| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_12385 | | multifunctional CCA tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase | 1.0 | CSW01_10760 | | glycine cleavage system transcriptional regulator | 0.68 | 8 |
| Pectobacterium carotovorum WPP14 | 0.62 | HER17_RS04020 | | multifunctional CCA addition/repair protein | 0.37 | HER17_RS15420 | | glycine cleavage system transcriptional repressor | — | — |
| Klebsiella pneumoniae MKP103 | 0.62 | KDGMDA_05285 | | multifunctional CCA addition/repair protein | 0.37 | KDGMDA_27750 | | glycine cleavage system transcriptional repressor | — | — |
| Shewanella sp. ANA-3 | 0.62 | Shewana3_3076 | | metal dependent phosphohydrolase (RefSeq) | 0.33 | Shewana3_1655 | | glycine cleavage system transcriptional repressor, putative (RefSeq) | — | — |
| Shewanella loihica PV-4 | 0.62 | Shew_1008 | | metal dependent phosphohydrolase (RefSeq) | 0.33 | Shew_1847 | | amino acid-binding ACT domain-containing protein (RefSeq) | — | — |
| Escherichia coli BL21 | 0.62 | ECD_02926 | | fused tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase and phosphatase | 0.39 | ECD_02371 | | transcriptional repressor, regulatory protein accessory to GcvA | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.62 | OHPLBJKB_00648 | | Multifunctional CCA protein | 0.39 | OHPLBJKB_01250 | | Glycine cleavage system transcriptional repressor | — | — |
| Escherichia coli BW25113 | 0.62 | b3056 | cca | fused tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase and phosphatase (NCBI) | 0.39 | b2479 | gcvR | transcriptional regulation of gcv operon (VIMSS) | — | — |
| Escherichia coli ECRC62 | 0.62 | BNILDI_01015 | cca | fused tRNA nucleotidyltransferase/2',3'-cyclic phosphodiesterase/2' nucleotidase/phosphatase Cca | 0.39 | BNILDI_12380 | gcvR | glycine cleavage system transcriptional repressor | — | — |
| Escherichia coli ECOR38 | 0.62 | HEPCGN_17570 | cca | fused tRNA nucleotidyltransferase/2',3'-cyclic phosphodiesterase/2' nucleotidase/phosphatase Cca | 0.39 | HEPCGN_21080 | gcvR | glycine cleavage system transcriptional repressor | — | — |
| Enterobacter asburiae PDN3 | 0.61 | EX28DRAFT_3084 | | tRNA nucleotidyltransferase/poly(A) polymerase | 0.37 | EX28DRAFT_0181 | | Glycine cleavage system regulatory protein | — | — |
| Escherichia coli ECOR27 | 0.61 | NOLOHH_10500 | cca | fused tRNA nucleotidyltransferase/2',3'-cyclic phosphodiesterase/2' nucleotidase/phosphatase Cca | 0.39 | NOLOHH_13570 | gcvR | glycine cleavage system transcriptional repressor | — | — |
| Dickeya dianthicola ME23 | 0.61 | DZA65_RS18255 | | multifunctional CCA addition/repair protein | 0.36 | DZA65_RS06455 | | glycine cleavage system transcriptional repressor | — | — |
| Dickeya dadantii 3937 | 0.61 | DDA3937_RS17120 | | multifunctional CCA addition/repair protein | 0.36 | DDA3937_RS06060 | | glycine cleavage system transcriptional repressor | — | — |
| Dickeya dianthicola 67-19 | 0.61 | HGI48_RS17170 | | multifunctional CCA addition/repair protein | 0.36 | HGI48_RS06105 | | glycine cleavage system transcriptional repressor | — | — |
| Enterobacter sp. TBS_079 | 0.61 | MPMX20_03893 | | Multifunctional CCA protein | 0.37 | MPMX20_03341 | | Glycine cleavage system transcriptional repressor | — | — |
| Escherichia coli ECRC98 | 0.61 | JDDGAC_22350 | cca | fused tRNA nucleotidyltransferase/2',3'-cyclic phosphodiesterase/2' nucleotidase/phosphatase Cca | 0.39 | JDDGAC_25855 | gcvR | glycine cleavage system transcriptional repressor | — | — |
| Escherichia fergusonii Becca | 0.61 | EFB2_00755 | | Multifunctional CCA protein | 0.39 | EFB2_01407 | | Glycine cleavage system transcriptional repressor | — | — |
| Escherichia coli ECRC100 | 0.61 | OKFHMN_18715 | cca | fused tRNA nucleotidyltransferase/2',3'-cyclic phosphodiesterase/2' nucleotidase/phosphatase Cca | 0.39 | OKFHMN_21910 | gcvR | glycine cleavage system transcriptional repressor | — | — |
