Conservation of cofitness between CSW01_16895 and CSW01_19035 in Vibrio cholerae E7946 ATCC 55056

67 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Vibrio cholerae E7946 ATCC 55056 1.0 CSW01_16895 DNA-binding response regulator 1.0 CSW01_19035 alpha-hydroxy-acid oxidizing enzyme 0.47 6
Burkholderia phytofirmans PsJN 0.50 BPHYT_RS06465 transcriptional regulator 0.26 BPHYT_RS31690 hypothetical protein low > 109
Enterobacter asburiae PDN3 0.49 EX28DRAFT_2284 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 0.80 EX28DRAFT_3855 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases low > 76
Enterobacter sp. TBS_079 0.49 MPMX20_01337 KDP operon transcriptional regulatory protein KdpE 0.81 MPMX20_00129 L-lactate dehydrogenase low > 85
Paraburkholderia graminis OAS925 0.49 ABIE53_001557 two-component system KDP operon response regulator KdpE 0.34 ABIE53_005317 (S)-mandelate dehydrogenase low > 113
Dechlorosoma suillum PS 0.48 Dsui_0271 response regulator with CheY-like receiver domain and winged-helix DNA-binding domain 0.27 Dsui_1668 alpha-hydroxyacid dehydrogenase, FMN-dependent L-lactate dehydrogenase low > 51
Pseudomonas aeruginosa PUPa3 0.48 DQ20_RS53940 response regulator 0.84 DQ20_RS52425 lldD;go_function=lactate FMN-dependent L-lactate dehydrogenase LldD low > 101
Pseudomonas aeruginosa PA14 0.48 IKLFDK_07850 DNA-binding response regulator 0.84 IKLFDK_29735 FMN-dependent L-lactate dehydrogenase LldD low > 98
Pseudomonas lactucae CFBP13502 0.47 GEMAOFIL_01790 KDP operon transcriptional regulatory protein KdpE 0.72 GEMAOFIL_04053 L-lactate dehydrogenase low > 96
Pseudomonas fluorescens SBW25-INTG 0.47 PFLU_RS08245 response regulator 0.76 PFLU_RS21125 FMN-dependent L-lactate dehydrogenase LldD low > 109
Pseudomonas sp. S08-1 0.47 OH686_01885 DNA-binding response regulator KdpE 0.84 OH686_17010 L-lactate dehydrogenase 0.53 4
Pseudomonas fluorescens SBW25 0.47 PFLU_RS08245 response regulator 0.76 PFLU_RS21125 FMN-dependent L-lactate dehydrogenase LldD low > 109
Pseudomonas orientalis W4I3 0.47 QF045_RS11020 response regulator 0.76 QF045_RS21085 FMN-dependent L-lactate dehydrogenase LldD low > 93
Dyella japonica UNC79MFTsu3.2 0.47 ABZR86_RS13215 response regulator 0.43 ABZR86_RS01315 alpha-hydroxy acid oxidase low > 74
Pseudomonas aeruginosa MRSN321 0.47 DY961_RS19835 response regulator 0.84 DY961_RS09615 lldD;go_function=lactate FMN-dependent L-lactate dehydrogenase LldD low > 100
Pseudomonas simiae WCS417 0.47 PS417_08305 transcriptional regulator 0.76 PS417_19130 L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) (from data) low > 88
Pseudomonas sp. BP01 0.47 JOY50_RS07160 response regulator 0.83 JOY50_RS26700 lldD FMN-dependent L-lactate dehydrogenase LldD low > 84
Methylophilus sp. DMC18 0.47 GFF2684 KDP operon transcriptional regulatory protein KdpE 0.27 GFF2539 4-hydroxymandelate oxidase low > 43
Pseudomonas sp. SVBP6 0.47 COO64_RS09705 response regulator 0.84 COO64_RS15315 lldD FMN-dependent L-lactate dehydrogenase LldD low > 93
Pseudomonas segetis P6 0.47 MPMX49_01014 Transcriptional regulatory protein KdpE 0.85 MPMX49_01172 L-lactate dehydrogenase low > 75
Escherichia coli BW25113 0.47 b0694 kdpE DNA-binding response regulator in two-component regulatory system with KdpD (NCBI) 0.83 b3605 lldD L-lactate dehydrogenase, FMN-linked (NCBI) low > 76
Escherichia fergusonii Becca 0.47 EFB2_03402 KDP operon transcriptional regulatory protein KdpE 0.82 EFB2_00205 L-lactate dehydrogenase low > 86
