Conservation of cofitness between BNILDI_14455 and BNILDI_19670 in Escherichia coli ECRC62

53 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli ECRC62 1.0 BNILDI_14455 mdtB multidrug efflux RND transporter permease subunit MdtB 1.0 BNILDI_19670 putA trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase 0.69 10
Escherichia coli ECRC99 1.00 KEDOAH_03955 mdtB multidrug efflux RND transporter permease subunit MdtB 1.00 KEDOAH_23140 putA trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase — —
Escherichia coli ECRC102 1.00 NIAGMN_22140 mdtB multidrug efflux RND transporter permease subunit MdtB 1.00 NIAGMN_23730 putA trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase — —
Escherichia coli Nissle 1917 1.00 ECOLIN_RS12200 multidrug efflux RND transporter permease subunit MdtB 1.00 ECOLIN_RS05290 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 55
Escherichia coli ECOR27 1.00 NOLOHH_15540 mdtB multidrug efflux RND transporter permease subunit MdtB 1.00 NOLOHH_21505 putA trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 75
Escherichia coli ECRC98 1.00 JDDGAC_28305 mdtB multidrug efflux RND transporter permease subunit MdtB 1.00 JDDGAC_08215 putA trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 86
Escherichia coli ECRC100 1.00 OKFHMN_24195 mdtB multidrug efflux RND transporter permease subunit MdtB 1.00 OKFHMN_04605 putA trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 80
Escherichia coli ECRC101 1.00 MCAODC_20745 mdtB multidrug efflux RND transporter permease subunit MdtB 1.00 MCAODC_23990 putA trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 87
Escherichia fergusonii Becca 1.00 EFB2_01780 Multidrug resistance protein MdtB 1.00 EFB2_03066 Bifunctional protein PutA low > 86
Escherichia coli BW25113 1.00 b2075 mdtB multidrug efflux system, subunit B (NCBI) 1.00 b1014 putA fused DNA-binding transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase (NCBI) low > 76
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_01629 Multidrug resistance protein MdtB 1.00 OHPLBJKB_02652 Bifunctional protein PutA low > 73
Escherichia coli BL21 0.99 ECD_01980 multidrug efflux system, subunit B 1.00 ECD_01017 fused DNA-binding transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase low > 61
Escherichia coli ECOR38 0.99 HEPCGN_02885 mdtB multidrug efflux RND transporter permease subunit MdtB 0.99 HEPCGN_23535 putA trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 87
Klebsiella michiganensis M5al 0.90 BWI76_RS19255 multidrug transporter subunit MdtB 0.90 BWI76_RS10795 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) (from data) low > 92
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3854 Multidrug transporter MdtB 0.91 GFF3301 Transcriptional repressor of PutA and PutP / Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) 0.45 53
Enterobacter sp. TBS_079 0.89 MPMX20_03061 Multidrug resistance protein MdtB 0.90 MPMX20_01702 Bifunctional protein PutA low > 85
Enterobacter asburiae PDN3 0.89 EX28DRAFT_0483 Cation/multidrug efflux pump 0.91 EX28DRAFT_1911 L-proline dehydrogenase (EC 1.5.99.8)/delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) low > 76
Serratia liquefaciens MT49 0.81 IAI46_18975 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.81 IAI46_15745 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 86
Pantoea sp. MT58 0.80 IAI47_06870 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.81 IAI47_08195 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 76
Erwinia tracheiphila SCR3 0.79 LU632_RS08690 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.77 LU632_RS13740 putA trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 74
Pectobacterium carotovorum WPP14 0.79 HER17_RS06320 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.73 HER17_RS01110 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 75
Dickeya dadantii 3937 0.77 DDA3937_RS15265 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.75 DDA3937_RS20115 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 74
Dickeya dianthicola ME23 0.77 DZA65_RS16165 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.74 DZA65_RS21300 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 75
Dickeya dianthicola 67-19 0.76 HGI48_RS15345 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.74 HGI48_RS20255 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 71
Herbaspirillum seropedicae SmR1 0.68 HSERO_RS07650 multidrug transporter 0.51 HSERO_RS00905 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) (from data) low > 78
Ralstonia solanacearum UW163 0.65 UW163_RS21010 multidrug transporter subunit MdtB 0.67 UW163_RS04885 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase — —
Ralstonia solanacearum IBSBF1503 0.65 RALBFv3_RS18120 multidrug transporter subunit MdtB 0.67 RALBFv3_RS08725 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 76