| Escherichia coli ECRC102 | 0.61 | NIAGMN_16480 | cca | fused tRNA nucleotidyltransferase/2',3'-cyclic phosphodiesterase/2' nucleotidase/phosphatase Cca | 0.39 | NIAGMN_19680 | gcvR | glycine cleavage system transcriptional repressor | — | — |
| Escherichia coli ECRC101 | 0.61 | MCAODC_09230 | cca | fused tRNA nucleotidyltransferase/2',3'-cyclic phosphodiesterase/2' nucleotidase/phosphatase Cca | 0.39 | MCAODC_12440 | gcvR | glycine cleavage system transcriptional repressor | — | — |
| Escherichia coli ECRC99 | 0.61 | KEDOAH_09430 | cca | fused tRNA nucleotidyltransferase/2',3'-cyclic phosphodiesterase/2' nucleotidase/phosphatase Cca | 0.39 | KEDOAH_06310 | gcvR | glycine cleavage system transcriptional repressor | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.61 | GFF3170 | | tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) | 0.39 | GFF2179 | | Glycine cleavage system transcriptional antiactivator GcvR | — | — |
| Escherichia coli Nissle 1917 | 0.61 | ECOLIN_RS17650 | | fused tRNA nucleotidyltransferase/2',3'-cyclic phosphodiesterase/2' nucleotidase/phosphatase Cca | 0.39 | ECOLIN_RS14150 | | glycine cleavage system transcriptional repressor | — | — |
| Serratia liquefaciens MT49 | 0.61 | IAI46_22075 | | multifunctional CCA addition/repair protein | 0.36 | IAI46_18785 | | glycine cleavage system transcriptional repressor | — | — |
| Klebsiella michiganensis M5al | 0.61 | BWI76_RS24475 | | multifunctional CCA tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase | 0.38 | BWI76_RS20910 | | glycine cleavage system transcriptional repressor | — | — |
| Pantoea agglomerans CFBP13505 P0401 | 0.60 | PagCFBP13505_RS11905 | | multifunctional CCA addition/repair protein | 0.33 | PagCFBP13505_RS15150 | | glycine cleavage system transcriptional repressor | — | — |
| Rahnella sp. WP5 | 0.60 | EX31_RS08160 | | multifunctional CCA addition/repair protein | 0.39 | EX31_RS22735 | | glycine cleavage system transcriptional repressor | — | — |
| Erwinia tracheiphila SCR3 | 0.60 | LU632_RS20690 | | multifunctional CCA addition/repair protein | 0.37 | LU632_RS08320 | | glycine cleavage system transcriptional repressor | — | — |
| Erwinia tracheiphila HP pepo 2.2 | 0.59 | IJEDHG_14370 | | multifunctional CCA addition/repair protein | 0.37 | IJEDHG_18430 | gcvR | glycine cleavage system transcriptional repressor | — | — |
| Erwinia amylovora T8 | 0.59 | OLJFJH_07620 | | multifunctional CCA addition/repair protein | 0.34 | OLJFJH_10630 | | glycine cleavage system transcriptional repressor | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.58 | Pf1N1B4_2520 | | tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) | 0.16 | Pf1N1B4_3331 | | Glycine cleavage system transcriptional antiactivator GcvR | — | — |
| Pseudomonas sp. S08-1 | 0.57 | OH686_15005 | | CCA tRNA nucleotidyltransferase | 0.15 | OH686_19210 | | Glycine cleavage system transcriptional antiactivator GcvR | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.56 | AO353_07350 | | 2', 3'-cyclic nucleotide 2'-phosphodiesterase | 0.15 | AO353_17665 | | glycine cleavage system protein R | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.56 | PfGW456L13_1193 | | tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) | 0.16 | PfGW456L13_4508 | | Glycine cleavage system transcriptional antiactivator GcvR | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.56 | Psyr_4634 | | Polynucleotide adenylyltransferase:Metal-dependent phosphohydrolase, HD subdomain protein | 0.15 | Psyr_1547 | | glycine cleavage system transcriptional repressor | low | > 86 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.56 | Psyr_4634 | | Polynucleotide adenylyltransferase:Metal-dependent phosphohydrolase, HD subdomain protein | 0.15 | Psyr_1547 | | glycine cleavage system transcriptional repressor | low | > 86 |
| Pseudomonas sp. RS175 | 0.55 | PFR28_04071 | | Multifunctional CCA protein | 0.16 | PFR28_00698 | | Glycine cleavage system transcriptional repressor | low | > 88 |
