Rru_A1530 | | 5,10-methylenetetrahydrofolate reductase (NCBI) | 0.88 | 6 |
| Phaeobacter inhibens DSM 17395 | 0.52 | PGA1_c23540 | | O-succinylhomoserine sulfhydrylase MetZ | 0.44 | PGA1_c11700 | | 5,10-methylenetetrahydrofolate reductase MetF | 0.90 | 5 |
| Sinorhizobium meliloti 1021 | 0.52 | SMc02217 | | O-succinylhomoserine sulfhydrylase | 0.50 | SMc01843 | | 5,10-methylenetetrahydrofolate reductase | 0.98 | 2 |
| Rhizobium sp. OAE497 | 0.51 | ABIE40_RS02340 | | O-succinylhomoserine sulfhydrylase | 0.52 | ABIE40_RS11950 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.98 | 3 |
| Agrobacterium fabrum C58 | 0.51 | Atu0432 | | O-succinylhomoserine sulfhydrylase | 0.48 | Atu2123 | | methylenetetrahydrofolate reductase | 0.60 | 83 |
| Rhodopseudomonas palustris CGA009 | 0.50 | TX73_024775 | | O-succinylhomoserine sulfhydrylase | 0.57 | TX73_019175 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.54 | 4 |
| Xanthobacter sp. DMC5 | 0.50 | GFF4634 | | O-succinylhomoserine sulfhydrylase | 0.64 | GFF4147 | | 5,10-methylenetetrahydrofolate reductase | — | — |
| Bosea sp. OAE506 | 0.50 | ABIE41_RS03970 | | O-succinylhomoserine sulfhydrylase | 0.63 | ABIE41_RS12475 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.59 | 22 |
| Caulobacter crescentus NA1000 Δfur | 0.50 | CCNA_02321 | | O-succinylhomoserine sulfhydrylase | 0.57 | CCNA_02224 | | methylenetetrahydrofolate reductase | low | > 67 |
| Caulobacter crescentus NA1000 | 0.50 | CCNA_02321 | | O-succinylhomoserine sulfhydrylase | 0.57 | CCNA_02224 | | methylenetetrahydrofolate reductase | 0.95 | 19 |
| Sphingomonas koreensis DSMZ 15582 | 0.46 | Ga0059261_3194 | | O-acetylhomoserine sulfhydrylase (EC:2.5.1.49) (from data) | 0.59 | Ga0059261_0992 | | 5,10-methylenetetrahydrofolate reductase, prokaryotic form | low | > 68 |
| Sphingobium sp. HT1-2 | 0.44 | GFF3455 | | O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) @ O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) | 0.59 | GFF217 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.89 | 39 |
| Paraburkholderia bryophila 376MFSha3.1 | 0.43 | H281DRAFT_06059 | | O-succinylhomoserine sulfhydrylase | 0.38 | H281DRAFT_05801 | | 5,10-methylenetetrahydrofolate reductase (NAD(P)) | 0.82 | 5 |
| Cupriavidus basilensis FW507-4G11 | 0.43 | RR42_RS14320 | | O-succinylhomoserine sulfhydrylase | 0.39 | RR42_RS01385 | | 5,10-methylenetetrahydrofolate reductase | 0.78 | 24 |
| Burkholderia phytofirmans PsJN | 0.43 | BPHYT_RS33835 | | O-succinylhomoserine sulfhydrylase | 0.37 | BPHYT_RS18705 | | 5,10-methylenetetrahydrofolate reductase | 0.57 | 91 |
| Dechlorosoma suillum PS | 0.43 | Dsui_3185 | | O-succinylhomoserine sulfhydrylase | 0.37 | Dsui_0640 | | 5,10-methylenetetrahydrofolate reductase | — | — |
| Paraburkholderia graminis OAS925 | 0.43 | ABIE53_004817 | | O-succinylhomoserine sulfhydrylase | 0.37 | ABIE53_000061 | | methylenetetrahydrofolate reductase (NADPH) | 0.93 | 7 |
| Acinetobacter radioresistens SK82 | 0.43 | MPMX26_01645 | | O-succinylhomoserine sulfhydrylase | 0.32 | MPMX26_01002 | | 5,10-methylenetetrahydrofolate reductase | low | > 36 |
| Paraburkholderia sabiae LMG 24235 | 0.42 | QEN71_RS17685 | | O-succinylhomoserine sulfhydrylase | 0.38 | QEN71_RS28715 | | methylenetetrahydrofolate reductase [NAD(P)H] | low | > 153 |
| Pedobacter sp. GW460-11-11-14-LB5 | 0.42 | CA265_RS13080 | | O-succinylhomoserine sulfhydrylase | 0.24 | CA265_RS23445 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.97 | 3 |
| Pontibacter actiniarum KMM 6156, DSM 19842 | 0.42 | CA264_02530 | | O-succinylhomoserine sulfhydrylase | 0.23 | CA264_16780 | | methylenetetrahydrofolate reductase [NAD(P)H] | low | > 74 |
| Acinetobacter baumannii LAC-4 | 0.41 | RR41_RS12630 | | O-succinylhomoserine sulfhydrylase | 0.33 | RR41_RS05725 | | methylenetetrahydrofolate reductase [NAD(P)H] | low | > 55 |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.41 | GFF301 | | O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) | 0.33 | GFF1692 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | — | — |
| Echinicola vietnamensis KMM 6221, DSM 17526 | 0.41 | Echvi_2283 | | Cystathionine beta-lyases/cystathionine gamma-synthases | 0.24 | Echvi_3637 | | 5,10-methylenetetrahydrofolate reductase, prokaryotic form | 0.93 | 15 |
