| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Sphingobium sp. HT1-2 | 1.0 | GFF1282 | | Transcriptional regulator, LysR family | 1.0 | GFF2992 | | Two-component transcriptional response regulator SMc02366, LuxR family | 0.76 | 4 |
| Dickeya dianthicola 67-19 | 0.65 | HGI48_RS01275 | | LysR family transcriptional regulator | 0.48 | HGI48_RS03485 | | heavy metal response regulator transcription factor | 0.36 | 67 |
| Sinorhizobium meliloti 1021 | 0.63 | SMa0557 | | LysR family transcriptional regulator | 0.55 | SMc02366 | | transcriptional regulator | low | > 103 |
| Azospirillum brasilense Sp245 | 0.63 | AZOBR_RS30040 | | transcriptional regulator | 0.58 | AZOBR_RS10800 | | XRE family transcriptional regulator | low | > 97 |
| Azospirillum sp. SherDot2 | 0.63 | MPMX19_03861 | | HTH-type transcriptional regulator PgrR | 0.60 | MPMX19_00794 | | Transcriptional activator protein CopR | low | > 112 |
| Pectobacterium carotovorum WPP14 | 0.61 | HER17_RS06580 | | LysR family transcriptional regulator | 0.46 | HER17_RS13650 | | heavy metal response regulator transcription factor | low | > 75 |
| Pseudomonas fluorescens FW300-N1B4 | 0.60 | Pf1N1B4_4966 | | Transcriptional regulator, LysR family | 0.49 | Pf1N1B4_4267 | | DNA-binding response regulator | — | — |
| Pseudomonas sp. DMC3 | 0.60 | GFF1673 | | HTH-type transcriptional regulator PgrR | 0.51 | GFF1578 | | Transcriptional regulatory protein CusR | low | > 89 |
| Ralstonia solanacearum IBSBF1503 | 0.60 | RALBFv3_RS17155 | | LysR family transcriptional regulator | 0.46 | RALBFv3_RS20860 | | DNA-binding response regulator | low | > 76 |
| Bosea sp. OAE506 | 0.59 | ABIE41_RS16645 | | LysR family transcriptional regulator | 0.55 | ABIE41_RS21440 | | response regulator transcription factor | low | > 77 |
| Ralstonia solanacearum PSI07 | 0.59 | RPSI07_RS06445 | | LysR family transcriptional regulator | 0.45 | RPSI07_RS02355 | | DNA-binding response regulator | low | > 81 |
| Ralstonia solanacearum GMI1000 | 0.59 | RS_RS24215 | | LysR family transcriptional regulator | 0.46 | RS_RS20255 | | DNA-binding response regulator | low | > 80 |
| Pseudomonas fluorescens FW300-N2C3 | 0.59 | AO356_24055 | | LysR family transcriptional regulator | 0.50 | AO356_23125 | | transcriptional regulator | low | > 104 |
| Escherichia fergusonii Becca | 0.59 | EFB2_03743 | | HTH-type transcriptional regulator PgrR | 0.48 | EFB2_03523 | | Transcriptional regulatory protein CusR | low | > 86 |
| Escherichia coli Nissle 1917 | 0.59 | ECOLIN_RS01950 | | LysR family transcriptional regulator | 0.48 | ECOLIN_RS03125 | | copper response regulator transcription factor CusR | — | — |
| Escherichia coli ECOR38 | 0.59 | HEPCGN_07680 | lysR | LysR family transcriptional regulator | 0.48 | HEPCGN_00585 | cusR | copper response regulator transcription factor CusR | low | > 88 |
| Pseudomonas orientalis W4I3 | 0.58 | QF045_RS18865 | | LysR family transcriptional regulator | 0.49 | QF045_RS14560 | | response regulator transcription factor | low | > 93 |
| Klebsiella pneumoniae MKP103 | 0.58 | KDGMDA_22985 | | LysR family transcriptional regulator | 0.48 | KDGMDA_00710 | | copper/silver response regulator transcription factor SilR | low | > 95 |
| Rahnella sp. WP5 | 0.58 | EX31_RS20830 | | LysR family transcriptional regulator | 0.45 | EX31_RS18870 | | heavy metal response regulator transcription factor | low | > 89 |