| Pseudomonas fluorescens FW300-N2E2 | 0.55 | Pf6N2E2_4798 | | tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) | 0.16 | Pf6N2E2_2748 | | Glycine cleavage system transcriptional antiactivator GcvR | — | — |
| Pseudomonas aeruginosa PUPa3 | 0.55 | DQ20_RS36400 | | multifunctional CCA addition/repair protein | 0.17 | DQ20_RS45355 | | glycine cleavage system protein R | — | — |
| Pseudomonas orientalis W4I3 | 0.55 | QF045_RS00245 | | multifunctional CCA addition/repair protein | 0.17 | QF045_RS09870 | | glycine cleavage system protein R | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.55 | AO356_14300 | | 2', 3'-cyclic nucleotide 2'-phosphodiesterase | 0.16 | AO356_04535 | | glycine cleavage system protein R | — | — |
| Pseudomonas sp. SVBP6 | 0.55 | COO64_RS22545 | | multifunctional CCA addition/repair protein | 0.14 | COO64_RS20240 | | glycine cleavage system protein R | — | — |
| Pseudomonas aeruginosa PA14 | 0.55 | IKLFDK_22490 | | multifunctional CCA addition/repair protein | 0.17 | IKLFDK_04580 | | glycine cleavage system protein R | — | — |
| Pseudomonas aeruginosa MRSN321 | 0.55 | DY961_RS22945 | | multifunctional CCA addition/repair protein | 0.17 | DY961_RS07435 | | glycine cleavage system protein R | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.54 | PFLU_RS27500 | | multifunctional CCA addition/repair protein | 0.16 | PFLU_RS07270 | | glycine cleavage system protein R | — | — |
| Pseudomonas segetis P6 | 0.54 | ACVTMO_RS04315 | | multifunctional CCA addition/repair protein | 0.16 | ACVTMO_RS08440 | | glycine cleavage system protein R | — | — |
| Pseudomonas fluorescens SBW25 | 0.54 | PFLU_RS27500 | | multifunctional CCA addition/repair protein | 0.16 | PFLU_RS07270 | | glycine cleavage system protein R | — | — |
| Pseudomonas simiae WCS417 | 0.54 | PS417_25845 | | 2', 3'-cyclic nucleotide 2'-phosphodiesterase | 0.17 | PS417_07160 | | glycine cleavage system protein R | — | — |
| Pseudomonas lactucae CFBP13502 | 0.54 | GEMAOFIL_05289 | | Multifunctional CCA protein | 0.17 | GEMAOFIL_01580 | | Glycine cleavage system transcriptional repressor | — | — |
| Dyella japonica UNC79MFTsu3.2 | 0.54 | ABZR86_RS12755 | | multifunctional CCA addition/repair protein | 0.15 | ABZR86_RS00780 | | glycine cleavage system protein R | — | — |
| Lysobacter sp. OAE881 | 0.53 | ABIE51_RS19085 | | multifunctional CCA addition/repair protein | 0.17 | ABIE51_RS07990 | | glycine cleavage system protein R | — | — |
| Xanthomonas campestris pv. campestris strain 8004 | 0.53 | Xcc-8004.960.1 | | tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25) | 0.18 | Xcc-8004.3086.1 | | Glycine cleavage system transcriptional antiactivator GcvR | — | — |
| Rhodanobacter denitrificans MT42 | 0.50 | LRK55_RS07010 | | multifunctional CCA addition/repair protein | 0.20 | LRK55_RS14795 | | glycine cleavage system protein R | — | — |
| Rhodanobacter denitrificans FW104-10B01 | 0.50 | LRK54_RS07280 | | multifunctional CCA addition/repair protein | 0.20 | LRK54_RS15080 | | glycine cleavage system protein R | — | — |
| Alteromonas macleodii MIT1002 | 0.39 | MIT1002_00942 | | Multifunctional CCA protein | 0.32 | MIT1002_02208 | | Gcv operon repressor | — | — |
| Pseudomonas putida KT2440 | 0.39 | PP_0394 | | tRNA nucleotidyltransferase - 2',3'-cyclic phosphodiesterase - 2' nucleotidase and phosphatase | 0.17 | PP_1236 | | putative Glycine cleavage system transcriptional repressor | — | — |
| Pseudomonas stutzeri RCH2 | 0.39 | Psest_3675 | | tRNA nucleotidyltransferase/poly(A) polymerase | 0.16 | Psest_1514 | | Glycine cleavage system regulatory protein | — | — |
| Pseudomonas sp. BP01 | 0.37 | JOY50_RS18105 | | multifunctional CCA addition/repair protein | 0.17 | JOY50_RS01715 | | glycine cleavage system protein R | — | — |
Not shown: 26 genomes with orthologs for CSW01_12385 only; 1 genomes with orthologs for CSW01_10760 only