Escherichia coli HS(pFamp)R (ATCC 700891) 0.47 OHPLBJKB_03023 KDP operon transcriptional regulatory protein KdpE 0.83 OHPLBJKB_00094 L-lactate dehydrogenase low > 74
Escherichia coli ECOR27 0.47 NOLOHH_23460 kdpE two-component system response regulator KdpE 0.83 NOLOHH_07650 lldD quinone-dependent L-lactate dehydrogenase 0.47 30
Escherichia coli Nissle 1917 0.47 ECOLIN_RS03750 two-component system response regulator KdpE 0.83 ECOLIN_RS20580 quinone-dependent L-lactate dehydrogenase — —
Escherichia coli ECRC62 0.47 BNILDI_21465 kdpE two-component system response regulator KdpE 0.83 BNILDI_03865 lldD quinone-dependent L-lactate dehydrogenase low > 75
Escherichia coli ECOR38 0.47 HEPCGN_01155 kdpE two-component system response regulator KdpE 0.83 HEPCGN_14610 lldD quinone-dependent L-lactate dehydrogenase low > 88
Variovorax sp. SCN45 0.46 GFF3521 DNA-binding response regulator KdpE 0.43 GFF5984 L-lactate dehydrogenase low > 127
Escherichia coli BL21 0.46 ECD_00651 response regulator in two-component regulatory system with KdpD 0.83 ECD_03463 L-lactate dehydrogenase, FMN-linked low > 61
Pseudomonas syringae pv. syringae B728a 0.46 Psyr_2051 Response regulator receiver:Transcriptional regulatory protein, C-terminal 0.73 Psyr_0908 FMN-dependent alpha-hydroxy acid dehydrogenase low > 86
Pseudomonas syringae pv. syringae B728a ΔmexB 0.46 Psyr_2051 Response regulator receiver:Transcriptional regulatory protein, C-terminal 0.73 Psyr_0908 FMN-dependent alpha-hydroxy acid dehydrogenase low > 86
Pseudomonas putida KT2440 0.46 PP_4157 two-component system DNA-binding response activator KdpE 0.83 PP_4736 L-lactate dehydrogenase low > 96
Escherichia coli ECRC102 0.46 NIAGMN_05135 kdpE two-component system response regulator KdpE 0.83 NIAGMN_13530 lldD quinone-dependent L-lactate dehydrogenase low > 80
Escherichia coli ECRC98 0.46 JDDGAC_10730 kdpE two-component system response regulator KdpE 0.83 JDDGAC_19395 lldD quinone-dependent L-lactate dehydrogenase low > 87
Pectobacterium carotovorum WPP14 0.46 HER17_RS15050 two-component system response regulator KdpE 0.85 HER17_RS20970 FMN-dependent L-lactate dehydrogenase LldD low > 75
Escherichia coli ECRC101 0.46 MCAODC_26295 kdpE two-component system response regulator KdpE 0.83 MCAODC_06280 lldD quinone-dependent L-lactate dehydrogenase low > 87
Pantoea sp. MT58 0.46 IAI47_13830 two-component system response regulator KdpE 0.82 IAI47_15020 FMN-dependent L-lactate dehydrogenase LldD low > 76
Escherichia coli ECRC99 0.46 KEDOAH_20890 kdpE two-component system response regulator KdpE 0.83 KEDOAH_12380 lldD quinone-dependent L-lactate dehydrogenase — —
Escherichia coli ECRC100 0.46 OKFHMN_07080 kdpE two-component system response regulator KdpE 0.83 OKFHMN_15770 lldD quinone-dependent L-lactate dehydrogenase low > 79
Xanthomonas campestris pv. campestris strain 8004 0.46 Xcc-8004.4378.1 sensor histidine kinase 0.83 Xcc-8004.142.1 L-lactate dehydrogenase (EC 1.1.2.3) low > 74
Variovorax sp. OAS795 0.46 ABID97_RS01005 two-component system response regulator KdpE 0.42 ABID97_RS08010 alpha-hydroxy acid oxidase low > 91
Acidovorax sp. GW101-3H11 0.46 Ac3H11_2407 sensor histidine kinase 0.42 Ac3H11_1623 L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) (from data) low > 79
Caulobacter crescentus NA1000 Δfur 0.46 CCNA_01667 two-component response regulator kdpE 0.64 CCNA_01209 L-lactate dehydrogenase low > 67
Caulobacter crescentus NA1000 0.46 CCNA_01667 two-component response regulator kdpE 0.64 CCNA_01209 L-lactate dehydrogenase low > 66
Klebsiella pneumoniae MKP103 0.46 KDGMDA_16625 two-component system response regulator KdpE 0.82 KDGMDA_07880 FMN-dependent L-lactate dehydrogenase LldD low > 95