| Pantoea agglomerans CFBP13505 P0401 | 0.58 | PagCFBP13505_RS07675 | | LysR family transcriptional regulator | 0.40 | PagCFBP13505_RS14010 | | response regulator transcription factor HprR | low | > 74 |
| Serratia liquefaciens MT49 | 0.57 | IAI46_12365 | | LysR family transcriptional regulator | 0.47 | IAI46_16745 | | heavy metal response regulator transcription factor | low | > 87 |
| Paraburkholderia graminis OAS925 | 0.57 | ABIE53_005634 | | DNA-binding transcriptional LysR family regulator | 0.46 | ABIE53_005703 | | two-component system copper resistance phosphate regulon response regulator CusR | low | > 113 |
| Dyella japonica UNC79MFTsu3.2 | 0.56 | ABZR86_RS17790 | | LysR family transcriptional regulator | 0.49 | ABZR86_RS12570 | | response regulator transcription factor | low | > 74 |
| Enterobacter asburiae PDN3 | 0.56 | EX28DRAFT_1046 | | Transcriptional regulator | 0.48 | EX28DRAFT_1165 | | heavy metal response regulator | low | > 76 |
| Cupriavidus basilensis FW507-4G11 | 0.56 | RR42_RS30480 | | LysR family transcriptional regulator | 0.45 | RR42_RS31535 | | transcriptional regulator | low | > 128 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.55 | Psyr_3801 | | transcriptional regulator, LysR family | 0.50 | Psyr_3127 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | low | > 86 |
| Pseudomonas syringae pv. syringae B728a | 0.55 | Psyr_3801 | | transcriptional regulator, LysR family | 0.50 | Psyr_3127 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | low | > 86 |
| Pseudomonas fluorescens FW300-N2E2 | 0.55 | Pf6N2E2_1914 | | Transcriptional regulator, LysR family | 0.50 | Pf6N2E2_504 | | DNA-binding response regulator | low | > 103 |
| Klebsiella michiganensis M5al | 0.55 | BWI76_RS18485 | | LysR family transcriptional regulator | 0.40 | BWI76_RS18590 | | DNA-binding response regulator | low | > 92 |
| Dickeya dianthicola ME23 | 0.55 | DZA65_RS07300 | | LysR family transcriptional regulator | 0.48 | DZA65_RS03595 | | copper/silver response regulator transcription factor SilR | low | > 75 |
| Enterobacter sp. TBS_079 | 0.53 | MPMX20_02525 | | HTH-type transcriptional regulator PgrR | 0.48 | MPMX20_02319 | | Transcriptional regulatory protein CusR | low | > 85 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.53 | OHPLBJKB_02353 | | HTH-type transcriptional regulator PgrR | 0.48 | OHPLBJKB_03138 | | Transcriptional regulatory protein CusR | low | > 74 |
| Escherichia coli BL21 | 0.53 | ECD_01306 | | murein peptide degradation regulator | 0.48 | ECD_00532 | | response regulator in two-component regulatory system with CusS | — | — |
| Escherichia coli BW25113 | 0.53 | b1328 | ycjZ | predicted DNA-binding transcriptional regulator (NCBI) | 0.48 | b0571 | cusR | DNA-binding response regulator in two-component regulatory system with CusS (NCBI) | low | > 76 |
| Escherichia coli ECRC101 | 0.53 | MCAODC_16005 | pgrR | DNA-binding transcriptional regulator PgrR | 0.48 | MCAODC_26920 | cusR | copper response regulator transcription factor CusR | low | > 87 |
| Escherichia coli ECRC100 | 0.53 | OKFHMN_02265 | pgrR | DNA-binding transcriptional regulator PgrR | 0.48 | OKFHMN_07705 | cusR | copper response regulator transcription factor CusR | low | > 79 |