Ralstonia solanacearum PSI07 0.65 RPSI07_RS05515 multidrug transporter subunit MdtB 0.67 RPSI07_RS08540 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 81
Ralstonia sp. UNC404CL21Col 0.65 ABZR87_RS19025 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.68 ABZR87_RS03970 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 80
Ralstonia solanacearum GMI1000 0.65 RS_RS22915 multidrug transporter subunit MdtB 0.67 RS_RS16540 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 80
Cupriavidus basilensis FW507-4G11 0.64 RR42_RS03310 multidrug transporter 0.69 RR42_RS20125 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) (from data) low > 128
Pseudomonas sp. RS175 0.63 PFR28_02194 Multidrug resistance protein MdtB 0.74 PFR28_05053 Bifunctional protein PutA low > 88
Pseudomonas fluorescens FW300-N2C3 0.62 AO356_25875 multidrug transporter 0.74 AO356_09015 transcriptional regulator low > 104
Rahnella sp. WP5 0.62 EX31_RS13380 MMPL family transporter 0.80 EX31_RS09420 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 89
Pseudomonas putida KT2440 0.62 PP_3584 multidrug efflux transport system - membrane subunit 0.74 PP_4947 proline dehydrogenase/1-pyrroline-5-carboxylate dehydrogenase low > 96
Pseudomonas fluorescens FW300-N2E2 0.62 Pf6N2E2_1272 Acriflavin resistance plasma membrane protein 0.74 Pf6N2E2_3685 Transcriptional repressor of PutA and PutP / Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) low > 103
Pseudomonas sp. S08-1 0.62 OH686_00925 Multidrug efflux system MdtABC-TolC, inner-membrane proton/drug antiporter MdtB (RND type) 0.70 OH686_06735 Transcriptional repressor of PutA and PutP / Proline dehydrogenase / Delta-1-pyrroline-5-carboxylate dehydrogenase low > 80
Pseudomonas fluorescens GW456-L13 0.62 PfGW456L13_3266 Acriflavin resistance plasma membrane protein 0.74 PfGW456L13_223 Transcriptional repressor of PutA and PutP / Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) low > 87
Pseudomonas fluorescens FW300-N2E3 0.62 AO353_22895 multidrug transporter 0.75 AO353_12810 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) (from data) low > 101
Pseudomonas fluorescens SBW25-INTG 0.61 PFLU_RS13430 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.74 PFLU_RS02230 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 109
Pseudomonas fluorescens SBW25 0.61 PFLU_RS13430 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.74 PFLU_RS02230 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 109
Pseudomonas simiae WCS417 0.61 PS417_12745 multidrug transporter 0.74 PS417_02175 transcriptional regulator low > 88
Pseudomonas fluorescens FW300-N1B4 0.61 Pf1N1B4_4665 Acriflavin resistance plasma membrane protein 0.74 Pf1N1B4_1489 Transcriptional repressor of PutA and PutP / Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) low > 87
Paraburkholderia sabiae LMG 24235 0.60 QEN71_RS23305 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.63 QEN71_RS29240 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 153
Paraburkholderia bryophila 376MFSha3.1 0.59 H281DRAFT_06492 multidrug efflux pump 0.63 H281DRAFT_02404 L-proline dehydrogenase /delta-1-pyrroline-5-carboxylate dehydrogenase low > 103
Acidovorax sp. GW101-3H11 0.59 Ac3H11_3618 Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA 0.61 Ac3H11_2850 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) (from data) low > 79
Pseudomonas syringae pv. syringae B728a 0.59 Psyr_2483 Acriflavin resistance protein 0.73 Psyr_0506 L-proline dehydrogenase / delta-1-pyrroline-5-carboxylate dehydrogenase low > 86
Pseudomonas syringae pv. syringae B728a ΔmexB 0.59 Psyr_2483 Acriflavin resistance protein 0.73 Psyr_0506 L-proline dehydrogenase / delta-1-pyrroline-5-carboxylate dehydrogenase low > 86
Burkholderia phytofirmans PsJN 0.58 BPHYT_RS07785 multidrug transporter 0.64 BPHYT_RS19355 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase low > 109
Paraburkholderia graminis OAS925 0.58 ABIE53_001783 multidrug efflux pump 0.59 ABIE53_000244 RHH-type proline utilization regulon transcriptional repressor/proline dehydrogenase/delta 1-pyrroline-5-carboxylate dehydrogenase low > 113
Castellaniella sp019104865 MT123 0.57 ABCV34_RS14620 multidrug efflux RND transporter permease subunit 0.57 ABCV34_RS05285 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase low > 48
Variovorax sp. SCN45 0.56 GFF6659 Multidrug efflux system MdtABC-TolC, inner-membrane proton/drug antiporter MdtB (RND type) 0.61 GFF5175 Transcriptional repressor of PutA and PutP / Proline dehydrogenase (EC 1.5.5.2) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) low > 127
Azospirillum sp. SherDot2 0.53 MPMX19_05477 Multidrug resistance protein MdtB 0.52 MPMX19_05932 Bifunctional protein PutA low > 112
Phaeobacter inhibens DSM 17395 0.13 PGA1_78p00510 multidrug transporter MdtB 0.35 PGA1_c11750 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) (from data) low > 62

Not shown: 12 genomes with orthologs for BNILDI_14455 only; 10 genomes with orthologs for BNILDI_19670 only