Pantoea agglomerans CFBP13505 P0401 0.46 PagCFBP13505_RS03475 two-component system response regulator KdpE 0.81 PagCFBP13505_RS10140 alpha-hydroxy-acid oxidizing protein low > 74
Rahnella sp. WP5 0.45 EX31_RS23330 two-component system response regulator KdpE 0.86 EX31_RS00640 FMN-dependent L-lactate dehydrogenase LldD low > 89
Serratia liquefaciens MT49 0.45 IAI46_06160 two-component system response regulator KdpE 0.86 IAI46_20620 FMN-dependent L-lactate dehydrogenase LldD low > 87
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.45 GFF4606 sensor histidine kinase 0.81 GFF409 L-lactate dehydrogenase (EC 1.1.2.3) low > 78
Brevundimonas sp. GW460-12-10-14-LB2 0.45 A4249_RS15625 response regulator 0.80 A4249_RS07680 FMN-dependent L-lactate dehydrogenase LldD low > 48
Ralstonia solanacearum PSI07 0.45 RPSI07_RS09645 two-component system response regulator KdpE 0.44 RPSI07_RS14000 alpha-hydroxy-acid oxidizing protein low > 81
Mycobacterium tuberculosis H37Rv 0.45 Rv1027c Probable transcriptional regulatory protein KdpE 0.32 Rv1872c Possible L-lactate dehydrogenase (cytochrome) LldD2 — —
Azospirillum sp. SherDot2 0.44 MPMX19_03749 KDP operon transcriptional regulatory protein KdpE 0.41 MPMX19_04146 L-lactate dehydrogenase low > 112
Acinetobacter radioresistens SK82 0.43 MPMX26_02240 Transcriptional regulatory protein KdpE 0.83 MPMX26_02257 L-lactate dehydrogenase — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.43 GFF4475 sensor histidine kinase 0.45 GFF2105 L-lactate dehydrogenase (EC 1.1.2.3) low > 90
Herbaspirillum seropedicae SmR1 0.43 HSERO_RS18850 transcriptional regulator 0.44 HSERO_RS12985 L-lactate dehydrogenase — —
Azospirillum brasilense Sp245 0.43 AZOBR_RS23980 Fis family transcriptional regulator 0.29 AZOBR_RS27055 L-lactate dehydrogenase low > 97
Sinorhizobium meliloti 1021 0.42 SMa2325 transcriptional regulator 0.45 SM_b20850 L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) (from data) low > 103
Acinetobacter baumannii LAC-4 0.42 RR41_RS06945 response regulator transcription factor 0.82 RR41_RS18505 FMN-dependent L-lactate dehydrogenase LldD low > 55
Magnetospirillum magneticum AMB-1 0.42 AMB_RS09660 DNA-binding response regulator 0.25 AMB_RS22540 alpha-hydroxy-acid oxidizing protein low > 64
Bosea sp. OAE506 0.42 ABIE41_RS24235 response regulator 0.42 ABIE41_RS12435 alpha-hydroxy acid oxidase low > 77
Xanthobacter sp. DMC5 0.41 GFF2981 KDP operon transcriptional regulatory protein KdpE 0.76 GFF2176 L-lactate dehydrogenase — —
Agrobacterium fabrum C58 0.40 Atu3786 two component response regulator 0.46 Atu2318 L-lactate dehydrogenase low > 89
Sphingomonas koreensis DSMZ 15582 0.40 Ga0059261_3886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 0.62 Ga0059261_2629 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases low > 68
Rhizobium sp. OAE497 0.39 ABIE40_RS24605 response regulator transcription factor 0.44 ABIE40_RS13790 alpha-hydroxy acid oxidase low > 107
Sphingobium sp. HT1-2 0.39 GFF2987 DNA-binding response regulator KdpE 0.76 GFF3400 L-lactate dehydrogenase low > 95
Rhodopseudomonas palustris CGA009 0.39 TX73_015545 response regulator transcription factor 0.46 TX73_022385 alpha-hydroxy acid oxidase low > 86
Alteromonas macleodii MIT1002 0.32 MIT1002_01389 KDP operon transcriptional regulatory protein KdpE 0.83 MIT1002_03330 L-lactate dehydrogenase [cytochrome] low > 70

Not shown: 27 genomes with orthologs for CSW01_16895 only; 6 genomes with orthologs for CSW01_19035 only