| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_16895 | | DNA-binding response regulator | 1.0 | CSW01_09910 | | alpha/beta hydrolase | 0.51 | 2 |
| Burkholderia phytofirmans PsJN | 0.50 | BPHYT_RS06465 | | transcriptional regulator | 0.11 | BPHYT_RS12645 | | alpha/beta hydrolase | low | > 109 |
| Paraburkholderia bryophila 376MFSha3.1 | 0.49 | H281DRAFT_04533 | | two-component system, OmpR family, KDP operon response regulator KdpE | 0.12 | H281DRAFT_00503 | | Pimeloyl-ACP methyl ester carboxylesterase | low | > 103 |
| Paraburkholderia graminis OAS925 | 0.49 | ABIE53_001557 | | two-component system KDP operon response regulator KdpE | 0.13 | ABIE53_002755 | | pimeloyl-ACP methyl ester carboxylesterase | low | > 113 |
| Pseudomonas aeruginosa PUPa3 | 0.48 | DQ20_RS53940 | | response regulator | 0.19 | DQ20_RS53870 | | alpha/beta fold hydrolase | low | > 101 |
| Pseudomonas fluorescens FW300-N2E3 | 0.48 | AO353_18935 | | transcriptional regulator | 0.19 | AO353_01705 | | alpha/beta hydrolase | low | > 101 |
| Pseudomonas aeruginosa PA14 | 0.48 | IKLFDK_07850 | | DNA-binding response regulator | 0.19 | IKLFDK_07775 | | alpha/beta hydrolase | low | > 98 |
| Pseudomonas fluorescens FW300-N1B4 | 0.48 | Pf1N1B4_311 | | sensor histidine kinase | 0.19 | Pf1N1B4_3525 | | hydrolase, alpha/beta fold family | low | > 87 |
| Pseudomonas sp. DMC3 | 0.47 | GFF4642 | | Transcriptional regulatory protein KdpE | 0.20 | GFF4803 | | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase | low | > 89 |
| Pseudomonas fluorescens SBW25-INTG | 0.47 | PFLU_RS08245 | | response regulator | 0.21 | PFLU_RS09085 | | alpha/beta fold hydrolase | low | > 109 |
| Pseudomonas orientalis W4I3 | 0.47 | QF045_RS11020 | | response regulator | 0.21 | QF045_RS11720 | | alpha/beta hydrolase | low | > 93 |
| Pseudomonas lactucae CFBP13502 | 0.47 | GEMAOFIL_01790 | | KDP operon transcriptional regulatory protein KdpE | 0.21 | GEMAOFIL_01935 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | low | > 96 |
| Dyella japonica UNC79MFTsu3.2 | 0.47 | ABZR86_RS13215 | | response regulator | 0.16 | ABZR86_RS13395 | | alpha/beta hydrolase | low | > 74 |
| Pseudomonas sp. S08-1 | 0.47 | OH686_01885 | | DNA-binding response regulator KdpE | 0.22 | OH686_01935 | | Hydrolase, alpha/beta fold family | low | > 80 |
| Pseudomonas fluorescens SBW25 | 0.47 | PFLU_RS08245 | | response regulator | 0.21 | PFLU_RS09085 | | alpha/beta fold hydrolase | low | > 109 |
| Pseudomonas sp. BP01 | 0.47 | JOY50_RS07160 | | response regulator | 0.19 | JOY50_RS19195 | | alpha/beta hydrolase | low | > 84 |
| Pseudomonas aeruginosa MRSN321 | 0.47 | DY961_RS19835 | | response regulator | 0.19 | DY961_RS19760 | | alpha/beta fold hydrolase | low | > 100 |
| Pseudomonas simiae WCS417 | 0.47 | PS417_08305 | | transcriptional regulator | 0.20 | PS417_09030 | | alpha/beta hydrolase | low | > 88 |
| Pseudomonas sp. SVBP6 | 0.47 | COO64_RS09705 | | response regulator | 0.18 | COO64_RS19025 | | alpha/beta hydrolase | low | > 93 |
| Pseudomonas segetis P6 | 0.47 | MPMX49_01014 | | Transcriptional regulatory protein KdpE | 0.17 | MPMX49_02680 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | low | > 75 |
| Pseudomonas fluorescens FW300-N2E2 | 0.47 | Pf6N2E2_2490 | | sensor histidine kinase | 0.18 | Pf6N2E2_5880 | | hydrolase, alpha/beta fold family | low | > 103 |