| Escherichia coli ECRC98 | 0.53 | JDDGAC_04810 | pgrR | DNA-binding transcriptional regulator PgrR | 0.48 | JDDGAC_11350 | cusR | copper response regulator transcription factor CusR | low | > 87 |
| Escherichia coli ECRC62 | 0.53 | BNILDI_18115 | pgrR | DNA-binding transcriptional regulator PgrR | 0.48 | BNILDI_22095 | cusR | copper response regulator transcription factor CusR | low | > 75 |
| Escherichia coli ECOR27 | 0.53 | NOLOHH_19965 | pgrR | DNA-binding transcriptional regulator PgrR | 0.48 | NOLOHH_24085 | cusR | copper response regulator transcription factor CusR | low | > 76 |
| Escherichia coli ECRC102 | 0.53 | NIAGMN_26435 | pgrR | DNA-binding transcriptional regulator PgrR | 0.48 | NIAGMN_05760 | cusR | copper response regulator transcription factor CusR | low | > 80 |
| Escherichia coli ECRC99 | 0.53 | KEDOAH_26505 | pgrR | DNA-binding transcriptional regulator PgrR | 0.48 | KEDOAH_20265 | cusR | copper response regulator transcription factor CusR | — | — |
| Ralstonia solanacearum UW163 | 0.45 | UW163_RS23075 | | LysR family transcriptional regulator | 0.46 | UW163_RS21995 | | DNA-binding response regulator | — | — |
| Pseudomonas aeruginosa MRSN321 | 0.44 | DY961_RS20365 | | LysR family transcriptional regulator | 0.47 | DY961_RS03005 | | heavy metal response regulator transcription factor | low | > 100 |
| Pseudomonas aeruginosa PA14 | 0.44 | IKLFDK_08395 | | LysR family transcriptional regulator | 0.47 | IKLFDK_14215 | | DNA-binding response regulator | low | > 98 |
| Pseudomonas aeruginosa PUPa3 | 0.44 | DQ20_RS54455 | | LysR family transcriptional regulator | 0.47 | DQ20_RS32585 | | heavy metal response regulator transcription factor | low | > 101 |
| Agrobacterium fabrum C58 | 0.44 | Atu0261 | | transcriptional regulator, LysR family | 0.54 | Atu0978 | | two component response regulator | low | > 89 |
| Rhizobium sp. OAE497 | 0.41 | ABIE40_RS08100 | | LysR family transcriptional regulator | 0.55 | ABIE40_RS05700 | | response regulator transcription factor | low | > 107 |
| Rhodospirillum rubrum S1H | 0.40 | Rru_A1060 | | Transcriptional Regulator, LysR family (NCBI) | 0.60 | Rru_A2913 | | Two component Transcriptional regulator, Winged helix family (NCBI) | low | > 58 |
| Ralstonia sp. UNC404CL21Col | 0.38 | ABZR87_RS04130 | | LysR family transcriptional regulator | 0.43 | ABZR87_RS21725 | | heavy metal response regulator transcription factor | low | > 80 |
| Pseudomonas fluorescens FW300-N2E3 | 0.37 | AO353_14725 | | transcriptional regulator | 0.50 | AO353_17925 | | transcriptional regulator | low | > 101 |
| Lysobacter sp. OAE881 | 0.37 | ABIE51_RS02430 | | LysR family transcriptional regulator | 0.58 | ABIE51_RS04165 | | response regulator transcription factor | low | > 62 |
| Pseudomonas simiae WCS417 | 0.37 | PS417_14680 | | LysR family transcriptional regulator | 0.49 | PS417_11825 | | transcriptional regulator | 0.17 | 21 |
| Herbaspirillum seropedicae SmR1 | 0.35 | HSERO_RS21720 | | transcriptional regulator | 0.45 | HSERO_RS12420 | | transcriptional regulator | low | > 78 |
| Acidovorax sp. GW101-3H11 | 0.32 | Ac3H11_4132 | | Transcriptional regulator, LysR family | 0.47 | Ac3H11_4210 | | DNA-binding heavy metal response regulator | low | > 79 |
Not shown: 11 genomes with orthologs for GFF1282 only; 42 genomes with orthologs for GFF2992 only