| Pseudomonas stutzeri RCH2 | 0.41 | Psest_2578 | | O-succinylhomoserine sulfhydrylase | 0.39 | Psest_0313 | | 5,10-methylenetetrahydrofolate reductase, prokaryotic form | 0.94 | 9 |
| Variovorax sp. OAS795 | 0.40 | ABID97_RS21630 | | O-succinylhomoserine sulfhydrylase | 0.32 | ABID97_RS25015 | | methylenetetrahydrofolate reductase [NAD(P)H] | — | — |
| Pseudomonas sp. S08-1 | 0.40 | OH686_04415 | | O-succinylhomoserine sulfhydrylase | 0.37 | OH686_10820 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.89 | 2 |
| Variovorax sp. SCN45 | 0.40 | GFF3088 | | O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) @ O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) | 0.32 | GFF2055 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.40 | Psyr_1669 | | O-succinylhomoserine sulfhydrylase | 0.37 | Psyr_0459 | | 5,10-methylenetetrahydrofolate reductase | 0.62 | 60 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.40 | Psyr_1669 | | O-succinylhomoserine sulfhydrylase | 0.37 | Psyr_0459 | | 5,10-methylenetetrahydrofolate reductase | low | > 86 |
| Marinobacter adhaerens HP15 | 0.39 | HP15_1820 | | methionine gamma-lyase | 0.39 | HP15_2917 | | 5,10-methylenetetrahydrofolate reductase-like protein | 0.96 | 2 |
| Pseudomonas putida KT2440 | 0.39 | PP_2001 | | O-succinylhomoserine sulfhydrylase | 0.37 | PP_4977 | | 5,10-methylenetetrahydrofolate reductase | 0.53 | 58 |
| Pseudomonas sp. RS175 | 0.39 | PFR28_02810 | | O-succinylhomoserine sulfhydrylase | 0.37 | PFR28_04202 | | 5,10-methylenetetrahydrofolate reductase | 0.38 | 42 |
| Pseudomonas aeruginosa PA14 | 0.39 | IKLFDK_15810 | | O-succinylhomoserine sulfhydrylase | 0.38 | IKLFDK_23270 | | methylenetetrahydrofolate reductase [NAD(P)H] | low | > 100 |
| Pseudomonas sp. BP01 | 0.39 | JOY50_RS16560 | | O-succinylhomoserine sulfhydrylase | 0.37 | JOY50_RS09810 | metF | methylenetetrahydrofolate reductase [NAD(P)H] | 0.95 | 24 |
| Pseudomonas fluorescens SBW25 | 0.39 | PFLU_RS20510 | | O-succinylhomoserine sulfhydrylase | 0.38 | PFLU_RS28165 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.84 | 6 |
| Pseudomonas fluorescens SBW25-INTG | 0.39 | PFLU_RS20510 | | O-succinylhomoserine sulfhydrylase | 0.38 | PFLU_RS28165 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.86 | 6 |
| Pseudomonas segetis P6 | 0.39 | MPMX49_03060 | | O-succinylhomoserine sulfhydrylase | 0.37 | MPMX49_00645 | | 5,10-methylenetetrahydrofolate reductase | 0.61 | 53 |
| Pseudomonas simiae WCS417 | 0.39 | PS417_18530 | | O-succinylhomoserine sulfhydrylase | 0.37 | PS417_26510 | | 5,10-methylenetetrahydrofolate reductase | 0.45 | 77 |
| Pseudomonas fluorescens FW300-N2C3 | 0.39 | AO356_21470 | | O-succinylhomoserine sulfhydrylase | 0.37 | AO356_13605 | | 5,10-methylenetetrahydrofolate reductase | 0.96 | 10 |
| Pseudomonas fluorescens FW300-N2E3 | 0.39 | AO353_20695 | | O-succinylhomoserine sulfhydrylase | 0.37 | AO353_08015 | | 5,10-methylenetetrahydrofolate reductase | 0.85 | 29 |
| Pseudomonas sp. DMC3 | 0.39 | GFF799 | | O-succinylhomoserine sulfhydrylase | 0.38 | GFF171 | | 5,10-methylenetetrahydrofolate reductase | 0.97 | 26 |
| Pseudomonas fluorescens FW300-N2E2 | 0.39 | Pf6N2E2_77 | | O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) | 0.37 | Pf6N2E2_4638 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.75 | 35 |
| Pseudomonas lactucae CFBP13502 | 0.39 | GEMAOFIL_03934 | | O-succinylhomoserine sulfhydrylase | 0.38 | GEMAOFIL_05433 | | 5,10-methylenetetrahydrofolate reductase | low | > 93 |
| Pseudomonas sp. SVBP6 | 0.39 | COO64_RS05595 | | O-succinylhomoserine sulfhydrylase | 0.37 | COO64_RS17485 | metF | methylenetetrahydrofolate reductase [NAD(P)H] | 0.98 | 19 |
| Pseudomonas fluorescens GW456-L13 | 0.38 | PfGW456L13_3934 | | O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) | 0.38 | PfGW456L13_1050 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.97 | 3 |
| Cellulophaga baltica 18 | 0.37 | M666_RS08150 | | aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme | 0.22 | M666_RS08215 | | methylenetetrahydrofolate reductase [NAD(P)H] | low | > 67 |
| Methylophilus sp. DMC18 | 0.36 | GFF662 | | O-succinylhomoserine sulfhydrylase | 0.36 | GFF1492 | | 5,10-methylenetetrahydrofolate reductase | — | — |
Not shown: 1 genomes with orthologs for MPMX19_01364 only; 64 genomes with orthologs for MPMX19_00635 only