| Pseudomonas fluorescens FW300-N2C3 | 0.47 | AO356_03295 | | transcriptional regulator | 0.18 | AO356_19820 | | alpha/beta hydrolase | low | > 104 |
| Pseudomonas sp. RS175 | 0.47 | PFR28_00943 | | KDP operon transcriptional regulatory protein KdpE | 0.19 | PFR28_03070 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | low | > 88 |
| Pseudomonas putida KT2440 | 0.46 | PP_4157 | | two-component system DNA-binding response activator KdpE | 0.19 | PP_4164 | | Alpha/beta hydrolase | low | > 96 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.46 | Psyr_2051 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | 0.20 | Psyr_2027 | | epoxide hydrolase, Serine peptidase, MEROPS family S33 | low | > 86 |
| Pseudomonas syringae pv. syringae B728a | 0.46 | Psyr_2051 | | Response regulator receiver:Transcriptional regulatory protein, C-terminal | 0.20 | Psyr_2027 | | epoxide hydrolase, Serine peptidase, MEROPS family S33 | low | > 86 |
| Xanthomonas campestris pv. campestris strain 8004 | 0.46 | Xcc-8004.4378.1 | | sensor histidine kinase | 0.21 | Xcc-8004.5207.1 | | 2-hydroxymuconic semialdehyde hydrolase (EC 3.7.1.9) | low | > 74 |
| Pseudomonas fluorescens GW456-L13 | 0.46 | PfGW456L13_2205 | | sensor histidine kinase | 0.19 | PfGW456L13_2052 | | hydrolase, alpha/beta fold family | low | > 87 |
| Cupriavidus basilensis FW507-4G11 | 0.46 | RR42_RS00500 | | transcriptional regulator | 0.13 | RR42_RS06215 | | alpha/beta hydrolase | low | > 128 |
| Ralstonia solanacearum PSI07 | 0.45 | RPSI07_RS09645 | | two-component system response regulator KdpE | 0.12 | RPSI07_RS18520 | | alpha/beta hydrolase | low | > 81 |
| Ralstonia solanacearum IBSBF1503 | 0.45 | RALBFv3_RS07605 | | two-component system response regulator KdpE | 0.13 | RALBFv3_RS14840 | | alpha/beta hydrolase | low | > 76 |
| Ralstonia solanacearum UW163 | 0.45 | UW163_RS06015 | | two-component system response regulator KdpE | 0.13 | UW163_RS12310 | | alpha/beta hydrolase | — | — |
| Ralstonia solanacearum GMI1000 | 0.45 | RS_RS15505 | | two-component system response regulator KdpE | 0.12 | RS_RS05650 | | alpha/beta hydrolase | low | > 80 |
| Lysobacter sp. OAE881 | 0.44 | ABIE51_RS10000 | | response regulator transcription factor | 0.21 | ABIE51_RS01290 | | alpha/beta hydrolase | low | > 62 |
| Ralstonia sp. UNC404CL21Col | 0.44 | ABZR87_RS03270 | | two-component system response regulator KdpE | 0.14 | ABZR87_RS10500 | | alpha/beta hydrolase | low | > 80 |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.43 | GFF4475 | | sensor histidine kinase | 0.12 | GFF278 | | Alpha/beta hydrolase fold | low | > 90 |
| Herbaspirillum seropedicae SmR1 | 0.43 | HSERO_RS18850 | | transcriptional regulator | 0.13 | HSERO_RS16425 | | alpha/beta hydrolase | — | — |
| Shewanella sp. ANA-3 | 0.35 | Shewana3_0059 | | two component transcriptional regulator (RefSeq) | 0.25 | Shewana3_2387 | | alpha/beta hydrolase fold (RefSeq) | low | > 73 |
| Shewanella oneidensis MR-1 | 0.34 | SO0059 | kdpE | transcriptional regulatory protein KdpE (NCBI ptt file) | 0.26 | SO2582 | | hydrolase, alpha/beta fold family (NCBI ptt file) | low | > 76 |
| Alteromonas macleodii MIT1002 | 0.32 | MIT1002_01389 | | KDP operon transcriptional regulatory protein KdpE | 0.23 | MIT1002_02589 | | Tropinesterase | low | > 70 |
Not shown: 55 genomes with orthologs for CSW01_16895 only; 8 genomes with orthologs for CSW01_09910 only